检索结果-南通市图书馆

Dynamics of Entanglement in the Cavity with Nonlinear Medium

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Physics 2013年第5期4卷 604-607页

作者： shaojiang du Hairan Feng Physics and Information Engineering Department Jining University Qufu China

We investigate the evolution of initial entangled two-atom in cavity with single-mode light field. Using the method of negative eigenvalue of partially transposed matrix we analysis the evolution of the entanglement of the two-atom in a field of number state and Kerr-media environment and find that entanglement sudden death phenomenon occurs in the number of particles field. When the atoms interact with the Kerr medium, we obtain that the phenomenon of sudden death can be eliminated in the particle-number field, and the entanglement of two-atom oscillates around a high-value.

关键词： Quantum Optics Kerr Medium Negativity Entanglement Sudden Death

Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第2期11卷 921-934页

作者： Hui-Qing Zhang Fanyang Kong Xiangyu Kong Tingting Jiang Muyuan Ma shaojiang Zheng Junli Guo Keping Xie The Third Department of Medical Oncology Jiangxi Cancer HospitalNanchangJiangxi 330006China Departments of Gastroenterology Changhai HospitalSecond Military Medical UniversityShanghai 200433China Center for Pancreatic Cancer Research The South China University of Technology School of MedicineGuangzhouGuangdong 510006China Hainan Clinical Medical Research Center of the First Affiliated Hospital Hainan Women and Children's Medical CenterHainan Medical UniversityHaikouHainan 570102China Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province Key Laboratory of Emergency and Trauma of Ministry of EducationHainan Medical UniversityHaikouHainan 571199China

Ubiquitously transcribed tetratricopeptide repeat on chromosome X(UTX),also known as lysine(K)-specific demethylase 6A(KDM6A),functions as a tumor suppressor gene or oncogene depending on the tumor type and ***,its tumor-suppressive mechanisms remain largely ***,we investigated the clinical significance and biological effects of UTX expression in pancreatic ductal adenocarcinoma(PDA)and determined the potential mechanisms of its *** expression and its association with clinicopathologic characteristics of PDA patients were analyzed using *** mRNA and protein expression and their regulation in PDA cell lines were measured using quantitative polymerase chain reaction and Western blot *** biological functions of UTX in PDA cell growth,migration,and invasion were determined using gain-and loss-of-function assays with both in vitro and in vivo animal *** expression was reduced in human PDA cell lines and *** UTX expression was associated with poor differentiation and prognosis in *** UTX expression inhibited PDA proliferation,migration,and invasion in vitro and PDA growth and metastasis in vivo,whereas knockdown of UTX expression did the ***,UTX expression was trans-activated by GATA6 ***6-mediated PDA progression could be blocked,at least partially,by silencing UTX *** conclusion,loss of GATA6-mediated UTX expression was evident in human PDA and restored UTX expression suppressed PDA growth and ***,UTX is a tumor suppressor in PDA and may serve as a prognostic biomarker and therapeutic target.

关键词： Growth Invasion Metastasis Pancreatic cancer UTX

Haploids can be induced in knockout mutants of OsPLA1,but not OsDMP3 or OsDMP6,in rice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Crop Journal 2024年第1期12卷 213-221页

作者： Zongkai Liu Yu Zhong Xiaolong Qi Tai An Shuwei Guo Dong Wang Yuwen Wang Bin Feng Zuofeng Zhu shaojiang Chen Chenxu Liu National Maize Improvement Center Engineering Research Center of Ministry of EducationChina Agricultural UniversityBeijing 100193China National Center for Evaluation of Agricultural Wild Plants(Rice) Department of Plant Genetics and BreedingChina Agricultural UniversityBeijing 100193China

