检索结果-南通市图书馆

2 GeV Electron beam Irradiation Effects in Advanced Metallic Glasses

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Minerals and Materials Characterization and Engineering 2022年第2期10卷 106-112页

作者： Monica Sorescu Fatiha benmokhtar douglas Higinbotham Marcy Stutzman Department of Physics Duquesne University Pittsburgh USA Thomas Jefferson National Accelerator Facility Newport News Virginia USA

Six amorphous alloys (Alloy 1: Fe56Co24Nb4b13Si2Cu1, Alloy 2: Fe68.5Co5Nb3Cu1Si15.5b7, Alloy 3: Fe75.3Ni0.8Cr0.9Si8.7b14.3, Alloy 4: Fe56Co24Cr10Nb4b3Si1Cu2, Alloy 5: Fe72.9Nb3Cu1Si16.2b6.9, Alloy 6: Fe83.3Si8.6Nb5.5b... 详细信息

Six amorphous alloys (Alloy 1: Feb>56b>Cob>24b>Nbb>4b>bb>13b>Sib>2b>Cub>1b>, Alloy 2: Feb>68.5b>Cob>5b>Nbb>3b>Cub>1b>Sib>15.5b>bb>7b>, Alloy 3: Feb>75.3b>Nib>0.8b>Crb>0.9b>Sib>8.7b>bb>14.3b>, Alloy 4: Feb>56b>Cob>24b>Crb>10b>Nbb>4b>bb>3b>Sib>1b>Cub>2b>, Alloy 5: Feb>72.9b>Nbb>3b>Cub>1b>Sib>16.2b>bb>6.9b>, Alloy 6: Feb>83.3b>Sib>8.6b>Nbb>5.5b>bb>1.4b>Cub>1.2b>) were selected in terms of their composition and magnetostriction constants and uniformly irradiated in a high radiation environment in Hall A of the Thomas Jefferson National Accelerator Facility. The 2 GeV electron beam irradiation-induced effects were characterized by Mӧssbauer spectroscopy. The microstructural changes were related to the evolution of the hyperfine magnetic field distributions and isomer shifts. In particular, the occurrence of stress centers in the amorphous materials was evidenced.

关键词： Metallic Glasses Hyperfine Interactions Magnetostriction Radiation Effects Mӧssbauer Spectroscopy

Sequence-sorted redox-switchable hetero[3]rotaxanes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Organic Chemistry Frontiers 2022年第1期9卷 64-74页

作者： Marius Gaedke Henrik Hupatz Felix Witte Susanne M.Rupf Clara douglas Hendrik V.Schröder Lukas Fischer Moritz Malischewski beate Paulus Christoph A.Schalley Institut für Chemie und biochemie der Freien Universität berlin Arnimallee 2014195 BerlinGermany Institut für Chemie und biochemie der Freien Universität berlin Arnimallee 2214195 BerlinGermany Institut für Chemie und biochemie der Freien Universität berlin Fabeckstr.34/3614195 BerlinGermany

From a library of five crown ether macrocycles with different ring sizes and redox-active moieties,such as tetrathiafulvalene(TTF)and naphthalene dimiide(NDI),directional heterocircuit[3]rotaxanes were *** an axle with two binding sites with different steric accessibility,the concept of integrative self-sorting was applied to program the sequence of functional units in heteropseudo[3]*** on binding strength and ring size of the smaller macrocycles,different heteropseudo[3]rotaxane selectivities and stabilities were determined by 2D NMR spectroscopy and tandem mass spectrometry.A heteropseudo[3]rotaxane with rotaxane-like behaviour was isolated chromatographically,displaying electrochemically“frustrated”properties.A robust synthetic procedure was developed allowing the synthesis of four new hetero[3]rotaxanes incorporating specific sequences of functional *** pseudoisomeric rotaxanes which have the naphthalene diimide subunit at two different positions show distinct electrochemical *** calculations suggest that this differences could arise from a folding of the structure,in which the redox-active moieties stack with a stopper *** study presents a blueprint for the construction of hetero[3]rotaxanes with sequential control of the functional units along the track of the axle and paves the way to extend the functionality of mechanically interlocked molecules.

