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Changes in retinal vessel diameters in migraine patients during attack-free period

International Journal of Ophthalmology(English edition) 2017年第3期10卷 439-444页

作者： Metin Unlu duygu gulmez sevim Murat Gultekin Recep Baydemir Cagatay Karaca Ayse Oner Ophthalmology Department School of Medicine Erciyes University Kayseri 38039 Turkey Neurology Department School of Medicine Erciyes University Kayseri 38039 Turkey

AIM：To evaluate the retinal vessel diameters in patients with migraine by optical coherence tomography（OCT）.METHODS：In this cross-sectional study,124 eyes of 62 patients with a diagnosis of unilateral migraine during attack-free period and 42 age-and sex-matched control subjects were included. Migraine patients were divided into the ≤2 migraine attacks per month group and the ≥5 migraine attacks per month group. All subjects underwent complete ophthalmological and neurological examinations before measurements. Retinal vessel diameters and choroidal thickness were examined with the Spectralis ***：The mean diameters of the arteries in the eyes on the headache side of control group,≥5 migraine attacks per month and ≤2 migraine attacks per month group at 480 μm from the optic disk（Raster 3）were 119.54±46.69,136.68±25.93 and 119.34±31.75 μm respectively with a steady decline to 105.57±32.15,118.18±31.87 and 108.05±38.77 μm at 1440 μm（Raster 7）,the last measurement point,respectively. The retinal artery diameter measurements were significantly increased in ≥5 migraine attacks per month patients at four out of five measured points compared to control group（P〈0.05）. There were no statistical differences at any of the points of vein measurements. The choroidal thickness measurements were significantly decreased in ≥5 migraine attacks per month patients at all measured points compared to control group（P〈0.05）.CONCLUSION：The retinal artery diameter is found to increase significantly and the choroidal thickness is found to decrease in the eyes on the headache side in ≥5 migraine attacks per month patients compared to control group.

关键词： migraine optical coherence tomography retinal vessel diameter choroidal thickness

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A novel terminologic “naming-meshing” system using anterior chamber sedimentation for early diagnosis and prompt treatment of ocular or systemic diseases: is it hypopyon or pseudohypopyon?

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1337-1349页

作者： Cem Evereklioglu Hidayet Sener Hatice Kubra Sonmez Osman Ahmet Polat duygu gulmez sevim Hatice Arda Fatih Horozoglu Department of Ophthalmology Division of Uvea-Behçet UnitErciyes University Medical FacultyKayseri 38030Türkiye

A novel,algorithmic“naming-meshing”system was introduced for the distinction of hypopyon from pseudohypopyon to make an early diagnosis and prompt treatment of anterior chamber collection standardized to encompass all sediment *** this reason,a literature review of“hypopyon”and“pseudohypopyon”was conducted in MEDLINE/PubMed,Scopus,and Web of Science from 1966 to May 15,*** issues were clarified:1)which strategies should the ophthalmologist follow when asked to evaluate an eye with anterior chamber sedimentation to distinguish hypopyon from pseudohypopyon,and 2)in which systemic disorders should a non-ophthalmologist order a prompt ophthalmic consultation to distinguish pseudohypopyon from *** characteristics of the sediment were examined;scleral show(warm/cold),location(corneal/anterior chamber/capsular/posterior),visibility(macro/micro/occult-angle),orientation(horizontal/vertical/oblique),number(single/double),shape(convex/triangular/pyramidal/ring/lumpy/inverse),and color(white/yellow/pink/brown/black).Associated findings were then assessed;acute/chronic,spontaneous/provoked,unilateral/bilateral,inflammatory/non-inflammatory,suppurative(nonsterile)/non-suppurative(sterile),granulomatous/nongranulomatous,recurrent/non-recurrent,shifting/nonshifting,and transient/*** type of precipitation was named(naming)and matched(meshing)to a potential list of etiologies(inflammatory,infective,therapeutic,masquerades).Given that(pseudo)hypopyon predominantly afflicts younger patients in their most productive years,clinicians supervising such patients should be aware of all sediment *** ophthalmologist should never ask non-ophthalmologists to run the full battery of tests in a patient with(pseudo)hypopyon,and rather indicate which type of collection is present,what its pathognomonic feature is,and what the most likely diagnoses to be excluded are.

