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Insights from a proteomic atlas of human Alzheimer's disease brain tissue

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Neural Regeneration Research 2025年第3期20卷 799-800页

作者： Tomas Kavanagh Eleanor drummond Brain and Mind Centre and School of Medical Sciences University of SydneyCamperdownNSWAustralia

There is an urgent need to identify new drug targets for Alzheimer's disease(AD). While new immunotherapies show promise, clinical benefit appears low, and side effects are high. A greater understanding of the disease mechanisms driving AD is an essential factor that will facilitate the identification of new, effective drug targets.

关键词： Alzheimer clinical driving

迈向完整、准确的诊断准确性研究报告:STARD计划

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中国循证医学杂志 2006年第7期6卷 523-528页

作者： Patrick M.Bossuyt Johannes B.Reitsma David E.Bruns Constantine A.Gatsonis Paul P.Glasziou Les M.Irwig Jeroen G.Lijmer David Moher drummond rennie Henrica C.W.de Vet the STARD Group 刁骧秦莉姚巡荷兰阿姆斯特丹大学学术医学中心临床流行病学与生物统计学系美国夏洛茨维吉尼亚大学病理系美国普罗维登斯布朗大学统计学中心罗德岛ri02912 澳大利亚昆士兰大学全科实习中心澳大利亚悉尼大学公共卫生与社区医学系加拿大安大略省渥太华Chalmers研究组美国旧金山加利福尼亚大学卫生政策研究学院荷兰阿姆斯特丹自由大学外部研究学院

背景要理解诊断准确性研究的结果,读者必须了解其设计、实施、分析及结果。这只能通过作者完全公开研究资料才能实现。目的提高诊断准确性研究报告的准确性和完整性,以便读者评估研究的偏倚可能性及推广性。方法诊断准确性研究报告标准(... 详细信息

背景要理解诊断准确性研究的结果,读者必须了解其设计、实施、分析及结果。这只能通过作者完全公开研究资料才能实现。目的提高诊断准确性研究报告的准确性和完整性,以便读者评估研究的偏倚可能性及推广性。方法诊断准确性研究报告标准(STARD)指导委员会通过文献检索,找出正确实施和报告的诊断性试验,并提取可能有用的条目形成一份泛表。再由研究人员、编辑及相关专业组织成员在为期两天的共识会议中对这份泛表进行缩减,以制定出一份诊断准确性研究的清单和通用流程图。结果检索已发表的诊断性研究指南,共找到33份清单,从中提取出75项可能有用的条目。根据当前可得的所有提示偏倚的证据,将之缩减至25项条目。制定出的典型流程图提供了招募患者的方法、执行“诊断措施”的顺序及接受试验诊断措施或／和金标准诊断措施的患者人数等信息。结论判断研究的价值有赖于完整、准确的报告。若医学期刊采用此清单和流程图,诊断准确性研究报告的质量将会有所提高,更好地服务于临床医生、研究人员、评价者、期刊及公众。

关键词：诊断准确性研究报告诊断性试验文献检索研究人员患者人数医学期刊流程图研究资料评估研究

It takes more than tau to tangle:using proteomics to determine how phosphorylated tau mediates toxicity in neurodegenerative diseases

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Neural Regeneration Research 2021年第11期16卷 2211-2212页

作者： Geoffrey Pires Eleanor drummond Center for Cognitive Neurology Department of NeurologyNew York University School of MedicineNew YorkNYUSA Alzheimer’s and Prion Diseases Team Paris Brain InstituteCNRSUMR 7225INSERM 1127Sorbonne University UM75ParisFrance

