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Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer

Genes & Diseases 2024年第1期11卷 218-233页

作者： Zanwen Zuo Zerong Zhou Yuzhou Chang yan Liu Yuping Shen Qizhang Li lei Zhang Innovative Drug R&D Center College of Life SciencesHuaibei Normal UniversityHuaibeiAnhui 235000China National"111"Center for Cellular Regulation and Molecular Pharmaceutics Key Laboratory of Fermentation Engineering(Ministry of Education)Hubei Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province)and School of Food and Biological EngineeringHubei University of TechnologyWuhanHubei 430068China Department of Biomedical Informatics The Ohio State UniversityColumbusOH 43210USA School of Agriculture and Biology and Engineering Research Center of Cell&Therapeutic AntibodyMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Bioengineering Hunan University of Science and EngineeringYongzhouHunan425199China Department of Pharmaceutical Botany School of PharmacyNaval Medical UniversityShanghai 200433China

Ribonucleotide reductase M2(RRM2)is a small subunit in ribonucleotide reduc-tases,which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides,maintaining the dNTP pools for DNA biosynthesis,repair,and ***2 performs a critical role in the malignant biological behaviors of *** structure,regulation,and function of RRM2 and its inhibitors were ***2 gene can produce two transcripts encoding the same ***2 expression is regulated at multiple levels during the processes from transcription to ***,this gene is associated with resistance,regulated cell death,and tumor *** order to develop and design inhibitors of RRM2,appropriate strategies can be adopted based on different ***,a greater appreciation of the characteristics of RRM2 is a benefit for understanding tumorigenesis,resistance in cancer,and tumor ***,RRM2-targeted therapy will be more attention in future therapeutic approaches for enhancement of treatment effects and amelioration of the dismal prognosis.

关键词： Function Inhibition Regulation Resistance RRM2

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Laboratory and numerical modelling of irrigation infiltration and nitrogen leaching in homogeneous soils

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Pedosphere 2024年第1期34卷 146-158页

作者： lei WU Ruizhi LI yan WANG Zongjun GUO Jiaheng LI Hang yanG Xiaoyi MA Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas Ministry of EducationNorthwest A&F UniversityYangling 712100China Blackland Research and Extension Center Texas A&M AgriLife ResearchTexas A&M UniversityTemple TX 76502USA State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F UniversityYangling 712100China College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100China

Nitrogen (N) plays a key role in crop growth and production;however,data are lacking especially regarding the interaction of biochar,grass cover,and irrigation on N leaching in saturated soil *** soil columns with 20-cm diameter and 60-cm height were designed to characterize the effects of different grass cover and biochar combinations,i.e.,bare soil+0%biochar (control,CK),perennial ryegrass+0%biochar (C1),Festuca arundinacea+0%biochar (C2),perennial ryegrass+1%biochar (C3),perennial ryegrass+2%biochar (C4),perennial ryegrass+3%biochar (C5),***+1%biochar (C6),***+2% biochar (C7),and ***+3%biochar (C8),on periodic irrigation infiltration and N leaching in homogeneous loess soils from July to December *** in CK were 10.2%–35.3%higher than those in C1 and *** perennial ryegrass and *** decreased the volumes of leachates and delayed the leaching process in the 1%,2%,and 3%biochar treatments,and the vertical leaching rate decreased with biochar *** N leaching losses were concentrated in the first few leaching tests,and both total N (TN) and nitrate (NO_(3)^(-))-N concentrations in CK and C1–C8 decreased with increasing leaching test *** addition (1%,2%,and 3%) could further reduce the leaching risk of NO_(3)^(-)-N and the NO_(3)^(-)-N loss decreased with biochar ***,compared to 1%biochar,2% biochar promoted the leaching of TN under both grass cover *** N leaching losses in CK,C1,C2,C3,C4,C6,and C7 were primarily in the form of NO_(3)^(-)-*** these treatments,CK,C1,and C2had the highest cumulative leaching fractions NO_(3)^(-)-N (>90%),followed by those in C3,C4,C6,and C7 (>80%).The cumulative leaching fraction of NO_(3)^(-)-N decreased with increasing leaching test times and biochar addition,and 3%biochar addition (i.e.,C5 and C8) reduced it to approximately 50%.The one-dimensional advective-dispersive-reactive transport equation can be used as an effective nume

