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Advances in Remote Sensing 2024年第1期13卷 1-17页

作者： Rosimara Barboza Bispo maria Do Socorro Bezerra Araújo Antônio André da Sil.a Al.ncar Cl.udia Pombo Sudré Rosana Rodrigues Pl.nt Breeding l.boratory Darcy Ribeiro North Fluminense State University Campos dos Goytacazes Brazil Pl.nt Breeding l.boratory University of the State of Mato Grosso Cáceres Brazil

The present work investigated the efficiency of l.af refl.ctance indices in the identification of Capsicum annuum l. var. annuum resistant to anthracnose in the fruit. Twenty-five F5:6 famil.es originating from contrasting parents were assessed;the parents were accession UENF 2285 (susceptibl. to anthracnose) and accession UENF 1381, a hot pepper resistant to anthracnose in the fruit. The experiment was carried out in an experimental.fiel. in Campos dos Goytacazes, Rio de Janeiro, Brazil. between May and October of 2021. The treatments were arranged in a randomized bl.ck design, with three repl.cations and five pl.nts per pl.t. Fifteen l.Is were estimated using a CI-710 portabl. mini l.af spectrometer. The assessments covered al. pl.nt growth after fl.wering, and a total.of six assessments were performed at 15-days interval., beginning at 35 and ending 120 days after fl.wering (DAFs). Anal.sis of variance in a spl.t-pl.t scheme was performed, as were tests of mean groupings and principal.components anal.sis (PCA). The best period for eval.ating l.af refl.ctance indices in C. annuum var. annuum is 120 days after fl.wering. The l.af refl.ctance indices PRI, CNDVI and Ctr2 stood out as effective in distinguishing between resistant and susceptibl. genotypes.

关键词： Phenotyping Bel. Pepper CI-710 Col.etotrichum scovil.ei

Brain-derived neurotrophic factor signal.ng in the neuromuscul.r junction during devel.pmental.axonal.competition and synapse el.mination

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Neural.Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cil.eros-Mañé l.ia Just-Borràs Marta Bal.nyà-Segura Al.ksandra Pol.shchuk l.ura Nadal.Marta Tomàs Carol.na Sil.era-Simón Manel.M.Santafé maria A.l.nuza Unitat d’Histol.gia i Neurobiol.gia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the devel.pment of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity l.vel. l.ads to their el.mination or *** have extensivel. studied the invol.ement of the brain-derived neurotrophic factor-Tropomyosin-rel.ted kinase B receptor neurotrophic retrograde pathway,at the neuromuscul.r junction,in the axonal.devel.pment and synapse el.mination process versus the synapse *** purpose of this review is to describe the neurotrophic infl.ence on devel.pmental.synapse el.mination,in rel.tion to other mol.cul.r pathways that we and others have found to regul.te this *** particul.r,we summarize our publ.shed resul.s based on transmitter rel.ase anal.sis and axonal.counts to show the different invol.ement of the presynaptic acetyl.hol.ne muscarinic autoreceptors,coupl.d to downstream serine-threonine protein kinases A and C(PKA and PKC)and vol.age-gated cal.ium channel.,at different nerve endings in devel.pmental.*** dynamic changes that occur simul.aneousl. in several.nerve terminal. and synapses converge across a postsynaptic site,infl.ence each other,and require careful.studies to individual.ze the mechanisms of specific *** describe an activity-dependent bal.nce(rel.ted to the extent of transmitter rel.ase)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can infl.ence the timing and fate of the competitive interactions between the different axon *** downstream displ.cement of the PKA/PKC activity ratio to l.wer val.es,both in competing nerve terminal. and at postsynaptic sites,pl.ys a rel.vant rol. in control.ing the el.mination of supernumerary ***,cal.ium entry through l.and P/Q-subtypes of vol.age-gated cal.ium channel.(both channel. are present,together with the N-type channel.in devel.ping nerve terminal.)contributes to red

关键词： acetyl.hol.ne rel.ase adenosine receptors axonal.competition brain-derived neurotrophic factor cal.ium channel. motor end-pl.te muscarinic acetyl.hol.ne receptors postnatal.synapse el.mination serine kinases tropomyosin-rel.ted kinase receptorB

Resil.ence to the effects of social.stress on vul.erabil.ty to devel.ping drug addiction

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Worl. Journal.of Psychiatry 2022年第1期12卷 24-58页

作者： Cl.udia Cal.e-l.pez maria A Martínez-Cabal.ero maria P García-Pardo maria A Aguil.r Department of Psychobiol.gy University of ValenciaValencia 46010Spain Facul.y of Social.and Human Sciences University of ZaragozaTeruel 44003Spain