Two of the most common causes of dementia are Alzheimer’s disease(AD)and frontotemporal dementia(FTD).AD is an irreversible,progressive neurodegenerative disorder that is clinically characterized by severe memory loss and behavioral impairment that eventually interferes with everyday *** is neuropathologically defined by the presence of extracellularβ-amyloid plaques and intracellular accumulation of neurofibrillary tangles(NFTs)that primarily contain aggregated,hyperphosphorylated tau(pTau).Intriguingly,pTau is also the central protein in multiple subtypes of FTD(*** degeneration,progressive supranuclear palsy,Pick’s disease).FTD is an umbrella term for a group of neurological conditions that primarily affect the temporal and frontal regions of the *** in the tau gene(MAPT)can cause familial FTD,providing further evidence of the integral role of tau in ***,tau regulates microtubule structure and dynamics,as well as axonal transport through interaction with *** is also involved in neuronal development and *** AD and FTD,tau becomes hyperphosphorylated and undergoes major conformational changes,causing it to aggregate into the characteristic neuropathological lesions that define AD and *** the known involvement of tau in these diseases,exactly how tau mediates toxicity is still unclear.

关键词： tau involvement media

Neuronal changes resulting in up-regulation of alpha-1 adrenoceptors after peripheral nerve injury

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Neural Regeneration Research 2014年第14期9卷 1337-1340页

作者： Peter D.drummond Centre for Research on Chronic Pain and Inflammatory Diseases Murdoch University Perth Western Australia Australia

Under normal conditions, the sympathetic neurotransmitter noradrenaline inhibits the production and release of pro-inflammatory cytokines. However, after peripheral nerve and tissue injury, pro-inflammatory cytokines appear to induce the expression of the alphalA-adreno- ceptor subtype on immune cells and perhaps also on other cells in the injured tissue. In turn, noradrenaline may act on up-regulated alphal-adrenoceptors to increase the production of the pro-inflammatory cytokine interleukin-6. In addition, the release of inflammatory mediators and nerve growth factor from keratinocytes and other cells may augment the expression of alphal-adrenoceptors on peripheral nerve fibers. Consequently, nociceptive afferents acquire an abnormal excitability to adrenergic agents, and inflammatory processes build. These mechanisms could contribute to the development of sympathetically maintained pain in conditions such as post-herpetic neuralgia, cutaneous neuromas, amputation stump pain and complex regional pain syndrome.

关键词： alphal-adrenoceptors up-regulation peripheral nerve injury nerve growth factor pro-inflammatory mediators complex regional pain syndrome

The use of localized proteomics to identify the drivers of Alzheimer's disease pathogenesis

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Neural Regeneration Research 2017年第6期12卷 912-913页

作者： Eleanor drummond Thomas Wisniewski Center for Cognitive Neurology Department of Neurology New York University School of Medicine Departments of Neurology Pathology and Psychiatry New York University School of Medicine

Alzheimer’s disease（AD）is broadly defined by dementia and the presence of specific neuropathological features in the brain（amyloid plaques,neurofibrillary tangles（NFTs）and congophilic amyloid angiopathy）.However,the rate of disease progression,type of cognitive impairment,and extent of neuropathology vary widely in patients with AD（Murray et al.,2011）.

关键词： amyloid pathogenesis proteomics localized impairment plaques Murray targeted progression brains

Insights into kidney stem cell development and regeneration using zebrafish

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World Journal of Stem Cells 2016年第2期8卷 22-31页

作者： Bridgette E drummond Rebecca A Wingert Department of Biological Sciences Center for Zebrafish ResearchCenter for Stem Cells and Regenerative MedicineUniversity of Notre Dame

Kidney disease is an escalating global health problem,for which the formulation of therapeutic approaches using stem cells has received increasing research *** complexity of kidney anatomy and function,which includes the diversity of renal cell types,poses formidable challenges in the identification of methods to generate replacement *** work using the zebrafish has revealed their high capacity to regenerate the integral working units of the kidney,known as nephrons,following acute ***,we discuss these findings and explore the ways that zebrafish can be further utilized to gain a deeper molecular appreciation of renal stem cell biology,which may uncover important clues for regenerative medicine.

