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应客观评价微无创技术在妇产科疾病诊治中的应用

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中国实用妇科与产科杂志 2024年第9期40卷 913-917页

作者：陈春林段慧南方医科大学南方医院广东广州510515

微无创技术无确切的定义,郎景和院士认为微无创是一种理念、是一种原则,是通过创伤小甚至无创伤的技术实现治疗疾病的目的,从而就出现了微创技术、无创技术的名词。目前,无论是医生群体还是患者群体,都在极力追求推崇使用微创、无创的... 详细信息

微无创技术无确切的定义,郎景和院士认为微无创是一种理念、是一种原则,是通过创伤小甚至无创伤的技术实现治疗疾病的目的,从而就出现了微创技术、无创技术的名词。目前,无论是医生群体还是患者群体,都在极力追求推崇使用微创、无创的技术诊治相关疾病。但是需要清楚地认识到所有疾病的诊治均应建立在以人为本的宗旨上,应客观评价各项微无创技术对不同疾病诊治的适应证、禁忌证及利弊,为患者提供最适宜的治疗方案,在造福患者的同时,更好地发展微无创技术。

关键词：腹腔镜手术高强度聚焦超声消融子宫动脉栓塞术经阴道手术适应证禁忌证

Two-photon polymerization lithography for imaging optics

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International Journal of Extreme Manufacturing 2024年第4期6卷 21-60页

作者： Hao Wang Cheng-feng Pan Chi Li Kishan S Menghrajani Markus A Schmidt Aoling Li Fu Fan Yu Zhou Wang Zhang Hongtao Wang Parvathi Nair Suseela Nair John You En Chan Tomohiro Mori Yueqiang Hu Guangwei Hu Stefan A Maier Haoran Ren Huigao duan Joel K W Yang College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082People's Republic of China Engineering Product Development Singapore University of Technology and DesignSingapore 487372Singapore Greater Bay Area Institute for Innovation Hunan UniversityGuangzhou 511300People's Republic of China Department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3Singapore 117576Singapore School of Physics and Astronomy Faculty of ScienceMonash UniversityMelbourneVictoria 3800Australia Leibniz Institute of Photonic Technology 07745 JenaGermany Abbe Center of Photonics and Faculty of Physics FSU Jena07745 JenaGermany Otto Schott Institute of Material Research FSU Jena07745 JenaGermany Institute of Materials Research and Engineering A*STAR(Agency for Science Technology and Research)Singapore 138634Singapore Industrial Technology Center of Wakayama Prefecture Wakayama 6496261Japan School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore639798Singapore Department of Physics Imperial College LondonLondon SW72AZUnited Kingdom

Optical imaging systems have greatly extended human visual capabilities,enabling the observation and understanding of diverse *** technologies span a broad spectrum of wavelengths from x-ray to radio frequencies and impact research activities and our daily *** glass lenses are fabricated through a series of complex processes,while polymers offer versatility and ease of ***,modern applications often require complex lens assemblies,driving the need for miniaturization and advanced designs with micro-and nanoscale features to surpass the capabilities of traditional fabrication ***-dimensional(3D)printing,or additive manufacturing,presents a solution to these challenges with benefits of rapid prototyping,customized geometries,and efficient production,particularly suited for miniaturized optical imaging *** 3D printing methods have demonstrated advantages over traditional counterparts,yet challenges remain in achieving nanoscale ***-photon polymerization lithography(TPL),a nanoscale 3D printing technique,enables the fabrication of intricate structures beyond the optical diffraction limit via the nonlinear process of two-photon absorption within liquid *** offers unprecedented abilities,***-free fabrication,micro-and nanoscale capabilities,and rapid prototyping of almost arbitrary complex 3D *** this review,we emphasize the importance of the criteria for optical performance evaluation of imaging devices,discuss material properties relevant to TPL,fabrication techniques,and highlight the application of TPL in optical *** the first panoramic review on this topic,it will equip researchers with foundational knowledge and recent advancements of TPL for imaging optics,promoting a deeper understanding of the *** leveraging on its high-resolution capability,extensive material range,and true 3D processing,alongside advances in materials,fabrication,and design,we en

关键词： two-photon polymerization lithography 3D printing additive manufacturing imaging optics and nanophotonics

