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M^(6)A modification in cardiovascular disease:With a focus on programmed cell death

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Genes & Diseases 2024年第5期11卷 272-284页

作者： Wen Li Yao Liu ruiyan Xu Yuan Zong Lu He Jun Hu Guohua Li Institute of Cardiovascular Disease Key Laboratory for Arteriosclerology of Hunan ProvinceHunan International Scientific and Technological Cooperation Base of Arteriosclerotic DiseaseDepartment of PathophysiologyMOE Key Lab of Rare Pediatric DiseasesHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Cardiovascular Medicine The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Obstetrics and Gynecology The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Cardiovascular Surgery The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China

N^(6)-methyladenosine(m^(6)A)methylation is one of the most predominant internal RNA modifications in eukaryotes and has become a hot spot in the field of epigenetics in recent *** diseases(CVDs)are a leading cause of death *** evidence demonstrates that RNA modifications,such as the m^(6)A modification,are associated with the development and progression of many diseases,including *** increasing body of studies has indicated that programmed cell death(PCD)plays a vital role in ***,the molecular mechanisms underlying m^(6)A modification and PCD in CVDs remain poorly ***,elaborating on the highly complex connections between the m^(6)A mechanisms and different PCD signaling pathways and clarifying the exact molecular mechanism of m^(6)A modification mediating PCD have significant meaning in developing new strategies for the prevention and therapy of *** is great potential for clinical application.

关键词： Apoptosis Autophagy Cardiovascular diseases Ferroptosis N^(6)-methyladenosine Programmed cell death Pyroptosis

A Preliminary Discussion on Watercolor Creation and Emotional Expression of Female Themes in the 20th Century

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Cultural and Religious Studies 2024年第7期12卷 452-460页

作者： GENG ruiyan Zhejiang Normal University JinhuaChina

The history of watercolor painting spans over three centuries,and the study of watercolor creations focusing on female themes have been a hot topic in the subfield of art *** originated in the Age of Exploration,initially serving as a practical tool for natural history,and later evolving into an art form for the *** the 20th century,creations featuring female themes flourished and reached their *** to early works portraying female theses in mythology and religion,these paintings exhibit significant differences in expression,color,and texture,reflecting the gradual rise of women’s status and the artists’reflections on modern *** article delves into the development,emotional expression,creation,and inspiration of watercolor paintings with female *** analyzing representative works,we explore the artists’portrayal of women and the reflection of women’s living conditions,social status,and ideological consciousness in contemporary *** article also examines the profound influence and artistic value of these works on contemporary female-themed paintings from the perspective of art studies.

关键词： female themes watercolor creation emotional expression

自发性水平眼震强度在急性孤立性眩晕疾病中的定位诊断意义

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首都食品与医药 2022年第23期29卷 59-61页

作者：贾伟杜瑞艳北京怀柔医院北京101400

目的探讨自发性水平眼震的强度等级在急性孤立性眩晕疾病中的定位诊断意义.方法回顾性分析2015年1月-2020年12月于北京怀柔医院神经内科住院的634例孤立性眩晕患者,眼震电图记录患者发病后72小时内自发性水平眼震的方向、强度等级,按... 详细信息

目的探讨自发性水平眼震的强度等级在急性孤立性眩晕疾病中的定位诊断意义.方法回顾性分析2015年1月-2020年12月于北京怀柔医院神经内科住院的634例孤立性眩晕患者,眼震电图记录患者发病后72小时内自发性水平眼震的方向、强度等级,按眼震强度,分为三组,Ⅰ°自发性水平眼震组206人;Ⅱ°自发性水平眼震组217人,Ⅲ°自发性水平眼震组211人,总计归纳眼震强度与前庭周围性眩晕和前庭中枢性眩晕的定位关联性.结果前庭周围性疾病在I°自发性水平眼震组占比为73.79%,在Ⅱ°自发性水平眼震组占比为92.17%,在Ⅲ°自发性水平眼震组占比为93.84%,眼震强度越高,前庭周围性病变患者所占比例越高,差异有统计学意义(P<0.05).结论对于孤立性眩晕患者,自发性水平眼震强度越大,提示前庭周围性疾病可能性越大.

