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Meteorological and Environmental Research 2024年第4期15卷 66-70页

作者： shaohong MO Nanning Vocational and Technical University Nanning 530008China

The brand construction of agricultural products is a necessary path for agricultural development and an effective way to enhance the added value and market competitiveness of agricultural *** to do a good job in building agricultural product brands under the background of rural revitalization?This paper takes the honeysuckle industry in Mashan County,Nanning as a case study for comprehensive analysis,forming a driving force for the high-quality development of characteristic agricultural industries.

关键词： Rural revitalization Local specialty agricultural products Brand construction Honeysuckle

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两水隧道衬砌全断面拆换施工技术与风险控制

铁道建筑 2016年第12期56卷 57-59,76页

作者：王少宏杜凌坤王令朝中交二公局铁路工程有限公司陕西西安710065

在现场勘查的基础上,对两水隧道衬砌侵限、开裂原因进行了分析,提出了隧道全断面拆换的施工方案,详细论述了全断面拆换施工工序和重要工序的控制要点,并从拆除拱墙衬砌、拆换初支和仰拱拆除3个重要环节提出了风险控制措施。

关键词：隧道衬砌全断面拆换施工技术风险控制

基于BP神经网络与聚类分析的数学创新能力研究

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南京师大学报（自然科学版） 2019年第2期42卷 23-29页

作者：杜绍洪李文烁郑江溢谭远顺重庆交通大学数学与统计学院重庆400074 重庆交通大学经济与管理学院重庆400074

通过研究和分析给出提高研究生数学学习能力的针对性建议,以改善目前研究生数学学习能力跟不上科研水平的现状.该研究通过BP神经网络得出能够全面衡量数学学习能力的客观指标,得出数学学习能力的评价得分,并利用SPSS软件进行影响因素与... 详细信息

通过研究和分析给出提高研究生数学学习能力的针对性建议,以改善目前研究生数学学习能力跟不上科研水平的现状.该研究通过BP神经网络得出能够全面衡量数学学习能力的客观指标,得出数学学习能力的评价得分,并利用SPSS软件进行影响因素与该指标的相关性检验,以得出显著影响研究生数学学习能力的因素.最后,根据调查对象的不同特征将研究生个体进行聚类,对每一类个体提升数学学习能力给出针对性建议.

关键词： BP神经网络相关性分析聚类分析研究生数学学习能力

Tomographic inversion of OBS converted shear waves:case study of profile EW6 in the Dongsha area

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Acta Oceanologica Sinica 2024年第8期43卷 13-25页

作者： Genggeng Wen Kuiyuan Wan shaohong Xia Xiuwei Ye Huilong Xu Chaoyan Fan Jinghe Cao Shunshan Xu CEA Key Laboratory of Earthquake Monitoring and Disaster Mitigation Technology Guangdong Earthquake AgencyGuangzhou 510070China Guangdong Science and Technology Collaborative Innovation Center for Earthquake Prevention and Disaster Mitigation Guangzhou 510070China MOE Key Laboratory of Disaster Forecast and Control in Engineering-Urban Earthquake Safety Laboratory Guangzhou 510070China CAS Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China 6 Centro de Geociencias Universidad Nacional Autónoma de MéxicoQuerétaroC.P.76230Mexico

Studies of converted S-wave data recorded on the ocean bottom seismometer(OBS)allow for the estimation of crustal S-wave velocity,from which is further derived the Vp/Vs ratio to constrain the crustal lithology and geophysical *** a precise S-wave velocity model is important for deep structural research,and inversion of converted S-waves provides a potential ***,the inversion of the converted S-wave remains a weakness because of the complexity of the seismic ray path and the inconsistent conversion *** this study,we introduced two travel time correction methods for the S-wave velocity inversion and imaged different S-wave velocity structures in accordance with the corresponding corrected S-wave phases using seismic data of profile EW6 in the northeastern South China Sea(SCS).The two inversion models show a similar trend in velocities,and the velocity difference is<0.15 km/s(mostly in the range of 0–0.1 km/s),indicating the accuracy of the two travel time correction methods and the reliability of the inversion *** to simulations of seismic ray tracing based on different models,the velocity of sediments is the primary influencing factor in ray tracing for S-wave *** the sedimentary layer has high velocities,the near offset crustal S-wave refractions cannot be *** contrast,the ray tracing of Moho S-wave reflections was not significantly impacted by the velocity of the *** two travel time correction methods have their own advantages,and the application of different approaches is based on additional *** works provide an important reference for future improvements in converted S-wave research.

关键词： converted S-wave S-wave velocity structure inversion ocean bottom seismometer northeastern South China Sea

Impacts of cold exposure on energy metabolism

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Frigid Zone Medicine 2024年第2期4卷 65-71页

作者： Miao Yan Shanjie Wang shaohong Fang Mingyan E Bo Yu Department of Cardiology Second Affiliated Hospital of Harbin Medical UniversityHarbin 150001China The Key Laboratory of Myocardial Ischemia Chinese Ministry of EducationHarbin 150001China Department of Thoracic Radiotherapy Harbin Medical University Cancer HospitalHarbin 150081China

Cold stimulation has been shown to regulate glucose,lipid,and amino acid metabolism,while also increasing heat production and energy expenditure in the *** energy metabolism is a key factor in the onset and progression of chronic metabolic conditiones such as diabetes,obesity,and cardiovascular *** research has unveiled the myriad pathways through which cold stimulation affects human energy *** article provides an overview of how cold stimulation affects energy metabolism across the three major metabolic ***,it explores the implications and potential therapeutic applications of cold stimulation in the prevention and treatment of various metabolic diseases.

