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Single-chain variable fragment antibody constructs neutralize measles virus infection in vitro and in vivo

Cellular & Molecular Immunology 2021年第7期18卷 1835-1837页

作者： Cyrille Mathieu Marion Ferren Olivia Harder Francesca TBovier Tara CMarcink Camilla Predella Fabrizio Angius Jennifer drew-Bear NValerio Dorrello Alex LGreninger Anne Moscona Stefan Niewiesk Branka Horvat Matteo Porotto Center for Host-Pathogen Interaction Columbia University Vagelos College of Physicians and SurgeonsNew YorkNYUSA Department of Pediatrics Columbia University Vagelos College of Physicians and SurgeonsNew YorkNYUSA CIRI Centre International de Recherche en InfectiologieTeam IBIVUniv LyonInsermU1111UniversitéClaude Bernard Lyon 1CNRSUMR5308ENS de LyonF-69007LyonFrance Department of Veterinary Biosciences College of Veterinary MedicineThe Ohio State UniversityColumbusOHUSA epartment of Experimental Medicine UniversitàVanvitelliCasertaItaly Department of Laboratory Medicine University of Washington School of MedicineSeattleWAUSA Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research CenterSeattleWAUSA Department of Microbiology&Immunology Columbia University Vagelos College of Physicians and SurgeonsNew YorkNYUSA Department of Physiology&Cellular Biophysics Columbia University Vagelos College of Physicians and SurgeonsNew YorkNYUSA

Despite the availability of an effective measles virus(MeV)vaccine and efforts to increase vaccine coverage by the WHO,UNICEF,and their partners,MeV has not been eradicated,and the estimated global measles death rose from 89,780 in 2016 to 207,500 in 2019.1 Because there is an effective measles vaccine,antiviral development for measles has not been prioritized,but recent outbreaks have highlighted the need for drugs to prevent transmission in unvaccinated populations and to protect and treat immunocompromised *** identified several neutralizing mouse monoclonal antibodies(mAbs)that target the MeV fusion(F)protein in its prefusion state2 and inhibit fusion and viral *** engineered a single-chain variable fragment(scFv)from the most potent anti-MeV F *** scFv retains the ability to inhibit fusion and prevents infection in vitro,and intranasal administration of the scFv antibody construct prevents infection in vivo.

关键词： neutral priori UNICEF

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家的感觉（英文）

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大学英语 2018年第10期 15-20页

作者： drew Kunz 不详

'There’s no place like home' is a popular expression in ***, it means that there is nowhere in the world quite so special as the place that one calls home.I’m sure that this is a sentiment with which most of my stud... 详细信息

关键词：家感觉

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布兰南街888号

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建筑实践 2018年第5期 90-95页

作者： drew Kelly Gensler

布兰南街888号就像是一面镜子,折射旧金山市场南街区的变迁。无论是形态还是功能,这座历史建筑都"旧貌换新颜",以适应街区身份的变换。布兰南街888号始建于1917年,经历过数次翻新和扩建。设计团队面临的挑战是,如何将充满时代感的建筑... 详细信息

布兰南街888号就像是一面镜子,折射旧金山市场南街区的变迁。无论是形态还是功能,这座历史建筑都"旧貌换新颜",以适应街区身份的变换。布兰南街888号始建于1917年,经历过数次翻新和扩建。设计团队面临的挑战是,如何将充满时代感的建筑风格与审美的时代变化完美融合在一起,打造一个能够服务于租户和社区的理想所在。客户的目标是重新构想布兰南街888号的身份和潜力,以满足快速增长的科技市场的需求,同时保留珠宝首饰礼品中心年代久远的装置和设备,尊重这座建筑的

关键词：设计团队

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Possible Chemosensitizing and Potent Anticancer Effects of D-Fraction in Combination with Vitamin C on Three Prevalent Urologic Cancer Cells

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Journal of Cancer Therapy 2014年第14期5卷 1402-1411页

作者： drew Freilich Eric Moskowitz Nicholas Feuer Muhammad Choudhury John Phillips Sensuke Konno Department of Urology New York Medical College Valhalla USA

Chemotherapy is currently one of the most common therapeutic options for cancer patients despite the poor efficacy with considerable side effects. We then examined if D-fraction (DF), a bioactive mushroom extract, could potentiate (poor) anticancer effects of those drugs?in vitro. Three urologic cancers, prostate, bladder, and kidney cancers, were tested with various chemotherapeutic drugs and their combinations with DF. Compared to individual drugs alone, combinations of drugs and DF have improved anticancer activity, resulting in the significant (P < 0.05) cell viability reduction in all three cancer cells. As vitamin C (VC) has been postulated to potentiate the bioactivity of DF, this possibility was also examined. The specific combination of DF (300 μg/ml) and VC (200 μM) indeed led to the drastic (≥90%) viability reductions in all three cancer cells. To have a better understanding of such a profound viability reduction, the effect of DF/VC combination on cell cycle was examined next. Cell cycle analysis indicated that this combination induced a G1cell cycle arrest, which was also confirmed by the down-regulation of specific cell cycle regulators (CDK2, CDK4, and cyclin D1) detected on western blots. Moreover, it was crucial to address if the DF/VC-induced viability reduction could be also linked to apoptosis. Western blot analysis revealed that anti-apoptotic bcl-2 was down-regulated while pro-apoptotic Bax was up-regulated with DF/VC combination in all cancer cells, indicating induction of apoptosis. Therefore, the DF/VC combination could ultimately induce apoptosis, accounting for the severe cell viability reduction. In conclusion, DF appears to be a promising agent with chemosensitizing effect, enhancing the efficacy of chemotherapeutic drugs, and its combination with VC exhibits a potent anticancer effect, which is far superior to any combinations of drugs and DF tested in three prevalent urologic cancer cells.

关键词： Mushroom Extract Chemosensitizing Effect Anticancer Effect Combination Therapy Urologic Cancers

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AIDS病人的巨细胞病毒感染

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国外医学（内科学分册） 1990年第2期17卷 77-78,81页

作者： drew,WL

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七位敢于冒险并取得成功的首席执行官

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中国外资 2014年第17期 52-53页

作者： drew Hendricks

世界上许多最成功的企业家之所以拥有今天的成就,是因为他们进行的战略博弈最终带来了巨大的回报。当初他们在承担风险时,别人认为他们的决定愚蠢透顶。但是结果不容否认。下面的七位名人——比尔·盖茨、拉里·佩奇、史蒂夫·乔布斯、... 详细信息

世界上许多最成功的企业家之所以拥有今天的成就,是因为他们进行的战略博弈最终带来了巨大的回报。当初他们在承担风险时,别人认为他们的决定愚蠢透顶。但是结果不容否认。下面的七位名人——比尔·盖茨、拉里·佩奇、史蒂夫·乔布斯、切特·西蒙斯、拉里·埃里森、弗雷德·史密斯和卡伦·卡普兰——都曾勇于冒险,而走向各自领域的顶峰。对他们每个人来说,冒险都为他们带来了成功。

关键词：弗雷德·史密斯西蒙斯埃里森佩奇卡伦盖茨谷歌保罗·艾伦布斯帆船运动

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