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Current perspectives on mesenchymal stem cells as a potential therapeutic strategy for non-alcoholic fatty liver disease

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World Journal of Stem Cells 2024年第7期16卷 760-772页

作者： Yan jiang Narazah Mohd Yusoff jiang du Emmanuel Jairaj Moses Jun-Tang Lin School of Nursing Xinxiang Medical UniversityXinxiang 453000Henan ProvinceChina Department of Biomedical Sciences Advanced Medical and Dental InstituteUniversiti Sains MalaysiaKepala Batas 13200Pulau PinangMalaysia Advanced Medical and Dental Institute Universiti Sains MalaysiaKepala Batas 13200Pulau PinangMalaysia Henan Joint International Research Laboratory of Stem Cell Medicine School of Medical EngineeringXinxiang Medical UniversityXinxiang 453003Henan ProvinceChina Stem Cells and Biotherapy Engineering Research Center of Henan National Joint Engineering Laboratory of Stem Cells and BiotherapySchool of Life Science and TechnologyXinxiang Medical UniversityXinxiang 453003Henan ProvinceChina Henan Joint International Research Laboratory of Stem Cell Medicine School of Medical EngineeringXinxiang Medical UniversityXinxiang 453000Henan ProvinceChina

Non-alcoholic fatty liver disease(NAFLD)has emerged as a significant health challenge,characterized by its widespread prevalence,intricate natural progression and multifaceted *** NAFLD initially presents as benign fat accumulation,it may progress to steatosis,non-alcoholic steatohepatitis,cirrhosis,and hepatocellular *** stem cells(MSCs)are recognized for their intrinsic self-renewal,superior biocompatibility,and minimal immunogenicity,positioning them as a therapeutic innovation for liver ***,this review aims to elucidate the potential roles of MSCs in alleviating the progression of NAFLD by alteration of underlying molecular pathways,including glycolipid metabolism,inflammation,oxidative stress,endoplasmic reticulum stress,and *** insights are expected to provide further understanding of the potential of MSCs in NAFLD therapeutics,and support the development of MSC-based therapy in the treatment of NAFLD.

关键词： Non-alcoholic induced fatty liver disease Mesenchymal stem cells Lipid accumulation Inflammation Oxidative stress Endoplasmic reticulum stress Fibrosis

Understanding and addressing the challenges of online gambling addiction in China's Mainland

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General Psychiatry 2024年第2期37卷 315-318页

作者： Gangliang Zhong jiang du Min Zhao Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghaiChina CAS Center for Excellence in Brain Science and Intelligence Technology(CEBSIT) Chinese Academy of SciencesShanghaiChina

Introduction Gambling in China has a long and evolving history,from ancient court cockfighting to preliberation casinos with games like baccarat.1 Over time,gambling in China has evolved to include a wide range of activities,including gaming machines,online gambling and commercial *** being declared illegal and regulated after the establishment of the People’s Republic of China,gambling remains deeply ingrained in Chinese culture.

关键词： mainland fighting spite

Efficacy of spray flushing in the reprocessing of flexible endoscopes:A randomized controlled trial

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World Journal of Gastroenterology 2024年第31期30卷 3680-3688页

作者： jiang du Miao Zhang Si-Yuan Tao Lian-Song Ye Hui Gong Bing Hu Qiong-Ying Zhang Fu Qiao Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China School of Nursing Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Infection Control West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Digestive Endoscopy Medical Engineering Research Laboratory West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Commonly used cleaning brushes in the reprocessing of flexible endoscopes often cause damage within the working *** To develop a spray flushing system to achieving effective cleaning of the working channels while minimizing *** This prospective study included 60 used endoscopes and 60 Teflon tubes randomly divided into a control group(n=30)and an experimental group(n=30).The material of Teflon tubes was the same as that of the endoscope working *** in the control group were manually cleaned using traditional cleaning brushes,while those in the experimental group were cleaned using the newly developed spray flushing *** levels,cleanliness,and microbiological testing of the working channels were ***,Teflon tubes in the control group underwent 500 passes with a cleaning brush,while those in the experimental group were subjected to the spray flushing system,and channel damage was *** The ATP levels(RLU)in the two groups were 32.5(13-66)and 26(16-40),respectively(P>0.05).Cleanliness scores were 1.5(1-2)and 1(1-2),respectively(P>0.05).Debris was found in 73.3%of the control group,which was significantly higher than 46.7%in the experimental group(P<0.05).Microbiological tests for both groups yielded negative *** tube damage in the control group was rated at 4(4-5.25),which was significantly higher than in the experimental group 4(3-4)(P<0.01).CONCLUSION The spray flushing system demonstrated superior efficacy in removing debris and resulted in less damage to the endoscope working channels compared with traditional cleaning brushes.

