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Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2885-2900页

作者： Porkizhi Arjunan durga Kathirvelu Gokulnath Mahalingam Ashish Kumar Goel Uday George Zacharaiah Alok Srivastava Srujan Marepally Center for Stem Cell Research(A Unit of inStem Bengaluru)Christian Medical College CampusBagayamVellore 632002Tamil NaduIndia Manipal academy for higher education Mangalore 576104KarnatakaIndia Department of Hematology Christian Medical College&HospitalVellore 632004Tamil NaduIndia Department of Hepatology Christian Medical College&HospitalVellore 632004Tamil NaduIndia

Inherited genetic disorders of the liver pose a significant public health *** transplantation is often limited by the availability of donor livers and the exorbitant costs of immunosuppressive *** overcome these limitations,nucleic acid therapy provides a hopeful alternative that enables gene repair,gene supplementation,and gene silencing with suitable *** viral vectors are the most efficient and preferred for gene therapy,pre-existing immunity debilitating immune responses limit their *** a potential alternative,lipid nanoparticle-mediated vectors are being explored to deliver multiple nucleic acid forms,including pDNA,mRNA,siRNA,and ***,we discuss the broader applications of lipid nanoparticles,from protein replacement therapy to restoring the disease mechanism through nucleic acid delivery and gene editing,as well as multiple preclinical and clinical studies as a potential alternative to liver transplantation.

关键词： Lipid nanoparticle Liver disorders Gene therapy Gene editing Nucleic acid delivery pDNA mRNA siRNA ASO Clinical trials

Review of plasma exchange and rituximab for prevention of recurrent focal segmental glomerulosclerosis after a prior graft loss

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World Journal of Transplantation 2024年第4期14卷 133-139页

作者： Sophie Gharaei Hashim Abbas durga Anil Kanigicherla Manchester Medical School University of ManchesterManchester M139WLUnited Kingdom Department of Renal Medicine Manchester University NHS Foundation TrustManchester M139WLUnited Kingdom

BACKGROUND Focal segmental glomerulosclerosis(FSGS)often recurs after transplantation,leading to graft dysfunction and graft *** who have lost prior grafts due to recurrence are at particularly high risk of re-recurrence in subsequent *** and plasma exchange have been used pre-emptively to prevent post-transplant ***,the efficacy of such preventative measures remains *** To investigate the outcomes of preventative rituximab and plasma exchange for recurrent FSGS in transplant recipients after prior graft *** We conducted a systematic review of 11 studies with 32 patients who had experienced prior graft loss due to post-transplant FSGS recurrence and were treated with either pre-emptive plasma exchange alone,rituximab alone,or a combination of *** Overall,47%of the 32 patients experienced recurrence despite prophylactic ***-recurrence was seen in 25%(1/4)with pre-emptive rituximab alone,and 45%recurrence(9/20)with plasma exchange ***-recurrence was noted in 63%with the use of combined plasma exchange and *** There is a paucity of available evidence in the literature to draw clear conclusions on the benefits of pre-emptive measures to prevent FSGS *** small sample sizes and variations in protocols call for larger and controlled studies to serve this patient population at high risk of recurrence and graft loss.

关键词： Focal segmental glomerulosclerosis Glomerular disease Plasma exchange Rituximab Transplantation

Study of Electronic Density of States: Zintl Alloys

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Communications in Theoretical Physics 2011年第2期55卷 362-364页

作者： Ashwani Kumar durga prasad Ojha Post Graduate Department of Physics Andhra Loyola College

In the present work the electronic density of states of liquid,viz.,Zintli alloys,have been studied only at the composition of their maximum resistivity to have an elementary idea about the behaviors of the alloys with respect to nearly free electron *** study reveals that the anomalous electronic behavior of liquid Li-Pb,Na-Pb,Li-Sn,and Na-Sn can be attributed to the preferential ordering of unlike atoms.

