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A semi-empirical model for top-down cracking depth evolution in thick asphalt pavements with open-graded friction courses

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Journal of Traffic and Transportation engineering(english edition) 2022年第2期9卷 244-260页

作者： Francesco Canestrari Lorenzo paolo Ingrassia Amedeo Virgili Dipartimento di Ingegneria Civile Edile e Architettura(DICEA)UniversitàPolitecnica delle MarcheAncona 60131Italy

Thick asphalt pavements with open-graded friction course(OGFC) are exposed to topdown cracking(TDC), a distress consisting of longitudinal cracks that initiate on the pavement surface close to the wheel path and propagate downwards. The main objective of this study is to develop a semi-empirical model for the prediction of TDC depth evolution for such pavements. For this purpose, a series of cores were taken from different Italian motorway pavements affected by TDC and analyzed in the laboratory. Cracked cores taken from the wheel path area were analyzed to determine TDC depth, whereas intact cores taken from the middle of the lane(not affected by traffic loadings) were tested to obtain the volumetric and mechanical properties of the OGFC mixture. The proposed model, developed on the basis of the results already available in literature and on the findings of the laboratory investigation, predicts the evolution of TDC depth as a function of the applied traffic loadings(in terms of 12-ton fatigue equivalent single axle loads, i.e., eSALs). The model is sigmoidal with a maximum TDC depth assumed equal to 150 mm. The shape parameter of the sigmoidal function depends on the indirect tensile strength(ITS) of the OGFC mixtures(which takes into account indirectly also the volumetrics and stiffness of the OGFC), whereas the evolutive translation factor depends on the age of the OGFC mixture. After excluding some outliers, the model was able to predict the measured TDC depth very well. Moreover, in-situ observations allowed a preliminary validation of the proposed model. This model can be used in pavement management systems(PMSs) to plan surface repairs due to TDC in a timely manner, thus minimizing pavement damage and maintenance costs.

关键词： Top-down cracking(TDC) Asphalt pavement Open-graded friction course(OGFC) Porous asphalt(PA) Pavement management system(PMS) Modelling

The Literati＇s Polyphonic Answers to Social Changes in Late Imperial China

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Frontiers of History in China 2017年第3期12卷 357-432页

作者： paolo Santangelo Department of Asian and Oriental Studies La Sapienza University of Rome 00185 Rome Italy

The article aims to rethink the pluralistic intellectual currents and social changes of the last centuries in China： How literati reacted to the historical changes, the economic developments, the collapse of the hierarchical order, and the social mobility from the end of the Ming to the middle of the Qing dynasty. Urbanisation, the great silver inflow, the acceleration of trade, and social mobility raised new challenges to the orthodox view of the world and to Neo-Confucian norms. These new attitudes of the Chinese literati--which can be inferred both from literary and philosophical works--uncover new attitudes in the mental structure of the intellectual strata of the time. In the history of ideas we notice a progressive detachment from the orthodox view of the conflictual relationship between principle and desires, especially in the ambit of the Taizhou school. The elaboration of a new anthropological mindset aimed at the rehabilitation of passions and desires culminated with Li Zhi. This trend went on in the Qing period, from Wang Fuzhi to Dai Zhen. In literature, a similar trend, the so-called ＂cult of qing,＂ can be found with the moral justification of emotion-desire （establishing emotion as a genuine and active source of virtue）, and with the vitalistic identification of emotions as the source of life and reproduction. Another indication of change is the challenge of common and accepted truisms through the praise of ＂folly＂ in real life situations and literary works： To be ＂crazy＂ and ＂foolish＂ became a sign of distinction among certain intellectual circles, in contrast with the pedant orthodox scholars and officials and the vulgar nouveaux ziches. The unconventional character of the anti-hero Baoyu is emblematic, with his aversion for any kind of official ceremony and convention, his abnormal sensibility and impractical and naive mentality, and his consciousness of being different from others. The crisis of the established ladder of values can be seen in the e

关键词： literati modemisation desires and principles Li Zhi cult of qing,foolishness Yuan Mei retribution human responsibility

Biocompatible and Bioeliminable Hydrophilic Polymers

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复旦学报（自然科学版） 2007年第5期46卷 607-609页

作者： paolo FerrutiUniversità degli Studi di Milano Dipartimento di Chimica Organica e Industriale via Venezian 2120133 MilanoItalia

1 Introduction This presentation will report on some recent results obtained in Milan on two polymer families of biomedical interest, namely poly(N-vinyl-2-pyrrolidinone) and polyamidoamines. 2 Results and DiscussionPoly(N-vinyl-2-pyrrolidinone) (PVP) is a well known bioactive and biocompatible polymer. In its soluble form, it is largely used as excipient of oral pharmaceutical formulations, especially for its high water solubilising *** its crosslinked form, it plays a relevant role as biomateria...

