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World Journal of Orthopedics 2024年第4期15卷 310-311页

作者： e carlos rodriguez-merchan Department of Orthopedic Surgery La Paz University Hospital-IdiPazMadrid 28046Spain

In this editorial I comment on the article by Ahmed et al published in a recent issue of the World J Orthop 2023;14:*** is well known that patients who have undergone a liver transplant(LT)may need to have a total hip arthroplasty(THA)or total knee arthroplasty(TKA)*** et al stated that the mortality rate in these patients was similar to the one of the general ***,there are three articles previously published that found higher mortality in LT patients who experienced THA/TKA than in the general population(individuals without LT).Therefore,in this editorial I would like to point out that there is controversy in the literature regarding whether LT patients undergoing THA/TKA have higher mortality than the general ***,future research should attempt to resolve this controversy.

关键词： Liver transplant Total knee arthroplasty Total hip arthroplasty Results Mortality

Bridge plating in the setting of radiocarpal instability:Does distal fixation to the second or third metacarpal matter?A cadaveric study

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World Journal of Orthopedics 2023年第4期14卷 207-217页

作者： eloy Tabeayo James M Saucedo Ramesh C Srinivasan Amita R Shah efstathios Karamanos Jason Rockwood e carlos rodriguez-merchan Department of Orthopedic Surgery Albert Einstein College of MedicineMontefiore Medical CenterNew YorkNY 10461United States Houston Methodist Institute for Academic Medicine Houston Methodist Orthopedics and Sports MedicineHoustonTX 77479United States Hand Center of San Antonio and the Department of Orthopedic Surgery University of Texas Health Science CenterThe Hand Center of San AntonioSan AntonioTX 78240United States University of Texas Health Science Center at San Antonio University of North Carolina at Chapel HillSan AntonioTX 78229United States Surgeon in the Division of Acute Care Surgery in the Department of Surgery at Henry Ford Hospital in Detroit UT Health San AntonioSan AntonioTX 78229United States Naval Hospital Yokosuka Yokosuka96350-1600Japan Department of Orthopedic Surgery La Paz University Hospital-IdiPazMadrid 28046Spain

BACKGROUND Radiocarpal dislocations are rare but potentially devastating *** outcomes are associated with inadequate or lost reduction,such as ulnar translocation,but no consensus exists on the ideal fixation *** bridge plate fixation has been described for various settings in the treatment of complex distal radius fractures and can be fixed distally to the second or third metacarpal,but its application for radiocarpal dislocations has not been *** To determine whether distal fixation to the second or third metacarpal *** Using a cadaveric radiocarpal dislocation model,the effect of distal fixation was studied in two stages:(1)A pilot study that investigated the effect of distal fixation alone;and(2)a more refined study that investigated the effect of described techniques for distal and proximal *** were measured in various parameters to determine the quality of the reduction *** The pilot study found that focusing on distal fixation alone without changing proximal fixation results in ulnar translocation and volar subluxation when fixing distally to the second metacarpal compared with the *** second iteration demonstrated that anatomic alignment in coronal and sagittal planes could be achieved with each *** In a cadaveric radiocarpal dislocation model,anatomic alignment can be maintained with bridge plate fixation to the second metacarpal or the third metacarpal if the described technique is *** considering dorsal bridge plate fixation for radiocarpal dislocations,the surgeon is encouraged to understand the nuances of different fixation techniques and how implant design features may influence proximal placement.

关键词： Wrist Instability Bridge plate Dorsal spanning plate Radiocarpal dislocation model Cadaveric study

Foot and ankle surgery:Tourniquet placement site to cause as little postoperative pain as possible

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World Journal of Orthopedics 2024年第6期15卷 498-500页

作者： emerito carlos rodriguez-merchan Department of Orthopedic Surgery La Paz University Hospital-IdiPazMadrid 28046Spain Osteoarticular Surgery Research Hospital La Paz Institute for Health Research-IdiPAZ(La Paz University Hospital-Autonomous University of Madrid)Madrid 28046Spain

There is controversy in the literature on where to place the tourniquet(thigh,calf,ankle)for foot and ankle *** some authors prefer the ankle tourniquet to the calf tourniquet,others state that the surgeon can decide between using the thigh tourniquet or the ankle tourniquet,since there was no difference in postoperative pain between *** to place the tourniquet during foot and ankle surgery to cause the least possible postoperative pain to the patient as a result of the tourniquet is a common question in clinical *** reality is that,unfortunately,there is no consensus on this *** the only possible way to answer this question would be to conduct a comparative study with sufficient statistical power to reach scientifically sound *** does not seem easy to carry out such a study,but it would be important to be able to answer the question posed in the title of this editorial once and for all.