关键词： Endoscope ATP Flexible endoscope Disinfection Reprocessing

Biliary spontaneous dislodgement spiral stent for short-term biliary drainage in patients undergoing complete stone removal:A randomized controlled study

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Chinese Medical Journal 2024年第11期137卷 1363-1365页

作者： Liansong Ye Lifan Zhang Yi Mou Xianglei Yuan Wei Liu Chuncheng Wu Yonghong Luo jiang du Shuai Bai Jia Xie Qiongying Zhang Qinghua Tan Ling Liu Bing Hu Department of Gastroenterology and Hepatology West China HospitalMed-X Center for MaterialsSichuan UniversityChengduSichuan 610041China Digestive Endoscopy Medical Engineering Research Laboratory West China HospitalSichuan UniversityChengduSichuan 610041China West China School of Nursing Sichuan UniversityChengduSichuan 610041China

To the Editor:Endoscopic retrograde cholangiopancreatography(ERCP)is strongly recommended for stone removal of *** there is still risk of complications such as post-ERCP cholangitis(PEC)and post-ERCP pancreatitis(PEP).Biliary drainage including endoscopic nasobiliary drainage(ENBD)and biliary stent is considered to reduce the occurrence of PEC and ***,the ENBD tube will cause patient discomfort,and some patients may extract the tube by ***,additional endoscopic stent removal is required after insertion of conventional biliary stent for short-term biliary drainage,increasing medical costs.

关键词： biliary patients stent

基于Kano模型的西南地区农贸市场更新设计研究

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包装工程 2024年第18期45卷 84-92页

作者：都江张宇昆明理工大学昆明650504

目的旨在从情感化设计的角度出发,结合Kano模型的相关方法,根据用户的具体需求,对昆明篆新农贸市场的更新设计策略进行研究。方法通过分析情感化设计的三个层次,寻找用户痛点,设计并发放Kano问卷,分析统计各项需求的属性类别,并通过计算... 详细信息

目的旨在从情感化设计的角度出发,结合Kano模型的相关方法,根据用户的具体需求,对昆明篆新农贸市场的更新设计策略进行研究。方法通过分析情感化设计的三个层次,寻找用户痛点,设计并发放Kano问卷,分析统计各项需求的属性类别,并通过计算Better-Worse四象限散点图,对各功能进行优先级排序,最后得出昆明篆新农贸市场的更新设计重点。结果用户认为优化功能分区、摊位标准化设计、无障碍设计是市场必须要达到的要求;对导向设计、公共座椅、规划交通流线和停车位、预约停车位(小程序)具有强烈需求;对商品寄送到家(小程序)共享推车或共享菜篮、线上外卖点单(小程序)、特色摊位、餐饮区域、共享菜地、共享摊位,以及非遗文化展示售卖空间有较大期待。结论根据Kano模型的分析结果,按照必备属性、期望属性、魅力属性的顺序对功能进行设计,达到了集市空间的更新发展目标,有助于提升我国西南地区农贸市场活力、带动当地经济、保护和传承乡村文化,为我国西南地区农贸市场的更新发展提供新的研究视角。

关键词： Kano模型西南地区农贸市场情感化设计集市空间

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晶体石墨炔的最新研究进展与挑战

Science China Materials 2024年第3期67卷 729-751页

作者：刘心康赵亚松杜江王丹 Henan Province Industrial Technology Research Institute of Resources and Materials Zhengzhou UniversityZhengzhou 450001China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

石墨炔(GYs)是一种新型碳同素异形体,由sp和sp^(2)杂化碳原子组成.其中,石墨双炔(GDY)是目前研究和关注度最广泛的材料.其独特的sp杂化、均匀的孔隙和高度共轭的结构带来了优良的电子、光学和力学特性,其被广泛应用于电子器件、储能和... 详细信息

石墨炔(GYs)是一种新型碳同素异形体,由sp和sp^(2)杂化碳原子组成.其中,石墨双炔(GDY)是目前研究和关注度最广泛的材料.其独特的sp杂化、均匀的孔隙和高度共轭的结构带来了优良的电子、光学和力学特性,其被广泛应用于电子器件、储能和转换、催化、气体分离、海水淡化等领域.然而,GDY材料仍然面临着诸多挑战,包括高结晶GDY的合成和快速无损的表征方法.本文就高结晶度GDY的设计、合成和结构表征进行了综述.本文还描述了GDY在各个领域的应用,为高度均匀的单晶GDY材料带来新的机遇.