类胡萝卜素类原料在缓解视觉疲劳保健食品中的应用研究进展

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食品科学 2024年第6期45卷 317-325页

作者：段昊松伟王峰闫文杰北京联合大学生物化学工程学院生物活性物质与功能食品北京市重点实验室北京100023 北京联合大学应用文理学院北京联合大学生物活性物质与功能食品北京市重点实验室北京100191

视觉疲劳是由多种原因引起的眼部不适感,并且涉及的人群较为广泛。研究显示,通过合理的膳食补充,可有效改善视觉疲劳引起的眼部不适感,甚至减少视觉疲劳的发生。目前,以叶黄素为代表的类胡萝卜素类原料在缓解视觉疲劳功效方面的机理研... 详细信息

视觉疲劳是由多种原因引起的眼部不适感,并且涉及的人群较为广泛。研究显示,通过合理的膳食补充,可有效改善视觉疲劳引起的眼部不适感,甚至减少视觉疲劳的发生。目前,以叶黄素为代表的类胡萝卜素类原料在缓解视觉疲劳功效方面的机理研究还不够深入,缺少其在缓解视觉疲劳保健食品应用方面的综述。因此,本文阐述了类胡萝卜素类原料在机体内的消化、吸收及代谢的途径,并综述了类胡萝卜素类原料在缓解视觉疲劳方面的研究进展。同时,本文还统计分析了类胡萝卜素类原料在我国缓解视觉疲劳保健食品中的配伍应用情况,以期为缓解视觉疲劳保健食品的开发提供一定的参考依据和启发。

关键词：缓解视觉疲劳类胡萝卜素消化吸收及代谢保健食品

Multi-omics analysis reveals the molecular regulatory network underlying the prevention of Lactiplantibacillus plantarum against LPS-induced salpingitis in laying hens

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Journal of Animal Science and Biotechnology 2024年第1期15卷 427-441页

作者： Dan Song Aike Li Bingxu Chen Jia feng Tao duan Junlin Cheng Lixian Chen Weiwei Wang Yuna Min College of Animal Science and Technology Northwest A&F UniversityShaanxiPeople’s Republic of China Key Laboratory of Grain and Oil Biotechnology of National Food and Strategic Reserves Administration Academy of National Food and Strategic Reserves AdministrationBeijingPeople’s Republic of China

Background Salpingitis is one of the common diseases in laying hen production, which greatly decreases the economic outcome of laying hen farming. Lactiplantibacillus plantarum was effective in preventing local or systemic inflammation, however rare studies were reported on its prevention against salpingitis. This study aimed to investigate the preventive molecular regulatory network of microencapsulated Lactiplantibacillus plantarum(MLP) against salpingitis through multi-omics analysis, including microbiome, transcriptome and metabolome *** The results revealed that supplementation of MLP in diet significantly alleviated the inflammation and atrophy of uterus caused by lipopolysaccharide(LPS) in hens(P < 0.05). The concentrations of plasma IL-2 and IL-10 in hens of MLP-LPS group were higher than those in hens of LPS-stimulation group(CN-LPS group)(P < 0.05). The expression levels of TLR2, MYD88, NF-κB, COX2, and TNF-α were significantly decreased in the hens fed diet supplemented with MLP and suffered with LPS stimulation(MLP-LPS group) compared with those in the hens of CN-LPS group(P < 0.05). Differentially expressed genes(DEGs) induced by MLP were involved in inflammation, reproduction, and calcium ion transport. At the genus level, the MLP supplementation significantly increased the abundance of Phascolarctobacterium, whereas decreased the abundance of Candidatus_Saccharimonas in LPS challenged hens(P < 0.05). The metabolites altered by dietary supplementation with MLP were mainly involved in galactose, uronic acid, histidine, pyruvate and primary bile acid metabolism. Dietary supplementation with MLP inversely regulates LPSinduced differential metabolites such as Lyso PA(24:0/0:0)(P < 0.05).Conclusions In summary, dietary supplementation with microencapsulated Lactiplantibacillus plantarum prevented salpingitis by modulating the abundances of Candidatus_Saccharimonas, Phascolarctobacterium, Ruminococcus_torques_group and Eubacterium_hallii_group w

关键词： Laying hen Metabolome Microbiome Microencapsulated Lactiplantibacillus plantarum Salpingitis Transcriptome

