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基于构造复杂区厚煤层开采的技术研究

价值工程 2024年第17期43卷 63-65页

作者：杜显峰山东能源枣庄矿业集团柴里煤矿滕州277519

本文从资源回收入手,打破矿井多年来以上分层工作面开采边界为下分层工作面设计范围的固有定式,加大地质构造分析力度,改变巷道布置方式,优化工作面设计,着重考虑过断层期间的顶板和回采巷道外扩布置的支护安全。轨道巷掘进期间,加大层... 详细信息

本文从资源回收入手,打破矿井多年来以上分层工作面开采边界为下分层工作面设计范围的固有定式,加大地质构造分析力度,改变巷道布置方式,优化工作面设计,着重考虑过断层期间的顶板和回采巷道外扩布置的支护安全。轨道巷掘进期间,加大层位调查和资料分析力度,根据探测成果及时绘制预想剖面图,分析前方掘进施工层位,保证回采期间破矸范围最少,资源回收率最大。保障了回采过程中对接场所及其附近的顶板完整、支护完好;合茬时工作面补切眼支架和运输机精确的对接。采取降低轨道巷层位和更换机尾两套6800支架的措施,减少破矸石厚度和范围,减少三角煤损失,提高煤质,为工作面过断层创造良好条件。

关键词：资源回收外扩布置区域煤层开采

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浅谈绿色矿山建设的推广与应用

价值工程 2024年第9期43卷 133-135页

作者：黄铜玲杜显峰袁汝安王振亭山东能源枣庄矿业集团公司柴里煤矿滕州277519

建设绿色矿山,发展绿色矿业,是践行习近平总书记“绿水青山就是金山银山”重要思想,促进生态文明建设,落实新发展理念的重要举措。为坚持科学发展观,切实履行企业社会责任,不断构建资源节约型、环境友好型企业,圆满完成柴里煤矿绿色矿... 详细信息

建设绿色矿山,发展绿色矿业,是践行习近平总书记“绿水青山就是金山银山”重要思想,促进生态文明建设,落实新发展理念的重要举措。为坚持科学发展观,切实履行企业社会责任,不断构建资源节约型、环境友好型企业,圆满完成柴里煤矿绿色矿山建设工作。

关键词：绿色矿山科学发展资源节约企业

Progress in processing of porous titanium: a review

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Rare Metals 2024年第5期43卷 1932-1955页

作者： Xiao-Li Yang xian-feng du Zhi-Lin Xu Zhong-Shuai Liang Li-Long Xiong Engineering Research Center of Energy Storage Materials and Devices Ministry of Education School of Chemistry Xi'an Jiaotong University

As a novel structural and functional material,porous titanium and its alloys have been widely used in the aerospace, marine engineering and biomedical fields due to their high corrosion resistance, low density, good biocompatibility and excellent mechanical properties. Therefore, in this paper, a comprehensive review of powder metallurgy(PM)(including additive manufacturing(AM)processes) for fabricating porous titanium is firstly covered in terms of their working principles, capabilities, shortcomings and strengths. Simultaneously, the influencing factors of various methods on final pore structure of porous Ti are involved. Secondly, a summary of the chemical methods(CM) to obtain the porous Ti is also provided,such as dealloying method and reduction method. Finally,the tendency and direction of preparation technology as well as application of porous titanium were prospected.

关键词： Porous titanium Powder metallurgy Chemical method Pore structure Processing process

决奈达隆在心房颤动导管消融空白期应用的安全性和有效性

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中国新药与临床杂志 2024年第4期43卷 268-272页

作者：方任远杜先锋何斌丰明俊边昶冷冰王彬浩卓伟东周忠李恒栋孙汉泽沈文均赵乾磊谢达奇吴斌储慧民宁波大学附属第一医院浙江宁波315000 浙江大学医学院附属第二医院浙江杭州310003 浙江大学明州医院浙江宁波315800 中国科学院大学宁波华美医院浙江宁波315099 慈溪市人民医院浙江宁波315399 宁波市医疗中心李惠利医院浙江宁波315040 宁波大学附属人民医院浙江宁波315020 宁波市第九医院浙江宁波315032 宁波市海曙区第二医院浙江宁波315099

目的评估决奈达隆在心房颤动导管消融空白期应用的真实世界安全性和有效性。方法纳入2021年5月1日至2021年12月31日间在各合作中心接受导管消融治疗的心房颤动患者150例,空白期予口服决奈达隆片,每次400 mg,早晚各1次,持续3个月。术后3... 详细信息