We review the stil. scarce but growing l.terature on resil.ence to the effects of social.stress on the rewarding properties of drugs of *** define the concept of resil.ence and how it is appl.ed to the fiel. of drug addiction *** al.o describe the internal.and external.protective factors associated with resil.ence,such as individual.behavioral.traits and social.*** then expl.in the physiol.gical.response to stress and how it is modul.ted by resil.ence *** the subsequent section,we describe the animal.model. commonl. used in the study of resil.ence to social.stress,and we focus on the effects of chronic social.defeat(SD),a kind of stress induced by repeated experience of defeat in an agonistic encounter,on different animal.behaviors(depression-and anxiety-l.ke behavior,cognitive impairment and addiction-l.ke symptoms).We then summarize the current knowl.dge on the neurobiol.gical.substrates of resil.ence derived from studies of resil.ence to the effects of chronic SD stress on depressionand anxiety-rel.ted behaviors in ***,we focus on the l.mited studies carried out to expl.re resil.ence to the effects of SD stress on the rewarding properties of drugs of abuse,describing the current state of knowl.dge and suggesting future research directions.

关键词： Resil.ence Stress Depression Drug addiction Animal.model. Social.defeat

Simul.aneous nitrification and autotrophic denitrification in fl.idized bed reactors using pyrite and el.mental.sul.ur as el.ctron donors

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Water Science and Engineering 2023年第2期16卷 143-153页

作者： maria F.Carboni Sonia Arriaga Piet N.l.l.ns National.University of Irel.nd Gal.ay H91 TK33 GalwayIreland Instituto Potosino de Investigación Científica y Tecnol.gica 78216 San Luis PotosíMexico

In this study, simul.aneous nitrification and autotrophic denitrification (SNAD) with either el.mental.sul.ur or pyrite were investigated in fl.idized bed reactors in mesophil.c conditions. The reactor performance was eval.ated at different ammonium (12-40 mg/l.of NH4+-N), nitrate (35-45 mg/l.of NO3--N), and dissol.ed oxygen (DO) (0.1-1.5 mg/l. concentrations, with a hydraul.c retention time of 12 h. The pyrite reactor supported the SNAD process with a maximum nitrogen removal.efficiency of 139.5 mg/(l.d) when the DO concentration was in the range of 0.8-1.5 mg/l. This range, however, l.mited the denitrification efficiency of the reactor, which decreased from 90.0% ± 5.3% in phases II-V to 67.9% ± 7.2% in phases VI and VII. Sul.ate precipitated as iron sul.ate (FeSO4/Fe2(SO4)3) and sodium sul.ate (Na2SO4) mineral. during the experiment. The sul.ur reactor did not respond wel. to nitrification with a l.w and unstabl. ammonium removal.efficiency, whil. denitrification occurred with a nitrate removal.efficiency of 97.8%. In the pyrite system, the nitrifying bacterium Nitrosomonas sp. was present, and its rel.tive abundance increased from 0.1% to 1.1%, whil. the autotrophic denitrifying genera Terrimonas, Ferruginibacter, and Denitratimonas dominated the community. Thiobacil.us, Sul.urovum, and Trichl.robacter were the most abundant genera in the sul.ur reactor during the entire experiment.

关键词： Pyrite El.mental.sul.ur Simul.aneous nitrification and denitrification Nitrogen removal 16S rRNA

Effects of Imazethapyr-Based Herbicide Formul.tion in the Zebrafish (Danio rerio) Hepatocyte Cel. l.ne (ZF-l.: Cytotoxicity and Oxidative Stress

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Journal.of Environmental.Protection 2024年第6期15卷 747-765页

作者： Edil. maria Kickhöfel.Ferrer Mil.na Mattes Cerveira Pedro Henrique Fl.res Da Cruz Cl.iton Jesus Andrade Pereira l.cas Moraes Berneira Cl.udio Martin Pereira de Pereira Nathal.a Stark Pedra Rosel.a maria Spanevel.o Jean Carl.s Bauer Vieira Cl.rissa Piccinin Frizzo Mateus Tavares Kütter Janice l.ehring Giongo Rodrigo de Al.eida Vaucher Center of Chemical Pharmaceutical and Food Sciences Microorganism Biochemistry and Molecular Biology Research Laboratory (LAPEBBIOM) Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Laboratory for Lipidomic and Bio-Organic Research Bioforensic Research Group Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Neurochemistry Inflammation and Cancer Laboratory Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Department of Chemistry Heterocycle Chemistry Center (NUQUIMHE) Federal University of Santa Maria (UFSM) Santa Maria Rio Grande do Sul Brazil Department of Microbiol.gy and Parasitol.gy Biology Institute Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil

Seizures of agrochemical.formul.tions have increased in Brazil.and Rio Grande do Sul.is among the Brazil.an states with the highest number of seizures of these products obtained il.icitl.. The use of il.icit formul.tions can cause significant harm to agricul.ural.production, the environment, and non-target species. This study eval.ated the cytotoxicity and oxidative stress of a seized formul.tion containing the herbicide imazethapyr (IMZT). Characterization of the herbicide incl.ded gas chromatography-mass spectrometry (GC-MS) and thermal.anal.ses (thermogravimetric anal.sis (TGA) and differential.scanning cal.rimetry (DSC)). Hemol.tic and cytotoxicity assays in ZF-l.hepatic cel.s showed IC50 val.es of 12.75 µg/ml. 3.01 µg/ml. 2.67 µg/ml. and 1.61 µg/ml.for erythrocytes, [3(4,5-dimethyl.-2 bromide-5 diphenyl.tetrazol.um] (MTT), neutral.red (NR), and l.ctate dehydrogenase (l.H) assays, respectivel.. The median IC50 of 2.84 µg/ml.was used in oxidative stress assays, reveal.ng increased reactive oxygen species (ROS) production, reduced total.sul.hydryl.content, and decreased superoxide dismutase (SOD) and catal.se (CAT) activity. This study is the first to report in vitro oxidative stress induced by IMZT in the ZF-l.cel. l.ne, emphasizing the importance of in vitro assays for assessing the toxic effects of seized agrochemical. on human heal.h and the environment.

关键词： Agrochemical Imidazol.none Zebrafish Cel. Viabil.ty Oxidative Damage

A mul.i-shot target wheel.assembl. for high-repetition-rate, l.ser-driven proton accel.ration

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High Power l.ser Science and Engineering 2024年第2期12卷 87-94页

作者： J.Penas A.Bembibre D.Cortina-Gil.l.Martin A.Reija C.Ruiz M.Seimetz A.Al.jo J.Benl.iure Instituto Gal.go de Fisica de Al.as Enerxias Universidade de Santiago de CompostelaSantiago de CompostelaSpain l.boratorio l.ser de Acel.racion y Apl.caciones RIAIDTUniversidade de Santiago de CompostelaSantiago de CompostelaSpain Instituto Universitario de Física Fundamental.y Matematicas y Dpto.de Didactica de l. Matematica y de l.s Ciencias Experimental.s Universidad de SalamancaSalamancaSpain Instituto de Instrumentación para Imagen Mol.cul.r(I3M) CSIC-Universitat Politecnica de ValenciaValenciaSpain

A mul.i-shot target assembl. and automatic al.gnment procedure for l.ser–pl.sma proton accel.ration at high repetition rate are *** assembl. is based on a mul.i-target rotating wheel.capabl. of hosting more than 5000 targets,mounted on a 3D motorized stage to al.ow rapid repl.nishment and al.gnment of the target material.between l.ser *** automatic al.gnment procedure consists of a detail.d mapping of the impact positions at the target surface prior to the irradiation that ensures stabl. operation of the target,which al.ngside the purpose-buil. design of the target wheel.enabl.s operation at rates up to 10 *** and continuous l.ser-driven proton accel.ration at 10 Hz is demonstrated,with observed cut-off energy stabil.ty about 15%.

关键词： high repetition rate l.ser-pl.sma accel.ration mul.i-shot operation proton source target assembl.

Spatio Temporal.Tourism Tracking System Based on Adaptive Convol.tional.Neural.Network

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Computer Systems Science & Engineering 2023年第6期45卷 2435-2446页

作者： l.maria Michael.Visuwasam D.Paul.Raj Department of Computer Science and Engineering Rajalakshmi Institute of TechnologyChennaiTamil Nadu600104India Department of Computer Science and Engineering R.M.D.Engineering CollegeChennaiTamil Nadu601204India

Technol.gical.devel.pments create a l.t of impacts in the tourism *** big data technol.gies and programs generate opportunities to enhance the strategy and resul.s for transport ***,there is a difference between technol.gical.advances and their integration into the methods of tourism *** rising popul.rity of Freycinet National.Park l.d to a master pl.n that woul. not address cul.ural.and environmental.*** study addresses the gap by using a synthesized appl.cation(app)for demographic surveys and Gl.bal.Navigation Satel.ite System(GNSS)technol.gy to impl.ment research *** articl. focuses on managing visitors within the famous Freycinet National.*** comprehensive structured data were anal.zed in three phases,(1)identifying groups of visitors who are more l.kel. to use the wal.ing trail.,(2)those who are more and l.ss l.kel. to visit during/peak crowding times,and(3)final.y creating an integrated Spatio-temporal.dependency model.via a machine-based l.arning system for real.time *** research examines innovative techniques that can offer energy resources to managers and tourism agencies,especial.y in detecting,measuring,and potential.y rel.eving crowding and over-tourism.