关键词： Surgery Foot Ankle Tourniquet Site Postoperative pain

Orthopedic disorders of the knee in hemophilia:A current concept review

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World Journal of Orthopedics 2016年第6期7卷 370-375页

作者： e carlos rodriguez-merchan Leonard A Valentino Department of Orthopedic Surgery La Paz University Hospital-Idi Paz Rush University Medical Center

The knee is frequently affected by severe orthopedic changes known as hemophilic arthropathy(HA) in patients with deficiency of coagulation factor Ⅷ or Ⅸ and thus this manuscript seeks to present a current perspective of the role of the orthopedic surgeon in the management of these *** factor replacement therapy(FRT) is optimal to prevent HA,however adherence to this regerous treatment is challenging leading to breakthrough *** patients with chronic hemophilic synovitis,the prelude to HA,radiosynovectomy(RS) is the optimal to ameliorate *** in people with hemophilia(PWH) is associated with a high risk of bleeding and infection,and must be performed with FRT.A coordinated effort including orthopedic surgeons,hematologists,physical medicine and rehabilitation physicians,physiotherapists and other team members is key to optimal ***,orthopedic procedures should be performed in specialized hospitals with experienced *** we are able to prevent orthopedic problems of the knee in PWH will have to continue performing orthopedic procedures(arthrocentesis,RS,arthroscopic synovectomy,hamstring release,arthroscopic debridement,alignment osteotomy,and total knee arthroplasty).By using the aforementioned procedures,the quality of life of PWH will be improved.

关键词： Hemophilia Knee Orthopedic problems Prevention Surgical treatment

Avian responses to an extreme weather event:The case of the‘Filomena’snowstorm in Madrid(central Spain)

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Avian Research 2024年第2期15卷 180-186页

作者： carlos Lazaro carlos Sanchez-García Fabian Casas e.Jorge Tizado Department of Research Fundacion Artemisan13001 Ciudad RealSpain Department of Zoology Faculty of SciencesUniversity of GranadaGranadaSpain Department of Biodiversity and environmental Management Universidad de Leon24401 PonferradaSpain

Cold spells and severe weather may have detrimental effects in wild birds,but owing to the stochastic nature of these events,it is not always possible to measure their *** January 2021,a strong snowstorm known as‘Filomena’affected Spain,mainly the region of Madrid(Central Spain),which was fully covered with snow and suffered freezing temperatures for a *** bird surveys conducted in the winter-spring of 2020 and 2021(before and after Filomena)at same locations,we addressed the possible impact of the cold spell in three widespread gamebirds:Wood Pigeon(Columba palumbus),eurasian Magpie(Pica pica)and Red-legged Partridge(Alectoris rufa).No significant abundance differences were found between years for none of the species and hunting pressure was only significantly reduced for Partridges,hence this species may have been negatively affected by *** suggest that in response to Filomena,Pigeons conducted partial migration in search of better conditions,while Magpies aggregated in certain areas of Madrid and Partridges endured the harsh conditions within their home *** results highlight the importance to alleviate negative impacts of extreme weather events in wild birds through management actions,especially for sedentary species.

关键词： Alectoris rufa Climate change Cold spell Columba palumbus Migration Pica pica Winter

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How to fill the biodiversity data gap:Is it better to invest in fieldwork or curation?

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Plant Diversity 2024年第1期46卷 39-48页

作者： carlos A.Vargas Marius Bottin Tiina Sarkinen James e.Richardson Marcela Celis Boris Villanueva Adriana Sanchez Programa de Biología Facultad de Ciencias NaturalesUniversidad del RosarioBogotaD.C.Colombia Subdireccion Científica Jardín Botanico de Bogota“Jose Celestino Mutis”BogotaD.C.Colombia Independent Researcher BogotaD.C.Colombia Tropical Diversity Section Royal Botanic Garden EdinburghUK School of Biological Earth and Environmental SciencesUniversity College CorkCorkIreland Departamento de Química y Biología Universidad del NorteKm.5 Vía Puerto ColombiaArea Metropolitana de Barranquilla 081007Colombia

Data gaps and biases are two important issues that affect the quality of biodiversity information and downstream *** how best to fill existing gaps and account for biases is necessary to improve our current information most *** current main approaches for obtaining and improving data include(1)curation of biological collections,and(2)***,the comparative effectiveness of these approaches in improving biodiversity data remains little *** used the Flora de Bogota project to study the magnitude of change in species richness,spatial coverage,and sample coverage of plant records based on curation versus *** process of curation resulted in a decrease in species richness(synonym and error removal),but it significantly increased the number of records per *** contributed to a slight increase in species richness,via accumulation of new ***,curation led to increases in spatial coverage,species observed by locality,the number of plant records by species,and localities by species compared to ***,curationwas more efficient in producing new information compared to fieldwork,mainly because of the large number of records available in *** recommend intensive curatorial work as the first step in increasing biodiversity data quality and quantity,to identify bias and gaps at the regional scale that can then be targeted with *** stepwise strategy would enable fieldwork to be planned more costeffectively given the limited resources for biodiversity exploration and characterization.

