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Unveiling the intricacies of irritable bowel syndrome

World Journal of Gastroenterology 2024年第44期30卷 4763-4767页

作者： duygu kirkik Sevgi Kalkanli Tas Department of Immunology University of Health SciencesHamidiye Medicine FacultyIstanbul 34668Türkiye Department of Medical Biology University of Health SciencesHamidiye Medicine FacultyIstanbul 34668Türkiye

Irritable bowel syndrome(IBS)remains a challenging condition both for patients and clinicians,characterized by its chronic nature and the elusive complexity of its underlying *** multifaceted relationship between the neuroendocrine axis,gut microbiota,and inflammatory response has emerged as a focal point in recent research,offering new insights into the pathophysiology of *** neuroendocrine axis plays a crucial role in maintaining the delicate balance between the brain and the gut,often referred to as the“gut-brain axis”.This bidirectional communication is essential for regulating gastrointestinal function,stress responses,and overall *** of this axis,as highlighted by elevated cortisol and serotonin levels in IBS patients,suggests that neuroendocrine imbalances may significantly contribute to the severity of gastrointestinal *** findings underscore the need for a broader understanding of how stress and emotional factors influence IBS,potentially guiding more effective,personalized treatment *** important is the role of the gut microbiota,a diverse and dynamic ecosystem that directly impacts gut *** dysbiosis disrupts gut function and appears to exacerbate the neuroendocrine and inflammatory *** findings align with the growing recognition that gut microbiota is a critical player in IBS,influencing both the disease's onset and progression.

关键词： Gastrointestinal symptoms Inflammatory response Intestinal microbiota Irritable bowel syndrome Neuroendocrine axis

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