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The biochemical efficacy of primary cryoablation combined with prolonged total androgen suppression compared with radiotherapy on high-risk prostate cancer： a 3-year pilot study

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Asian Journal of Andrology 2010年第6期12卷 827-834页

作者： Young Hwii Ko Seok Ho Kang Young Je Park Hong Seok Park Du Geon Moon Jeong Gu Lee duck ki yoon Je Jong kim Jun Cheon Department of Urology MIS ＆ Robotic Urologic Surgery Centre Korea University School of Medicine Seoul 136-705Korea Department of Radiation Oncology Korea University School of Medicine Seoul 136-705 Korea

To gain beneficial effects in the management of high-risk prostate cancer, an integrated approach that combines local therapy and androgen deprivation therapy （ADT） was used. We compared biochemical responses between primary cryosurgical ablation of the prostate （CSAP） combined with prolonged ADT and radiation combined with ADT, which is the established modality in high-risk disease. A total of 33 high-risk patients received CSAP combined with ADT for 3 months before and up to 24 months after treatment. This patient group was matched with another 33 patients who had undergone three-dimensional conformal radiation therapy （3D-CRT） with the same protocol for ADT. Biochemical recurrence （BCR） was assessed by the American Society for Therapeutic Radiation Oncology （ASTRO） definition, the Phoenix definition and a prostate-specific antigen （PSA） cutoff of 0.5 ng mL^-1. Median follow-up was 61.0 ± 11.9 months for the CSAP ＋ ADT group and 86.0±15.8 months for the 3D-CRT ＋ ADT group. In the CSAP group, major complications including rectourethral fistula and incontinence were not noted. In the CSAP ＋ ADT group, 57.0% had BCR using the ASTRO definition, 21.2% using the Phoenix definition and 54.5% using a PSA cutoff of 0.5 ng mL^-1. In the 3D-CRT ＋ ADT group, 54.5%, 21.2% and 54.5% had BCR using the ASTRO, Phoenix and PSA definition, respectively. In the CSAP ＋ ADT group, the BCR-free survival （BRFS） was 54 ± 10 months using the ASTRO definition, 65 ± 5 months using the Phoenix definition and 51 ± 4 months using a PSA cutoff of 0.5 ng mL-1. In the 3D-CRT ＋ ADT group, the BRFS was 68 ± 12, 93 ± 19 and 70 ± 18 months using the ASTRO, Phoenix and PSA definition, respectively. By the log-rank test, the BRFS values for each group were not statistically different. This intermediate-term result indicated that primary CSAP combined with prolonged ADT offers a parallel biochemical response compared with radiotherapy in high-risk prostate cancer.

关键词： androgen ablation therapy cryoablation for the prostate radiotherapy

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Does robot-assisted laparoscopic radical prostatectomy enable to obtain adequate oncological and functional outcomes during the learning curve?From the Korean experience

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Asian Journal of Andrology 2009年第2期11卷 167-175页

作者： Young Hwii Ko Jeong Hyeon Ban Seok Ho Kang Hong Seok Park Jeong Gu Lee duck ki yoon Je Jong kim Jun Cheon Vipul RPatel Department of Urology MIS&Robotic Urologic Surgery CenterKorea University School of MedicineSeoul 136705Korea Global Robotics Institute University of Central FloridaFlorida HospitalOrlandoFL 32803USA

To estimate the short-term results of robot-assisted laparoscopic radical prostatectomy(RALRP)during the learning curve,in terms of surgical,oncological and functional outcomes,we conducted a prospective survey on *** July 2007,a single surgeon performed 63 robotic prostatectomies using the same operative *** data,including pathological and early functional results of the patient,were collected prospectively and *** with the accumulation of the cases,the total operative time,setup time,console time and blood loss were significantly *** major complication was present in any *** was needed in six patients;all of them were within the initial 15 *** positive surgical margin rate was 9.8%(5/51)in pT2 *** most frequent location of positive margin in this stage was the lateral aspect(60%),but in pT3 disease multiple margins were the most frequent(41.7%).Overall,53(84.1%)patients had totally continent status and the median time to continence was 6.56 *** 17 patients who maintained preoperative sexual activity(Sexual Health Inventory for Men≥17),stage below pT2,followed up for>6 months with minimally one side of neurovascular bundle preservation procedure,12(70.6%)were capable of intercourse postoperatively,and the mean time for sexual intercourse after operation was 5.7 *** this series,robotic prostatectomy was a feasible and reproducible technique,with a short learning curve and low perioperative complication *** during the initial phase of the learning curve,satisfactory results were obtained with regard to functional and oncological outcome.

