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Spleen volume is associated with overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with portal hypertension

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2054-2064页

作者： Chun-Juan Zhao Chao Ren Zhen Yuan Guo-Hui Bai Jin-Yu Li Long Gao Jin-Hui Li Ze-Qi Duan dui-p.ng feng Hui Zhang College of Medical Imaging Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Radiology The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Occupational Health School of Public HealthShanxi Key Laboratory of Environmental Health Impairment and PreventionNHC Key Laboratory of PneumoconiosisMOE Key Laboratory of Coal Environmental Pathogenicity and PreventionShanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Oncological and Vascular Intervention The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Shanxi provincial Clinical Research Center for Interventional Medicine The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina First Clinical Medical College Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Shanxi Key Laboratory of Intelligent Imaging and Nanomedicine The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Intelligent Imaging Big Data and Functional Nano-imaging Engineering Research Center of Shanxi province The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

BACKGROUND portal shunt and immune status related to the spleen are related to the occurrence of hepatic encephalopathy(HE).It is unknown whether spleen volume before transjugular intrahepatic portosystemic shunt(TIpS)is related to postoperative *** To investigate the relationship between spleen volume and the occurrence of *** This study included 135 patients with liver cirrhosis who underwent TIpS,and liver and spleen volumes were elevated upon computed tomography *** Kaplan-Meier curve was used to compare the difference in the incidence rate of HE among patients with different spleen *** and multivariate Cox regression analyses were performed to identify the factors affecting overt HE(OHE).Restricted cubic spline was used to examine the shapes of the dose-response association between spleen volumes and OHE *** The results showed that 37(27.2%)of 135 patients experienced OHE during a 1-year follow-up *** with preoperative spleen volume(901.30±471.90 cm3),there was a significant decrease in spleen volume after TIpS(697.60±281.0 cm^(3))in OHE *** the severity of OHE increased,the spleen volume significantly decreased(ppared with patients with a spleen volume≥782.4 cm^(3),those with a spleen volumeppleen volume was an independent risk factor for post-TIpS OHE(hazard ratio=0.494,ppline model showed that with an increasing spleen volume,OHE risk showed an initial increase and then decrease(ppleen volume is related to the occurrence of OHE after *** spleen volume is an independent risk factor for post-TIpS OHE.

关键词： Hepatic encephalopathy Transjugular intrahepatic portosystemic shunt Spleen volume portal hypertension Cirrhosis

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Impressive recompensation in transjugular intrahepatic portosystemic shunt-treated individuals with complications of decompensated cirrhosis based on Baveno VII criteria

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World Journal of Gastroenterology 2023年第38期29卷 5383-5394页

作者： Long Gao Man-Biao Li Jin-Yu Li Yang Liu Chao Ren dui-p.ng feng Department of Oncological and Vascular Intervention First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Shanxi provincial Clinical Research Center for Interventional Medicine First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina College of Medical Imaging Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

BACKGROUND Transjugular intrahepatic portosystemic shunt(TIpS)is the standard second-line treatment option for individuals with complications of decompensated cirrhosis,such as variceal bleeding and refractory *** To investigate whether recompensation existed in TIpS-treated patients with decompensated cirrhosis according to Baveno VII *** This retrospective analysis was performed on 64 patients who received TIpS for variceal bleeding or refractory *** definition of recompensation referred to Baveno VII criteria and previous *** events,laboratory tests,and radiological examinations were regularly conducted during a preset follow-up *** recompensation ratio in this cohort was *** that,univariate and multivariate regression models were conducted to identify the predictors of *** Of the 64 patients with a 12-mo follow-up,20(31%)achieved ***[odds ratio(OR):1.124;95%confidence interval(CI):1.034-1.222]and postTIpS portal pressure gradientpendent predictors of recompensation in patients with decompensated cirrhosis after *** The present study demonstrated that nearly one-third of the TIpS-treated patients achieved recompensation within this *** to our findings,recompensation is more likely to be achieved in younger *** addition,postoperative portal pressure gradient reduction below 12 mmHg contributes to the occurrence of recompensation.