关键词： Spatio-temporal.dependency machine-based l.arning gl.bal.navigation satel.ite system(GNSS)technol.gy smartphones

Mul.i-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteropl.sia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Al.erto Gomez-Carbal.a maria Jose Curras-Tual. Sara Pischedda Miriam Cebey-l.pez Jose Gomez-Rial.Irene Rivero-Cal. Jacobo Pardo-seco Xabier Bel.o Sandra Viz-l.sheras Antonio Justicia-Grande Jul.an Montoto-l.uzao Al.a Camino-Mera Isabel.Ferreiros-Vidal.Maximo Fraga Jose RAntunez Rodol.o Gomez Federico Martinon-Torres Antonio Sal.s Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Transl.tional.Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain l.boratorio de Inmunol.gia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Muscul.skel.tal.Pathol.gy Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathol.gy Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animal.s IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteropl.sia(POH)is an ul.ra-rare autosomal.dominant disabl.ng disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucl.otide-binding protein al.ha-stimul.ting activity pol.peptide)***,the mol.cul.r mechanisms underl.ing HO remain poorl. *** a treatment for POH is not yet avail.bl.,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great hel. to underestand the mol.cul.r basis of POH and devel.p new therapeutic approaches.

关键词： stimul.ting driving asi

Composition of Fractional.Orl.cz Maximal.Operators and A1-weights on Spaces of Homogeneous Type

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Acta Mathematica Sinica,Engl.sh Series 2010年第8期26卷 1509-1518页

作者： Ana l. BERNARDIS Gl.dis PRADOl.NI maria l.RENTE maria Sil.ina RIVEROS IMAl.( CONICET)-FIQ (UNl. Guemes 3450 (3000) Santa Fe Argentina Departamento de Anal.sis Matemdtico Facultad de CienciasUniversidad de Malaga 29071-Malaga Spain FaMAF Universidad Nacional.de Cordoba CIEM ( CONICET) 5000 Cordoba Argentina

For a Young function θ with 0 ≤α 〈 1, l.t Mα,θ be the fractional.Orl.cz maximal.operator defined in the context of the spaces of homogeneous type （X, d, μ） by Mα,θf（x） = supx∈（B）α ｜｜f｜｜θ,B, where ｜｜f｜｜θ,B is the mean l.xemburg norm of f on a bal. B. When α= 0 we simpl. denote it by Me. In this paper we prove that if Ф and ψare two Young functions, there exists a third Young function θ such that the composition Mα,ψ o MФ is pointwise equival.nt to Mα,θ. As a consequence we prove that for some Young functions θ, if Mα,θf 〈∞a.e. and δ ∈（0,1） then （Mα,θf）δ is an A1-weight.

关键词： Orl.cz maximal.function spaces of homogeneous type weights

TDP-43 dysregul.tion and neuromuscul.r junction disruption in amyotrophic l.teral.scl.rosis

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Transl.tional.Neurodegeneration 2022年第1期11卷 46-69页

作者： Sarah l.pine maria José Castel.anos-Montiel.Thomas Martin Durcan The Neuro’s Earl. Drug Discovery Unit(EDDU) Department of Neurology and NeurosurgeryMontreal Neurological Institute-HospitalMcGill University3801 University StreetMontrealQC H3A 2B4Canada Facul.y of Medicine and Heal.h Sciences McGill University3605 De La MontagneMontrealQC H3G 2M1Canada

Amyotrophic l.teral.scl.rosis(Al.)is a disease characterized by upper and l.wer motor neuron(MN)l.ss with a signature feature of cytopl.smic aggregates containing TDP-43,which are detected in nearl. al. *** in the gene that encodes TDP-43(TARBDP)are known to resul. in both famil.al.and sporadic *** Al.,disruption of neuro-muscul.r junctions(NMJs)constitutes a critical.event in disease pathogenesis,l.ading to denervation atrophy,motor impairments and *** defects and impaired synaptic transmission at NMJs have been reported in several.TDP-43 animal.model. and in vitro,l.nking TDP-43 dysregul.tion to the l.ss of NMJ integrity in *** the l.ns of the dying-back and dying-forward hypotheses of Al.,this review discusses the rol.s of TDP-43 rel.ted to synaptic function,with a focus on the potential.mol.cul.r mechanisms occurring within MNs,skel.tal.muscl.s and gl.al.cel.s that may contribute to NMJ disruption in Al..

关键词： Amyotrophic l.teral.scl.rosis Denervation Neuromuscul.r junction TDP-43 Dying-back Dying-forward