关键词： properties redox Sequence

Neoadjuvant Therapy for Resectable and borderline Resectable Pancreatic Cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2016年第1期7卷 24-40页

作者： Susan Tsai Kathleen K. Christians ben George Paul Ritch Kiyoko Oshima Parag Tolat Ashley Krepline beth A. Erickson douglas b. Evans Division of Surgical Oncology Medical College of Wisconsin Milwaukee WI USA Division of Hematology/Oncology Medical College of Wisconsin Milwaukee WI USA Division of Pathology Medical College of Wisconsin Milwaukee WI USA Division of Radiation Oncology Medical College of Wisconsin Milwaukee WI USA

The majority of patients with localized pancreatic cancer (PC) who undergo surgery followed by adjuvant therapy will develop metastatic disease, suggesting that surgery alone is not sufficient for cure and micrometastases are present even when are not clinically detected. As such, the delivery of early systemic therapy may be a rational alternative to a surgery-first approach, in an effort to provide oncologic therapies which are commensurate with the disease stage, and improve surgical selection. This review details the rationale for a neoadjuvant approach to localized PC and provides specific recommendations for both pretreatment staging and treatment sequencing for patients with resectable and borderline resectable PC.

关键词： Pancreas Cancer Neoadjuvant Therapy Review

A Versatile Phenotyping System and Analytics Platform Reveals Diverse Temporal Responses to Water Availability in Setaria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2015年第10期8卷 1520-1535页

作者： Noah Fahlgren Maximilian Feldman Malia A. Gehan Melinda S. Wilson Christine Shyu douglas W. bryant Steven T. Hill Colton J. McEntee ankalpi N. Warnasooriya Indrajit Kumar Tracy Ficor Stephanie Turnipseed Kerrigan b. Gilbert Thomas P. brutnell James C. Carrington Todd C. Mockler Ivan baxter Donald Danforth Plant Science Center St. Louis MO 63132 USA USDA-ARS Donald Danforth Plant Science Center St. Louis MO 63132 USA These authors contributed equally to this article.

Phenotyping has become the rate-limiting step in using large-scale genomic data to understand and improve agricultural crops. Here, the bellwether Phenotyping Platform for controlled-environment plant growth and automated multimodal phenotyping is described. The system has capacity for 1140 plants, which pass daily through stations to record fluorescence, near-infrared, and visible images. Plant Computer Vision （PlantCV） was developed as open-source, hardware platform-independent software for quantitative image analysis. In a 4-week experiment, wild Setaria viridis and domesticated Setaria italica had fundamentally different temporal responses to water availability. While both lines produced similar levels of biomass under limited water conditions, Setaria viridis maintained the same water-use efficiency under water replete conditions, while Setaria italica shifted to less efficient growth. Overall, the bellwether Phenotyping Platform and PlantCV software detected significant effects of genotype and environment on height, biomass, water-use efficiency, color, plant architecture, and tissue water status traits. All -79 000 images acquired during the course of the experiment are publicly available.

关键词： abiotic/environmental stress water relations bioinformatics development phenotyping

Seasonal variation and host sex affect bat–bat fly interaction networks in the Amazonian savannahs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2024年第3期19卷 400-416页

作者： Paulo MEJIA Gustavo Lima URbIETA bruna da Silva XAVIER IsaíJorge de CASTRO JoséJúlio DE TOLEDO Gustavo GRACIOLLI Lucio AndréVIANA DIAS William douglas CARVALHO Programa de Pós-Graduação em biodiversidade Tropical Universidade Federal do Amapá(UNIFAP)MacapáAPBrazil Programa de Pós-Graduação em Ecologia Instituto de BiologiaCentro de Ciências da SaúdeUniversidade Federal do Rio de Janeiro(UFRJ)Rio de JaneiroRJBrazil Laboratório de Mamíferos Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá(IEPA)MacapáAPBrazil Programa de Pós-Graduação em biologia Animal Laboratório de SistemáticaEcologia e Evolução(LSEE)Instituto de BiociênciasUniversidade Federal de Mato Grosso do Sul(UFMS)Campo GrandeMTBrazil Terrestrial Ecology Group(TEG-UAM) Departamento de EcologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Centro de Investigación en biodiversidad y Cambio Global(CIbC-UAM) Universidad Autónoma de MadridMadridSpain