关键词： naming-meshing hypopyon pseudohypopyon

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Automated evaluation of parapapillary choroidal microvasculature in crowded optic discs:a controlled,optical coherence tomography angiography study

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 113-118页

作者： Hatice Arda Hidayet Sener Ozge Temizyurek Hatice Kubra Sonmez duygu gulmez sevim Cem Evereklioglu Fatih Horozoglu Ayse Busra Gunay Sener Department of Ophthalmology Erciyes University Medical FacultyKayseri 38090Turkey Department of Medical Informatics and Biostatistics Erciyes University Medical FacultyKayseri 38090Turkey

AIM:To compare superficial and deep vascular properties of optic discs between crowded discs and controls using optical coherence tomography angiography(OCT-A).METHODS:Thirty patients with crowded discs,and 47 control subjects were enrolled in the *** eye of each individual was included and OCT-A scans of optic discs were obtained in a 4.5×4.5 mm^(2) rectangular *** peripapillary capillary(RPC)density,peripapillary retinal nerve fiber layer(pRNFL)thickness,cup volume,rim area,disc area,cup-to-disc(c/d)area ratio,and vertical c/d ratio were obtained automatically using device *** parapapillary choroidal microvasculature(PPCMv)density was calculated using MATLAB *** the vertical c/d ratio of the optic disc was absent or small cup,it was considered as a crowded ***:The mean signal strength index of OCT-A images was similar between the crowded discs and control eyes(P=0.740).There was no difference in pRNFL between the two groups(P=0.102).There were no differences in RPC density in whole image(P=0.826)and peripapillary region(P=0.923),but inside disc RPC density was higher in crowded optic discs(P=0.003).The PPCMv density in the inner-hemisuperior region was also lower in crowded discs(P=0.026).The pRNFL thickness was positively correlated with peripapillary RPC density(r=0.498,P<0.001).The inside disc RPC density was negatively correlated with c/d area ratio(r=-0.341,P=0.002).CONCLUSION:The higher inside disc RPC density and lower inner-hemisuperior PPCMv density are found in eyes with crowded optic discs.

关键词： crowded optic disc ischemic optic neuropathy optical coherence tomography angiography parapapillary choroidal microvasculature

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Cross-Validation of the Turkish Version of the 28-Item Impact of Vision Impairment Profile Test

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Open Journal of Ophthalmology 2019年第4期9卷 194-202页

作者： Neslihan Sinim Kahraman duygu gulmez sevim Ayse Oner Ophthalmology Department Acibadem Kayseri HospitalKayseriTurkey Ophthalmology Department of Erciyes University Medical SchoolKayseriTurkey

Purpose: To translate the original 28-item Impact of Vision Impairment Profile into Turkish and to investigate its validity and reliability. Methods: Patients with no limitations to respond and affected by a chronic eye disease including retinitis pigmentosa (RP), age-related macular degeneration (ARMD) and diabetic macular edema which cause low vision were enrolled. The Turkish version of the IVI test was administered to all participants. The linguistic translation followed the international guidelines of forward and backward translation. 256 subjects who had a Snellen visual acuity of 6/12 or worse in the eye with best corrected visual acuity (BCVA) completed the Turkish version of the IVI-28 item. Psychometric evaluation of the Turkish IVI test involved the assessment of internal consistency, test-retest reliability, convergent and known-groups validity. Results: The mean (±SD) age of the participants was 53.67 ± 17.22 years. There were 256 patients with one of the following conditions: 105 RP (41%), 77 ARMD (30%), 74 DME (29%). Patients with lower visual acuity (VA) had lower index scores than those with higher VA (p = 0.001), which showed a sufficient responsiveness. Conclusion: Statistical analysis showed that Turkish version of the IVI-28 item is a valid and reliable instrument to measure vision-related quality of life (VRQoL) in patients with low vision.

关键词： IVI Test Quality of Life Questionnaire Validation Visual Function Retinitis Pigmentosa Age-Related Macular Degeneration Diabetic Macular Edema

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Role of alcohol in the regulation of iron metabolism

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World Journal of Gastroenterology 2007年第37期13卷 4924-4930页

作者： duygu Dee Harrison-Findik Division of Gastroenterology and Hepatology Department of Internal Medicine University of Nebraska Medical Center Omaha NE 681985820 United States

Patients with alcoholic liver disease frequently exhibit increased body iron stores, as reflected by elevated serum iron indices (transferrin saturation, ferritin) and hepatic iron concentration. Even mild to moderate alcohol consumption has been shown to increase the prevalence of iron overload. Moreover, increased hepatic iron content is associated with greater mortality from alcoholic cirrhosis, suggesting a pathogenic role for iron in alcoholic liver disease. Alcohol increases the severity of disease in patients with genetic hemochromatosis, an iron overload disorder common in the Caucasian population. Both iron and alcohol individually cause oxidative stress and lipid peroxidation, which culminates in liver injury. Despite these observations, the underlying mechanisms of iron accumulation and the source of the excess iron observed in alcoholic liver disease remain unclear. Over the last decade, several novel iron-regulatory proteins have been identified and these have greatly enhanced our understanding of iron metabolism. For example, hepcidin, a circulatory antimicrobial peptide synthesized by the hepatocytes of the liver is now known to play a central role in the regulation of iron homeostasis. This review attempts to describe the interaction of alcohol and iron-regulatory molecules. Understanding these molecular mechanisms is of considerable clinical importance because both alcoholic liver disease and genetic hemochromatosis are common diseases, in which alcohol and iron appear to act synergistically to cause liver injury.