塔克拉玛干沙漠腹地近地层春季铅直湍流的小波分析

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气象与减灾研究 2008年第4期31卷 1-7页

作者：缪启龙温雅婷段春锋南京信息工程大学江苏省气象灾害重点实验室江苏南京210044 解放军理工大学气象学院军事气象系江苏南京211101

利用塔克拉玛干沙漠腹地近地层10m高度处快速响应探测系统的湍流资料,对春季晴天和沙尘暴天气下不同稳定层结的铅直湍流脉动进行小波变化及其方差分析,以期了解铅直湍流的尺度结构特征。结果表明,不稳定层结条件下,春季晴天近地层的铅... 详细信息

利用塔克拉玛干沙漠腹地近地层10m高度处快速响应探测系统的湍流资料,对春季晴天和沙尘暴天气下不同稳定层结的铅直湍流脉动进行小波变化及其方差分析,以期了解铅直湍流的尺度结构特征。结果表明,不稳定层结条件下,春季晴天近地层的铅直湍流脉动以12—17s的周期为主,最小周期为1—1.5s;春季沙尘暴时最主要的周期则为6—10s,最小周期为0.4—0.6s。沙尘暴时不稳定层结的湍流尺度总体上小于晴天,较小尺度波动振荡更加明显,湍流运动比晴天更加频繁。稳定层结条件下,春季晴天以10—16s的周期振荡为主,最小周期为1.3—1.8s;春季沙尘暴则以11—20s的周期振荡为主,最小周期为0.5—0.8s。晴天稳定层结时的铅直脉动比沙尘暴时周期小,小周期的湍流运动更明显一些,但周期更小的波动在沙尘暴天气时则多一些。

关键词：塔克拉玛干沙漠腹地近地层湍流小波分析.

有机无机肥配施对西北地区不同土壤类型氮素矿化影响

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农业机械学报 2024年第5期55卷 344-355页

作者：段晨骁李佳蓓吴淑芳冯浩西北农林科技大学旱区农业水土工程教育部重点实验室陕西杨凌712100 西北农林科技大学水利与建筑工程学院陕西杨凌712100 中国科学院水利部水土保持研究所陕西杨凌712100

为揭示不同施肥措施和土壤类型对我国西北地区典型农田土壤氮素矿化特征的影响,通过室内恒温好气培养法,分别研究不施肥(CK)、单施尿素(U)、单施有机肥(M)和尿素配施有机肥(U+M)施肥模式对土壤氮素矿化动态过程的影响,并对土壤累积矿化... 详细信息

为揭示不同施肥措施和土壤类型对我国西北地区典型农田土壤氮素矿化特征的影响,通过室内恒温好气培养法,分别研究不施肥(CK)、单施尿素(U)、单施有机肥(M)和尿素配施有机肥(U+M)施肥模式对土壤氮素矿化动态过程的影响,并对土壤累积矿化氮量进行一级动力学方程拟合及相关性分析。结果表明,施肥和土壤类型均显著影响土壤铵态氮含量、硝态氮含量和累积矿化氮量,且两者之间存在显著的交互作用。不同类型土壤累积矿化氮量和矿化速率由大到小依次为塿土、黄绵土、黄河灌淤土、灰棕漠土。与CK处理相比,不同施肥处理显著增加土壤累积矿化氮量、矿化速率常数(k)和矿化势(N0),处理间差异显著(P<0.05)。单施尿素和尿素配施有机肥处理的累积矿化氮量和矿化速率分别较CK处理增加2.83~6.71倍和3.83~7.70倍。相关分析表明,土壤累积矿化氮量与土壤有机质含量和全氮含量呈显著正相关关系。研究结果表明,有机无机肥配施处理可显著促进西北地区不同土壤类型氮素矿化,提高氮素有效性和供氮能力,有利于保持土壤矿质氮含量,对农田氮素高效利用有重要作用。

关键词：有机无机肥配施土壤类型氮素矿化累积矿化量西北地区

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近50年孝感市降水变化特征分析

暴雨灾害 2010年第1期29卷 81-84页

作者：张涛段春锋方芳王俐湖北省孝感市气象局孝感432000 南京信息工程大学大气科学学院南京210044 湖北省天门市气象局天门431700

利用趋势分析、小波变换等方法，分析了湖北省孝感市1957--2006年近50年降水的多时间尺度变化特征。结果表明：孝感市年降水量呈弱增加趋势，春秋季降水量呈下降趋势，冬夏季降水量呈增加趋势，其中以冬季降水增加趋势最为显著，降水量... 详细信息