目的评估决奈达隆在心房颤动导管消融空白期应用的真实世界安全性和有效性。方法纳入2021年5月1日至2021年12月31日间在各合作中心接受导管消融治疗的心房颤动患者150例,空白期予口服决奈达隆片,每次400 mg,早晚各1次,持续3个月。术后3个月±14 d至门诊随访,复查24 h动态心电图、经胸心脏彩超、肝功能、肾功能等,记录随访期间发生的不良事件。结果与手术前相比,术后用药3个月时患者的心率、PR间期及左室射血分数无显著变化,QTc间期延长[(434.0±29.2)ms vs.(443.5±31.8)ms,P=0.017],左房内径[(40.6±6.5)mm vs.(38.4±6.0)mm,P=0.007]及左室舒张末内径[(47.9±4.3)mm vs.(46.4±5.1)mm,P=0.012]减小。6例患者空白期内停药,包括高度房室传导阻滞1例、显著心动过缓2例、QTc间期显著延长1例及消化系统症状2例。未出现与抗心律失常药物相关的心血管死亡、心力衰竭、再住院的复合终点。术后随访3个月时,患者窦性心律维持率85.3%(128/150)。结论决奈达隆在心房颤动导管消融空白期应用安全、有效,依从性好。

关键词：决奈达隆心房颤动射频消融术抗心律失常药空白期

Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy

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Chinese Journal of Chemistry 2024年第10期42卷 1175-1189页

作者： Guo-feng Luo Wei-Hai Chen xian-Zheng Zhang state Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei KeyLaboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanHubei 430079China Key Laboratoryof Biomedical Polymers of Ministry of Education&Departmentof Chemistry Wuhan UniversityWuhanHubei 430072China

Tumor stroma composing diverse extracellular matrixes(ECM)and stromal cells shapes a condensed physical barrier,which severely hampers the efficient accessibility of nanomedicine to tumor cells,especially these deep-seated in the core of tumor.Such barrier significantly compromises the antitumor effects of drug-loaded nanomedicine,revealing the remarkable importance of disrupting stromal barrier for improved tumor therapy with deep penetration ability.To achieve this goal,various nanoparticle-based strategies have been developed,including direct depleting ECM components via delivering anti-fibrotic agents or targeting stromal cells to suppress ECM expression,dynamic regulation of nanoparticles’physicochemical properties(i.e.,size,surface charge,and morphology),mechanical force-driven deep penetration,natural/biomimetic self-driven nanomedicine,and transcytosis-inducing nanomedicine.All these nanostrategies were systemically summarized in this review,and the design principles for obtaining admirable nanomedicine were included.With the rapid development of nanotechnology,elaborate design of multifunctional nanomedicine provides new opportunities for overcoming the critical stromal barriers to maximize the therapeutic index of various therapies,such as chemotherapy,photodynamic therapy,and immunotherapy.

关键词： Nanomedicine Tumor stroma Deep penetration Enhanced drug perfusion Cancer therapy Drug carriers Biomaterials Nanotechnology

Heteroepitaxial growth of Au@Pd core–shell nanocrystals with intrinsic chiral surfaces for enantiomeric recognition

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Rare Metals 2024年第1期43卷 225-235页

作者： feng-Xia Wu feng-Hua Li Xia-Li Lv Qi-xian Zhang Guo-Bao Xu Wen-Xin Niu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Shaoxing Institute of Technology Shanghai UniversityShaoxing 312000China University of Science and Technology of China Hefei 230026China School of Materials Science and Engineering Shanghai UniversityShanghai 200436China Zhejiang Institute of Advanced Materials Shanghai UniversityJiashan 314113China University of Chinese Academy of Sciences Beijing 100039China

Noble metal surfaces with intrinsic chirality serve as an ideal candidate for investigating enantioselective chemistry due to their superior chemical durability and high catalytic activity.Recently,significant advance has been made in synthesizing metal nanocrystals with intrinsic chirality.Nonetheless,the majority reports are limited to gold.Herein,through a heteroepitaxial growth strategy,the synthesis of metal nanocrystals with intrinsic chirality to palladium was extended for the first time and their application in enantioselective recognition was demonstrated.The heteroepitaxial growth strategy allows for transferring the chirality of homochiral Au nanocrystals to Au@Pd core–shell nanocrystals.By employing the chiral Au@Pd nanocrystals as enantiomeric recognizing elements,a series of electrochemical sensors for chiral discrimination were developed.Under optimal conditions,the peak potential between D-dihydroxyphenylalanine(D-DOPA)and L-dihydroxyphenylalanine(L-DOPA)is about 80 m V,and the peak current of D-DOPA is 2 times as much as that of L-DOPA,which enables the determination of the enantiomeric excess(EE,%)of L-DOPA.Overall,this report not only introduces a heteroepitaxial growth strategy to synthesize metal nanocrystals with intrinsic chirality,but also demonstrates the superior capability of integrating intrinsic chirality and catalytic properties into metal nanocrystals for chiral recognition.