关键词： Kidney Renal stem cell Renal progenitor Regeneration Nephron Blood filter Renal corpuscle Tubule

Entanglement and nonlocality in multi-particle systems

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Frontiers of physics 2012年第1期7卷 72-85页

作者： Margaret D. Reid (1) Qiong-Yi He (1) Peter D. drummond (1) 1. ARC Centre of Excellence for Quantum-Atom Optics Centre for Atom Optics and Ultrafast Spectroscopy Swinburne University of Technology Melbourne 3122 Australia

Entanglement, the Einstein-Podolsky Rosen （EPR） paradox and Bell＇s failure of local-hidden- variable （LHV） theories are three historically famous forms of ＂quantum nonlocality＂. We give experimental criteria for these three forms of nonlocality in multi-particle systems, with the aim of better understanding the transition from microscopic to macroscopic nonlocality. We examine the nonlocality of N separated spin J systems. First, we obtain multipartite Bell inequalities that address the correlation between spin values measured at each site, and then we review spin squeezing inequal- ities that address the degree of reduction in the variance of collective spins. The latter have been particularly useful as a tool for investigating entanglement in Bose Einstein eondensates （BEC）. We present solutions for two topical quantum states： multi-qubit Greenberger-Horne Zeilinger （GHZ） states, and the ground state of a two-well BEC.

关键词： entanglement quantum nonlocality multi-particle two-well Bose-Einstein condensates(BEC)

Quantum coherence~ correlations and dynamics of ultracold atoms： From fundamental research to future technology

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Frontiers of physics 2012年第1期7卷 1-2页

作者： Chaohong Lee (1) Peter D. drummond (2) Masahito Ueda (3) 1. State Key Laboratory of Optoelectronic Materials and Technologies School of Physics and Engineering Sun Yat-Sen University Guangzhou 510275 China2. Centre for Atom Optics and Ultrafast Spectroscopy Swinburne University of Technology Melbourne 3122 Australia3. Department of Physics University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan

Coherence and correlation are at. the heart of all quantum sciences The emerging quan- tum technologies crucially depend on exot, ic coherence and correlations that cannot, be found in classical systems, To realize qu... 详细信息

关键词： Quantum coherence correlations future technology

Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity:a review

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Journal of Integrative Medicine 2018年第4期16卷 211-222页

作者： Bruno Jose Martins Da Silva Amanda Anastacia Pinto Hage Edilene Oliveira Silva Ana Paula drummond Rodrigues Laboratory of Parasitology and Laboratory of Structural Biology Institute of Biological SdencesFederal University of PardBelemPard 66075-110Brazil National Institute of Science and Technology in Structural Biology and Bioimaging Rio de JaneiroRio de Janeiro 21941-901Brazil Laboratory of Electron Microscopy Department of Health SurveillanceMinistry of HealthEvandro Chagas InstituteBelemPard 66087-082Brazil

Leishmaniasis, a neglected disease caused by Leishmania protozoans, primarily affects people in tropical and subtropical areas. Chemotherapy based on the use of pentavalent antimonials, amphotericin B, paromomycin, miltefosine and liposomal amphotericin B is currently the only effective treatment. However, adverse effects, long-term treatment and the emergence of parasite resistance have led to the search for alternative treatments. Natural products used in traditional medicine provide an unlimited source of molecules for the identification of new drugs, and the Amazon region has abundant biodiversity that includes several species of plants and animals, providing a rich source of new products and com- pounds. Although the literature describes numerous promising compounds and extracts for combating Leishmania protozoans, the results of such research have not been embraced by the pharmaceutical industry for the development of new drugs. Therefore, this review focused on the antileishmanial activity of extracts, isolated compounds and essential oils commonly used by the local population in the Brazilian Amazonian region to treat several illnesses and described in the literature as promising compounds for combating leishmaniasis.

关键词： Amazonian plants Leishmaniasis treatment Plant compounds Plant extracts Plant oils