关键词： Colombia Flora de Bogota Sample coverage Species richness Tropical Andes

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Advanced strategies for marine antifouling based on nanomaterial-enhanced functional PDMS coatings

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Nano Materials Science 2024年第4期6卷 375-395页

作者： Xiaohui Shi Hao Wei Wenjun Zhou Paul e.D.Soto rodriguez Cunguo Lin Lei Wang Zhijia Zhang School of Materials Science and Chemical engineering Harbin Engineering University Qingdao Innovation and Development Center of Harbin engineering University State Key Laboratory for Marin Corrosion and Protection Luoyang Ship Material Research Institute (LSMRI) Instituto de estudios Avanzados IUDeA Departamento de Física Universidad de La Laguna C/Astrofísico Francisco Sanchez School of Chemistry and Chemical engineering Harbin Institute of Technology

Marine biofouling seriously affects human marine exploitation and transportation activities, to which marine antifouling(AF) coatings are considered to be the most cost-effective solution. Since the mid-20th century, human beings have dedicated their efforts on developing AF coatings with long cycle and high performance, leading to a large number of non-target organisms? distortion, death and marine environmental pollution. Polydimethylsiloxane(PDMS), is considered as one of the representative environment-friendly AF materials thanks to its non-toxic, hydrophobic, low surface energy and AF properties. However, PDMS AF coatings are prone to mechanical damage, weak adhesion strength to substrate, and poor static AF effect, which seriously restrict their use in the ocean. The rapid development of various nanomaterials provides an opportunity to enhance and improve the mechanical properties and antifouling properties of PDMS coating by embedding *** on our research background and the problems faced in our laboratory, this article presents an overview of the current progress in the fields of PDMS composite coatings enhanced by different nanomaterials, with the discussion focused on the advantages and main bottlenecks currently encountered in this field. Finally, we propose an outlook, hoping to provide fundamental guidance for the development of marine AF field.

关键词： Nanomaterials Antifouling PDMS composites environment-friendly Marine biofouling

Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-Galán Cristina Jiménez-Luna Isabel rodriguez elisabeth Maza carlos García-Collado Antonio Rodríguez-Fernández Javier Luis López-Hidalgo Octavio Caba Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathology and Regenerative Medicine(IBIMeR) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Department of Medicina Nuclear Virgen de las Nieves University HospitalGranada 18014Spain Department of Anatomía Patológica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUND Metastatic pancreatic ductal adenocarcinoma(PDAC)is a lethal malignancy with dispiriting survival *** is a promising approach to many cancer types,but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor *** describe a case of metastatic PDAC effectively treated with *** SUMMARY We report the case of a 67-year-old woman with unresectable locally advanced PDAC,treated with gemcitabine plus nab-paclitaxel followed by radiotherapy plus *** nine months,pancreatic tumor progression was observed at the level of the hepatic hilum with the appearance of a new pulmonary nodule suggestive of a second primary,confirmed by left lung *** immunotherapy was then initiated with pembrolizumab,an immune checkpoint inhibitor targeting programmed cell death protein-1 that covers the two tumor *** patient showed a complete metabolic response that was maintained throughout the *** patient continues to be disease-free at 5.6 years since the start of *** These results suggest that the administration of pembrolizumab after chemoradiotherapy has a beneficial effect in patients with metastatic *** our knowledge,this is the first reported case of a patient with metastatic PDAC and metastatic lung cancer showing such a long-lasting complete response after pembrolizumab treatment without curative *** studies are required to determine biomarkers that identify PDAC patients most likely to benefit from this immunotherapy.