关键词： leaching loss nitrate nitrogen biochar grass cover analytical modelling

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Acoustic emission characteristics of damage evolution of multi-scale fiber reinforced rubberized concrete under uniaxial compression and tension after being subjected to high temperatures

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Frontiers of Structural and Civil Engineering 2024年第8期18卷 1237-1266页

作者： Shaoqi ZHANG Yao ZHANG Qianru lei Yumeng yanG Yichao WANG Fei XU Zhiguo yan Hehua ZHU Laboratory of Fire Safety School of Safety Engineering and Emergency ManagementShijiazhuang Tiedao UniversityShijiazhuang 050043China Structural Health Monitoring and Control Key Laboratory of Hebei Province Shijiazhuang Tiedao UniversityShijiazhuang 050043China Department of Geotechnical Engineering Tongji UniversityShanghai 200092China

Recently developed multi-scale fiber(i.e.,CaCO3 whisker,polyvinyl alcohol(PVA)fiber,and steel fiber)reinforced rubberized concrete exhibits excellent mechanical properties and spalling resistance at high *** of macro properties such as strength and Young’s modulus cannot reveal and characterize damage mechanisms,particularly those relating to the multi-scale fiber strengthening *** this study,acoustic emission(AE)technology is applied to investigate the impact of multi-scale fiber on the damage evolution of rubberized concrete exposed to high temperatures,under the uniaxial compression and tension loading *** mechanical properties,AE event location,peak frequency,b-value,the ratio of rise time to amplitude(RA),average frequency(AF)values,and AE energy of specimens are *** results show that the number of events observed using AE gradually increases as the loading *** crumb rubber and fibers inhibit the generation and development of the *** is concluded that both the peak frequency and b-value reflect the extension process of *** the cracks develop from the micro scale to the macro scale,the peak frequency tends to be distributed in a lower frequency range,and the b-value decreases *** the peak stress point,the AE energy increases rapidly and the b-value *** specimens without multi-scale fibers exhibit brittle failure,while the specimens with fibers exhibit ductile *** addition,adding multi-scale fibers and crumb rubber increases the peak frequency in the medium and high frequency ranges,indicating a positive effect on inhibiting crack *** being subjected to high temperatures,the maximum and minimum b-values decrease,reflecting an increase in the number of initial cracks due to thermal ***,the RA and AF values are used to classify tensile and shear *** specimens fracture with more shear cracks under compression,and there are more tensile

关键词： multi-scale fibers acoustic emission fracture damage evolution rubberized concrete

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Configuring single-layer MXene nanosheet onto natural wood fiber via C-Ti-C covalent bonds for high-stability Li-S batteries

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Journal of Energy Chemistry 2024年第8期95卷 701-711,I0016页

作者： yangyang Chen Yu Liao Ying Wu lei Li Zhen Zhang Sha Luo Yiqiang Wu yan Qing College of Materials Science and Technology Central South University of Forestry and TechnologyChangsha 410004HunanChina