关键词： cold stimulation energy metabolism glucose metabolism lipid metabolism amino acid metabolism chronic metabolic diseases

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硅片表面杂质浓度扩散方程的差分方法

西华师范大学学报（自然科学版） 2017年第1期38卷 92-96页

作者：杜绍洪谭迎春杨际祥重庆交通大学数学与统计学院重庆400074 重庆市第十一中学校重庆400061

对硅片表面杂质浓度扩散方程,通过对初、边值条件的仔细观察,根据其具有的特点,提出了一种差分求解格式,数值试验表明该格式条件稳定、有效。

关键词：扩散方程差分格式数值解有效性条件稳定

Development and Diagnosis Performance of IgM-Based Rapid Antigen Test for Early Detection of SARS-CoV-2 Infection in a Large Cohort of Suspected COVID-19 Cases—USA,Poland,and Sweden,2021-2022

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China CDC weekly 2024年第37期6卷 953-961,I0009,I0010页

作者： Yihua Huang Yiyi Pu Youhong Weng Yahan Wu Qing He Sofia Litchev Longyou Zhao Haojie Ding Yunru Lai Jie Li Xiaojun Zheng Jinshu Chen XianqinXiong shaohong Lu Fei Gao Meng Gao Qingming Kong Department of Laboratory Medicine Lishui Second People's Hospital Affiliated to Wenzhou Medical UniversityLishui CityZhejiang ProvinceChina Key Laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang province School of Laboratory Medicine and BioengineeringHangzhou Medical CollegeHangzhou CityZhejiang ProvinceChina School of Basic Medicine and Forensics Key Laboratory of Bio-tech Vaccine of Zhejiang ProvinceEngineering Research Center of Novel Vaccine of Zhejiang ProvinceHangzhou Medical CollegeHangzhou CityZhejiang ProvinceChina The Fifth Affiliated Hospital of Wenzhou Medical University Lishui CityZhejiang ProvinceChina Baylor College of Medicine HoustonTXUSA Department of Research and Development Hangzhou AllTest Biotech Co.LtdHangzhou CityZhejiang ProvinceChina

Introduction:Antigen testing has been crucial in effectively managing the coronavirus disease 2019(COVID-19)*** study evaluated the clinical performance of a nasopharyngeal swab(NPS)-based antigen rapid diagnostic test(Ag-RDT)compared to the gold standard real-time reverse transcription-polymerase chain reaction(RT-PCR)for early detection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods:We developed an IgM-based rapid antigen test for early detection of SARS-CoV-2 *** July 2021 and January 2022,we analyzed 1,030 NPS samples from participants at three centers in different countries,using both antigen rapid diagnostic tests(Ag-RDT)and ***:The Ag-RDT demonstrated minimal detection limits as low as 0.1 ng/mL for recombinant N antigen and 100 TCID50/mL for heat-inactivated SARS-CoV-2 *** assessments involving four human coronaviruses and 13 other respiratory viruses showed no *** Ag-RDT assay(ALLtest)exhibited high sensitivity(93.18%-100%)and specificity(99.67%-100%)across all *** such as cycle threshold(Ct)values and the timing of symptoms since onset were influential,with sensitivity increasing at lower Ct values(<30)and within the first week of ***:The ALLtest Ag-RDT demonstrated high reliability and significant potential for diagnosing suspected COVID-19 cases.

关键词： Antigen specificity centers

Recombinant human thrombopoietin in alleviating endothelial cell injury in sepsis

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Journal of Intensive Medicine 2024年第3期4卷 384-392页