关键词： learning curve outcomes assessment radical prostatectomy robotics

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Effects of casting speed on microstructure and segregation of electromagnetically stirred Aluminum alloy in continuous casting process

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Rare Metals 2006年第Z2期25卷 118-123页

作者： LEE Dock-Young KANG Suk-Won CHO duck-Ho kiM ki-Bae Division of Materials Korea Institute of Science and Technology P.O. Box 131 Cheongryang Seoul 130-650 Korea Department of Applied Materials Engineering Hanbat National University Daejeon 305-719 Korea

Recently, a semi-solid metal processing has been acknowledged as a cost-effective technique to be able to manufacture high quality product for the transportation industry. In this study a hypo-eutectic Al alloy was fabricated by means of an electromagnetic stirrer in continuous casting process and the microstructural change during solidification due to a fluid flow by electromagnetic stirring was examined. Due to the forced fluid flow during solidification a dendritic phase of primary α phase of Al alloy was turned into a globular phase, which can make the Al alloy get a thixotropic behavior in the semi-solid region. In order to establish the quantitative relationship between microstructure and the process parameters, the morphology shape, a silicon distribution and a size of primary α phase were observed according to casting speed in continuous casting machine. The primary α phase was turned into the degenerate dendrites approaching a spherical configuration with increasing casting speed. The fine-grained and equiaxed microstructure appeared at higher casting speed. A segregation behavior of Si element was declined with increasing casting speed and a very uniform distribution of Si element was observed on the billet at a casting speed of 600 mm·min-1. A thickness of the solidifying shell of the billet was shortened with increasing the casting speed.

关键词： semi-solid slurry electromagnetic stirring casting speed segregation Al alloy

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Modification strategies improving the electrochemical and structural stability of high-Ni cathode materials

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Journal of Energy Chemistry 2024年第9期96卷 185-205页

作者： yoon Bo Sim Hami Lee Junyoung Mun ki Jae kim Department of Energy Science Sungkyunkwan UniversitySuwon 16419Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

With the increasing spotlight in electric vehicles,there is a growing demand for high-energy-density batteries to enhance driving ***,several studies have been conducted on high-energy-density LiNi_(x)Co_(y)Mn_(z)O_(2)***,there is a limit to permanent performance deterioration because of side reactions caused by moisture in the atmosphere and continuous microcracks during cycling as the Ni content to express high energy increases and the content of Mn and Co that maintain structural and electrochemical stabilization *** direct modification of the surface and bulk regions aims to enhance the capacity and long-term performance of high-Ni cathode ***,an efficient modification requires a study based on a thorough understanding of the degradation mechanisms in the surface and bulk *** this review,a comprehensive analysis of various modifications,including doping,coating,concentration gradient,and single crystals,is conducted to solve degradation issues along with an analysis of the overall degradation mechanism occurring in high-Ni cathode *** also summarizes recent research developments related to the following modifications,aims to provide notable points and directions for post-studies,and provides valuable references for the commercialization of stable high-energy-density cathode materials.

关键词： High energy density High-Ni cathode materials Degradation Structural stability Lithium-ion battery

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Characterization of plasma electrolytic oxide formed on AZ91 Mg alloy in KMnO_4 electrolyte

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中国有色金属学会会刊：英文版 2009年第4期19卷 829-834页

作者： duck-Young HWANG ki-Ryong SHIN Bongyoung YOO Dong-Heon LEE Deok-Yong PARK Dong-Hyuk SHIN Department of Metallurgy and Materials Science Hanyang University Ansan 426-791 Korea Department of Applied Materials Engineering Hanbat National University Daejon 305-719 Korea 不详

The aim of this work is to investigate microstructure,corrosion resistance characteristics and nanohardness of the oxide layer on AZ91 Mg alloy by applying different voltage with KMnO4 contained *** are lots of closed pores that are filled with another oxide compound compared with the typical surface morphology with pore coated until 350 V of coating *** thickness of oxide layer increases with increasing coating *** oxide layer formed on AZ91 Mg alloy in electrolyte with potassium permanganate consists of MgO and *** potential of the oxide layer on AZ91 Mg alloy obtained at different plasma electrolytic oxidation(PEO) reaction stages increases with increasing coating *** corrosion resistance of AZ91 Mg alloy depends on the existence of the manganese oxide in the oxide *** inner barrier layer composed of the MgO and Mn2O3 may serve as diffusion barrier to enhance the corrosion resistance and may partially explain the excellent anti-corrosion performance in corrosion *** values increase with increasing coating *** increase in the nanohardness may be due to the effect of manganese oxide in the oxide layer on AZ91 Mg alloy coated from electrolyte containing KMnO4.