Lithium-sulfur batteries(LSBs)are considered promising candidates for next-generation battery technologies owing to their outstanding theoretical energy density and ***,the low conductivity and polysulfide shuttling effect of S cathodes severely hamper the practical performance of ***,in situ-generated single layer MXene nanosheet/hierarchical porous carbonized wood fiber(MX/PCWF)composites are prepared via a nonhazardous eutectic activation strategy coupled with pyrolysis-induced gas *** unique architecture,wherein single layer MXene nanosheets are constructed on carbonized wood fiber walls,ensures rapid polysulfide conversion and continuous electron transfer for redox *** C-Ti-C bonds formed between MXene and PCWF can considerably expedite the conversion of polysulfides,effectively suppressing the shuttle *** impressive capacity of 1301.1 m A h g^(-1)at 0.5 C accompanied by remarkable stability is attained with the MX/PCWF host,as evidenced by the capacity maintenance of 722.6 m A h g^(-1)after 500 ***,the MX/PCWF/S cathode can still deliver a high capacity of 886.8 m A h g^(-1)at a high S loading of 5.6 mg cm^(-2).The construction of two-dimensional MXenes on natural wood fiber walls offers a competitive edge over S-based cathode materials and demonstrates a novel strategy for developing high-performance batteries.

关键词： Lithium-sulfur batteries S cathodes MXene nanosheets Wood fiber C-Ti-C bonds

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An ultra-deep TSV technique enabled by the dual catalysis-based electroless plating of combined barrier and seed layers

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Microsystems & Nanoengineering 2024年第3期10卷 409-419页

作者： Yuwen Su Yingtao Ding lei Xiao Ziyue Zhang yangyang yan Zhifang Liu Zhiming Chen Huikai Xie School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijingChina Chongqing Institute of Microelectronics and Microsystems Beijing Institute of TechnologyChongqingChina

Silicon interposers embedded with ultra-deep through-silicon vias(TSVs)are in great demand for the heterogeneous integration and packaging of opto-electronic chiplets and microelectromechanical systems(MEMS)*** the cost-effective and reliable manufacturing of ultra-deep TSVs,the formation of continuous barrier and seed layers remains a crucial challenge to ***,we present a novel dual catalysis-based electroless plating(ELP)technique by tailoring polyimide(PI)liner surfaces to fabricate dense combined Ni barrier/seed layers in ultradeep *** additional to the conventional acid catalysis procedure,a prior catalytic step in an alkaline environment is proposed to hydrolyze the PI surface into a polyamide acid(PAA)interfacial layer,resulting in additional catalysts and the formation of a dense Ni layer that can function as both a barrier layer and a seed layer,particularly at the bottom of the deep *** with depths larger than 500μm and no voids are successfully fabricated in this *** fabrication process involves low costs and *** a fabricated 530-μm-deep TSV with a diameter of 70μm,the measured depletion capacitance and leakage current are approximately 1.3 pF and 1.7 pA at 20 V,respectively,indicating good electrical *** proposed fabrication strategy can provide a cost-effective and feasible solution to the challenge of manufacturing ultra-deep TSVs for modern 3D heterogeneous integration and packaging applications.

关键词： properties catalysis alkaline

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Retinal layer segmentation using gradient feature calculation in OCT

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 137-147页

作者： lei Liu Yeman Liu Xiaoteng yan Haiyi Bian Hang Xu Chunzhong Li Hongnan duan Faculty of Electronic Information Engineering Huaiyin Institute of Technology Huai'an Jiangsu 223003P.R.China Department of Ophthalmology A±liated Huai'an Hospital of Xuzhou Medical University Huai'an Jiangsu 223003P.R.China

Retinal diseases pose significant challenges to global healthcare systems,necessitating accurate and e±cient diagnostic *** Coherence Tomography(OCT)has emerged as a valuable tool for diagnosing and monitoring retinal conditions due to its noncontact and noninvasive *** paper presents a novel retinal layering method based on OCT images,aimed at enhancing the accuracy of retinal lesion *** method utilizes gradient analysis to effectively identify and segment retinal *** selecting a column of pixels as a segmentation line and utilizing gradient information from adjacent pixels,the method initiates and proceeds with the layering *** approach addresses potential issues arising from partial layer overlapping,minimizing deviations in layer *** results demonstrate the e±cacy of the proposed method in accurately segmenting eight retinal boundaries,with an average absolute position deviation of 1.75 *** providing accurate segmentation of retinal layers,this approach contributes to the early detection and management of ocular conditions,ultimately improving patient outcomes and reducing the global burden of vision-related ailments.

