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Comparison Study of Funduscopic Exam of Pediatric Patients Using the D-EYE Method and Conventional Indirect Ophthalmoscopic Methods

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Open Journal of Ophthalmology 2017年第3期7卷 145-152页

作者： drew Dickson Samiksha Fouzdar-Jain Collin MacDonald Helen Song Daniel Agraz Linda Morgan Donny Suh University of Nebraska Medical Center Omaha Nebraska USA Children’s Hospital and Medical Center Omaha Nebraska USA

Purpose: The D-EYE device, a new fundoscopic smartphone lens, has demonstrated its utility in a clinical setting to detect and document ocular pathology, but has not been tested in the pediatric population. A prospective study was performed to explore the application of D-EYE in pediatric fundus examinations. Methods: Patients ages 3 - 18 years old underwent dilated fundus examinations by masked examiners using the video function of the D-EYE, while indirect ophthalmoscopy was performed by apediatric ophthalmologist. The examiners independently analyzed the D-EYE videos for the presence or absence of abnormalities, cup-to-disc (c/d) ratios and optic nerve size and color. The D-EYE video findings were compared to indirect ophthalmoscopy findings. Results: The study included 172 eyes from 87 patients. In comparing D-EYE to indirect ophthalmoscopy for detecting fundus abnormalities, the sensitivity was 0.72, specificity was 0.97, positive predictive value (PPV) was 0.77, negative predictive value (NPV) was 0.97, positive likelihood ratio (LR) was 27.8, and negative LR was 0.29. The agreement rate between the D-EYE video graders for the c/d ratio within a value of 0.1 was 97.0%. Multiple, distinct abnormalities were discovered using the D-EYE device, including nystagmus, optic nerve hypoplasia, optic disc edema, peripapillary atrophy, disc pallor, and optic disc drusen. Conclusion: Fundoscopic imaging using the D-EYE smartphone lens reliably detects the presence of fundus abnormalities and has good reliability in assessing c/d ratios. The video capability is useful in patients with nystagmus or those who are poorly compliant with the examination and allowed for effective teaching by the pediatric ophthalmologist.

关键词： D-EYE Fundoscopic Imaging Pediatric Ophthalmologist

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Highly efficient fiber to Si waveguide free-form coupler for foundry-scale silicon photonics

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Photonics Research 2024年第5期12卷 1055-1066页

作者： LUIGI RANNO JIA Xu BRIAN SIA COSMIN POPESCU drew WENINGER SAMUEL SERNA SHAOLIANG YU LIONEL C.KIMERLING ANURADHA AGARWAL TIAN GU JUEJUN HU Department of Materials Science&Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA Centre for Micro-&Nano-Electronics(CMNE) Nanyang Technological UniversitySingapore 639798Singapore Department of Physics Photonics and Optical EngineeringBridgewater State UniversityBridgewaterMassachusetts 02324USA Zhejiang Laboratory Hangzhou 311100China Materials Research Laboratory Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA

As silicon photonics transitions from research to commercial deployment,packaging solutions that efficiently couple light into highly compact and functional sub-micrometer silicon waveguides are imperative but remain *** 220 nm silicon-on-insulator(SOI)platform,poised to enable large-scale integration,is the most widely adopted by foundries,resulting in established fabrication processes and extensive photonic component *** development of a highly efficient,scalable,and broadband coupling scheme for this platform is therefore of paramount *** two-photon polymerization(TPP)and a deterministic free-form micro-optics design methodology based on the Fermat’s principle,this work demonstrates an ultraefficient and broadband 3-D coupler interface between standard SMF-28 single-mode fibers and silicon waveguides on the 220 nm SOI *** coupler achieves a low coupling loss of 0.8 dB for the fundamental TE mode,along with 1 dB bandwidth exceeding 180 *** broadband operation enables diverse bandwidthdriven applications ranging from communications to ***,the 3-D free-form coupler also enables large tolerance to fiber misalignments and manufacturing variability,thereby relaxing packaging requirements toward cost reduction capitalizing on standard electronic packaging process flows.

关键词： fiber waveguide enable

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美国人民靠自己跟踪新冠疫情

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商业周刊（中文版） 2020年第21期 32-35页

作者： drew Armstrong 汪泽(译) 不详

2020年初,阿曼达·弗伦奇(Amada French)正处于学术工作的空当中。她母亲大约一年前去世了,她休了假打理一些事情。之后疫情来袭,打断了她的求职计划,她独自住在北卡罗来纳州的罗利,无事可做,只能每天凄凄惨惨地刷Twitter——她自己这... 详细信息

2020年初,阿曼达·弗伦奇(Amada French)正处于学术工作的空当中。她母亲大约一年前去世了,她休了假打理一些事情。之后疫情来袭,打断了她的求职计划,她独自住在北卡罗来纳州的罗利,无事可做,只能每天凄凄惨惨地刷Twitter——她自己这么说的。

关键词：阿曼达北卡罗来纳州凄凄惨惨弗伦奇疫情

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A review of the effects of healthcare disparities on the experience and survival of ovarian cancer patients of different racial and ethnic backgrounds

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Journal of Cancer Metastasis and Treatment 2019年第2期4卷 77-86页

作者： Matthew Kaufman Ana Cruz Janese thompson Srinivasa Reddy Nisha BansaI Joshua GCohen Yanyuan Wu Jay Vadgama Robin Farias-Eisner Obstetrics and Gynecology University of CaliforniaLos AngelesCA 90024USA School of Medicine Meharry Medical CollegeNashvilleTN 37208USA Internal Medicine Charles Drew UniversityLos AngelesCA 90059USA