Doubled haploid(DH)technology is an important tool in crop breeding because it can significantly accelerate the breeding ***1/MATL/NLD and ZmDMP are two key genes controlling haploid induction(HI)in maize,exhibiting a synergistic ***,it is unknown whether knock out of ZmDMP orthologs can stimulate HI in *** this study,a ZmPLA1 ortholog(OsPLA1)and two ZmDMP orthologs(OsDMP3 and OsDMP6)were identified in *** three genes encode plasma membrane-localized proteins and were highly expressed in mature *** of OsPLA1 in both Minghui 63 and Nipponbare resulted in reduced seed setting rate(SSR)and caused *** osdmp3,osdmp6 and the double mutant failed to trigger HI independently,nor increased the haploid induction rate(HIR)when combined with *** pollinations operations of QX654A with the ospla1 mutant significantly improve SSR,while reducing ***-seq profiling of mature ospla1 mutant anthers indicated that a large number of differentially expressed genes(DEGs)were enriched in redox homeostasis and lipid metabolic GO terms,plant hormone signal transduction,and MAPK signaling *** findings provide important insights towards construction of an efficient DH breeding technology and study of the molecular mechanism of HI in rice.

关键词： Doubled haploid breeding Haploid induction Mutation anlaysis Rice

Network pharmacology to decipher the mechanism of Danggui Longhui Wan against chronic myeloid leukemia

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Traditional Medicines 2024年第4期19卷 177-191页

作者： Xuehan Ma Qiulin Yan shaojiang Song Guodong Yao Key Laboratory of Computational Chemistry Based Natural Antitumor Drug Research&Development Liaoning ProvinceSchool of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016China

Chronic myeloid leukemia(CML)is a hematopoietic myeloproliferative *** Chinese prescription Danggui Longhui Wan(DGLHW)has been utilized in CML treatment,but its underlying mechanisms remain *** this study,we gathered 794 constituents,1249 drug targets,1654 disease genes and 129 intersection *** and KEGG were used to analyze the function of these *** of prescription study showed that monarch drug,minister drug,assistant and guide drug played a synergistic role in the treatment of *** addition,we obtained 20 hub genes and 12 key *** docking indicated that the main compounds and core proteins had good binding *** results of this study also showed that DGLHW might play a role in the treatment of CML by affecting MAPK,PI3K/AKT,FoxO and p53 signaling pathways.

关键词： chronic myeloid leukemia Danggui Longhui Wan network pharmacology compatibility analysis

基于改进相变方程的形状记忆合金弹性耦合系统特性分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

机械工程学报 2024年第14期60卷 194-205页

作者：朱孙科闵旭董绍江重庆交通大学机电与车辆工程学院重庆400074

为准确描述形状记忆合金(Shape memory alloy,SMA)弹性耦合系统的驱动特性,考虑模型复杂程度与工程实际需求,提出了一种基于Brinson本构方程和SMA相变原理的改进相变模型。针对Brinson相变模型SMA马氏体正相变过程中马氏体分数不连续的... 详细信息

为准确描述形状记忆合金(Shape memory alloy,SMA)弹性耦合系统的驱动特性,考虑模型复杂程度与工程实际需求,提出了一种基于Brinson本构方程和SMA相变原理的改进相变模型。针对Brinson相变模型SMA马氏体正相变过程中马氏体分数不连续的问题,将孪晶马氏体相转化为孪晶马氏体相和非孪晶马氏体相相混合相终点时各晶体体积分数,作为马氏体正相变终点时的晶体体积分数,视马氏体正相变为一个连续的过程,对原Brinson相变模型中马氏体正相变方程进行修正。以偏置式SMA丝驱动器为研究对象,建立了SMA弹性耦合系统模型,采用改进的Brinson相变模型分别对具有不同偏置弹簧的系统进行仿真分析,并与相应试验结果比较。结果表明,改进相变模型的计算结果与试验吻合较好,且在相变过程中马氏体相和奥氏体相体积分数和为1,符合实际情况。分析发现,对于SMA弹性耦合系统,偏置弹簧的刚度越大,驱动器响应速度越慢,相变温度区间和完全马氏体逆相变所需的加热电流越大,驱动应变先增加后减小。研究结果可更准确地描述SMA驱动器的作动过程,为偏置式SMA丝驱动器的设计提供参考。

