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An efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng e Qian He Nanyang Wang Hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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Optimal timing and route of nutritional support after esophagectomy: A review of the literature

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World Journal of Gastroenterology 2019年第31期25卷 4427-4436页

作者： Richard Zheng Courtney L Devin Michael J Pucci Adam C Berger ernest L rosato Francesco Palazzo Department of Surgery Thomas Jefferson University Hospital.Sidney Kimmel Medical College Philadelphia University and Thomas Jefferson University

Some controversy surrounds the postoperative feeding regimen utilized in patients who undergo *** in practices during the perioperative period exists including the type of nutrition started,the delivery route,and its *** nutrition is essential for this patient population as these patients often present with weight loss and have altered eating patterns after surgery,which can affect their ability to regain or maintain *** of feeding after an esophagectomy include total parenteral nutrition,nasoduodenal/nasojejunal tube feeding,jejunostomy tube feeding,and oral *** evidence suggests that early oral feeding is associated with shorter LOS,faster return of bowel function,and improved quality of *** recovery pathways after surgery pathways after esophagectomy with a component of early oral feeding also seem to be safe,feasible,and cost-effective,albeit with limited ***,data on anastomotic leaks is mixed,and some studies suggest that the incidence of leaks may be higher with early oral *** risk of anastomotic leak with early feeding may be heavily modulated by surgical *** definitive data is currently available to definitively answer this question,and further studies should look at how these early feeding regimens vary by surgical *** review aims to discuss the existing literature on the optimal route and timing of feeding after esophagectomy.

关键词： esophagectomy Oral feeding early feeding Delayed feeding enteral nutrition esophageal cancer Jejunostomy tube Postoperative complications

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Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： eunhee Kim Rudolph eTanzi Se Hoon Choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

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Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAeI H.GHANDVAR e.JUMAeV S.KHATIR T.CUONG-Le School of Mechanical engineering Babol Noshirvani University of Technology Department of Mechanical engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for engineering Application and Technology Solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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Long-term survival of occult hepatitis B associated hepatocellular carcinoma following surgery and antiviral therapy

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Hepatoma Research 2020年第8期6卷 29-35页

作者： Tina Boortalary ernest rosato Christopher Roth Xiangdong David Ren Selena YLin Hie-Won Hann Department of Medicine Thomas Jefferson University HospitalPhiladelphiaPA 19107USA Department of Surgery Thomas Jefferson University HospitalPhiladelphiaPA 19107USA Department of Radiology Thomas Jefferson University HospitalPhiladelphiaPA 19107USA Reniguard Life Sciences Inc. MalvernPA 19355USA JBS Science Inc.DoylestownPA 18902USA Division of Liver Disease Prevention Center Division of Gastroenterology and HepatologyThomas Jefferson University HospitalPhiladelphiaPA 19107USA.

Occult hepatitis B infection(OBI)is characterized by absent hepatitis B surface antigen(HBsAg),low or undetectable serum hepatitis B viral DNA(HBV-DNA),and detectable DNA in the *** is debate over whether OBI increases the risk of hepatocellular carcinoma(HCC).We present a patient with negative HBsAg and a large HCC tumor who underwent a large right hepatic ***,the etiology of HCC was unknown,but through more sensitive molecular testing,it was believed to be due to *** this case report,we discuss the patient’s clinical course,the effect of antiviral therapy,mechanism of carcinogenesis in OBI,and the need for more rigorous HBV DNA assay testing for the detection of OBI.

关键词： Occult hepatitis B infection OBI-associated HCC HBsAg negative HCC

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Men Should Beware of the 'Andropause'

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当代外语研究 2001年第2期 10-14页

作者： Bill rosato 董游颐

生老病死,凡人皆不可抗拒,其中也包括性功能的衰退。女性在进入更年期后会出现绝经,类似地,男性也会出现“绝精”。在这些难以启齿的生理变化面前,似乎男性更倾向于回避。但专家提醒:不可掉以轻心!注意学习标题里的andropause,它是由两... 详细信息

生老病死,凡人皆不可抗拒,其中也包括性功能的衰退。女性在进入更年期后会出现绝经,类似地,男性也会出现“绝精”。在这些难以启齿的生理变化面前,似乎男性更倾向于回避。但专家提醒:不可掉以轻心!注意学习标题里的andropause,它是由两个词拼缀而成:andro(精子)+pause卵(终止)】

关键词： TRT Andropause Men Should Beware of the 更年期

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Co-encapsulation of curcumin and doxorubicin in albumin nanoparticles blocks the adaptive treatment tolerance of cancer cells

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Biophysics Reports 2019年第1期5卷 19-30页

作者： Seyed Mohammad Motevalli Ahmed Shaker eltahan Lu Liu Andrea Magrini Nicola rosato Weisheng Guo Massimo Bottini Xing-Jie Liang CAS Key Laboratory for Biomedical effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China University of Chinese Academy of Sciences Department of experimental Medicine University of Rome Tor Vergata Department of Biomedicine and Prevention University of Rome Tor Vergata Nanoscience & Nanotechnology & Innovative Instrumentation (NAST) Centre University of Rome Tor Vergata Inflammatory and Infectious Disease Center Sanford-Burnham Medical Research Institute