关键词： AZ91镁合金等离子体电解高锰酸钾氧化特性电解液氧化层厚度纳米硬度耐腐蚀性

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Unilateral foveomacular retinitis resembling solar retinopathy among young soldiers in Korean army and associated multimodal imaging findings

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 112-119页

作者： Chang ki yoon Kyu Hyung Park Se Joon Woo Department of Ophthalmology Seoul National University College of MedicineSeoul National University Bundang HospitalSeongnam 13620Korea Department of Ophthalmology Hallym University College of MedicineHallym University Kangnam Sacred Heart HospitalSeoul 07441Korea

AIM: To describe the clinical features and multimodal images of unilateral foveomacular retinitis in young Korean soldiers. METHODS: Ten patients having foveomacular retinitis were included. Fluorescein angiography, fundus autofluorescence(FAF), infrared reflectance(IR), and spectral-domain optical coherence tomography(SD-OCT) were ***: All patients were young males experienced insidious visual decline without exposure to bright light. Initial and final vision ranged from hand movement to 20/20(median 20/200) and 20/2000 to 20/20(median 20/500), respectively. Vision decreased in 6 patients while improved in two. Typical macular abnormality was yellow granular spots. SD-OCT showed ellipsoid zone(EZ) or interdigitation zone(IZ) disruption of fovea. The degree of EZ/IZ damage correlated with vision. Lesions were clearly visualized through IR and matched with SD-OCT ***: This is the first case series of foveomacular retinitis diagnosed with multimodal imaging. Foveomacular retinitis should be suspected in sudden unilateral visual decline especially in young soldiers. SD-OCT is the most important diagnostic modality.

关键词： foveomacular retinitis Korean multimodal imaging solar retinopathy soldiers unilateral

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Quantum-dot and organic hybrid light-emitting diodes employing a blue common layer for simple fabrication of full-color displays

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Nano Research 2022年第7期15卷 6477-6482页

作者： Suhyeon Lee Donghyo Hahm Suk-Young yoon Heesun Yang Wan ki Bae Jeonghun Kwak Department of Electrical and Computer Engineering Seoul National UniversitySeoul 08826Republic of Korea Inter-university Semiconductor Research Center(ISRC) Seoul National UniversitySeoul 08826Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT) School of Nano Science&TechnologySungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Materials Science and Engineering Hongik UniversitySeoul 04066Republic of Korea

Colloidal quantum-dot(QD)light-emitting diodes(QLEDs)have been in the forefront of future display devices due to their outstanding optoelectronic ***,a complicated solution-process for patterning the red,green,and blue QDs deteriorates the QLED performance and limits the resolution of full-color ***,we report a novel concept of QD–organic hybrid light-emitting diodes by introducing an organic blue common layer(BCL)which is deposited through a common mask over the entire *** from the optimized device structure,red and green QLEDs retained their color coordinates despite the presence of the ***,adopting the BCL improved the external quantum efficiency of green and red QLEDs by 38.4%and 11.7%,respectively,due to the Förster resonance energy transfer from the BCL to the adjacent QD *** the BCL structure,we could simply demonstrate a full-color QD-organic hybrid device in a single *** believe that this device architecture is practically applicable for easier fabrication of solution-processed,highresolution,and full-color displays with reduced process steps.

关键词： quantum-dot light-emitting diode(QLEDs) organic light-emitting diode blue common layer full-color display reduced process step

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Morbidity analysis of left hepatic trisectionectomy for hepatobiliary disease and live donor

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 362-369页

作者： Young-In yoon Sung-Gyu Lee Deok-Bog Moon Shin Hwang ki-Hun kim Hui-Ju kim ki-Hoon Choi Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine388-1 Poongnap-dongSongpa-guSeoul 138-736Korea Department of Surgery Gold Coast University HospitalSouthportQLD 4215Australia

