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Implications of Dynamic Interactions between Meteorological Patterns and Surface Water Quality on Environmental Health—A Case Study of the Nairobi River

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Journal of Geoscience and Environment Protection 2024年第5期12卷 113-146页

作者： Haron Safari Hongbin Chen Edwin Kipkirui duncan Mbuge College of Environmental Science and Engineering Tongji University Shanghai China National Engineering Research Center for Urban Pollution Control Shanghai China College of Environmental and Biosystems Engineering University of Nairobi Nairobi Kenya

Urban areas face significant challenges in maintaining water quality amidst increasing urbanization and changing climatic patterns. This study investigates the complex interplay between meteorological variables and water quality parameters in Nairobi City, focusing on the impacts of rainfall and temperature on surface water quality. Data from multiple sources, including the Water Resources Authority, Nairobi Water and Sewerage Company, and the World Bank’s Climate Change Knowledge Portal, were analyzed to assess the relationships between meteorological variables (rainfall and temperature) and water quality parameters (such as electroconductivity, biochemical oxygen demand, chloride, and pH). The analysis reveals varying impacts of rainfall and temperature on different water quality parameters. While parameters like iron and pH show strong relationships with both rainfall and temperature, others such as ammonia and nitrate exhibit moderate relationships. Additionally, the study highlights the influence of runoff, urbanization, and industrial activities on water quality, emphasizing the need for holistic management approaches. Recommendations encompass the establishment of annual publications on Nairobi River water quality, online accessibility of water quality data, development of hydrological models, spatial analysis, and fostering cross-disciplinary research collaborations. Implementing these recommendations can enhance water quality management practices, mitigate risks, and safeguard environmental integrity in Nairobi City.

关键词： Water Quality Meteorological Conditions Urban Environment Environmental Health Nairobi Water Quality Parameters

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还原病毒营销真相

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广告主 2007年第10期 67-67页

作者： duncan J.watt Jonah Peretti 全智

要可靠地设计出具有病毒性特征的信息是极端困难的,要预测出哪些特定的个人一定会传播这些信息也是如此。

关键词：病毒营销真相还原信息

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Combination Activity of Standard Antituberculosis Drugs and Extracts of Medicinal Plants Commonly Used in Traditional Treatment of Tuberculosis in Uganda

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Advances in Infectious Diseases 2024年第3期14卷 511-522页

作者： Moses Mpeirwe Kevin Komakech duncan Ssesazi Patrick Engeu Ogwang Joel Bazira Department of Microbiology Mbarara University of Science and Technology Mbarara Uganda Department of Medical Microbiology Mycobacteriology (BSL-3) Laboratory Makerere University Kampala Uganda Department of Pharmaceutical Sciences Mbarara University of Science and Technology Mbarara Uganda Department of Pharmacy Mbarara University of Science and Technology Mbarara Uganda

Introduction: Resistance to antituberculosis drugs and adverse drug reactions remain the leading causes of tuberculosis therapeutic failure globally. Despite the increasing acceptance of medicinal plant use in combination with conventional antituberculosis drugs in treatment of tuberculosis (TB) in Uganda, there is paucity of knowledge on their combination effect. Aim: This research aimed to determine combination activity of standard antituberculosis drugs with extracts of Zanthoxylum leprieurii Guill. & Perr. and Rubia cordifolia L., the two common antituberculosis medicinal plants in Uganda, against pansensitive (H37Rv) and multi-drug resistant (MDR) Mycobacterium tuberculosis strains. Materials and Methods: Two reference MTB strains (H37Rv and MDR strain) were inoculated on Middlebrook 7H11 medium containing a combination of standard antituberculosis drugs and methanol extracts of Z. leprieurii and R. cordifolia at varying concentrations. The number of colonies on the plates was observed and counted weekly for up to 8 weeks. In vitro combination activity was determined using proportion method. Mean percentage inhibition was calculated for the reduction of number of colonies on drug-extract combination medium in relation to drug-extract-free control medium. Results: Drug-extract combinations showed good combination activity against Mycobacterium tuberculosis strains when compared with individual standard anti-TB drugs. This was more exhibited against MDR strain. There was however a reduction in percentage inhibition when extracts were combined with ethambutol and streptomycin against H37Rv strain. Conclusions: Zanthoxylum leprieurii and Rubia cordifolia in combination with standard anti-TB drugs exhibited increased in vitro activity against Mycobacterium tuberculosis, especially MDR-TB strain. This justifies the local use of these plants in traditional treatment of tuberculosis especially in resistant cases in Uganda.