作者： Yun Xie Hui Lv Daonan Chen Peijie Huang shaohong Wu Hongchao Shi Qi Zhao Ruilan Wang Department of Critical Care Medicine Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Background To evaluate the effect of recombinant human thrombopoietin(rhTPO)on clinical prognosis by exploring changes in endothelial cell injury markers and inflammatory factors in patients with sepsis after treatment with *** This retrospective observational study involved patients with sepsis(diagnosed according to Sepsis 3.0)admitted to Shanghai General Hospital intensive care unit from January 1,2019 to December 31,*** were divided into two groups(control and rhTPO)according to whether they received *** information,clinical data,prognosis,and survival status of the patients,as well as inflammatory factors and immune function indicators were *** main monitoring indicators were endothelial cell-specific molecule(ESM-1),human heparin-binding protein(HBP),and CD31;secondary monitoring indicators were interleukin(IL)-6,tumor necrosis factor(TNF)-α,extravascular lung water index,platelet,antithrombin III,fibrinogen,and international normalized *** used intraperitoneal injection of lipopolysaccharide(LPS)to establish a mouse model of *** were randomly divided into four groups:normal saline,LPS,LPS+rhTPO,and LPS+rhTPO+*** indicators in mice were measured by enzyme-linked immunosorbent *** A total of 84 patients were included in the *** 7 days of treatment,ESM-1 decreased more significantly in the rhTPO group than in the control group compared with day 1(median=38.6[interquartile range,IQR:7.2 to 67.8]pg/mL ***=23.0[IQR:−15.7 to 51.5]pg/mL,P=0.008).HBP and CD31 also decreased significantly in the rhTPO group compared with the control group(median=59.6[IQR:−1.9 to 91.9]pg/mL ***=2.4[IQR:−23.2 to 43.2]pg/mL;median=2.4[IQR:0.4 to 3.5]pg/mL ***=−0.6[IQR:−2.2 to 0.8]pg/mL,P<0.001).Inflammatory markers IL-6 and TNF-αdecreased more significantly in the rhTPO group than in the control group compared with day 1(median=46.0[IQR:15.8 to 99.1]pg/mL ***=31.2[IQR:19.7 to 171.0]

关键词： Thrombopoietin Sepsis Endothelial cells

Climate Changes in Northeastern China during Last Four Decades

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Chinese Geographical Science 2007年第4期17卷 317-324页

作者： ZHAO Dongsheng ZHENG du WU shaohong WU Zhengfang Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China College of Urban and Environmental Sciences Northeast Normal University Changchun 130024 China

The northeastern China is a sensitive region of climate change, whose detailed trend of climate changes is highly interesting. In this study, this kind of variation trend was analyzed. Potential evapotranspiration (PE) and moisture index (MI) were modeled by using Thornthwaite scheme based on the observation data of 1961-2004 from 94 meteorological stations. To describe the climate fluctuation in the northeastern China in 1961-2004, the linear regression method was used to analyze the variation trends of mean annual temperature, mean annual precipitation, PE and MI. Mann-Kendall method was used to test the significant difference. The results show a general increasing tendency in mean annual temperature, mean annual precipitation, PE and MI. However increasing tendency was more significant in mean annual temperature and PE than in mean annual precipitation and MI. Analysis of seasonal climate variation indicates that there showed positive trends in winter and in spring, while the positive trend was more significant in winter than in spring. Furthermore, the relations between climate changes and geographical factors were analyzed, the results show that both climate factors and their interannual variability were correlated to latitude, longitude and altitude, suggesting that latitude is the most climate factor affecting climate changes, followed by altitude and longitude.

关键词： climate changes potential evapotranspiration moisture index northeastern China

Gene replacement therapy in Bietti crystalline corneoretinal dystrophy:an open-label,single-arm,exploratory trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2275-2284页

作者： Jinyuan Wang Jinlu Zhang Shicheng Yu Hongyan Li shaohong Chen Jingting Luo Haibo Wang Yuxia Guan Haihan Zhang Shiyi Yin Huili Wang Heping Li Junle Liu Jingyuan Zhu Qiong Yang Ying Sha Chuan Zhang Yuhang Yang Xuan Yang Xifang Zhang Xiuli Zhao Likun Wang Liping Yang Wenbin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical University100730 BeijingChina School of Clinical Medicine Tsinghua University100084 BeijingChina Chigenovo Co. Ltd.102206 BeijingChina Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NervePeking University Third Hospital100191 BeijingChina Department of Ophthalmology The Third People’s Hospital of Dalian116091 DalianChina Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina Institute of Systems Biomedicine Department of PathologySchool of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina

Bietti crystalline corneoretinal dystrophy is an inherited retinal disease caused by mutations in CYP4V2,which results in blindness in the working-age population,and there is currently no available ***,we report the results of the first-in-human clinical trial(NCT04722107)of gene therapy for Bietti crystalline corneoretinal dystrophy,including 12 participants who were followed up for 180-365 *** open-label,single-arm exploratory trial aimed to assess the safety and efficacy of a recombinant adeno-associated-virus-serotype-2/8 vector encoding the human CYP4V2 protein(rAAV2/8-hCYP4V2).Participants received a single unilateral subretinal injection of 7.5×10^(10)vector genomes of rAAV2/***,73 treatment-emergent adverse events were reported,with the majority(98.6%)being of mild or moderate intensity and considered to be procedure-or corticosteroid-related;no treatment-related serious adverse events or local/systemic immune toxicities were *** with that measured at baseline,77.8%of the treated eyes showed improvement in best-corrected visual acuity(BCVA)on day 180,with a mean±standard deviation increase of 9.0±10.8 letters in the 9 eyes analyzed(p=0.021).By day 365,80%of the treated eyes showed an increase in BCVA,with a mean increase of 11.0±10.6 letters in the 5 eyes assessed(p=0.125).Importantly,the patients’improvement observed using multifocal electroretinogram,microperimetry,and Visual Function Questionnaire-25 further supported the beneficial effects of the *** conclude that the favorable safety profile and visual improvements identified in this trial encourage the continued development of rAAV2/8-hCYP4V2(named ZVS101e).

关键词： cor dystrophy crystalline