关键词： Alcoholic liver disease C/EBP alpha Divalentmetal transporter 1 Ferroportin Hepcidin

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A broker-based semantic agent for discovering Semantic Web services through process similarity matching and equivalence considering quality of service

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Science China(Information Sciences) 2013年第1期56卷 18-41页

作者： ELK duygu EL Atilla Computer Engineering Department Istanbul Aydin University Electrical-Elecronics Engineering Department Aksaray University

The lack of semantic descriptions for "web service properties" makes it difficult to find suitable web *** solutions are mostly based on broker/mediator agent ***,these techniques are syntactical,rather than semantics *** article presents a semantic matching approach for discovering Semantic Web services through a broker-based semantic agent(BSA).The BSA includes knowledge-bases and several processing *** BSA’s knowledge-bases are concept,task,and process ontologies built to describe both functional and non-functional parameters of *** BSA executes semantic-based matching algorithms to discover similar services through the semantic matching step,process equivalence task,and matching of quality of service *** services are ranked by client preferences utilizing the semantic descriptions of available *** matchmaker studies are reviewed and compared with the *** of the BSA algorithm is compared with SAM using published data and an experimental *** results indicate that our approach is better and more effective in some respects.

关键词： Semantic Web Semantic Web services broker web applications ontologies semantic agents

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Fair-News: Digital Journalism Model to Prevent Information Pollution and Manipulation

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Computers, Materials & Continua 2023年第6期75卷 6059-6082页

作者： Savas Takan duygu Ergün Gökmen Katipoglu Department of Artificial Intelligence and Data Engineering Ankara UniversityAnkara06830Turkey Faculty of Fine Arts Design&Architecture Fine Arts and Elective CoursesAtılım UniversityAnkara06830Turkey Department of Computer Engineering Kafkas UniversityKars36100Turkey

As digital data circulation increases,information pollution and manipulation in journalism have become more *** this study,a new digital journalism model is designed to contribute to the solution of the main current problems,such as information pollution,manipulation,and account-ability in digital *** model uses blockchain technology due to its transparency,immutability,and ***,it is tough to provide the mechanisms necessary for journalism,such as updating one piece of information,instantly updating all other information affected by the updated information,establishing logical relationships between news,making quick comparisons,sorting and indexing news,and keeping the changing informa-tion about the news in the system,with the blockchain data *** this reason,in our study,we have developed a new data structure that provides both the immutability,transparency and traceability properties of the blockchain and can support the communication mechanisms necessary for *** functionality of our proposed data structure is demonstrated in terms of communication mechanisms such as mutability,context,consistency,and reliability through example ***,our data structure is compared with the data structure of blockchain technology in terms of time,space,and maintenance ***,while the model size increases linearly in blockchain,the model’s size remains approximately constant since the structure we developed is *** this way,maintenance costs are *** our model also has an indexing mechanism,it reduces the linear time search complexity to logarithmic *** a result,the data structure we developed is found to have higher performance than blockchain in the journalism *** future studies,it is planned to test all aspects of the model with a pilot application,eliminate its shortcomings,and develop a holistic approach to the root causes of the problems in the journalism

关键词： Digital journalism data structure news-sharing platform verification mechanism distributed ledger new media information pollution and manipulation

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Unveiling the intricacies of irritable bowel syndrome

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World Journal of Gastroenterology 2024年第44期30卷 4763-4767页

作者： duygu Kirkik Sevgi Kalkanli Tas Department of Immunology University of Health SciencesHamidiye Medicine FacultyIstanbul 34668Türkiye Department of Medical Biology University of Health SciencesHamidiye Medicine FacultyIstanbul 34668Türkiye