关键词： Combination Activity Medicinal Plants Zanthoxylum leprieurii Rubia cordifolia Standard Antituberculosis Drugs

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Considerations for the use of porcine organ donation models in preclinical organ donor intervention research

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Animal Models and Experimental Medicine 2024年第3期7卷 283-296页

作者： Frazer I.Heinis Shaheed Merani Nicholas W.Markin Kim F.duncan Michael J.Moulton Lance Fristoe William E.Thorell Raechel A.Sherrick Tami R.Wells Matthew T.Andrews Marian Urban School of Natural Resources Institute of Agriculture and Natural ResourcesUniversity of Nebraska-LincolnLincolnNebraskaUSA Division of Transplantation and Vascular Surgery Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Department of Anesthesiology University of Nebraska Medical CenterOmahaNebraskaUSA Division of Cardiothoracic Surgery Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Clinical Perfusion Nebraska Medicine-Nebraska Medical CenterOmahaNebraskaUSA Department of Neurosurgery University of Nebraska Medical CenterOmahaNebraskaUSA Nutrition and Health Sciences College of Education and Human SciencesUniversity of Nebraska-LincolnLincolnNebraskaUSA Department of Comparative Medicine University of Nebraska Medical CenterOmahaNebraskaUSA

Use of animal models in preclinical transplant research is essential to the optimization of human allografts for clinical *** models of organ donation and preservation help to advance and improve technical elements of solid organ recovery and facilitate research of ischemia-reperfusion injury,organ preservation strategies,and future donor-based *** considerations include cost,public opinion regarding the conduct of animal research,translational value,and relevance of the animal model for clinical *** present an overview of two porcine models of organ donation:donation following brain death(DBD)and donation following circulatory death(DCD).The cardiovascular anatomy and physiology of pigs closely resembles those of humans,making this species the most appropriate for pre-clinical *** are also considered a potential source of organs for human heart and kidney *** is imperative to minimize animal loss during procedures that are surgically *** present our experience with these models and describe in detail the use cases,procedural approach,challenges,alternatives,and limitations of each model.

关键词： animal model brain death circulatory death organ transplantation

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Management of distal cholangiocarcinoma with arterial involvement: Systematic review and case series on the role of neoadjuvant therapy

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2689-2701页

作者： Lewis A Hall duncan Loader Santiago Gouveia Marta Burak James Halle-Smith Peter Labib Moath Alarabiyat Ravi Marudanayagam Bobby V Dasari Keith J Roberts Syed S Raza Michail Papamichail David C Bartlett Robert P Sutcliffe Nikolaos A Chatzizacharias Department of Hepatopancreatobiliary Surgery and Liver Transplantation University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom College of Medical and Dental Sciences University of BirminghamBirmingham B152TTUnited Kingdom Institute of Clinical Sciences University of BirminghamBirmingham B152TTUnited Kingdom

BACKGROUND The use of neoadjuvant therapy(NAT)in distal cholangiocarcinoma(dCCA)with regional arterial or extensive venous involvement,is not widely accepted and evidence is *** To synthesise evidence on NAT for dCCA and present the experience of a highvolume tertiary-centre managing dCCA with arterial *** A systematic review was performed according to PRISMA guidance to identify all studies reporting outcomes of patients with dCCA who received *** patients from 2017 to 2022 who were referred for NAT for dCCA at our centre were retrospectively collected from a prospectively maintained *** characteristics,NAT type,progression to surgery and oncological outcomes were *** Twelve studies were *** definition of“unresectable”locally advanced dCCA was *** studies reported outcomes for 9 patients who received NAT for dCCA with extensive vascular involvement.R0 resection rate ranged between 0 and 100%but without survival benefit in most *** studies considered either NAT in resectable dCCA or inclusive with extrahepatic *** presented case series includes 9 patients(median age 67,IQR 56-74 years,male:female 5:4)referred for NAT for borderline resectable or locally advanced *** patients progressed to surgery and 2 were *** patient died at 14 months with evidence of recurrence at 6 months and the other died at 51 months following recurrence 6 months *** Evidence for benefit of NAT is *** on criteria for uniform definition of resectability for dCCA is *** propose using the established National-Comprehensive-Cancer-Network®criteria for pancreatic ductal adenocarcinoma.