Background:Despite remarkable advances in surgical techniques and perioperative management,left hepatic trisectionectomy(LHT)remains a challenging procedure with a somewhat high postoperative morbidity rate compared with less-extensive *** study aimed to analyze the short-and long-term outcomes of LHT and identify factors associated with the postoperative morbidity of this technically demanding surgical ***:The medical records of 53 patients who underwent LHT between June 2005 and October 2019 at a single institution were retrospectively *** independent prognostic factor of postoperative morbidity was analyzed using the logistic regression ***:Hepatocellular carcinoma was the most common indication for surgery(n=21),followed by hilar cholangiocarcinoma(n=14),intrahepatic cholangiocarcinoma(n=10),and other pathologies(including colorectal liver metastasis,hepatolithiasis,gallbladder cancer,living donor,hemangioma,and multilocular biliary cyst;n=8).The rates of postoperative morbidities of Clavien-Dindo grade 3 or higher and 90-day mortality were 39.6% and 1.9%,*** 1-,3-,and 5-year overall survival rates were 81.1%,61.4%,and 44.6%,*** analysis revealed that preoperative jaundice[hazard ratio(HR)=6.15,95%confidence interval(CI):1.57-24.17,P=0.009]and operative time>420 min(HR=4.66,95%CI:1.27–17.17,P=0.021)were independent predictors of postoperative ***:The in-hospital mortality of LHT surgery can be minimalized by a reliable preoperative evaluation of liver function and selection of the dominant anatomic features of right posterior sector,active and appropriate preoperative management for obstructive cholangitis and compensatory hypertrophy of the future remnant posterior sector,and the experience of the surgeon.

关键词： Left hepatic trisectionectomy Major hepatectomy Liver neoplasms Survival rate Morbidity

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Development of practical postprocessor for 5-axis machine tool with non-orthogonal rotary axes

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Journal of Central South University 2011年第1期18卷 159-164页

作者： JUNG Hyoun-Chul HWANG Jong-Dae PARK ki-Beom JUNG yoon-Gyo School of Mechatronics Changwon National University

In order to develop a practical postprocessor for 5-axis machine tool,the general equations of numerically controlled(NC) data for 5-axis configurations with non-orthogonal rotary axes were exactly expressed by the inverse kinematics,and a windows-based postprocessor written with Visual Basic was developed according to the proposed *** developed postprocessor is a general system suitable for all kinds of 5-axis machines with orthogonal and non-orthogonal rotary *** implementation of the developed postprocessor and verification by a cutting simulation and machining experiment,the effectiveness of the proposed algorithm is *** is improved by allowing exchange of data formats such as rotational total center position(RTCP) controlled NC data,vector post NC data,and program object file(POF) cutter location(CL) data,and convenience is increased by adding the function of work-piece origin ***,a practical post-processor for 5-axis machining is developed.

关键词： post-processor 5-axis machining non-orthogonal rotary axes numerically controlled (NC) data CL data

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Trilobite Biostratigraphy of the lower Paleozoic(Cambrian–Ordovician)Joseon Supergroup,Taebaeksan Basin,Korea

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Acta Geologica Sinica(English Edition) 2016年第6期90卷 1976-1999页

作者： CHOI duck K LEE Jeong Gu LEE Seung-Bae PARK,Tae-yoon S. HONG Paul S. Research Institute of Basic Sciences Seoul National UniversitySeoul 151-747Korea Ministry of Science ICTand Future PlanningGwacheon 427-700Korea Korea Institute of Geoscience and Mineral Resources Daejeon 305-350Korea Korea Polar Research Institute Incheon 406-840Korea

In Korea, trilobites are among the most intensively studied fossil groups in the past century and provide invaluable information about lower Paleozoic stratigraphy, paleogeography, and tectonics of the Korean Peninsula. Trilobites occur in the lower Paleozoic Joseon Supergroup of the Taebaeksan Basin which was part of the Sino-Korean Craton in the Paleozoic. The Joseon Supergroup is divided into the Taebaek, Yeongwol, and Mungyeong groups. The Taebaek and Yeongwol groups are richly fossiliferous, while the Mungyeong Group is poorly fossiliferous. Contrasting trilobite faunal contents of the Taebaek and Yeongwol groups resulted in two separate biostratigraphic schemes for the Cambrian–Ordovician of the Taebaeksan Basin. A total of 22 biozones or fossiliferous horizons were recognized in the Taebaek Group; 19 zones were established in the Yeongwol Group; and four biozones were known from the Mungyeong Group. These trilobite biozones of the Taebaeksan Basin indicate the Joseon Supergroup ranges in age from the Cambrian Series 2 to Middle Ordovician and can be correlated well with the formations of North China, South China, and Australia.

关键词： Trilobites biostratigraphy Cambrian–Ordovician Taebaeksan Basin

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