Ovarian cancer (OC) is a serious condition that often presents at advanced stages and has high mortality rates, with the current mode of early-stage screening lacking sensitivity and specificity. OC often presents asymptomatically, which renders early diagnosis difficult. Furthermore, many patients lack significant risk factors or family history of the disease. Five-year survival rates differ between patients with OC among racial, ethnic, and social groups as a result of different social barriers. This review article aims to present the currently existing data regarding health care disparities among OC patients of different ethnic, demographic, and socioeconomic backgrounds, and what next steps should be taken to better understand and eventually eliminate these potentially devastating health care disparities. Increasing data support the notion that a combination of genomic, socioeconomic status, social factors, and cultural differences lead to differential treatments and therefore health care disparities. While genomic and biological factors are important, language barriers, geographic and travel barriers, differences in comorbidity likelihood between populations, and different treatment plans seem to have a greater impact on 5-year survival rates of patients from diverse backgrounds. Language barriers limit a shared-decision model of care. Transportation limitations and geographic differences can lead to limited follow-up and insufficient care in resource and equipment restrictive settings. Patients with these barriers also tend to have a higher incidence of comorbidities that raise the mortality rate of OC. Further research needs to explore effective ;solutions to bridge health care disparities and understand why they occur.

关键词： Ovarian cancer healthcare disparities public health racial disparities epidemiology literature review

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World Wide Web数据库开发人员指南第一版

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丛书名：现代数据库技术丛书

1998年

作者：（美）（M.斯旺克）Mark Swank （美）（D.基特尔）drew Kittel 王建华等译

本书全面而详细地介绍了如何设计、开发和运用可供Internet和Intranet Web网站上的客户机访问安全客户机/服务器数据库的方法；告诉你如何使用HTML、CGI、相应的语言和脚本来创建、使用基于表单的数据，并且给出了大量专业性数据库开发... 详细信息

ISBN: (纸本)7111063155

本书全面而详细地介绍了如何设计、开发和运用可供Internet和Intranet Web网站上的客户机访问安全客户机/服务器数据库的方法；告诉你如何使用HTML、CGI、相应的语言和脚本来创建、使用基于表单的数据，并且给出了大量专业性数据库开发应用的实例。

关键词：互连网络数据库管理系统软件开发

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Restoration of Motor Function through Delayed Intraspinal Delivery of Human IL-10-Encoding Nucleoside-Modified mRNA after Spinal Cord Injury

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Research 2023年第4期2023卷 131-144页

作者： LászlóGál Tamás Bellák Annamária Marton Zoltán Fekécs drew Weissman Dénes Török Rachana Biju Csaba Vizler Rebeka Kristóf Mitchell B.Beattie Paulo J.C.Lin Norbert Pardi Antal Nógrádi Krisztián Pajer Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary National Biotechnology Laboratory Institute of GeneticsBiological Research CentreSzegedHungary Institute of Biochemistry Biological Research CentreSzegedHungary Department of Medicine University of PennsylvaniaPhiladelphiaPA19104USA Acuitas Therapeutics VancouverBCV6T 1Z3Canada

Efficient in vivo delivery of anti-inflammatory proteins to modulate the microenvironment of an injured spinal cord and promote neuroprotection and functional recovery is a great ***-modified messenger RNA(mRNA)has become a promising new modality that can be utilized for the safe and efficient delivery of therapeutic ***,we used lipid nanoparticle(LNP)-encapsulated human interleukin-10(hIL-10)-encoding nucleoside-modified mRNA to induce neuroprotection and functional recovery following rat spinal cord contusion *** administration of hIL-10 mRNA-LNP to rats led to a remarkable reduction of the microglia/macrophage reaction in the injured spinal segment and induced significant functional recovery compared to ***,hIL-10 mRNA treatment induced increased expression in tissue inhibitor of matrix metalloproteinase 1 and ciliary neurotrophic factor levels in the affected spinal segment indicating a time-delayed secondary effect of IL-105 d after *** results suggest that treatment with nucleoside-modified mRNAs encoding neuroprotective factors is an effective strategy for spinal cord injury repair.

关键词： protective Restoration utilized

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路虎卫士挑战赛

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汽车与运动 2015年第6期 138-145页

作者： HENRY CATCHPOLE drew GIBSON 马爽

虽然赛车速度不是很快,但"卫士挑战赛"一点都不缺乏刺激,在这充满WRC风格的森林赛道和令人生畏的越野障碍中穿梭,我的身心都在忍受着极度的"摧残""这真的有点疯狂,要知道今天可是星期六,按道理我应该和家人坐在电视机旁观看《英国偶像》... 详细信息

虽然赛车速度不是很快,但"卫士挑战赛"一点都不缺乏刺激,在这充满WRC风格的森林赛道和令人生畏的越野障碍中穿梭,我的身心都在忍受着极度的"摧残""这真的有点疯狂,要知道今天可是星期六,按道理我应该和家人坐在电视机旁观看《英国偶像》。"Jon说道。我们驾驶着这辆卫士挑战赛车在黑暗的越野路段中以近乎130km/h的速度"上蹿下跳"着,我的惊呼声也随着一次次的颠簸而被打断,我甚至感觉我的脊椎也随着减振器的上下幅度做着往复式运动。忽然。

关键词：惊呼声路虎往复式橘黄色达喀尔拉力赛座驾越野能力四四方方你喜欢轮圈

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