关键词： poly(N-vinyl-2-pyrrolidinone)(PVP) polyamidoamines polymer

Clinical significance of erectile dysfunction developing after acute coronary event： exception to the rule or confirmation of the artery size hypothesis？

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Asian Journal of Andrology 2015年第1期17卷 21-25,I0006页

作者： Piero Montorsi paolo M Ravagnani Charalambos Vlachopoulos Department of Clinical Sciences and Community Health Cardiovascular Section University of Milan Centro Cardiologico Monzino IRCCS Milan Italy Department of Cardiology Athens Medical School Greece.

erectile dysfunction （eD） has been found to frequently precedes the onset of coronary artery disease （CAD）, representing an early marker of subclinical vascular disease, included CAD. Its recognition is, therefore, a ＂window opportunity＂ to prevent a coronary event by aggressive treatment of cardiovascular risk factors. The artery size hypothesis （ASH） has been proposed as a putative mechanism to explain the relationship between eD and CAD. Since atherosclerosis is a systemic disorder all major vascular beds should be affected to the same extent. However, symptoms at different points in the system rarely become evident at the same time. This is likely the result of smaller vessels （i.e. the penile artery） being able to less well tolerate the same amount of plaque when compared with larger ones （i.e. the coronary artery）. If true, eD will develop before CAD. We present a case in which eD developed after a coronary event yet before a coronary recurrence potentially representing a late marker of vascular progression. Reasons for this unusual sequence are discussed as they might still fit the ASH.

关键词： artery size hypothesis coronary artery disease erectile dysfunction

Study of the robustness of a low-temperature dual-pressure process for removal of CO2 from natural gas

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Frontiers of Chemical Science and engineering 2018年第2期12卷 209-225页

作者： Stefania Moioli Laura A. Pellegrini paolo Vergani Fabio Brignoli Department of Chemistry Materials and Chemical Engineering "G. Natta" Politecnico di Milano Piazza Leonardo da Vinci 32 1-20133 Milano Italy Maire Tecnimont S.p.A. Via Gaetano De Castillia 6/A 1-20124 Milano Italy

The growing use of energy by most of world population and the consequent increasing demand for energy are making unexploited low quality gas reserves interesting from an industrial point of view. To meet the required specifications for a natural gas grid, some compounds need to be removed from the sour stream. Because of the high content of undesired compounds （i.e., CO2） in the stream to be treated, traditional purification processes may be too energy intensive and the overall system may result unprofitable, therefore new technologies are under study. In this work, a new process for the purification of natural gas based on a low temperature distillation has been studied, focusing on the dynamics of the system. The robustness of the process has been studied by dynamic simulation of an industrial-scale plant, with particular regard to the performances when operating conditions are changed. The results show that the process can obtain the methane product with a high purity and avoid the solidification of carbon dioxide.

关键词： CO2 capture innovative process cryogenic distillation dynamic simulation solid-liquid-vapor equilibrium

Comparison of smart panels for tonal and broadband vibration and sound transmission active control

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International Journal of Smart and Nano Materials 2020年第4期11卷 431-484页

作者： paolo Gardonio emanuele Turco Loris Dal Bo Dipartimento Politecnico Di Ingegneria e Architettura UniversitàDegli Studi Di UdineUdineItaly

This paper presents a comprehensive overview of the principal features of smart panels equipped with feed-forward and feedback systems for the control of the flexural response and sound transmission due respectively to tonal and to stochastic broadband *** smart panels are equipped with two types of actuators:first,distributed piezoelectric actuators formed either by small piezoelectric patches or large piezoelectric films bonded on the panels and second,point actuators formed by proof-mass electromagnetic ***,the panels encompass three types of sensors:first,small capacitive microphone sensors placed in front of the panels;second,distributed piezoelectric sensors formed by large piezoelectric films bonded on the panels and third point sensors formed by miniaturized *** proposed systems implement both single-channel and multi-channel feed-forward and feedback control *** study shows that,the vibration and sound radiation control performance of both feed-forward and feedback systems critically depends on the sensor-actuator configurations.