关键词：形状记忆合金驱动特性相变方程偏置弹簧

基于TCN和残差自注意力的变工况下滚动轴承剩余寿命迁移预测

在线全文

学校读者我要写书评

暂无评论

振动与冲击 2024年第1期43卷 145-152页

作者：潘雪娇董绍江朱朋周存芳宋锴重庆交通大学交通运输学院重庆400074 重庆交通大学机电与车辆工程学院重庆400074 重庆大学机械与运载工程学院重庆400044 重庆长安汽车股份有限公司重庆401120

针对变工况环境下采集到的滚动轴承寿命状态数据存在特征分布差异,深度神经网络模型泛化能力差的问题,结合时间卷积网络(temporal convolutional neural network,TCN)和残差自注意力机制提出了一种端到端的滚动轴承剩余寿命(remaining u... 详细信息

针对变工况环境下采集到的滚动轴承寿命状态数据存在特征分布差异,深度神经网络模型泛化能力差的问题,结合时间卷积网络(temporal convolutional neural network,TCN)和残差自注意力机制提出了一种端到端的滚动轴承剩余寿命(remaining useful life,RUL)迁移预测方法。首先,将传感器采集到的一维时域信号利用短时傅里叶变换转换为频域信号;其次,剩余寿命迁移预测网络通用特征提取层采用残差自注意力TCN网络,该网络在较好提取时间序列信息的同时,进一步通过残差自注意力机制捕获轴承局部退化特征,增强模型的迁移特征提取能力;再次,采用提出的联合领域自适应策略匹配变工况下滚动轴承寿命状态数据特征分布差异,实现不同工况下轴承寿命状态知识的迁移预测;最后,在公开的滚动轴承全寿命数据集上进行试验验证,结果表明所提方法能有效实现变工况下的滚动轴承RUL预测,并获得较好的预测性能。

关键词：剩余寿命(RUL) 滚动轴承时间卷积网络(TCN) 残差自注意力迁移学习

变双曲圆弧齿线圆柱齿轮传动界面磨损规律及敏感性分析

在线全文

学校读者我要写书评

暂无评论

机械工程学报 2024年第5期60卷 81-94页

作者：魏永峭张晋王少江漆小虎郭瑞杨海江兰州理工大学机电工程学院兰州730050 兰州理工大学温州泵阀工程研究院温州325105 国机重型装备集团股份有限公司德阳618099

为揭示变双曲圆弧齿线圆柱齿轮(VH-CATT圆柱齿轮)齿面磨损特性,结合Archard磨损理论与主平面重合的椭圆等效接触模型,建立了VH-CATT圆柱齿轮传动界面磨损模型,利用有限元方法获取了齿面法向载荷与接触压力,通过数值计算验证了所建立模... 详细信息

为揭示变双曲圆弧齿线圆柱齿轮(VH-CATT圆柱齿轮)齿面磨损特性,结合Archard磨损理论与主平面重合的椭圆等效接触模型,建立了VH-CATT圆柱齿轮传动界面磨损模型,利用有限元方法获取了齿面法向载荷与接触压力,通过数值计算验证了所建立模型的正确性,并探究了准静态工况下VH-CATT圆柱齿轮传动的齿面磨损规律。研究结果表明,VH-CATT圆柱齿轮沿齿线方向的磨损深度呈半椭圆形分布,在齿根附近磨损深度最大,在节圆附近磨损深度最小,啮合频次的增加对齿面磨损深度的影响逐渐趋于平缓;通过设计参数的敏感性分析可知,增大传动比、模数、齿线半径、压力角可以有效地改善齿面磨损。研究可为提高VH-CATT圆柱齿轮传动精度与效率、减磨延寿提供理论基础。

