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Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite

Journal of Bionic Engineering 2015年第4期12卷 604-612页

作者： Nenad Ignjatovic Zorica Aj dukovic Jelena Rajkovic Stevo Najman dragan mihailovic dragan Uskokovic Centre for Fine Particles Processing and Nanotechnologies Institute of Technical Sciences of the Serbian Academy of Science and Arts Knez Mihailova 35/4 11000 Belgrade Serbia University of Nis Faculty of Medicine Department of Prosthodontics Clinic of Stomatology Nis Serbia University of Nis Department of Biology and Ecology Faculty of Science and Mathematics Nis Serbia University of Nis Faculty of Medicine Institute of Pathology Nis Serbia

Hydroxyapatite （HAp） is an extensively studied material with known biocompatible and osteoconductive properties in bone tissue reconstruction. The improvement of the osteogenetic potential of HAp has been tested through modification of its structure, by replacing Ca2＋ ions with Co2＋ ions. In our study, we comparatively analyze the osteogenetic potential of the syn- thesized HAp and Co2＋-substituted HAp （HAp/Co） designed on the nano-scale with the aim of specifically stimulating osteo- genesis in vivo. We present a quantitative study of the microscopic organization and structure of the newly formed tissue in a bone defect after 12 weeks and 24 weeks. A quantitative analysis of the calcium, magnesium and phosphorus content in the defect and its close environment was used to determine the deposition of minerals after bone reconstruction. The defect recon- structed with HAp/Co nanoparticles （Co2＋ content 12 wt%） was filled with a new tissue matrix composed of dense collagen fibers containing centers of mineralization after 24 weeks. The mineral deposition rate was also higher when the defect was reconstructed with HAp/Co than when it was filled with pttre HAp. A histological analysis confirmed that the alveolar bone, in which osteoporosis-induced defects were repaired using HAp/Co nanoparticles, was recuperated.

关键词： advanced osteogenesis cobalt-substituted hydroxyapatite nanoparticles histomorphometry

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Amplified optical transduction of proteins derived from Mo6S9-xIx nanowires

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Progress in Natural Science:Materials International 2013年第3期23卷 326-330页

作者： Nijuan Sun Martin McMullan Pagona Papakonstantinou dragan mihailovic Meixian Li College of Chemistry and Molecular Engineering Peking University School of Engineering University of UlsterNewtownabbeyCo.Antrim BT37 0QBNorthern IrelandUK Jozef Stefan Institute Jamova 39SI-1000 LjubljanaSlovenia

We demonstrate that Mo6S9-xIx nanowires(MoSI NWs) enable the detection of proteins with cytochrome c as a model protein using UV-vis *** association of cytochrome c with the nanowires was verified by scanning electroctron microscopy,X-ray photoelectron,light scattering and micro-FTIR *** results show that MoSI NWs is a promising nanostructure material for the development of ultrasensitive sensors for detecting *** new MoSI NW derived amplification bioassay is expected to provide a straightforward and effective strategy for protein analysis and biosensor construction.

关键词： Mo6S9-xIx nanowires Cytochrome c UV-vis spectrometry Amplification

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