bats are the second-most diverse group of mammals in the world,and bat flies are their main ***,significant knowledge gaps remain regarding these antagonistic interactions,especially since diverse factors such as seasonality and host sex can affect their network ***,we explore the influence of such factors by comparing species richness and composition of bat flies on host bats,as well as specialization and modularity of bat–bat fly interaction networks between seasons and adult host *** captured bats and collected their ectoparasitic flies at 10 sampling sites in the savannahs of AmapáState,northeastern region of the brazilian *** female bats being more parasitized and recording greater bat fly species richness in the wet season,neither relationship was statistically *** pooled network could be divided into 15 compartments with 54 links,and all subnetworks comprised>12 *** total number of links ranged from 27 to 48(for the dry and wet seasons,respectively),and female and male subnetworks had 44 and 41 links,*** values were very low for the pooled network and for all *** results revealed higher bat fly species richness and abundance in the wet season,whereas specialization and modularity were higher in the dry ***,the subnetwork for female bats displayed higher specialization and modularity than the male ***,both seasonality and host sex contribute in different ways to bat–bat fly network *** studies should consider these factors when evaluating bat–bat fly interaction networks.

关键词： Amapá Amazon biome bat flies bats interaction networks

N-linked glycoproteomic profiling in esophageal squamous cell carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第29期28卷 3869-3885页

作者： Qi-Wei Liu Hao-Jie Ruan Wei-Xia Chao Meng-Xiang Li Ye-Lin Jiao douglas G Ward She-Gan Gao Yi-Jun Qi Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment/Henan Key Laboratory of Cancer Epigenetics/Cancer Hospital The First Affiliated HospitalCollege of Clinical MedicineHenan University of Science and TechnologyLuoyang 471003Henan ProvinceChina Department of Pathology The First People’s Hospital of Luo YangLuoyang 471000Henan ProvinceChina Institute of Cancer and Genomic Sciences College of Medical and Dental SciencesUniversity of BirminghamBirmingham B152TTUnited Kingdom

bACKGROUND Mass spectrometry-based proteomics and glycomics reveal post-translational modifications providing significant biological insights beyond the scope of genomic *** To characterize the N-linked glycoproteomic profile in esophageal squamous cell carcinoma(ESCC)via two complementary *** Using tandem multilectin affinity chromatography for enrichment of N-linked glycoproteins,we performed N-linked glycoproteomic profiling in ESCC tissues by two-dimensional gel electrophoresis(2-DE)-based and isobaric tags for relative and absolute quantification(iTRAQ)labeling-based mass spectrometry quantitation in parallel,followed by validation of candidate glycoprotein biomarkers by Western *** 2-DE-based and iTRAQ labeling-based quantitation identified 24 and 402 differentially expressed N-linked glycoproteins,respectively,with 15 in common,demonstrating the outperformance of iTRAQ labeling-based quantitation over 2-DE and complementarity of these two *** showed the distinct compositions of functional categories between proteins and glycoproteins with differential expression associated with *** blot analysis validated the up-regulation of total procathepsin D and high-mannose procathepsin D,and the downregulation of total haptoglobin,high-mannose clusterin,and GlcNAc/sialic acid-containing fraction of 14-3-3ζ in ESCC *** serum levels of glycosylated fractions of clusterin,prolinearginine-rich end leucine-rich repeat protein,and haptoglobin in patients with ESCC were remarkably higher than those in healthy *** Our study provides insights into the aberrant N-linked glycoproteome associated with ESCC,which will be a valuable resource for future investigations.