关键词： Liver cirrhosis Cirrhosis recompensation Complications portal hypertension Transjugular intrahepatic portosystemic shunt predictors

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Cross-talk between microRNA-let7c and transforming growth factor-β2 during epithelial-to-mesenchymal transition of retinal pigment epithelial cells

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 693-700页

作者： Qu-Zhen Deji feng Yan Wang-dui Zhaba Ya-Jun Liu Jie Yin Zhen-p.ng Huang Department of Ophthalmology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina Department of Neurosurgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina Department of Ophthalmology Affiliated Drum Tower HospitalMedical School of Nanjing UniversityNanjing 210008Jiangsu ProvinceChina

AIM: To explore the roles of microRNA-let7 c(miR-let7 c) and transforming growth factor-β2(TGF-β2) and cellular signaling during epithelial-to-mesenchymal transition(EMT) of retinal pigment epithelial cells. METHODS: Retinal pigment epithelial(ARpE-19) cells were cultured with no serum for 12 h, and then with recombinant human TGF-β2 for different lengths of time. ARpE-19 cells were transfected with 1×106 TU/mL miR-let7 c mimcs(miR-let7 cM), miR-let7 c mimcs negative control(miR-let7cMNC) and miR-let7 c inhibitor(miR-let7 cI) using the transfection reagent. The expression of keratin-18, vimentin, N-cadherin, IKB alpha, p65 were detected by Western blot, quantitative polymerase chain reaction and immunofluorescence. RESULTS: The expression of miR-let7c was dramatically reduced and the nuclear factor-kappa B(NF-κB) signaling pathway was activated after induction by TGF-β2(ppressed miR-let7 c significantly inhibited TGF-β2-induced EMT(png pathway was inhibited by BAY11-7082(png pathway in ARpE-19 cells.

关键词： microRNA-let7c transforming growth factor-β2 epithelial-to-mesenchymal transition human retinal pigment epithelial cells nuclear factor-kappa B pathway

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The role of mechanical stretch and TGF-β2 in epithelial-mesenchymal transition of retinal pigment epithelial cells

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International Journal of Ophthalmology(English edition) 2019年第12期12卷 1832-1838页

作者： Qian Cao Qu-Zhen Deji Ya-Jun Liu Wei Ye Wang-dui Zhaba Qin Jiang feng Yan Eye Hospital Nanjing Medical UniversityNanjing 210002Jiangsu ProvinceChina The Fourth School of Clinical Medicine Nanjing Medical UniversityNanjing 210002Jiangsu ProvinceChina Affiliated Jinling Hospital Medical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina Departm ent of Ophthalm ology N anjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina School of Second Military Medical University Department of OphthalmologyJinling HospitalNanjing 210002Jiangsu ProvinceChina

AIM: To explore the effects and mechanisms of mechanical stress and transforming growth factor-beta2(TGF-β2) on epithelial-mesenchymal transition(EMT) in cultured human retinal pigment epithelial(RpE) cells. METHODS: Human RpE cells were inoculated on BioF ex 6-well plates and RpE cells received 0, 1, 2, 3, or 4 mild stretch injuries delivered 3h apart after 24h of culture. The device of mechanical stress parameters were set to sine wave, frequency 1 Hz, stretch strength 20%. For treatment with TGF-β2, when the inoculated RpE cells in 6-well plates were around 60% confluent, serum was reduced to 0 for 12h and recombinant human TGF-β2(0, 1, 5, 10 ng/mL)was added for 48h. α-SMA, Vimentin and N-Cadherin, fibronectin proteins expressions were detected by Western blotting, confocal cell immunofluorescence and quantitative real-time polymerase chain reaction(q RT-pCR). Then we detected the change of mi RNA-29b and ascertained the changes of phosphatidylinositol 3-kinase-serine threonine protein kinase(pI3K/Akt) pathway after RpE cells were stretched by the device of mechanical stress and induced by TGF-β2 by Western blotting, confocal cell immunofluorescence and qR T-pCR. RESULTS: Mechanical stress induce EMT and activate the pI3K/Akt pathway in ways that lead to the EMT process. TGF-β2 induce RpE cells EMT and in a certain range and TGF-β2 decrease the miR NA-29b expression in RpE cells, and the inhibitory effect is more obvious with the increase of TGF-β2 concentration. CONCLUSION: Our findings are crucial steps in determining the critical roles of the pI3K/Akt signaling pathway and mi RNA-29b in pathogenesis of proliferative vitreoretinopathy(pVR) which may be a potential target for preventing or treating pVR.