关键词： Active structural acoustic control active vibration control feed-forward control feedback control piezoelectric transducers proof-mass electromagnetic actuators

Sigma-1 receptor and neuroprotection:current outlook and potential therapeutic effects

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Neural Regeneration Research 2016年第9期11卷 1392-1393页

作者： Giovanni Li Volti paolo Murabito Department of Biomedical and Biotechnological Sciences University of Catania Azienda Ospedaliera Universitaria Policlinico "G. Rodolico" University of Catania

Oxidative stress plays a major role in neurodegenerative disease since central nervous system is particularly vul- nerable to reactive oxygen species （ROS） due to several reasons： high consumption ROS and nitrosative species, of O2; high production of which originate from spe- cific neurochemical reactions （e.g., dopamine oxidation）; high deposition of metal ions in the brain with aging leading to Fenton＇s reactions; high abundance of lipids which are particularly sensitive to oxidation.

关键词： MCAO Sigma-1 receptor and neuroprotection

Productive and physiological implications of top-dress addition of branched-chain amino acids and arginine on lactating sows and offspring

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Journal of Animal Science and Biotechnology 2023年第3期14卷 1080-1101页

作者： Diana Luise Federico Correa Claudio Stefanelli Aude Simongiovanni Tristan Chalvon-Demersay Maddalena Zini Luciano Fusco paolo Bosi paolo Trevisi Department of Agricultural and Food Sciences University of Bologna40127 BolognaItaly Department for Life Quality Studies Alma Mater StudiorumUniversity of Bologna47921 RiminiItaly Metex Noovistago 32 Rue Guersant75017 ParisFrance Department of Biomedical and Neuromotor Sciences Alma Mater StudiorumUniversity of Bologna40126 BolognaItaly Freelancer Reggio nell’EmiliaItaly.

Background Branched-chain amino acids(BCAAs),including L-leucine(L-Leu),L-isoleucine(L-Ile),L-valine(L-Val),and L-arginine(L-Arg),play a crucial role in mammary gland development,secretion of milk and regulation of the catabolic state and immune response of lactating ***,it has recently been suggested that free amino acids(AAs)can also act as microbial *** study aimed at evaluating whether the supplementation of lactating sows with BCAAs(9,4.5 and 9 g/d/sow of L-Val,L-Ile and L-Leu,respectively)and/or L-Arg(22.5 g/d/sow),above the estimated nutritional requirement,could influence the physiological and immunological parameters,microbial profile,colostrum and milk composition and performance of sows and their *** At d 41,piglets born from the sows supplemented with the AAs were heavier(P=0.03).The BCAAs increased glucose and prolactin(Pe sows’serum at d 27,tended to increase immunoglobulin A(IgA)and IgM in the colostrum(P=0.06),increased the IgA(P=0.004)in the milk at d 20 and tended to increase lymphocyte%in the sows’blood at d 27(P=0.07).Furthermore,the BCAAs tended to reduce the Chao1 and Shannon microbial indices(Pe sows’*** BCAA group was discriminated by Prevotellaceae_UCG-004,erysipelatoclostridiaceae UCG-004,the Rikenellaceae_RC9_gut_group and *** reduced piglet mortality pre-(d 7,d 14)and post-weaning(d 41)(Permore,Arg increased the IgM in the sow serum at d 10(P=0.05),glucose and prolactin(Pe sow serum at d 27 and the monocyte percentage in the piglet blood at d 27(P=0.025)and their jejunal expression of NFKB2(P=0.035)while it reduced the expression of GPX-2(P=0.024).The faecal microbiota of the sows in Arg group was discriminated by *** combination of BCAAs and Arg tended to increase spermine at d 27(P=0.099),tended to increase the Igs(IgA and IgG,Pe milk,favoured the faecal colonisation of Oscillospiraceae UCG

关键词： Microbiota Post-weaning mortality Prolactin Sows diet

Seasonal variance in P system models for metapopulations

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Progress in Natural Science:Materials International 2007年第4期17卷 392-400页

作者： Daniela Besozzi paolo Cazzaniga Dario Pescini Giancarlo Mauri Università degli Studi di Milano Dipartimento di Informatica e ComunicazioneVia Comelico 3920135 MilanoItaly Università degli Studi di Milano-Bicocca Dipartimento di InformaticaSistemistica e ComunicazioneVia Bicocca degli Arcimboldi 820126 MilanoItaly

Metapopulations are ecological models describing the interactions and the behavior of populations living in fragmented habitats. In this paper, metapopulations are modelled by means of dynamical probabilistic P systems, where additional structural features have been defined (e.g., a weighted graph associated with the membrane structure and the reduction of maximal parallelism). In particular, we investigate the influence of stochastic and periodic resource feeding processes, owing to seasonal variance, on emergent metapopulation dynamics.

关键词： P system metapopulation stochastic ecological model.