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Prevalence of Association of Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Disease at the National Teaching Hospital of Cotonou in Benin

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Open Journal of Blood Diseases 2023年第3期13卷 93-101页

作者： Alban Zohoun Tatiana Baglo-Agbodande Thierry Adje Bienvenu Houssou Romaric Massi Gnon Gourou Orou Guiwa Justin Dèhoumon Josiane Mehou Ludovic Anani Anne Vovor dorothée kinde-gazard Laboratoire d’Hématologie Clinique Universitaire des Maladies du Sang CNHU-HKM Cotonou Benin Faculté des Sciences de la Santé de Cotonou Université d’Abomey Calavi Cotonou Benin Faculté des Sciences de la Santé Université de Lomé Lomé Togo

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency and sickle cell disease are common genetic defects of red blood cells that lead to hemolytic anemia. The prevalence of G6PD deficiency in sickle cell patients is unknown in Benin. Objective: This study aimed to determine the prevalence of G6PD deficiency in sickle cell patients at the CNHU-HKM of Cotonou. Methods: This prospective study was conducted from April to November 2022 at the blood-related diseases teaching clinic and included sickle cell patients in the stationary phase. G6PD determination was performed using the enzymatic method on a Mindray BS 200 machine following the Herz method. Hematological parameters were determined using the XT 4000i analyzer and supplemented by a blood smear stained with May Grunwald Giemsa. Data were analyzed using epi Info 3.5.4 software. Results: One hundred and sixty-four sickle cell patients (80 SS homozygotes and 84 SC heterozygotes) in the intercritical phase, with a mean age of 26.30 ± 10.76 years, were included. The prevalence of G6PD deficiency was 9.1% (15 cases found in 7 SS patients and 8 SC patients). In G6PD-deficient patients, the mean concentration of the enzyme was lower in Hb SC heterozygotes than in Hb SS homozygotes: 3.56 IU/g Hb versus 4.98 IU/g Hb. The mean reticulocyte count was 231.43 G/L in the deficient group, compared to 216.32 G/L in the non-deficient group. Conclusion: The preliminary results of our study reveal a high prevalence of G6PD deficiency in sickle cell patients. The impact of this association on hematologic and biological parameters should be evaluated for better management of sickle cell disease.

关键词： Sickle Cell Disease G6PD Deficiency Prevalence Hemogram

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evaluation of the Anti-Salivary IgG Response Specific to Anopheles Vectors of Malaria in Children under Five Seen in Health Care Settings in Areas of Low and High Insecticide Resistance in Southern Benin

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Advances in Infectious Diseases 2023年第2期13卷 269-282页

作者： Tokponnon T. Filémon Ossè Razaki Noukpo Herbert Legba Thibaut Koukpo Zinsou Come Oke Mariam Fassinou Arsène Akakpo evelyne Fassinou Hector Padonou Gil Germain Remoue Franck kinde-gazard dorothée Akogbeto Martin ecole Polytechnique d’Abomey-Calavi Université d’Abomey-Calavi Abomey-Calavi Bénin Centre de Recherche entomologique de Cotonou (CReC) Cotonou Benin Ministry of Health Cotonou Benin Centre Béninois de la Recherche Scientifique et de l’Innovation (CBRSI) Cotonou Bénin ecole de Gestion et d’exploitation des Systèmes d’elevage Université Nationale d’Agriculture Kétou Benin National Malaria Control Programme Cotonou Benin Faculté des Sciences de la Santé de l’Université d’Abomey Calavi Cotonou Benin Institut de Recherche pour le Développement (IRD) Montpellier France

The widespread use of long-lasting insecticidal nets (LLINs) is a major intervention method for malaria control. While coverage of LLINs has increased, there is a need for information on the operational effectiveness of nets deployed in the field in the context of malaria vector resistance to insecticides used for impregnation. The development of specific anti-malarial biomarkers to assess exposure to mosquito bites is an important development in evaluations. The aim of this study was to characterize the human IgG antibody response to Anopheles gSG6-P1 saliva, a salivary peptide antigen previously shown to be a relevant biomarker of human exposure to Anopheles bites, in order to assess the LLINs under field conditions in areas of low and high vector resistance to insecticides. We analyzed data from 240 randomly selected children ( 0.05). Furthermore, the same finding was observed for antibody expression in children whether or not they used LLINs on the day before the survey (p = 0.7724). Similarly, gender and especially age, major factors of variation in the adaptive immune response, did not have a significant effect on IgG expression.

关键词： Case-Controls LLINs Malaria Morbidity Pyrethroids Resistance Antibodies Bite exposure Biomarkers Benin

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evaluation at the Level of Health Facilities, of the Protective efficacy of LLINs in Children under 5 Years Old from Localities of Low and High Resistance of Vectors to Pyrethroid Insecticides in Benin in West Africa

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Advances in Infectious Diseases 2022年第1期12卷 57-73页

作者： Tokponnon Tatchémè Filémon Ossè Razaki Arthur Sovi Wakpo Abel Hounto Ogouyémi Aurore Sissinto Yolande Adechoubou Alioun Houansou Télesphore Oke Mariam kinde-gazard dorothée Massougbodji Achille Akogbeto Martin Centre de Recherche entomologique de Cotonou (CReC) Cotonou Benin Ministry of Health Cotonou Benin Centre Béninois de le Recherche Scientifique et de l’Innovation Cotonou Benin ecole Polytechnique d’Abomey-Calavi Université d’Abomey-Calavi Abomey-Calavi Bénin ecole de Gestion et d’exploitation des systèmes d’élevage Université Nationale d’Agriculture Kétou Benin Faculté des Sciences de la Santé de l’Université d’Abomey Calavi Cotonou Benin National Malaria Control Programme Cotonou Benin World Health Organization Cotonou Benin

Context: The resistance to pyrethroids in malaria vectors continues to grow in Africa and could therefore compromise or reduce substantially the effectiveness of LLINs in preventing malaria. It is therefore of paramount importance to evaluate the protective efficacy of LLINs in children sleeping in areas of vector resistance to insecticides in order to draw lessons for future interventions. This study assesses the effect of the use of LLINs on malaria morbidity in clusters of low and high resistance of vectors to pyrethroids. Methods: This is a cross-sectional case-control study with one control for one case that was conducted in the communes of Kétou, Ifangni, Kétou, and Pobè in the Plateau department of southern Benin. The use of LLINs and malaria morbidity was measured and compared in children from clusters of low and high vector resistance to insecticides. In each commune, 30 cases and 30 controls were recruited for a total of 240 children under 5 years of age from villages with low and high insecticide resistance. Results: According to the localities of origin of the children, of all parents of children surveyed, 169 (70.4%) asserted the children slept under an LLIN the day before they arrived at the health center. This rate represents 70.8% (85 children) among the cases and 70.0% (84 children) among the controls without significant difference (p = 0.8). The use of LLINs the day before the survey, the frequency of their use during the two weeks preceding the day of the survey, their availability at the household level, the use of other tools for protection against mosquito bites are the same in the two groups of children (cases and controls) (p > 0.05) as well in low and high resistance villages. On the other hand, the parasite prevalence, the splenomegaly and the geometric means of the parasite densities, are significantly higher in the cases than in the controls (p Conclusion: The evaluation of epidemiological indicators in children under five years old at th

关键词： Case-Controls LLINs Malaria Morbidity Pyrethroids Resistance Benin

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Advances in Infectious Diseases（传染病进展） 2023年第2期

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