关键词： crystalline graphdiyne controlled synthesis energy conversion energy storage

滇池流域“一颗印”传统民居更新的用户体验设计研究

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家具与室内装饰 2024年第1期31卷 134-138页

作者：都江张宇昆明理工大学艺术与传媒学院云南昆明650500

文章旨在研究用户体验设计在滇池流域“一颗印”传统民居更新中的应用。文章基于用户体验设计的理论,重新审视了目前的民居更新设计思路,并通过对昆明“一颗印”民居的调研分析,从感官层次、交互层次、情感层次、社会层次、自我层次五... 详细信息

文章旨在研究用户体验设计在滇池流域“一颗印”传统民居更新中的应用。文章基于用户体验设计的理论,重新审视了目前的民居更新设计思路,并通过对昆明“一颗印”民居的调研分析,从感官层次、交互层次、情感层次、社会层次、自我层次五个层次进行探讨,构件以用户为中心的设计策略,从用户的需求入手,解决“一颗印”传统民居的关键问题。用户体验设计理论为“一颗印”民居更新设计带来了新的启示,有利于为用户提供优质高效的居住体验,对于改善农村人居环境及乡村振兴等方面具有积极意义。

关键词：用户体验设计用户需求传统民居更新 “一颗印”民居

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数字经济、绿色创新与企业绿色全要素生产率

统计与决策 2024年第2期40卷 35-40页

作者：龚新蜀杜江石河子大学经济与管理学院新疆石河子832003

文章从绿色创新视角切入,以2011—2022年中国沪深A股重污染行业上市公司为样本,实证考察了城市数字经济对重污染企业绿色全要素生产率的影响效应和内在机制。研究发现:数字经济对重污染企业绿色全要素生产率具有显著的提升作用,且对国... 详细信息

文章从绿色创新视角切入,以2011—2022年中国沪深A股重污染行业上市公司为样本,实证考察了城市数字经济对重污染企业绿色全要素生产率的影响效应和内在机制。研究发现:数字经济对重污染企业绿色全要素生产率具有显著的提升作用,且对国有性质和中小城市的重污染企业的促进作用更强;绿色创新是数字经济驱动重污染企业绿色生产的重要传导机制,但仅绿色发明专利申请量有中介效应,增加绿色实用新型专利不是数字经济提升重污染企业绿色全要素生产率的有效途径;数字经济对重污染企业绿色全要素生产率的推动作用表现出边际效应递增的非线性特征,且两者之间的关系存在绿色创新的门槛约束,随着绿色发明专利和绿色实用新型专利申请量的增加,数字经济对重污染企业绿色全要素生产率的促进作用分别表现出效应增强和效应减弱的非线性特征。

关键词：数字经济绿色发明专利绿色实用新型专利绿色全要素生产率重污染企业

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基于FBM行为模型的自动体外除颤器设计研究

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包装工程 2024年第16期45卷 422-430页

作者：都江杜宇超周晓敏昆明理工大学昆明650500

目的依据FBM行为模型,研究如何提高自动体外除颤器的可用性和易用性,从而增加施救者对产品的使用率及成功率,为院外心脏骤停患者赢得更大的生存机会。方法通过对用户体验行为的深入分析,挖掘并总结救助者在救助过程中的体验痛点。依据FB... 详细信息

目的依据FBM行为模型,研究如何提高自动体外除颤器的可用性和易用性,从而增加施救者对产品的使用率及成功率,为院外心脏骤停患者赢得更大的生存机会。方法通过对用户体验行为的深入分析,挖掘并总结救助者在救助过程中的体验痛点。依据FBM行为模型,增强施救者的意愿、简化施救的目标行为、并根据动机与能力的差异给予不同提示,从动机、能力、触发机制三方面探究劝导式设计下的自动体外除颤产品设计策略。结果通过劝导策略对自动体外除颤器进行功能规划,促使非专业人士在遇到心脏骤停患者的紧急情况下,也能够正确有效地使用自动体外除颤产品。结论FBM行为模型为提高自动体外除颤产品的可用性和易用性提供了有效的方法指导,进而提高院前复苏率,改善患者预后。

关键词： Fogg行为模型自动体外除颤器劝导式设计院外心脏骤停

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