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Molecular mechanisms of insulin resistance in chronic hepatitis C

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World Journal of gastroenterology 2009年第35期15卷 4356-4364页

作者： Mark W douglas Jacob george Storr Liver Unit Westmead Millennium InstituteUniversity of Sydney at Westmead Hospita

It is now widely recognized that chronic hepatitis C (CHC)is associated with insulin resistance(IR)and type 2 diabetes,so can be considered a metabolic *** is most strongly associated with hepatitis C virus(HCV)genotype 1,in contrast to hepatic steatosis, which is associated with genotype 3 *** from the well-described complications of diabetes,IR in CHC predicts faster progression to fibrosis and cirrhosis that may culminate in liver failure and hepatocellular *** recently,it has been recognized that IR in CHC predicts a poor response to antiviral therapy. The molecular mechanisms for the association between IR and HCV infection are not well *** review will elaborate on the clinical associations between CHC and IR and summarize current knowledge regarding the molecular mechanisms that potentially mediate HCV-associated IR.

关键词： Hepatitis C virus Insulin resistance Treatment response Interferon

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统计笔记公式中的括号

英国医学杂志中文版 2011年第6期14卷 357-358页

作者： douglas g.altman J Martin Bland 王棵 Centre for Statistics in Medicine University of Oxford Oxford OX2 6UD Department of Health Sciences University of YorkYork YO10 5DD 北京协和医学院基础医学研究所流行病学教研室

每年York大学健康科学专业新人学的研究生都要参加一个简单的数学测验。然而大部分研究生都未能正确地计算出20—3×5的结果。根据传统的四则运算法则，乘除运算优先于加减运算，

关键词：笔记统计运算法则研究生

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抽样误差以外的不确定性

英国医学杂志中文版 2015年第4期18卷 218-219页

作者： douglas g.altman J Martin Bland 罗凯 Centre for Statistics in Medicine Nuffield Department of OrthopaedicsRheumatology and Musculoskeletal Sciences University of Oxford Oxford OX37LD UK Department of Health Sciences University of York York YO10 5DD UK 中国医学科学院基础医学研究所

研究结果的统计分析主要是利用可信区间及假设检验获知研究结果的不确定性，这种不确定性是在从研究人员主要关注的较大总体中抽取研究参加者样本而产生的’。但是，除抽样变异问题外，更重要的是需考虑其他来源的不确定性。在（研究结... 详细信息

研究结果的统计分析主要是利用可信区间及假设检验获知研究结果的不确定性，这种不确定性是在从研究人员主要关注的较大总体中抽取研究参加者样本而产生的’。但是，除抽样变异问题外，更重要的是需考虑其他来源的不确定性。在（研究结果）测量中，应区分精确性与准确性。精确性是指用同一方法在相同时间对同一个体进行的测量是如何不同，而准确性是指测量结果与我们想知道的真正结果是如何接近。

关键词：抽样误差不确定性医疗卫生行业医学研究

Is iron overload in alcohol-related cirrhosis mediated by hepcidin?

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World Journal of gastroenterology 2009年第46期15卷 5864-5866页

作者： Tariq Iqbal Azzam Diab douglas g Ward Matthew J Brookes Chris Tselepis Jim Murray Elwyn Elias Department of gastroenterology University Hospital BirminghamVincent Drive Depart ment of Cancer Studies University of BirminghamVincent Drive Department of Hematology University Hospital BirminghamVincent Drive

In this case report we describe the relationship between ferritin levels and hepcidin in a patient with alcohol-related spur cell anemia who underwent liver *** demonstrate a reciprocal relation-ship between serum or urinary hepcidin and serum ferritin,which indicates that inadequate hepcidin production by the diseased liver is associated with elevated serum *** ferritin level falls with increasing hepcidin production after *** inflammatory indices(IL6)nor erythropoietin appear to be related to hepcidin expression in this *** suggest that inappropriately low hepcidin production by the cirrhotic liver may contribute substantially to elevated tissue iron stores in cirrhosis and speculate that hepcidin replacement in these patients may be of therapeutic benefi t in the future.