关键词： Esophageal squamous cell carcinoma N-linked glycoprotein Post-translational modification Lectin Cathepsin D Haptoglobin 14-3-3ζ

健康信息学：21世纪临床医生们的必备技能——信息学素养应该成为所有医学教育的必修内容

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

英国医学杂志中文版 2018年第10期21卷 610-611页

作者： douglas b Fridsma 严雪敏(译) 沈锡宾(校) American Medical Informatics Association Bethesda MD USA 北京协和医院消化内科中华医学会新媒体部

这个世界每天约产生超过2．5quintillion字节的数据（1个quintillion是1后面18个0），到2025年，基因组数据的总量可能会超过天文学、YouTube和Twitter数据的总和’。随着健康数据的增加，卫生专业人员也获得了各种新的技术来收集、分... 详细信息

这个世界每天约产生超过2．5quintillion字节的数据（1个quintillion是1后面18个0），到2025年，基因组数据的总量可能会超过天文学、YouTube和Twitter数据的总和’。随着健康数据的增加，卫生专业人员也获得了各种新的技术来收集、分析和使用这些信息。他们用电子健康档案记录医疗照护，用临床数据仓库来组织疾病相关数据或质控指标，通过群体健康分析识别疾病高危人群的预警特征，以及使用机器学习人工智能的新科技。

关键词：健康信息学信息学素养医学教育医疗卫生行业

近场全波形反演:芦山7.0级地震及余震矩张量解

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

地球物理学报 2013年第12期56卷 4037-4047页

作者：林向东葛洪魁徐平 douglas Dreger 苏金蓉王宝善武敏捷中国地震局地震观测与地球物理成像重点实验室(中国地震局地球物理研究所) 北京100081 北京市地震局北京100080 中国石油大学(北京)非常规天然气研究院北京102249 美国加州大学伯克利分校地震实验室 947204760 四川省地震局成都610041

2013年4月20日四川芦山发生了7.0级地震.该地震是自2008年汶川8.0级地震以来发生在龙门山断裂带上的最强地震,截至5月5日,四川省数字遥测台网记录到了52个(ML≥4.0)余震.我们搜集了信噪比相对较高的宽频带数据,根据已有的三个分别适合... 详细信息

2013年4月20日四川芦山发生了7.0级地震.该地震是自2008年汶川8.0级地震以来发生在龙门山断裂带上的最强地震,截至5月5日,四川省数字遥测台网记录到了52个(ML≥4.0)余震.我们搜集了信噪比相对较高的宽频带数据,根据已有的三个分别适合于四川盆地和龙门山断裂东南地区、西南山区、西北山区速度模型,利用TDMT_INVC方法计算矩张量,获得了芦山主震及其16个余震的高质量矩张量解;根据P轴、b轴和T轴的倾角对主震及余震的断层类型进行了分类,结果表明:芦山地震的震级为Mw6.46(矩震级),地震矩为0.61×1019 Nm,震源深度为13km,震源机制类型为逆断层.芦山余震类型简单,主要为逆冲型;芦山地震序列震中分布于龙门山断裂带西南端的彭县—灌县断裂上,本研究获得的主震和余震的震源机制主要为逆冲型,这表明了龙门山断裂西南端主要为逆冲特征.芦山地震震源性质与汶川地震相近,发震间隔时间短,且均发生于同一构造单元内,表明了该地震与汶川地震可能有密切关系.

关键词：芦山地震余震矩张量龙门山断裂

Pressure dependence of brillouin frequency shift in bare silica optical fibers

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese Optics Letters 2012年第10期10卷 20-22页

作者：顾海栋董惠娟张广玉何俊徐宁 douglas.J.brown School of Mechatronics Engineering Harbin Institute of Technology State Key Laboratory of Robotics and System Harbin Institute of Technology Department of Electrical and Computer Engineering University of New BrunswickFrederictonNB E3B 5A3Canada

The effect of hydrostatic pressure （up to 28 MPa） on brillouin frequency shift （bFS） within two types of bare, single-mode fibers is studied via brillouin optical time domain analysis technique. Experimental results show a negative linear relation between pressure and bFS, with almost the same sensitivity in both types of fibers. The average value of experimental slopes is –0.742 MHz/MPa. This value is found to be well suited to theoretical analysis on the basis of data on bulk silica glass in previous reports. This preliminary evaluation may result in a new method for distributed pressure sensing along silica optical fiber.

关键词： Frequency shift keying Hydrostatic pressure Silica Time domain analysis