关键词： alloys thermodynamics of solutions density of states phase diagram

Source Code Prioritization Using Forward Slicing for Exposing Critical Elements in a Program

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Journal of Computer Science & Technology 2011年第2期26卷 314-327页

作者： Mitrabinda Ray Kanhaiya lal Kumawat durga prasad Mohapatra Department of Computer Science and Engineering National Institute of Technology

Even after thorough testing, a few bugs still remain in a program with moderate complexity. These residual bugs are randomly distributed throughout the code. We have noticed that bugs in some parts of a program cause frequent and severe failures compared to those in other parts. Then, it is necessary to take a decision about what to test more and what to test less within the testing budget. It is possible to prioritize the methods and classes of an object-oriented program according to their potential to cause failures. For this, we propose a program metric called influence metric to find the influence of a program element on the source code. First, we represent the source code into an intermediate graph called extended system dependence graph. Then, forward slicing is applied on a node of the graph to get the influence of that node. The influence metric for a method m in a program shows the number of statements of the program which directly or indirectly use the result produced by method m. We compute the influence metric for a class c based on the influence metric of all its methods. As influence metric is computed statically, it does not show the expected behavior of a class at run time. It is already known that faults in highly executed parts tend to more failures. Therefore, we have considered operational profile to find the average execution time of a class in a system. Then, classes are prioritized in the source code based on influence metric and average execution time. The priority of an element indicates the potential of the element to cause failures. Once all program elements have been prioritized, the testing effort can be apportioned so that the elements causing frequent failures will be tested thoroughly. We have conducted experiments for two well-known case studies -- Library Management System and Trading Automation System -- and successfully identified critical elements in the source code of each case study. We have also conducted experiments to compar

关键词： program slice extended system dependence graph influence of a class test priority

Dynamics of additional food provided predator-prey system with habitat fragmentation

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International Journal of Biomathematics 2023年第4期16卷 45-80页

作者： K.durga prasad B.S.R.V.prasad Department of Mathematical and Computational Sciences Sri Sathya Sai University for Human Ercellence Kamalapur KalaburagiKarnataka 585313India Department of Mathematics School of Advanced Sciences VIT(Deemed to be University)Vellore Tamilnadu 632014India

Due to human-caused deforestation,global warming,and other environmental factors,habitat fragmentation became *** fragmentation has a variety of detrimental repercussions for many species as well as humans,especially in the agricultural *** causes insect outbreaks,the expansion of alien species,and disrupts biological management by rendering the habitat unsuitable for natural enemies in *** natural enemies with additional food is one method to improve the ecosystem and support *** this study,we assumed that the ecosystem is separated into two patches and that predators can easily migrate from one patch to the next,while prey stays inside its patch's *** looked at the impact of offering more food to predators in a patchy environment using dynamical systems *** permanence,stability,and various bifurcations that occur in the system are studied using a rigorous mathematical *** study looks at how predator's access to other food sources affects pest *** adjusting the provided food's characteristic qualities,such as(nutritional)quality and quantity,one can limit and manage the pest in one or both patches,as well as eliminate predators from the *** research reveals that providing predators with additional food(of specified quality and quantity)can help in controlling chaotic behavior in the *** findings of the study are supported by numerical simulations.

关键词： Pest predator additional food habitat fragmentation Hopf bifurcation chaos biological control

Performance enhancement of IMC-PID controller design for stable and unstable second-order time delay processes

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Journal of Central South University 2020年第1期27卷 88-100页

作者： Munna KUMAR durga prasad Ram Sharan SINGH Department of Chemical Engineering Indian Institute of Technology (BHU)

An IMC-PID controller was proposed for unstable second-order time delay system which shows the characteristics of inverse response(RHP zero). A plot of Ms versus λ was suggested to calculate the suitable tuning parameter λ, which provides a trade-off between performance and robustness. Six different forms of process models were selected from literature to show the applicability of the present method. Performance of controller was calculated by ITAE and total variation TV and compared with recently published tuning rules. Undesirable overshoot was removed by using a set-point weighting parameter. Robustness was tested by introducing a perturbation into the various model parameters and closed-loop results show that the designed controller is robust in the case of model uncertainty. The proposed method shows an overall better closed-loop response as compared to other recently reported methods.

关键词： maximum sensitivity internal model control unstable process set-point weighting integral of time-weighted absolute error

CURING KINETICS AND THERMAL STABILITY OF EPOXY BLENDS CONTAINING PHOSPHOROUS-OXIRANE WITH AROMATIC AMIDE-AMINE AS CURING AGENTS

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Chinese Journal of Polymer Science 2012年第5期30卷 694-704页

作者： Geeta durga A.K.Narula School of Basic and Applied Sciences Guru Gobind Singh Indraprastha University