关键词： mechanical stress transforming growth factor-beta2 microRNA 29b epithelial-mesenchymal transition phosphatidylinositol 3-kinase-serine threonine protein kinase pathway proliferative vitreoretinopathy

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长毛风毛菊提取物治疗肾性水肿的化学成分和作用机制研究

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沈阳药科大学学报 2024年第4期41卷 438-450页

作者：王昭君詹兰兰姚闽钟国跃冯育林李军茂占堆江西中医药大学中药固体制剂制造技术国家工程研究中心江西南昌330006 江西省药品检验检测研究院江西南昌330004 创新药物与高效节能降耗制药设备国家重点实验室江西南昌330006 西藏藏医药大学西藏拉萨850000

目的阐明藏药长毛风毛菊的药效及化学成分,探讨其有效成分、关键靶点和相关通路,明确其治疗肾性水肿的作用机制。方法将SD大鼠分为空白组、阿霉素诱导肾性水肿模型组,长毛风毛菊给药低剂量组、高剂量组。测定血清生化指标,探讨各组总蛋... 详细信息

目的阐明藏药长毛风毛菊的药效及化学成分,探讨其有效成分、关键靶点和相关通路,明确其治疗肾性水肿的作用机制。方法将SD大鼠分为空白组、阿霉素诱导肾性水肿模型组,长毛风毛菊给药低剂量组、高剂量组。测定血清生化指标,探讨各组总蛋白(total protein,Tp)、尿素氮(blood u-rea nitrogen,BUN)、血肌酐(serum creatinine,SCr)、甘油三酯(triglyceride,TG)、总胆固醇(serum total cholestero,TC)、低密度脂蛋白(low density lipoprotein,LDL-C)、高密度脂蛋白(high density lipopro-tein,HDL-C)指标的情况。采用UpLC-Q-TOF-MS/MS技术对藏药长毛风毛菊的化学成分进行分析;在SwissTargetprediction、GeneCards数据库分别获取长毛风毛菊化学成分靶点和肾性水肿靶点,取交集获得治疗肾性水肿作用靶点;通过STRIng数据库进行蛋白互作分析;利用Metascape平台进行gene ontology(GO)功能和京都基因和基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)通路分析;将药物、靶点等导入到Cytoscape3.7.2构建“药物-成分-靶点-疾病-通路”网络图。筛选出排名靠前的6个基因和12个有效成分,通过分子对接技术验证网络药理预测的准确性,揭示长毛风毛菊治疗肾性水肿的作用机制。结果大鼠血清中Tp、HDL-C指标上调,BUN、SCr、TC、TG和LDL-C指标均下调。从藏药长毛风毛菊提取物中共鉴定了71个化合物,包括7个苯丙素类、16个绿原酸类和39个黄酮类等成分。通过预测得出75个长毛风毛菊治疗肾性水肿靶点,GO富集共涉及生物过程、细胞组分、分子功能3个方面,KEGG富集结果显示pI3K/AKT、AGE-RAGE、MApK等是显著通路。分子对接结果显示,有效成分与关键靶点结合能Vina评分均小于0,高效验证了网络药理预测的准确性。结论该研究基于药效学实验,结合UpLC-Q-TOF-MS/MS鉴定、网络药理学分析和分子对接技术,表明长毛风毛菊能够治疗肾性水肿,可能通过调控pI3K/AKT、AGE-RAGE、MApK信号通路中Tp53、pI3K、AKT等相关靶点来发挥作用。

关键词：长毛风毛菊 UpLC-Q-TOF-MS/MS 网络药理学分子对接肾性水肿

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基于ARMA预测模型的中药材价格预警研究

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中国中药杂志 2014年第9期39卷 1721-1723页

作者：常峰茅鸯对中国药科大学江苏南京211198

该研究搭建了中药材价格预警系统框架,采用中药材价格指数为预警指标建立中药材价格黑色预警模型,以价格指数波动率为警情指标,以物价原则确立警限,将警度划分为负向重警、负向轻警、无警、正向轻警、正向重警5个区间,对应5种不同颜色... 详细信息

该研究搭建了中药材价格预警系统框架,采用中药材价格指数为预警指标建立中药材价格黑色预警模型,以价格指数波动率为警情指标,以物价原则确立警限,将警度划分为负向重警、负向轻警、无警、正向轻警、正向重警5个区间,对应5种不同颜色的信号灯以描述中药材价格市场的变动程度。采集2010年11月至2013年10月的月度价格指数作为时间序列,对中药材价格指数进行预测预警实证研究。在构建ARMA预测模型测算指数预测值的基础上,进一步获取中药材价格预警结果并作出分析,最后向中药材种植户、商业公司、消费者与政府提出了建议。

关键词：中药材价格预警价格指数 ARMA模型

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Study on Insect-resistant Transgenic Cotton Harbouring Double-gene and Its Resistance to Insect pests

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Agricultural Sciences in China 2001年第1期 70-76页

