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The Alzheimer's disease-associated gene TREML2 modulates inflammation by regulating microglia polarization and NLRP3 inflammasome activation

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Neural Regeneration Research 2023年第2期18卷 434-438页

作者： Si-Yu Wang Xin-Xin Fu Rui duan Bin Wei Hai-Ming Cao Yan E Shuai-Yu Chen Ying-Dong Zhang Teng Jiang Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Clinical Pharmacy School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjingJiangsu ProvinceChina

Triggering receptor expressed on myeloid cells-like 2(TREML2)is a newly identified susceptibility gene for Alzheimer's disease(AD).It encodes a microglial inflammation-associated *** date,the potential role of mic roglial TREML2 in neuroinflammation in the context of AD remains *** this study,APP/PS1 mice were used to investigate the dynamic changes of TREML2 levels in brain during AD *** addition,lipopolysaccharide(LPS)stimulation of primary microglia as well as a lentivirus-mediated TREML2 overexpression and knockdown were employed to explore the role of TREML2 in neuroinflammation in the context of *** res ults show that TREML2 levels gradually increased in the brains of AP P/PS1 mice during disease *** stimulation of primary microglia led to the release of inflammato ry cytokines including interleukin-1β,inte rleukin-6,and tumor necrosis factor-a in the culture *** LPS-induced mic roglial release of inflammatory cytokines was enhanced by TREML2 overexpression and was attenuated by TREML2 knoc *** increased the levels of mic roglial M1-type polarization marker inducible nitric oxide *** effect was enhanced by TREML2 overexpression and ameliorated by TREML2 ***,the levels of microglial M2-type polarization markers CD206 and ARG1 in the primary microglia were reduced by TREML2 overexpression and elevated by TREML2 *** stimulation increased the levels of NLRP3 in primary *** LPS-induced increase in NLRP3 was further elevated by TREML2 overexpression and alleviated by TREML2 *** summary,this study provides the first evidence that TREML2 modulates inflammation by regulating microglial polarization and NLRP3 inflammasome *** findings reveal the mechanisms by which TREML2 regulates microglial inflammation and suggest that TREML2 inhibition may represent a novel therapeutic strategy for AD.

关键词： Alzheimer's disease APP/PS1 mice inflammatory cytokine lipopolysaccharide microglia neuroinflammation NLRP3 inflammasome polarization susceptibility gene TREML2

Energy Efficient and Dynamic Hierarchical Clustering for Wireless Sensor Networks

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通讯和计算机（中英文版） 2013年第11期10卷 1422-1432页

作者： Tong duan Ken Ferens Witold Kinsner Department of Electrical and Computer Engineering Universioba of Manitoba Winnipeg ManitobaR3T 5V6 Canada

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长柄扁桃叶绿体基因组比较

生物工程学报 2020年第12期36卷 2850-2859页

作者：段春燕张凯段义忠河南科技大学农学院河南洛阳471003 榆林学院生命科学学院陕西榆林719000

蔷薇科桃属植物长柄扁桃Amygdalus pedunculata Pall.是我国重点发展的12种木本油料作物之一。将自然生长在陕西省榆林市毛乌素沙地的长柄扁桃进行高通量测序、组装得到了GenBank登录号为MG602257的长柄扁桃叶绿体基因组。与NCBI中其他... 详细信息

蔷薇科桃属植物长柄扁桃Amygdalus pedunculata Pall.是我国重点发展的12种木本油料作物之一。将自然生长在陕西省榆林市毛乌素沙地的长柄扁桃进行高通量测序、组装得到了GenBank登录号为MG602257的长柄扁桃叶绿体基因组。与NCBI中其他两个长柄扁桃叶绿体基因组(MG869261和KY101153)进行序列比对发现:长柄扁桃叶绿体基因组均呈现典型的4分区域结构;基因组序列GC含量均是36.8%;总长度MG602257

关键词：长柄扁桃蔷薇科叶绿体基因组密码子高通量测序

Construction of the homogenized temperature series during 1910-2014 and its changes in Hunan Province

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Journal of Geographical Sciences 2017年第3期27卷 297-310页

作者： PENG Jiadong LIAO Yufang JIANG Yuanhua ZHANG Jianming duan Lijie Hunan Climate Center Key Laboratory of Preventing-Diminishing Meteorological Disasters in Hunan Prov- ince Changsha 410118 China Lanshan Meteorological Bureau Lanshan 425800 Hunan China