关键词： Retinal diseases optical coherence tomography retinal layer segmentation.

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Boosted Electrocatalytic Glucose Oxidation Reaction on Noble-Metal-Free MoO_(3)-Decorated Carbon Nanotubes

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Transactions of Tianjin University 2024年第1期30卷 63-73页

作者： Yu-Long Men Ning Dou Yiyi Zhao yan Huang lei Zhang Peng Liu Department of Chemical Engineering School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Thyroid Breast and Vascular Surgery Shanghai Fourth People’s Hospital Affi liated to Tongji University School of MedicineShanghai 200081China Department of Vascular Surgery Changhai HospitalNaval Medical UniversityShanghai 200433China

Electrocatalytic glucose oxidation reaction(GOR)has attracted much attention owing to its crucial role in biofuel cell ***,we load MoO_(3)nanoparticles on carbon nanotubes(CNTs)and use a discharge process to prepare a noblemetal-free MC-60 catalyst containing MoO_(3),Mo_(2)C,and a Mo_(2)C–MoO_(3)*** the GOR,MC-60 shows activity as high as 745μA/(mmol/L cm^(2)),considerably higher than those of the Pt/CNT(270μA/(mmol/L cm^(2)))and Au/CNT catalysts(110μA/(mmol/L cm^(2))).In the GOR,the response minimum on MC-60 is as low as 8μmol/L,with a steady-state response time of only 3 ***,MC-60 has superior stability and anti-interference ability to impurities in the *** better performance of MC-60 in the GOR is attributed to the abundant Mo sites bonding to C and O atoms at the MoO_(3)–Mo_(2)C *** Mo sites create active sites for promoting glucose adsorption and oxidation,enhancing MC-60 performance in the ***,these results help to fabricate more effi cient noble-metal-free catalysts for the fabrication of glucose-based biofuel cells.

关键词： Interface eff ect Electrocatalysis Molybdenum oxide Glucose Oxidation reaction

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Highly sensitive nanozyme strip:An effective tool for forensic material evidence identification

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Nano Research 2024年第3期17卷 1785-1791页

作者： Juanji Hong Zhanjun Guo Dihan duan Yi Zhang Xin Chen Yongjiu Li Zheng Tu lei Feng lei Chen Xiyun yan Lizeng Gao Minmin Liang Demin duan Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China College of Bioscience and Biotechnology Shenyang Agricultural UniversityShenyang 110866China Chongqing kangjuquanhong biology science and technology Co. ltdChongqing 400026China Key Laboratory of Forensic Genetics Institute of Forensic ScienceMinistry of Public SecurityBeijing 100038China CAS Engineering Laboratory for Nanozyme Key Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academic of ScienceBeijing 100101China

during criminal case investigations,blood evidence tracing is critical for criminal ***,the blood stains are often cleaned or covered up after the crime,resulting in trace residue and difficult ***,a highly sensitive and specific method for the rapid detection of human blood stains remains *** solve this problem,we established a nanozyme-based strip for rapid detection of blood evidence with high sensitivity and *** construct reliable nanozyme strips,we synthesized CoFe_(2)O_(4) nanozymes with high peroxidase-like activity by scaling up to gram level,which can be supplied for six million tests,and conjugated antibody as a detection probe in nanozyme *** developed CoFe_(2)O_(4) nanozyme strip can detect human hemoglobin(HGB)at a concentration as low as 1 ng/mL,which is 100 times lower than the commercially available colloidal gold strips(100 ng/mL).Moreover,this CoFe_(2)O_(4) nanozyme strip showed high generality on 12 substrates and high specificity to human HGB among 13 animal blood ***,we applied the developed CoFe_(2)O_(4) nanozyme strip to successfully detect blood stains in three real cases,where the current commercial colloidal gold strip failed to *** results suggest that the CoFe_(2)O_(4) nanozyme strip can be used as an effective on-scene detection method for human blood stains,and can further be used as a long-term preserved material evidence for traceability inquiry.