关键词：自发性水平眼震眼震强度孤立性眩晕定位诊断

头部震动法在前半规管良性阵发性位置性眩晕治疗中的临床疗效分析

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首都食品与医药 2023年第3期30卷 31-34页

作者：杜瑞艳李召晨北京怀柔医院北京101400

目的探讨头部震动法在前半规管良性阵发性位置性眩晕治疗中的疗效.方法选择2018年1月-2021年12月于北京怀柔医院神经内科门诊就诊的246例前半规管BPPV患者作为研究对象,随机分为三组,观察组均采用头部震动法,共88例;对照组1均采用Semont... 详细信息

目的探讨头部震动法在前半规管良性阵发性位置性眩晕治疗中的疗效.方法选择2018年1月-2021年12月于北京怀柔医院神经内科门诊就诊的246例前半规管BPPV患者作为研究对象,随机分为三组,观察组均采用头部震动法,共88例;对照组1均采用Semont法,共76例;对照组2均采用Yacovino法,共82例,对比三组患者的复位疗效、前庭症状指数(VSI)、眩晕残障量表(DHI)和治疗后1个月内复发率上的差异.结果观察组1次治疗有效率为72.73%、2次治疗有效率86.36%、3次治疗有效率97.73%;均高于对照组1的60.53%、68.42%、84.21%和对照组2的58.54%、68.29%、81.71%,差异有统计学意义(P0.05),治疗后三组前庭症状指数评分及DHI评分均较治疗前有显著下降,但观察组下降幅度更大,差异有统计学意义(P0.05).结论头部震动法治疗前半规管BPPV的疗效优于Semont法和Yacovino法,且操作方法更简便、患者配合度更好,适合临床推广应用.

关键词：良性阵发性位置性眩晕头部震动法 Semont法 Yacovino法疗效

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内蒙古赤峰缸瓦窑与河北定窑白瓷的对比分析

文物保护与考古科学 2022年第1期34卷 55-62页

作者：杜瑞妍冯吉祥张茂林杨敬好郁永彬吴琳景德镇陶瓷大学古陶瓷研究中心江西景德镇333001 内蒙古自治区文物考古研究所内蒙古呼和浩特010010 河北曲阳县定窑遗址文物保管所河北保定073104

缸瓦窑为内蒙古地区辽代规模较大的窑场,为辽代官窑,与宋代五大名窑中的定窑同处一个历史时期。为科学揭示缸瓦窑与定窑之间胎、釉制作工艺关系,运用能量色散X射线荧光光谱法(EDXRF),分析了缸瓦窑与定窑白瓷的胎、釉化学组成,同时结合... 详细信息

缸瓦窑为内蒙古地区辽代规模较大的窑场,为辽代官窑,与宋代五大名窑中的定窑同处一个历史时期。为科学揭示缸瓦窑与定窑之间胎、釉制作工艺关系,运用能量色散X射线荧光光谱法(EDXRF),分析了缸瓦窑与定窑白瓷的胎、釉化学组成,同时结合显微结构和烧成温度分析,并辅助以往的研究资料,将宋辽时期河北定窑与赤峰缸瓦窑白瓷胎、釉化学组成及制作工艺等进行系统的对比分析,发现缸瓦窑受定窑影响较大,缸瓦窑白瓷的生产体现了宋辽两地制瓷工艺的交流传播。

关键词：缸瓦窑白瓷定窑 EDXRF

Thirty-day Outcomes of First-in-man Implantation of a Novel Transcatheter Edge-to-edge Mitral Repair System in Patients With Severe Mitral Regurgitation

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Cardiology Discovery 2024年第2期4卷 142-147页

作者： Kai Xu Yan Wang Shaoliang Chen Xiangbin Pan Ben He ruiyan Zhang Bin Wang Junjie Zhang Zhengbin Zhu Bin Wang Da Zhu Yaling Han Department of Cardiology General Hospital of Northern Theater CommandShenyangLiaoning 110016China Department of Cardiology Xiamen Cardiovascular Hospital Xiamen UniversityXiamenFujan 361102China Department of Cardiology Nanjing First HospitalNanjingJiangsu 210006China Department of Structure Heart Disease Fuwai Yunnan Cardiovascular HospitalKunmingYunnan 650102China Department of Cardiology Shanghai Chest HospitalShanghai 200030China Department of Cardiology Rujin Hospital Shanghai Jiaotong University School of MedicineShanghai 200025China