This article describes the synthesis of a series of aromatic amide-amines and their potential use as epoxy hardeners. These amines were synthesized by the reaction of L-phenylalanine （PA） with diamines of different structures i.e. 1,4- phenylene diamine （PD）, 1,5-diamino naphthalene （N）, 4,4＇-（9-fluorenyllidene）-dianiline （F）, 4,4＇-diaminodiphenyl sulphide （DS） and 3,4＇-oxydianiline （O） in a stoichiometric ratio （I ：1）. Structural characterization of synthesized amide-amines was done with the help of elemental analysis and spectroscopic techniques viz. FT-IR, 1H-NMR and 13C-NMR. An epoxy blend was prepared by mixing tris（glycidyloxy） phosphine oxide （TGPO） with conventional epoxy i.e. diglycidyl ether of bisphenol-A （DGEBA） in an equivalent ratio of 2：3 to incorporate phosphorous into the main chain. The curing kinetics of the epoxy blend with synthesized aromatic amide-amines was investigated by non-isothermal DSC technique using multiple heating rate method （5, 10, 15 and 20 K/min.）. The activation energies were determined by fitting the experimental data into Kissinger and Ozawa kinetic models. The activation energies obtained through Ozawa method were slightly higher than those of Kissinger method but were comparable. However, both the energies were found to be dependent on the structure of amines. The thermal stability and weight loss behavior of isothermally cured thermosets were also investigated using thermogravimetric analysis （TGA） in nitrogen atmosphere. All the samples showed improved thermal stability in terms of char yield than using only amines as hardeners.

关键词： Phosphorylated epoxy Amide-Amines Curing kinetics Char yield Thermal stability.

Effect of glycine addition on the in-vitro corrosion behavior of AZ31 magnesium alloy in Hank’s solution

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Journal of Materials Science & Technology 2021年第22期81卷 97-107页

作者： durga Bhakta Pokharel Liping Wu Junhua Dong Amar prasad Yadav Dhruba Babu Subedi Madhusudan Dhakal Lin Zha Xin Mu Aniefiok Joseph Umoh Wei Ke Shenyang National Laboratory for Materials Science(SYNL) Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Material Science and Engineering University of Science and Technology of ChinaHefei230026China Environmental Corrosion Center Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Central Department of Chemistry Tribhuvan UniversityKirtipurNepal

This study reports on the effect of the addition of Glycine to Hank’s solution on the in-vitro corrosion behavior of AZ31 magnesium(Mg)alloy at 37℃and a pH of 7.4 studied by using potentiodynamic polarization(PDP),hydrogen collecting techniques and electrochemical impedance spectroscopy(EIS)in combination with surface characterization techniques such as optical microscopy(OM),scanning electron microscopy(SEM),energy dispersive spectroscopy(EDS),X-ray diffraction(XRD)and X-ray photoelectron spectroscopy analysis(XPS).The results reveal that adsorption of glycine initially subdues the dissolution of AZ31 Mg alloy while in long run it enhances the dissolution of the alloy due to the commencement of the chelation effect of glycine with Ca^(2+) released from *** chelation of glycine with Ca^(2+) induces the formation of cracks in the surface film which further promotes the dissolution of AZ31 Mg alloy thereby forming a porous corrosion products layer on the surface of the *** a result,both the continuous dissolution of AZ31 magnesium alloy and the hydrogen evolution rate(HER)are enhanced with increasing the immersion time in Hank’s solution.

关键词： AZ31 Mg alloy Glycine Hank’s solution EIS Chelating effect

Variability and divergence in horsegram (Dolichos uniflorus)

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Journal of Arid Land 2012年第1期4卷 71-76页

作者： Kanaka K durga Seed Research & Technology Centre RajendranagarHyderabadAPIndia

Horsegram is an important and unexploited tropic and sub-tropic legume crop grown mostly in dry land agriculture. The study involving 23 cultivars of horsegram （Dolichos uniflorus） was conducted at the Seed Research ＆ Technology Centre in Rajendranagar, Hyderabad, India during the early spring seasons of 2008 and 2009 to assess the nature and magnitude of variability in the existing species and also to identify diverse parents for use in further breeding programmes. The results indicated significant differences among the 23 cultivars for all characters studied, indicating the presence of sufficient genetic variation. High variability and heritability coupled with high genetic advance were reported for seed yield per plant and pod hulm per plant, indicating additive gene action and a possible scope for the improvement of these characters. Mahalanobis D2 statistics grouped all the 23 cultivars of horsegram into six ,clusters. The maximum inter cluster distance （62.39） was noticed between cluster IV （HG 50） and cluster V （HG 11）. The maximum Jntra cluster distance ranged from 0 （clusters III, IV, V and VI） to 15.17 （cluster I）, indicating that the genotypes in these clusters were relatively more diverse than the genotypes within other clusters. Seed yield per plant contributed the maximum （33.20%） to the genetic divergence.

关键词： horsegram Dolichos uniflorus variability divergence genotype yield components seed quality parameters