关键词： Cholangiocarcinoma Neoadjuvant therapy Arterial involvement Locally advanced Systematic review

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Bio-friction

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Friction 2013年第2期1卷 100-113页

作者： Zhongmin JIN duncan DOWSON School of Mechanical Engineering Xi’an Jiaotong UniversityChina School of Mechanical Engineering University of LeedsUK

Friction studies in biological systems are reviewed,including synovial joints(cartilage,meniscus),eye,pleurae,fat pad,skin,and oral cavity as well as daily activities associated with shaving,brushing,slip,*** natural systems and medical interventions in terms of diagnoses and artificial replacements are *** relevant biomechanical,physiological,and anatomical factors are reviewed in conjunction with friction studies in terms of both methodologies and friction *** underlying tribological mechanisms related to friction are briefly discussed.A unified view on the lubrication mechanism responsible for the low friction in most soft biological tissues is presented.

关键词： biofriction soft tissues friction

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Monitoring film coalescence from aqueous polymeric dispersions using atomic force microscopy: Surface topographic and nano-adhesion studies

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Asian Journal of Pharmaceutical Sciences 2020年第1期15卷 104-111页

作者： Ziyi Yang duncan QMCraig School of Pharmaceutical Science Jiangnan University1800 Lihu RoadWuxi 214122China UCL School of Pharmacy 29-39 Brunswick SquareLondon WC1N1AXUK

The aim of the investigation was to develop the use of topographic and nano-adhesion atomic force microscopy(AFM) studies as a means of monitoring the coalescence of latex particles within films produced from a pharmaceutically relevant aqueous dispersion(Eudragit~?NE30 D). Films were prepared via spin coating and analysed using AFM, initially via tapping mode for topographic assessment followed by force-distance measurements which allowed assessment of site-specific adhesion. The results showed that colloidal particles were clearly observed topographically in freshly prepared samples, with coalescence detected on curing via the disappearance of discernible surface features and a decrease in roughness indices. The effects of temperature and humidity on film curing were also studied, with the former having the most pronounced effect. AFM force measurements showed that the variation in adhesive force reduced with increasing curing time, suggesting a novel method of quantifying the rate of film formation upon curing. It was concluded that the AFM methods outlined in this study may be used as a means of qualitatively and quantitatively monitoring the curing of pharmaceutical films as a function of time and other variables, thereby facilitating rational design of curing protocols.

关键词： Film curing Atomic force microscopy Spin coating Aqueous dispersion AFM pull-off force measurement

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COVID-19 in 2021:A Call for Collaboration

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China CDC weekly 2021年第7期3卷 130-131页

作者： duncan Selbie National Public Health Institutes

For many years now the world has anticipated a global *** of the devastating impact of pandemic influenza after the first World War,we have been awaiting a similar threat and the changes it would bring to our way of l... 详细信息

关键词： threat has devastating

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Astaxanthin Accumulation in the Green Alga Haematococcus pluvialis： Effects of Cultivation Parameters

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Journal of Integrative Plant Biology 2007年第4期49卷 447-451页

作者： Ping He James duncan James Barber Institute of Botany the Chinese Academy of Sciences Beijing 100093 China Division of Molecular Biosciences Imperial College London London SW7 2AY UK Graduate School of Beijing Forestry University Beijing 100083 China

The green alga, Haematococcus pluvlalis Flotow is used as a source of the ketocarotenoid astaxanthin for application in fish aquaculture, pharmaceutical and cosmetic industries. Ceils of the green alga were induced by the application of different light and starvation conditions to evaluate the effect in astaxanthin accumulate. The conditions used for the Induction were high light intensity （170 μmol·m^-2·s^-1）, iron starvation, sulfur starvation and phosphate starvation. The results show that stresses applied in culture, which interfere with cell division, trigger the accumulation of astaxanthin. Notably, sulfur starvation results in a massive accumulation of this commercially important carotenoid.

关键词： astaxanthin Haematococcus pluvialis iron light phosphate stress sulfur.

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Translation Studies versus Comparative Literature？

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Fudan Journal of the Humanities and Social Sciences 2015年第3期8卷 347-354页

作者： duncan Large British Centre for Literary Translation University of East Anglia Norwich NR4 7TJ UK

Comparative literature is one of the main disciplines out of which translation studies emerged, so it is hardly surprising if at times the relationship between the two subjects has been marked by antagonism. Comparative literary scholars, in particular--perennially anxious about the status of comparative lit- erature itself have argued that their discipline has been subsumed and superseded by translation studies. Yet in recent decades, the two subject areas have also been growing further apart, to the extent that Susan Bassnett, one of the key proponents of the antagonistic view, has modified her stance and argued instead for a rap- prochement between the two under the heading of intercultural studies.

关键词： Translation Comparative literature Susan Bassnett Intercultural studies

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