关键词： Core–shell nanostructures Chirality transfer Electrochemical sensors Chiral recognition Chiroplasmonics

Efficacy and safety of carrimycin in ten patients with severe pneumonia following solid organ transplantation

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World Journal of Clinical Cases 2024年第15期12卷 2542-2550页

作者： xian-Quan Cui Lu-Wei Zhang Peng Zhao Jing-Jing feng Department of Organ Transplantation Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of Blood Purification Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND The number of patients undergoing solid organ transplantation has increased annually.However,infections in solid organ transplant recipients can have a severe effect on patient survival owing to the continued use of immunosuppressants.Carrimycin is a novel macrolide antibiotic produced by genetically engineered streptomyces spiramyceticus harboring a 4’’-O-isovaleryltransferase gene(ist)from streptomyces thermotoleran.Carrimycin has good antibacterial and antiviral effects.However,no relevant studies have been conducted on the efficacy and safety of carrimycin in patients with severe pneumonia(SP)after solid organ transplantation.AIM To explore the efficacy and safety of carrimycin in patients with SP after solid organ transplantation to provide a medication reference for clinical treatment.METHODS In March 2022,ten patients with SP following solid-organ transplantation were treated at our hospital between January 2021 and March 2022.When the condition was critical and difficult to control with other drugs,carrimycin was administered.These ten patients'clinical features and treatment protocols were retrospectively analyzed,and the efficacy and safety of carrimycin for treating SP following solid organ transplantation were evaluated.RESULTS All ten patients were included in the analysis.Regarding etiological agent detection,there were three cases of fungal pneumonia,two cases of bacterial pneumonia,two cases of Pneumocystis pneumonia,and three cases of mixed infections.After treatment with carrimycin,the disease in seven patients significantly improved,the course of the disease was significantly shortened,fever was quickly controlled,chest computed tomography was significantly improved,and oxygenation was significantly improved.Finally,the patients were discharged after curing.One patient died of acute respiratory distress syndrome,and two patients discontinued treatment.CONCLUSION Carrimycin is a safe and effective treatment modality for SP following solid organ transplantation.Carrimycin may have anti

关键词： Carrimycin Organ transplantation Severe pneumonia Immunosuppressant Infection Antiviral drugs

Improvement of the nutritional support management system for patients in intensive care units

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World Journal of Psychiatry 2024年第1期14卷 44-52页

作者： Yuan-Yuan Zhang Chun-Yi Wang Dong-xian Guo Hai-Nu Gao xian-Shan Jin Yan-Li Wu Lu-Han Chen Zhi-xian feng Department of Critical Care Medicine Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Information Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Pharmacy Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Nutrition Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Administrative Office Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina

BACKGROUND Nutritional support for patients hospitalized in the intensive care unit(ICU)is an important part of clinical treatment and care,but there are significant implementation difficulties.AIM To introduce a modified nutritional support management system for ICU patients based on closed-loop information management and psychological counseling.METHODS The division of functions,personnel training,system construction,development of an intelligent decision-making software system,quality control,and improvement of the whole process were carried out to systematically manage nutritional support for ICU patients.RESULTS Following the implementation of the whole process management system,the scores of ICU medical staff’s knowledge,attitudes/beliefs,and practices regarding nutritional support were comprehensively enhanced.The proportion of hospital bed-days of total enteral nutrition(EN)in ICU patients increased from 5.58%to 11.46%,and the proportion of EN plus parenteral nutrition increased from 42.71%to 47.07%.The rate of EN initiation within 48 h of ICU admission increased from 37.50%to 48.28%,and the EN compliance rate within 72 h elevated from 20.59%to 31.72%.After the implementation of the project,the Self-rating Anxiety Scale score decreased from 61.07±9.91 points to 52.03±9.02 points,the Self-rating Depression Scale score reduced from 62.47±10.50 points to 56.34±9.83 points,and the ICU stay decreased from 5.76±2.77 d to 5.10±2.12 d.CONCLUSION The nutritional support management system based on closed-loop information management and psychological counseling achieved remarkable results in clinical applications in ICU patients.

关键词： Closed-loop information Psychological counseling Intensive care unit patients Nutritional support Management system

Carbon steel anticorrosion performance and mechanism of sodium lignosulfonate

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Rare Metals 2024年第1期43卷 356-365页

作者： Bo-Kai Liao Rui-Xuan Quan Ping-xian feng Huan Wang Wei Wang Li Niu School of Chemistry and Chemical Engineering Guangzhou Key Laboratory of Sensing Materials and DevicesJoint Institute of Guangzhou University and Institute of Corrosion Science and TechnologyGuangzhou UniversityGuangzhou 510006China

Lignin is a typical biological macromolecule with a three-dimensional network structure and abundant functional groups. It has excellent ionic complexation ability and amphiphilic molecular structure characteristics.In this study, the carbon steel anticorrosion performance of sodium lignosulfonate(SLS) in an acid solution was evaluated using the weight loss method, electrochemical measurements, scanning vibration electrode technique(SVET), and surface characterization methods. SLS exhibited excellent corrosion inhibition efficiency for Q235carbon steel in 1 mol·L^(-1) HCl, reaching a maximum value of 98%. A low SLS concentration of 20 mg·L^(-1) resulted in the maximum corrosion inhibition efficiency, which remained nearly constant at higher SLS concentrations.The SVET test demonstrated that the formation of an SLS adsorption film can impede corrosion. This study confirms the significance of the application of green biomass resources in the field of metal corrosion protection and green functional materials.

关键词： Lignin Sodium lignosulfonate Corrosion inhibitor Carbon Steel