关键词：变双曲圆弧齿线圆柱齿轮传动界面 Archard磨损理论齿面磨损敏感性分析

硫酸吲哚酚促进慢性肾脏病患者急性冠脉综合征机制的研究进展

在线全文

学校读者我要写书评

暂无评论

中国医学工程 2024年第7期32卷 55-60页

作者：唐毅田少江湖北医药学院附属十堰市人民医院肾病内科湖北十堰442000

急性冠脉综合征(ACS)是慢性肾脏病(CKD),尤其是尿毒症患者的主要死亡原因之一。ACS形成的主要原因与血管内皮功能损伤引起的动脉粥样硬化和动脉内血栓形成密切相关。硫酸吲哚酚(IS)是色氨酸在肠道细菌作用下的代谢产物,CKD患者,尤其是... 详细信息

急性冠脉综合征(ACS)是慢性肾脏病(CKD),尤其是尿毒症患者的主要死亡原因之一。ACS形成的主要原因与血管内皮功能损伤引起的动脉粥样硬化和动脉内血栓形成密切相关。硫酸吲哚酚(IS)是色氨酸在肠道细菌作用下的代谢产物,CKD患者,尤其是尿毒症患者,IS不能有效排出体外造成人体内蓄积而从多个方面造成内皮功能损伤并在ACS发生发展中发挥重要作用。本文主要对近年来国内外有关IS引起CKD患者内皮损伤和血栓形成机制的最新进展进行综述,并总结目前在CKD患者中减轻IS引起的ACS方面的新措施,为防治CKD患者心血管事件提供帮助。

关键词：慢性肾脏病内皮功能障碍内皮细胞急性冠脉综合征硫酸吲哚酚

空间滚动轴承MoS_(2)薄膜润滑分子动力学模拟

在线全文

学校读者我要写书评

暂无评论

重庆大学学报 2024年第7期47卷 43-52页

作者：董绍江程伟伦汤宝平胡小林重庆交通大学机电与车辆工程学院重庆400074 重庆大学机械传动国家重点实验室重庆400030 重庆工业大数据创新中心有限公司重庆400707

针对空间滚动轴承往复运动状态下二硫化钼薄膜润滑失效机理不明的难题,提出了采用分子动力学对薄膜润滑过程进行分析的方法。建立了单层二硫化钼薄膜摩擦原子模型,针对载荷和环境温度这2个空间滚动轴承的重要影响因素展开了二硫化钼薄... 详细信息

针对空间滚动轴承往复运动状态下二硫化钼薄膜润滑失效机理不明的难题,提出了采用分子动力学对薄膜润滑过程进行分析的方法。建立了单层二硫化钼薄膜摩擦原子模型,针对载荷和环境温度这2个空间滚动轴承的重要影响因素展开了二硫化钼薄膜的往复摆动模拟,得到了摩擦过程中二硫化钼薄膜的摩擦力、粘附力和磨损情况。模拟结果表明:Fe-Ni-Cr合金探针在单层二硫化钼薄膜上的摩擦为黏滑运动,载荷在20~100 nN范围内探针的摩擦过程不会对薄膜造成磨损,但在往复运动过程中润滑性能有所提高;载荷从200 nN开始探针的摩擦过程会对薄膜造成磨损,往复运动过程中摩擦系数不断提高,润滑性能下降;400 nN为单层薄膜的载荷极限,在该载荷下探针会刺穿薄膜与基底接触此时薄膜迅速磨损失去润滑作用。环境温度在1 773.15 K以下对薄膜的润滑作用影响不明显,但达到该温度后薄膜边界处开始缓慢熔化,当环境温度达到二硫化钼熔点时薄膜的熔化速度加快并失去润滑作用。从这些发现得到如下结论:二硫化钼单层薄膜在接触载荷8 GPa以下拥有优异的耐磨性和润滑性;在薄膜未破损的条件下,反复摩擦过程提升了润滑性能;二维层状结构对单层二硫化钼薄膜润滑性能有重要的影响,高温和重载都会对薄膜层状结构造成破坏。

关键词：二硫化钼 Fe-Ni-Cr合金分子动力学仿真微观摩擦空间滚动轴承