检索结果-南通市图书馆

A Versatile Phenotyping System and Analytics Platform Reveals Diverse Temporal Responses to w.ter Availability in Setaria

引用

Molecular Plant 2015年第10期8卷 1520-1535页

作者： Noah Fahlgren Maximilian Feldman Malia A. Gehan Melinda S. w.lson Christine Shyu douglas w. bryant Steven T. Hill Colton J. McEntee ankalpi N. w.rnasooriya Indrajit Kumar Tracy Ficor Stephanie Turnipseed Kerrigan B. Gilbert Thomas P. Brutnell James C. Carrington Todd C. Mockler Ivan Baxter Donald Danforth Plant Science Center St. Louis MO 63132 USA USDA-ARS Donald Danforth Plant Science Center St. Louis MO 63132 USA These authors contributed equally to this article.

Phenotyping has become the rate-limiting step in using large-scale genomic data to understand and improve agricultural crops. Here, the Bellw.ther Phenotyping Platform for controlled-environment plant grow.h and automated multimodal phenotyping is described. The system has capacity for 1140 plants, w.ich pass daily through stations to record fluorescence, near-infrared, and visible images. Plant Computer Vision （PlantCV） w.s developed as open-source, hardw.re platform-independent softw.re for quantitative image analysis. In a 4-w.ek experiment, w.ld Setaria viridis and domesticated Setaria italica had fundamentally different temporal responses to w.ter availability. w.ile both lines produced similar levels of biomass under limited w.ter conditions, Setaria viridis maintained the same w.ter-use efficiency under w.ter replete conditions, w.ile Setaria italica shifted to less efficient grow.h. Overall, the Bellw.ther Phenotyping Platform and PlantCV softw.re detected significant effects of genotype and environment on height, biomass, w.ter-use efficiency, color, plant architecture, and tissue w.ter status traits. All -79 000 images acquired during the course of the experiment are publicly available.

关键词： abiotic/environmental stress w.ter relations bioinformatics development phenotyping

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification of new.genetic risk factors for prostate cancer

引用

Asian Journal of Andrology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia Kote-Jarai Graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. Leongamomlert Stephen M. Edw.rds Jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda L. Hall Lynne T. O＇Brien Beatrice N. Gehr-Sw.in Rosemary A. w.lkinson Angela Cox Sarah Lew.s Paul M. Brow. Sameer G. Jhavar Malgorzata Tymrakiew.cz Artitaya Lophatananon Sarah L. bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons＇ Section of Oncology and The UK ProtecT Study Collaborators Alan Horw.ch Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher J. w.odhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson Colin S. Cooper Dallas R. English John L. Hopper David E. Neal douglas E Easton Rosalind A. Eeles Section of Cancer Genetics The Institute of Cancer Research Sutton Surrey SM2 5NG UK Cancer Epidemiology Centre The Cancer Council Victoria Carlton VIC 3053 Australia Centre for Molecular Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Cancer Research UK Genetic Epidemiology Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Department of Oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Genetic Epidemiology Laboratory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Department of Social Medicine University of Bristol Bristol BS8 2PR UK Academic Urology Unit University of Sheffield Sheffield SIO 2JF UK The Royal Marsden NHS Foundation Trust Sutton Surrey SM2 5PT and London SW3 6JJ UK University of Nottingham Medical School Queens Medical Centre Nottingham NG7 2UH UK Institute for Cancer Studies University of Sheffield Sheffield SIO 2RX UK Surgical Oncology （Uro-Oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A full list of authors is provided in the Supplementary Note online Ka Shing Centre Cambridge CB2 ORE UK Cancer Research UK Cambridge Research Institute Li Ka Shing Centre Cambridge CB2 ORE UK.

There is evidence that a substantial part of genetic predisposition to prostate cancer （PCa） may be due to low.r penetrance genes w.ich are found by genome-w.de association studies. w. have recently conducted such a study and seven new.regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes： MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together w.th results from other groups, there are now.23 germline genetic variants w.ich have been reported. These results have the potential to be developed into a genetic test. How.ver, w. consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow.up validation studies, as w.ll as studies to explore the psychological implications of genetic profile testing, w.ll be vital prior to roll out into healthcare.

关键词： prostate cancer genetics susceptibility loci SNPs relative risks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：