关键词： Alcohol Iron Anaemia Hepcidin Cirrhosis

High surface area biocarbon monoliths for methane storage

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green Energy & Environment 2023年第5期8卷 1308-1324页

作者： Elizabeth Michaelis Renfeng Nie douglas Austin Yanfeng Yue Department of Chemistry Delaware State UniversityDoverDE 19901United States College of Chemical Engineering Zhengzhou UniversityZhengzhouHenan450001China

New energy sources that reduce the volume of harmful gases such as SO_(x)and NO_(x)released into the atmosphere are in constant *** gas,primarily made up of methane,is being widely used as one reliable energy source for heating and electricity generation due to its high combustion ***,natural gas accounts for a large portion of electricity generation and chemical feedstock in manufacturing plastics and other commercially important organic *** the near future,natural gas will be widely used as a fuel for ***,a practical storage device for its storage and transportation is very beneficial to the deployment of natural gas as an energy source for new *** this tutorial review,biomaterials-based carbon monoliths(CMs),one kind of carbonaceous material,was reviewed as an adsorbent for natural gas(methane)adsorption and storage.

关键词： Activated carbon Carbon monolith Methane storage High surface area Activation agent

Comparison of Principal Components Analysis,Independent Components Analysis and Common Components Analysis

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Journal of Analysis and Testing 2018年第3期2卷 235-248页

作者： douglas N.Rutledge INRA UMR GENIALAgroParisTechUniversitéParis-SaclayMassyFrance

The aim of this work is to describe and compare three exploratory chemometrical tools,principal components analysis,independent components analysis and common components analysis,the last one being a modification of the multi-block statistical method known as common components and specific weights *** three methods were applied to a set of data to show the differences and similarities of the results obtained,highlighting their complementarity.

关键词： Exploratory data analysis Chemometrics Principal components analysis Independent components analysis Common components analysis Common components and specific weights analysis

Routine rectal retroflexion during colonoscopy has a low yield for neoplasia

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World Journal of gastroenterology 2008年第42期14卷 6503-6505页

作者： Abdo Saad douglas Kevin Rex Department of Medicine Division of Gastroenterology/Hepatology Indiana University School of Medicine Indianapolis IN 46202 United States

AIM： To investigate the value of retroflexion in detecting neoplasia in the distal rectum. METHODS： This was a prospective observational study performed in an academic endoscopy unit. Consecutive patients undergoing colonoscopy had careful forward viewing of the distal rectum by retroflexion. Of 1502 procedures, 1076 （72%） procedures were performed with a 140^o angle of view colonoscope and 426 （28%） were performed with a 170^o angle of view colonoscope. The outcome measurement was the yield of neoplasia in the distal rectum detected by forward viewing vs retroflexion. RESULTS： A total of 1502 patients, including 767 （51%） females and 735 （49%） males, with mean age of 58.8 ± 12.5 years were enrolled. Retroflexion was successful in 1411 （93.9%） patients, unsuccessful or not performed because the rectum appeared narrow in 91 （6.1%）. Forty patients had a polyp detected in the distal rectal mucosa. Thirty-three were visible in both the forward and retroflexed view （25 hyperplastic, 8 adenomatous）. Seven polyps were visualized only by retroflexion （6 hyperplastic sessile polyps, one 4 mm sessile tubular adenoma）. There was no significant difference in information added by retroflexion with 140^o vs 170^o angle of view instrument. CONCLUSION： To our knowledge, this is the largest reported evaluation of retroflexion in the rectum. Routine rectal retroflexion did not detect clinically important neoplasia after a careful forward examination of the rectum to the dentate line. Since retroflexion has risks and may cause discomfort, theuse of routine retroflexion should be at the discretion of the endoscopist.

关键词： Colonoscopy Colorectal polyps Retroflexion Rectum

Statistical techniques in business & economics / douglas A. Lind, William g. Marchal, Samuel A. Wathen. 12th ed.

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″Moving Inward As Well As North″: The Historical Imagination in Arthur Miller’s The Crucible and Timebends

丛书名： Mcgraw-Hill/Irwin series. Operations and decision sciences.

2005年

作者： douglas A. Lind William g. Marchal Samuel A. Wathen.

Student CD-ROM includes tutorials, quizzes, solved problems, data sets, and data files.

ISBN: (数字)0072868244

ISBN: (纸本)0072868252

Student CD-ROM includes tutorials, quizzes, solved problems, data sets, and data files.

关键词： Social sciences

来源：畅想之星图书光盘版（南... 评论

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外国文学研究 2005年第4期27卷 8-15页

作者： douglas Tallack University of Nottingham UK.

Arthur Miller, one of the most admirable of Americans to come out of the ″American century″, died in 2005, aged 89. In the UK, at least, his work has undergone a revival and the themes of his great plays remain resonant, even though, in many respects, they are historically specific. The relationship between literature and history-whether conceived as a symbolist or allegorical relationship-together with an instance of the past invading the present, is brought out in a compelling episode in Miller’s autobiography, Timebends, and offers a way of talking about those inter-connections in The Crucible.

关键词：亚瑟·米勒代表作品美国文学研究