Based on the statistical method and the historical evolution of meteorological sta- tions, the temperature time series for each station in Hunan Province during 1910-2014 are tested for their homogeneity and then corrected. The missing data caused by war and other reasons at the 8 meteorological stations which had records before 1950 is filled by interpola- tion using adjacent observations, and complete temperature time series since the estab- lishment of stations are constructed. After that, according to the representative analysis of each station in different time periods, the temperature series of Hunan Province during 1910-2014 are built and their changes are analyzed. The results indicate that the annual mean temperature has a significant warming trend during 1910-2014 and the seasonal mean temperature has the largest rising amplitude in winter and spring, followed by autumn, but no significant change in summer. Temperature variation over Hunan Province has several sig- nificant warm-cold alternations and more frequent than that in whole China. Annual and seasonal mean temperatures except summer and autumn have abrupt warming changes in the recent 100 years. The wavelet analysis suggests that the annual and four seasonal mean temperatures in recent 100 years have experienced two climatic shifts from cold to warm.

关键词： Hunan Province homogeneity temperature series change characteristics

审美与政治:当代西方美学的政治转向及其理论路径

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外国文学研究 2017年第6期39卷 151-160页

作者：段吉方华南师范大学文学院

当代西方美学的政治转向研究是当代美学研究基本问题域的深化和拓展,是现代性审美关系的另一种理论表达。从马克思美学遗产出发的西方马克思主义文化政治学、葛兰西的文化领导权理论、雅克·朗西埃及其"后阿尔都塞学派"的美学政治学、... 详细信息

当代西方美学的政治转向研究是当代美学研究基本问题域的深化和拓展,是现代性审美关系的另一种理论表达。从马克思美学遗产出发的西方马克思主义文化政治学、葛兰西的文化领导权理论、雅克·朗西埃及其"后阿尔都塞学派"的美学政治学、齐泽克的"后政治的生命政治"理论构成了当代西方美学政治转向的主要理论路径。这些理论路径在感性学的维度进一步强调美学研究的现实感和问题意识,研究重心集中于审美话语的现代性意义、历史衍变与现实表达,其中所探究的理论问题既是当代美学新的理论面向,又是对现代性社会发展中审美与政治、审美与社会、审美与伦理之间关系的一种重新梳理。

关键词：审美政治政治转向审美现代性

A New Variant of Combined Pulmonary Fibrosis and Emphysema from Long-Term High-Dose of Glucocorticoid Therapy: A Case Report

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Case Reports in Clinical Medicine 2017年第12期6卷 301-307页

作者： Qigang Zeng Chenxia duan Yong Dai Guangdong Hospital of Integrated Traditional Chinese and Western Medicine Foshan China

Recent studies have described the combination of both pulmonary emphysema and idiopathic interstitial lung disease (ILDs) by means of high-resolution computed axial tomography (HRCT). Definition of this syndrome was first named by Cottin as combined pulmonary fibrosis and emphysema (CPFE). Functional and radiological findings have showed that these patients are suffering from severe breathlessness, but whose pulmonary functional tests revealed no signs of obstruction, normal static lung volumes, and depressed DLco, most with a history of smoking [1] [2]. The radiological and endoscopic studies especially show that these patients have both areas of upper-lobe predominant emphysema and lesions compatible with fibrosis in both lung bases [3]. No prior research has reported any cases of such condition in person with no prior history of smoking as well as long-term high-dose of glucocorticoid therapy. In this case report, we discuss the presentation, diagnosis, and management of a 53-year-old non-smoker with increasing shortness of breath with a long-term high-dose of glucocorticoid therapy discovered to have an abnormal variant or presentation of CPFE. The cause of disease was attributed to a certain history of smoking in most studies;other potential risk factors have yet to be properly analyzed. This clinical report features a special case about the problem and solution surrounding this issue.

关键词： Emphysema Pulmonary Fibrosis High-Dose of Glucocorticoid Therapy Lung Diseases

Pastoral Investigation on the Form and Usage of Local-Style Dwelling Houses in Jiarong Tibetan Traditional Village of Danba County

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Journal of Building Construction and Planning Research 2018年第2期6卷 52-70页

作者： Bin Cheng Libin duan Yangliu Fu School of Civil Engineering and Architecture Southwest University of Science and Technology Mianyang China