The adaptive treatment tolerance(ATT) of cancer cells is the main encumbrance to cancer chemotherapy.A potential solution to this problem is to treat cancer cells with multiple drugs using nanoparticles(NPs).In this study, we tested the co-administration of curcumin(Cur) and doxorubicin(Dox) to MCF-7 resistant breast cancer cells to block the ATT and elicit efficient cell killing. Drugs were co-administered to cells both sequentially and simultaneously. Sequential drug co-administration was carried out by pre-treating the cells with albumin nanoparticles(ANPs) loaded with Cur(Cur@ANPs) followed by treatment with Dox-loaded ANPs(Dox@ANPs). Simultaneous drug co-administration was carried out by treating the cells with ANPs loaded with both the drugs(Cur/Dox@ANPs). We found that the simultaneous drug co-administration led to a greater intra-cellular accumulation of Dox and cell killing with respect to the sequential drug co-administration. However, the simultaneous drug co-administration led to a lower intracellular accumulation of Cur with respect to the sequential drug co-administration. We showed that this result was due to the aggregation and entrapment of Cur in the lysosomes as soon as it was released from Cur@ANPs, a phenomenon called lysosomotropism. In contrast, the simultaneous release of Dox and Cur from Cur/Dox@ANPs into the lysosomes led to lysosomal p H elevation, which, in turn, avoided Cur aggregation, led to lysosome swelling and drug release in the cytosol, and finally provoked efficient cell killing. Our study shed the light on the molecular processes driving the therapeutic effects of anti-cancer drugs co-administered to cancer cells in different manners.

关键词： Albumin nanoparticles Doxorubicin Curcumin P-glycoprotein Lysosomal pH

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Hyaluronan is a natural and effective immunological adjuvant for protein-based vaccines

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Cellular & Molecular Immunology 2021年第5期18卷 1197-1210页

作者： Anna Dalla Pietà Debora Carpanese Antonella Grigoletto Anna Tosi Silvia Dalla Santa Gabriel Kristian Pedersen Dennis Christensen Laura Meléndez-Alafort Vito Barbieri Paola De Benedictis Gianfranco Pasut Isabella Monia Montagner Antonio rosato Department of Surgery Oncology and GastroenterologyUniversity of PaduaPaduaItaly Veneto Institute of Oncology IOV-IRCCS PaduaItaly Department of Pharmaceutical and Pharmacological Sciences University of PaduaPaduaItaly Center for Vaccine Research Statens Serum InstitutCopenhagenDenmark FAO and National Reference Centre for Rabies Istituto Zooprofilattico Sperimentale delle VenezieLegnaroPDItaly

One of the main goals of vaccine research is the development of adjuvants that can enhance immune responses and are both safe and *** explored the application of the natural polymer hyaluronan(HA)as a promising immunological adjuvant for protein-based *** conjugation of HA to antigens strongly increased their immunogenicity,reduced booster requirements,and allowed antigen dose ***-based bioconjugates stimulated robust and long-lasting humoral responses without the addition of other immunostimulatory compounds and proved highly efficient when compared to other *** to its intrinsic biocompatibility,HA allowed the exploitation of different injection routes and did not induce inflammation at the inoculation *** polymer promoted rapid translocation of the antigen to draining lymph nodes,thus facilitating encounters with antigen-presenting ***,HA can be regarded as an effective and biocompatible adjuvant to be exploited for the design of a wide variety of vaccines.

关键词： Hyaluronan natural polymer immunological adjuvant HA-bioconjugate vaccines

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Correction:Deep Learning-enhanced Brain Tumor Prediction via entropy-Coded BPSO in CIeLAB Color Space

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Computers, Materials & Continua 2025年第1期82卷 1461-1461页

作者： Mudassir Khalil Muhammad Imran Sharif Ahmed Naeem Muhammad Umar Chaudhry Hafiz Tayyab Rauf Adham e.Ragab Department of Computer engineering Bahauddin Zakariya UniversityMultan60000Pakistan Department of Computer Science Kansas State UniversityManhattanKS 66506USA Department of Computer Science University of Management and TechnologyLahore54000Pakistan Independent Researcher BradfordBD80HSUK Industrial engineering Department Collage of EngineeringKing Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia

In the article“Deep Learning-enhanced Brain Tumor Prediction via entropy-Coded BPSO in CIeLAB Color Space”by Mudassir Khalil,Muhammad Imran Sharif,Ahmed Naeem,Muhammad Umar Chaudhry,Hafiz Tayyab Rauf,Adham *** Computers,Materials&Continua,2023,Vol.77,No.2,pp.2031–***:10.32604/cmc.2023.043687,URL:https://***/cmc/v77n2/54831,there was an error regarding the affiliation for the author Hafiz Tayyab *** of“Centre for Smart Systems,AI and Cybersecurity,Staffordshire University,Stoke-on-Trent,ST42De,UK”,the affiliation should be“Independent Researcher,Bradford,BD80HS,UK”.

关键词： Deep Code CIeLAB

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A pharmacologist's journey in medical education:a personal history

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Acta Pharmacologica Sinica 2004年第9期25卷 102-106页

作者： e e DANIeL AB T6G 2H7 Canada Department of Pharmacology Room 9-10 edmonton MSB University of Alberta

My journey as an educator in Pharmacology began in 1949, when, after finishing my MA in Biology at Johns Hopkins, Ⅰ decided that Ⅰ wanted to be involved in science with more relevance to humans. Ⅰhad been chasing f... 详细信息

关键词： ACe A pharmacologist’s journey in medical education

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