作者： LI Fu-guang CUI Jin-jie LIU Chuan-liang WU Zhi-xia LI feng-lian ZHOU Yong LI Xiu-lan GUO San-dui CUI Hong-zhi Cotton Research Institute Chinese Academy of Agriculcural SciencesKey Laboratory of Cotton Genetic ImprovementMinistry of AgricultureHenan Anyang 455112 Biotechnology Research Center Chinese Academy of Agriculcural SciencesBeijing 100081

By using the method of pollen tube pathway,the synthesized GFM CryIA gene and modified CpTI gene were transfered into the elite cotton(Gossypium hirsutun L.)varieties(lines).Through the field and lab identifications,the insect-resistant transgenic plants were *** analysis indicated that both the synthesized GFM CryIA gene and modified CpTI gene presented positive *** R1 the boliworm resistance of each transformant was different,and the insect-resistance of R3 of ZGK9708 was stable.

关键词： Insecticidal double-gene Upland cotton Genetic transfermation Bollworm Insect-resistance identification

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无氮(O_2/CO_2)环境下柴油机燃烧规律的试验研究

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合肥工业大学学报（自然科学版） 2013年第6期36卷 664-666,703页

作者：王对对左承基王作峰王华合肥工业大学机械与汽车工程学院安徽合肥230009

文章针对同时控制柴油机NOx与碳烟排放的难题,进行了无氮(O2/CO2)环境下柴油机燃烧规律研究,设计了柴油机无氮燃烧的试验装置,从柴油机缸内压力、压力升高率和燃烧放热率3个方面,对比研究了柴油机常规进气和无氮进气条件下的燃烧规律。... 详细信息

文章针对同时控制柴油机NOx与碳烟排放的难题,进行了无氮(O2/CO2)环境下柴油机燃烧规律研究,设计了柴油机无氮燃烧的试验装置,从柴油机缸内压力、压力升高率和燃烧放热率3个方面,对比研究了柴油机常规进气和无氮进气条件下的燃烧规律。结果表明:在无氮进气条件下,柴油机可以稳定正常工作,其放热率高于常规进气条件。所得结果为柴油机大规模应用无氮燃烧技术提供了试验依据。

关键词：无氮(O2 CO2)燃烧缸内压力压力升高率燃烧放热率

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几种大气稳定度分类标准计算方法的比较分析

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热带气象学报 2005年第4期21卷 402-409页

作者：毕雪岩刘烽吴兑中国气象局广州热带海洋气象研究所广东广州510080 Chair for environment meteorology in Brandenburg Technical University Germany

讨论了适用于城市环境中的稳定度参数(莫宁-奥布霍夫长度L、梯度理查森数Ri、总体理查森数Rib)的稳定度分类标准的计算问题,并利用北京市325m气象塔的梯度观测资料,采用***、Irwin和Houghton提出的3种不同的稳定度分类标准计算方法对总... 详细信息

讨论了适用于城市环境中的稳定度参数(莫宁-奥布霍夫长度L、梯度理查森数Ri、总体理查森数Rib)的稳定度分类标准的计算问题,并利用北京市325m气象塔的梯度观测资料,采用***、Irwin和Houghton提出的3种不同的稳定度分类标准计算方法对总体理查森数Rib进行分类,结果表明,对于北京地区,采用Irwin提出的稳定度分类标准相对合理。

关键词：大气稳定度分类稳定度分类标准北京稳定度参数

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中国水土流失与贫困的关系分析

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水土保持通报 2006年第3期26卷 67-72页

作者：第宝锋宁堆虎鲁胜力中国科学院水利部成都山地灾害与环境研究所水利部水土保持司北京100053

水土流失是我国目前面临的严重危机之一,所造成的危害不仅表现在水土资源破坏、生态环境退化等方面,而且已成为区域贫困的主要根源。应用统计分析等方法,研究证明了我国水土流失区与贫困人口的空间分布具有地理耦合性。二者相互影响,互... 详细信息

水土流失是我国目前面临的严重危机之一,所造成的危害不仅表现在水土资源破坏、生态环境退化等方面,而且已成为区域贫困的主要根源。应用统计分析等方法,研究证明了我国水土流失区与贫困人口的空间分布具有地理耦合性。二者相互影响,互为因果,生态的破坏导致了水土流失,水土流失又限制了对有限资源的有效利用,增加了环境的压力,成为生态恶化和贫困的根源,同时进一步的贫困又加速了水土流失和生态恶化。因此,全面推进水土保持,控制水土流失,可以实现水土资源的可持续利用,有效改善生态环境,增加农民收入,逐步从根本上减轻贫困。

关键词：水土流失贫困关系生态恶化水土保持

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