Under the dual background of rapid development and urbanization, the research is of practical significance for the construction and development of new rural harmonious society on the traditional villages, residential forms and ways of using. The purpose of this study is to learn the characteristics of the local residential forms and their usage, reveal the relationship between these characteristics and villagers’ lifestyles, and grasp the villagers’ evaluation of the satisfaction on living space, by the investigation of 168 questionnaires, 16 families in-depth interviews and survey mapping in the W, Y and Z villages of Suopo Township, Danba County, Sichuan Province. The resulted showed that: 1) Residents have obvious uniform features, mostly 3 - 5 layers of single-family residences, mostly in the area of 400 - 500 m2. The height of the house and the rooms has a relatively fixed modulus. 2) In the survey of the usage of local dwelling houses, it was found that farmers have a fixed model for the use of residential buildings. Most of the living activities are gathered in their own courtyards, and the utilization of the living room is usually limited. The floors above the second floor often have the terrace formed by the retreat to dry the food. There are often more bedrooms for spare, more than 90% of the family of four or more have two or more living rooms. 3) The residential area is embodied in both horizontal and vertical directions: the first floor of the indoor room from the courtyard to the dining room has the property of semi-open and semi-private space, and it is the main place for neighborhood interaction;and the rooms of the second and above are more private. 4) In the long process of life, the form and usage of houses will change with the changes of external factors. The traditional dwelling houses will be built or renovated, accounting for about 36% of the total amount surveyed.

关键词： Suopo Township in Danba Jiarong Tibetan Pastoral Investigation Residential Form Usage

Death-associated protein kinase 1 is associated with cognitive dysfunction in major depressive disorder

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Neural Regeneration Research 2023年第8期18卷 1795-1801页

作者： Xiao-Hui Li Hong-Can Zhu Xue-Min Cui Wang Wang Lin Yang Li-Bo Wang Neng-Wei Hu Dong-Xiao duan Department of Physiology and Neurobiology School of Basic Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina

We previously showed that death-associated protein kinase 1(DAPK1)expression is increased in hippocampal tissue in a mouse model of major depressive disorde and is related to cognitive dysfunction in Alzheimer's *** addition,depression is a risk factor for developing Alzheimer's disease,as well as an early clinical manifestation of Alzheimer's ***,cognitive dysfunction is a distinctive feature of major depressive ***,DAPK1 may be related to cognitive dysfunction in major depressive *** this study,we established a mouse model of major depressive disorder by housing mice individually and exposing them to chronic,mild,unpredictable *** found that DAPK1 and tau protein levels were increased in the hippocampal CA3 area,and tau was hyperphosphorylated at Thr231,Ser262,and Ser396 in these ***,DAPK1 shifted from axonal expression to overexpression on the cell *** and treatment with the antidepressant drug citalopram decreased DAPK1 expression and tau protein phosphorylation in hippocampal tissue and improved both depressive symptoms and cognitive *** results indicate that DAPK1 may be a potential reason and therapeutic target of cognitive dysfunction in major depressive disorder.

关键词： Alzheimer's disease antidepressant drug behavioral tests cognitive dysfunction death-associated protein kinase 1 exercise hippocampus major depressive disorder phosphorylation tau protein

Morphological changes of cell proliferation and apoptosis in rat jejunal mucosa at different ages

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World Journal of Gastroenterology 2003年第9期9卷 2060-2064页

作者： Li Wang Jian Li Qing Li Jian Zhang Xiang-Lin duan Life Science College,Hebei Normal University,Shijiazhuang 050016,Hebei Province,China Life Science College Hebei Normal University Shijiazhuang 050016 Hebei Province China.

AIM: To study the changes of cell proliferation and apoptosis in rat jejunal epithelium at different ***: Cell proliferation and apoptosis of the jejunal mucosal and glandulous epithelia from birth to postnatal 12th month were observed using immunocytochemistry (ICC), and TUNEL method. The height of villus, the thickness of muscle layer and the number of goblet cells in jejunal mucosal and glandulous epithelia were measured by BeiHang analytic software and analyzed by ***: (1) Proliferating cell nuclear antigen (PCNA) positive cells of jejunal glandulous recess were found and increased in number from birth to the postnatal 3rd month. The number of PCNA positive cells peaked in the postnatal 3rd month, and decreased from then on. (2) The number of apoptotic cells also peaked in the postnatal 3rd month, showing a similar trend to that of the PCNA positive cells. (3) The height of jejunal villus increased after birth, peaked in the postnatal 3rd month and decreased from then on. The jejunal muscle layer became thicker in the postnatal 3rd week and the postnatal 12th *** number of goblet cells of the jejunal mucosal and glandulous epithelia had a linear correlation with ***: (1) PCNA positive cells are distributed in the jejunal glandulous recess. (2) Apoptotic cell number peaks in the postnatal 3rd month, indicating that cell proliferation and apoptosis are developed with the formation of digestive metabolism as rat grows to maturity. (3) The thickness of jejunal muscle layer increases to a maximum in the postnatal 3rd week, which may be related to the change in diet from milk to solid food. (4) The number of goblet cells increases rapidly in the postnatal 3rd week, probably due to ingestion of solid food.

关键词：细胞增殖细胞凋亡空肠黏膜年龄细胞形态学