利用趋势分析、小波变换等方法，分析了湖北省孝感市1957--2006年近50年降水的多时间尺度变化特征。结果表明：孝感市年降水量呈弱增加趋势，春秋季降水量呈下降趋势，冬夏季降水量呈增加趋势，其中以冬季降水增加趋势最为显著，降水量变化的年代际差异较小，年际差异很大；降水量变化存在明显的多时间尺度特征，其中以3～7a和准11a周期表现显著。

关键词：降水趋势分析小波分析

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Chromosome-level genome assembly of the Asian citrus psyllid,Diaphorina citri

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Insect Science 2024年第1期31卷 13-27页

作者： Shuang Lei Shi-Jiang Yu Qi Pan Li-Li Ding Si-Chen Li Lu-Yan Cheng Shu-Qi Wang Bing-Hai Lou Jun He Cui-Yun Lei Lin Cong Hao-Qiang Liu Xue-feng Wang chun Ran Citrus Research Institute Southwest University/Chinese Academy of Agricultural SciencesNational Engineering Research Center for CitrusChongqingChina

Diaphorina citri is a global citrus *** a vector insect,it can transmit the causative agents of citrus huanglongbing,causing irreversible losses to the citrus *** acquisition of genomic information can provide a molecular genetic basis for effective control of ***,the DNBSEQ™,Oxford Nanopore Technologies,and Hi-C technologies are applied to generate a high-quality chromosome-level genome of *** genome size of *** was 523.78 Mb with a scaffold N50 of 47.05 Mb distributed on 13 chromosomes.A total of 250.64 Mb(47.85%)repeat sequences and 24048 protein-coding genes were *** resequencing of female and male individuals indicated that the sex chromosome system of *** is *** analysis demonstrated that *** and Pachypsylla venusta,which separated from their most recent common ancestor about 336.62 million years ago,were the most closely ***,we identified genes potentially involved in detoxification metabolism,pathogen transmission,and honeydew secretion for further *** high-quality genome provides an important reference for developing effective management strategies of ***.

关键词： Asian citrus psyllid chromosome-level genome comparative genomics cytochrome P450 detoxification Huanglongbing

MMP-9 deficiency accelerates the progress of periodontitis

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Genes & Diseases 2024年第5期11卷 117-121页

作者： chun-Yan Wan Yixin Yin Xiaoyan Li Meng Meng Liu Graham Goldman Li-An Wu feng Wang Dao-Shu Luo Zhuo Chen Wen-An Xu Stephen Chen Mary MacDougall Merry L.Lindsey Zhi Chen Shuo Chen Department of Endodontics The Affiliated Hospital of Qingdao UniversitySchool of StomatologyQingdao UniversityQingdaoShandong 266003China Department of Developmental Dentistry School of DentistryThe University of Texas Health Science Center at San AntonioSan AntonioTX 78229USA Oral Implantology Center Jinan Stomatological HospitalJinanShandong 250001China Department of Endodontics School and Hospital of StomatologyCheeloo College of MedicineShandong Key Laboratory of Oral Tissue RegenerationShandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationShandong UniversityJinanShandong 250012China Department of Pediatric Dentistry School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi 710032China Laboratory of Clinical Applied Anatomy Department of Human AnatomySchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujian 350108China Key Laboratory for Oral Biomedical Research of Zhejiang Province Affiliated Hospital of StomatologyMedical CollegeZhejiang UniversityHangzhouZhejiang 310027China Department of Stomatology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China UBC Faculty of Dentistry University of British ColumbiaVancouverBC V6T 1Z3Canada School of Graduate Studies and Research Meharry Medical College and Research BiologistResearch Service Nashville VA Medical CenterNashvilleTN 37208USA State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST) Key Laboratory for Oral Biomedicine of Ministry of Education(KLOBM)School and Hospital of StomatologyWuhan UniversityWuhanHubei 430079China

Periodontitis is a chronic inflammatory disease caused by periodontopathic bacteria that affects periodontal support tissues.1 If left untreated,it results in loss of periodontal attachment and alveolar bone *** one-half of adults in the United States older than 30 years have periodontal disease.2 Though the disease is initiated by bacterial infection,it activates host defense systems that eventually lead to the degradation of the *** periodontitis,the disease progress involves further production of pro-inflammatory mediators such as cytokines,proteolytic enzymes like matrix metalloproteinases(MMPs),and their inhibitors.

关键词： period eventually untreated