关键词： Pancreatic ductal adenocarcinoma Lung cancer Immunotherapy Pembrolizumab Programmed cell death protein-1 Case report

Identific tion of quantitative trait loci and associated candidate genes for pregnancy success in Angus–Brahman crossbred heifers

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Journal of Animal Science and Biotechnology 2024年第1期15卷 162-170页

作者： Quinn A.Hoorn Gabriel A.Zayas eduardo e.rodriguez Laura M.Jensen Raluca G.Mateescu Peter J.Hansen Department of Animal Sciences Donald Henry Barron Reproductive and Perinatal Biology Research Programand the Genetics InstituteUniversity of FloridaGainesvilleFLUSA School of Applied Systems Biology La Trobe UniversityBundooraVIC 3083Australia

Background In beef cattle, more than 50% of the energy input to produce a unit of beef is consumed by the female that produced the calf. Development of genomic tools to identify females with high genetic merit for reproductive function could increase the profitability and sustainability of beef *** Genome-wide association studies(GWAS) were performed using a single-step genomic best linear unbiased prediction approach on pregnancy outcome traits from a population of Angus–Brahman crossbred heifers. Furthermore, a validation GWAS was performed using data from another farm. Heifers were genotyped with the Bovine GGP F250 array that contains 221,077 SNPs. In the discovery population, heifers were bred in winter breeding seasons involving a single round of timed artificial insemination(AI) followed by natural mating for 3 months. Two phenotypes were analyzed: pregnancy outcome to first-service AI(PAI;n = 1,481) and pregnancy status at the end of the breeding season(PeBS;n = 1,725). The heritability was estimated as 0.149 and 0.122 for PAI and PeBS, respectively. In the PAI model, one quantitative trait locus(QTL), located between 52.3 and 52.5 Mb on BTA7, explained about 3% of the genetic variation, in a region containing a cluster of γ-protocadherin genes and SLC25A2. Other QTLs explaining between 0.5% and 1% of the genetic variation were found on BTA12 and 25. In the PeBS model, a large QTL on BTA7 was synonymous with the QTL for PAI, with minor QTLs located on BTA5, 9, 10, 11, 19, and 20. The validation population for pregnancy status at the end of the breeding season were Angus–Brahman crossbred heifers bred by natural mating. In concordance with the discovery population, the large QTL on BTA7 and QTLs on BTA10 and 12 were *** In summary, QTLs and candidate SNPs identified were associated with pregnancy outcomes in beef heifers, including a large QTL associated with a group of protocadherin genes. Confirmation of these associations

关键词： Beef cattle Fertility GWAS QTL

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Deforestation in Latin America in the 2000s predominantly occurred outside of typical mature forests

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The Innovation 2024年第3期5卷 88-98页

作者： Zhiyu Zhang Wenjian Ni Shaun Quegan Jingming Chen Peng Gong Luiz carlos estraviz rodriguez Huadong Guo Jiancheng Shi Liangyun Liu Zengyuan Li Yating He Qinhuo Liu Yosio Shimabukuro Guoqing Sun Key Laboratory of Remote Sensing and Digital earth Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Shijingshan DistrictBeijing 100049China Chinal of Mathematics and Statistics University of SheffieldSheffield S37RHUK Department of Geography and Program in Planning University of TorontoTorontoON M5S 3G3Canada Department of earth Sciences and Department of Geography University of Hong KongHong KongChina Forest Science Department Luiz de Queiroz College of AgricultureUniversity of São PauloAv.Pádua Dias11Piracicaba 13418-900Brazil National Space Science Center Chinese Academy of SciencesBeijing 100190China Institute of Forest Resource Information Techniques Chinese Academy of ForestryBeijing 100091China Research Institute of Forest Policy and Information Chinese Academy of ForestryBeijing 100091China Remote Sensing Department National Institute for Space Research(INPE)Av.dos Astronautas 1758São Josédos Campos 12227-010Brazil Department of Geographical Sciences University of MarylandCollege ParkMD 20742USA

The role of tropical forests in the global carbon budget remains controversial,as carbon emissions from deforestation are highly *** high uncertainty arises from the use of either fixed forest carbon stock density or maps generated from satellite-based optical reflectance with limited sensitivity to biomass to generate accurate estimates of emissions from *** space missions aiming to accurately map the carbon stock density rely on direct measurements of the spatial structures of forests using lidar and *** found that lost forests are special cases,and their spatial structures can be directly measured by combining archived data acquired before and after deforestation by space missions principally aimed at measuring ***,using biomass mapping,we obtained new estimates of carbon loss from deforestation ahead of forthcoming space ***,using a high-resolution map of forest loss and the synergy of radar and lidar to estimate the aboveground biomass density of forests,we found that deforestation in the 2000s in Latin America,one of the severely deforested regions,mainly occurred in forests with a significantly lower carbon stock density than typical mature forests.

关键词： forest Latin lidar