Objectives:The aim of this multicenter,prospective,single-arm pilot study(*** number:NCT05040074)was to observe the procedural and 30-day results of the novel transcatheter mitral valve repair system,SQ-Kyrin■-M Clip(Shenqi Medical,Shanghai,China),in patients with severe mitral regurgitation(MR).Methods:The heart team considered patients from 5 centers in China with clinically significant functional mitral regurgitation≥3+despite optimal medical therapy or degenerative mitral regurgitation≥3+with high surgical risk as candidates for transcatheter *** patients received transcatheter edge-to-edge mitral valve repair under general *** primary outcome was technical success,which included all of the following measured at the exit from the catheterization laboratory:(1)absence of procedural mortality;(2)successful access,delivery,and retrieval of the device delivery system;(3)successful deployment and correct positioning of the frst intended device;and(4)no emergency surgery or reintervention related to the device or access *** secondary outcomes included all-cause mortality,serious adverse events,device success,and procedural success 30 d after the ***:From June 2021 to December 2021,18 patients were enrolled in this study with age(75.7±7.4)*** patients had MR 4+,while 3 had MR 3+.Technical success was achieved in all patients,including 6 degenerative mitral regurgitation and 12 functional mitral regurgitation *** was no all-cause mortality at 30 *** patient had single leaflet device attachment within 30 d,which was regarded as a serious adverse event,and the patient was successfully treated with reintervention by implanting another *** patient's transmitral gradient was 6 mmHg(>5 mmHg),with an effective orifice area of 2.57 cm^(2) after the *** patients had device success and procedural success at 30 d *** patients had MR 1+,3 had MR 2+,and only 1

关键词： Heart failure Mitral regurgitation Transcatheter mitral valve repair Transcatheter edge-to-edge repair

A 2-D DOA Estimation Method Based on Blind Source Separation

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A 2-D DOA Estimation Method Based on Blind Source Separation

Space-Time Matrix Method for Joint Angle and Frequency Estimation

2009中国控制与决策会议

作者： Fulai Liu,Jinkuan Wang,ruiyan du,Bin Wang Engineering Optimization & Smart Antenna Institute Northeastern University,Qinhuangdao,066004

＜正＞A new two-dimensional direction of arrival（2-D DOA） estimation method is proposed,in this *** presented method makes using of blind source separation method based on the second-order identification to estimate the array response *** the rotational invariance techniques,we can estimate the 2-D DOA from the array response matrix *** estimated elevation angles and azimuth angles is automatically *** results are presented verifying the efficiency of the proposed method.

关键词： Blind Source Separation Two-Dimensional Direction of Arrival(2-D DOA) Second-Order Identification Array Response Matrix

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Space-Time Matrix Method for Joint Angle and Frequency Estim...

“以人为喻”的审美思想与“情”的审美细化——白居易文质观审美刍议

2008 11th IEEE International Conference on Communication Technology(ICCT2008)

作者： ruiyan du Jinkuan Wang Fulai Liu Engineering Optimization & Smart Antenna Institute Northeastern University at Qinhuangdao Qinhuangdao China

High-resolution parameter estimation techniques have recently been applied to jointly estimate multiple signal *** this paper,we consider the joint angle and frequency estimation （JAFE） *** define a novel spacetime matrix which includes the information of incident angles and *** joint angle and frequency estimation method used the defined space-time matrix is named as spacetime matrix *** using of the proposed method,the frequencies and incident angles can be estimated by the eigenvalues and corresponding eigenvectors of the defined spacetime matrix,***,the presented method can automatically determined the paring of the estimated angles and frequencies by the relationship between eigenvalues and *** with the previous work,the space-time matrix method can provide better performance with substantially reduced computational *** performances of some relevant algorithms are compared via simulations,and the effectiveness of the proposed method is verified.

关键词： joint angle-frequency estimation eigenvalue decomposition space-time matrix

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河南师范大学学报（哲学社会科学版） 2024年第4期51卷 117-122页

作者：蒋瑞琰柏红秀扬州大学文学院江苏扬州225009

在白居易之前,中国古代的“文”“质”理论历经审美融合的演变发展,体现出“以人为喻”的审美特征。基于辩证统一的文质思想,白居易在文质观的发展与转向中对“以人为喻”的审美传统作了承继,并提出“气力”说与“粹灵”说,拓展出具有... 详细信息

在白居易之前,中国古代的“文”“质”理论历经审美融合的演变发展,体现出“以人为喻”的审美特征。基于辩证统一的文质思想,白居易在文质观的发展与转向中对“以人为喻”的审美传统作了承继,并提出“气力”说与“粹灵”说,拓展出具有唐人以人论诗特征的审美理论,实现了对唐代审美才性论的理论总结。同时,白居易还将“文质”范畴中的“情”统筹细化为“情志”“情性”“情理”等审美概念,并进行相关的诗歌创作,使其具有理论探索与创作实践相结合的特点。考察白居易的文质观,对于白居易研究和中国古典诗学理论研究的深入与丰富均有重要的学术价值和意义。

关键词：白居易文质融合以人为喻 “气力”说 “粹灵”说