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Gallium containing bioactive materials: A review of anticancer, antibacterial, and osteogenic properties

Bioactive Materials 2022年第11期7卷 125-146页

作者： Fatih Kurtuldu Nurshen Mutlu Aldo R.Boccaccini dusan galusek FunGlass Alexander Dubcek University of TrencínStudentska 291150TrencínSlovakia Institute of Biomaterials Department of Material Science and EngineeringUniversity of Erlangen-Nuremberg91058ErlangenGermany Joint Glass Centre of the IIC SAS TnUAD and FChFT STUStudentska 291150TrencínSlovakia

The incorporation of gallium into bioactive materials has been reported to enhance osteogenesis,to influence blood clotting,and to induce anti-cancer and anti-bacterial ***-doped biomaterials prepared by various techniques include melt-derived and sol-gel-derived bioactive glasses,calcium phosphate bioceramics,metals and *** this review,we summarize the recently reported developments in antibacterial,anti-cancer,osteogenesis,and hemostasis properties of Ga-doped biomaterials and briefly outline the mechanisms leading to Ga biological *** key finding is that gallium addition to biomaterials has great potential for treating bone-related diseases since it can be efficiently transferred to the desired region at a controllable ***,it can be used as a potential substitute for antibiotics for the inhibition of infections during the initial and advanced phases of the wound healing *** is also used as an anticancer agent due to the increased concentration of gallium around excessive cell proliferation(tumor)***,we highlight the possibility to design different therapeutic approaches aimed at increasing the efficiency of the use of gallium containing bioactive materials for multifunctional applications.

关键词： Antibacterial Bioactive materials Cancer treatment Hemostasis Osteogenesis

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