关键词： CoFe_(2)O_(4)nanozyme nanozyme strip peroxidase-like activity human hemoglobin blood evidence

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Free-walking:Pedestrian inertial navigation based on dual foot-mounted IMU

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Defence Technology（防务技术） 2024年第3期33卷 573-587页

作者： Qu Wang Meixia Fu Jianquan Wang lei Sun Rong Huang Xianda Li Zhuqing Jiang yan Huang Changhui Jiang School of Automation Science and Electrical Engineering University of Science and Technology BeijingBeijing100083China Shunde Innovation School University of Science and Technology BeijingFo Shan528399China Research Institute of China Unicom Beijing100190China School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing100876China Department of Automation Tsinghua University Beijing100084China GEOLOC Laboratory Universite Gustave EiffelParis77454France

The inertial navigation system(INS),which is frequently used in emergency rescue operations and other situations,has the benefits of not relying on infrastructure,high positioning frequency,and strong real-time ***,the intricate and unpredictable pedestrian motion patterns lead the INS localization error to significantly diverge with *** paper aims to enhance the accuracy of zero-velocity interval(ZVI)detection and reduce the heading and altitude drift of foot-mounted INS via deep learning and equation constraint of dual *** at the observational noise problem of low-cost inertial sensors,we utilize a denoising autoencoder to automatically eliminate the inherent *** at the problem that inaccurate detection of the ZVI detection results in obvious displacement error,we propose a sample-level ZVI detection algorithm based on the U-Net neural network,which effectively solves the problem of mislabeling caused by sliding *** at the problem that Zero-Velocity Update(ZUPT)cannot suppress heading and altitude error,we propose a bipedal INS method based on the equation constraint and ellipsoid constraint,which uses foot-to-foot distance as a new observation to correct heading and altitude *** conduct extensive and well-designed experiments to evaluate the performance of the proposed *** experimental results indicate that the position error of our proposed method did not exceed 0.83% of the total traveled distance.

关键词： Indoor positioning Inertial navigation system(INS) Zero-velocity update(ZUPT) Internet of things(IoTs) Location-based service(LBS)

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The function of doping nitrogen on removing fluoride with decomposing La-MOF-NH_2:Density functional theory calculation and experiments

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Journal of Environmental Sciences 2024年第1期135卷 118-129页

作者： Hongguo Zhang KuilinWan Jia yan Qian Li Yufang Guo lei Huang Samuel Raj Babu Arulmani Jian Luo School of Environmental Science and Engineering Guangzhou UniversityGuangzhou 510006China Guangzhou University-Linkoping University Research Center on Urban Sustainable Development Guangzhou UniversityGuangzhou 510006China School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

Fluoride is an important pollutant in wastewater,and adsorption is an effective way to remove *** nitrogen plays an important role in adsorbent materials,computational models were developed to understand the changes in work function resulting from nitrogen ***-N-C-800℃,was prepared by pyrolyzing La-MOF-NH_(2)to verify the influence on the performance of removing fluoride by *** and electrochemical performance tests were performed to characterize La-N-C-800℃.Adsorption kinetics,adsorption thermodynamics,initial concentrations,pH,and ions competition were investigated using La-N-C-800℃for fluoride *** addition,density functional theory was applied to evaluate the function of *** nitrogen atoms were added,the density of states,partial density of states,populations,and different orbits of charge were calculated to discover deep *** strengthened the carbon structure and La_(2)O_(3)structure to remove *** addition,nitrogen can also act as an adsorption site in the carbon *** results provide design ideas for improving the performance of adsorbent materials by doping elements.

关键词： Capacitive deionization Fluoride La-MOFs Doping nitrogen

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