Irritable bowel syndrome(IBS)remains a challenging condition both for patients and clinicians,characterized by its chronic nature and the elusive complexity of its underlying *** multifaceted relationship between the neuroendocrine axis,gut microbiota,and inflammatory response has emerged as a focal point in recent research,offering new insights into the pathophysiology of *** neuroendocrine axis plays a crucial role in maintaining the delicate balance between the brain and the gut,often referred to as the“gut-brain axis”.This bidirectional communication is essential for regulating gastrointestinal function,stress responses,and overall *** of this axis,as highlighted by elevated cortisol and serotonin levels in IBS patients,suggests that neuroendocrine imbalances may significantly contribute to the severity of gastrointestinal *** findings underscore the need for a broader understanding of how stress and emotional factors influence IBS,potentially guiding more effective,personalized treatment *** important is the role of the gut microbiota,a diverse and dynamic ecosystem that directly impacts gut *** dysbiosis disrupts gut function and appears to exacerbate the neuroendocrine and inflammatory *** findings align with the growing recognition that gut microbiota is a critical player in IBS,influencing both the disease's onset and progression.

关键词： Gastrointestinal symptoms Inflammatory response Intestinal microbiota Irritable bowel syndrome Neuroendocrine axis

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Evaluating different levels of information on the calibration of building energy simulation models

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Building Simulation 2024年第4期17卷 657-676页

作者： Siyu Cheng Zeynep duygu Tekler Hongyuan Ji Wenxin Li Adrian Chong Department of the Built Environment College of Design and EngineeringNational University of Singapore4 Architecture DriveSingapore117566Singapore School of Civil Engineering and Architecture Chongqing University of Science and TechnologyChongqing401331China School of Energy and Environment Southeast UniversityNanjing210096China

A poorly calibrated model undermines confidence in the effectiveness of building energy simulation, impeding the widespread application of advanced energy conservation measures (ECMs). Striking a balance between information-gathering efforts and achieving sufficient model credibility is crucial but often obscured by ambiguities. To address this gap, we model and calibrate a test bed with different levels of information (LOI). Beginning with an initial model based on building geometry (LOI 1), we progressively introduce additional information, including nameplate information (LOI 2), envelope conductivity (LOI 3), zone infiltration rate (LOI 4), AHU fan power (LOI 5), and HVAC data (LOI 6). The models are evaluated for accuracy, consistency, and the robustness of their predictions. Our results indicate that adding more information for calibration leads to improved data fit. However, this improvement is not uniform across all observed outputs due to identifiability issues. Furthermore, for energy-saving analysis, adding more information can significantly affect the projected energy savings by up to two times. Nevertheless, for ECM ranking, models that did not meet ASHRAE 14 accuracy thresholds can yield correct retrofit decisions. These findings underscore equifinality in modeling complex building systems. Clearly, predictive accuracy is not synonymous with model credibility. Therefore, to balance efforts in information-gathering and model reliability, it is crucial to (1) determine the minimum level of information required for calibration compatible with its intended purpose and (2) calibrate models with information closely linked to all outputs of interest, particularly when simultaneous accuracy for multiple outputs is necessary.

关键词： calibration building energy simulation(BES) energy conservation measure(ECM) level of information field measurements

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World Journal of Hepatology 2010年第8期2卷 302-310页

作者： duygu D Harrison-Findik Division of Gastroenterology and Hepatology Department of Internal MedicineUniversity of Nebraska Medical Center

The regulation of iron metabolism involves multiple organs including the duodenum,liver and bone *** recent discoveries of novel iron-regulatory proteins have brought the liver to the forefront of iron *** iron overload disorder,genetic hemochromatosis,is one of the most prevalent genetic diseases in individuals of Caucasian ***,patients with non-hemochromatotic liver diseases,such as alcoholic liver disease,chronic hepatitis C or nonalcoholic steatohepatitis,often exhibit elevated serum iron indices(ferritin,transferrin saturation)and mild to moderate hepatic iron *** data indicate significant differences between men and women regarding liver injury in patients with alcoholic liver disease,chronic hepatitis C or nonalcoholic *** penetrance of genetic hemochromatosis also varies between men and *** has been suggested to act as a modifier gene in genetic *** is a circulatory antimicrobial peptide synthesized by the *** plays a pivotal role in the regulation of iron *** has been shown to be regulated by iron,inflammation,oxidative stress,hypoxia,alcohol, hepatitis C and *** and genetic background have also been shown to modulate hepcidin expression in *** role of gender in the regulation of human hepcidin gene expression in the liver is ***,hepcidin may play a role in gender-based differences in iron metabolism and liver *** understanding of the mechanisms associated with gender-related differences in iron metabolism and chronic liver diseases may enable the development of new treatment strategies.

关键词： Alcohol Hepcidin Hepatitis C Hemochromatosis Non-alcoholic steatohepatitis

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