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Introduction to Neural Plasticity Mechanism

Journal of Behavioral and Brain Science 2017年第2期7卷 41-49页

作者： Bogdan Feliks Kania Danuta Wronska dorota Zieba Veterinary Institute University Center for Veterinary Medicine Jagiellonian University&Agriculture UniversityHugon Kollataj Agricultural University in CracowCracowPoland Department of Physiology and Endocrinology of Animals Faculty of Animal SciencesHugon Kollataj Agricultural University in CracowCracowPoland Department of Animal Biotechnology Faculty of Animal SciencesHugon Kollataj Agricultural University in Cracowul.Redzina1BCracowPoland

In researches that examine neuroplasticity, many studies that are performed directly on isolated neurons in the pyramidal cells of CA1 area (CA1) and slices of the hippocampus indicate that changes occur at the molecular and cellular levels during long-term synaptic potentiation (LTP), and these changes are dependent on N-methyl-D-aspartate (NMDA) acid receptors and/or purinergic receptors. Electrophysiological studies and the chemical induction of LTP of synaptic neurotransmissions provide key evidence that LTP is dependent on the volume of Ca2+ influx through postsynaptic NMDA receptors, in addition to the subsequent activation and autophosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and the increase in the density of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors on postsynaptic neuronal membranes. The primary peculiarity of LTP in the central nervous system (CNS) excitatory synapses is the synthesis of additional AMPA receptors in the postsynaptic elements. Furthermore, the proteolysis of the extracellular matrix (ECM) has an important role in the synaptic neuroplasticity of the CNS. Proteases from the serine family and metalloproteinases of the extracellular matrix are localized within the synapses and are released into the extracellular space in proportion to the degree of neuronal excitation. These enzymes cause changes in the morphology, shape and size, as well as the overall number of synapses and synthesize new synaptic connections. The proteinases also change the function of receptors, and consequently, the secretions of neurotransmitters from the presynaptic elements are strengthened or weakened.

关键词： Neuroplasticity Heterosynaptic Metaplasticity Subjects

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Surface tensometry studies on formulations of surfactants with preservatives as a tool for antimicrobial drug protection characterization

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Journal of Biophysical Chemistry 2012年第4期3卷 324-333页

作者： Stanislaw Pogorzelski dorota Watrobska-Swietlikowska Malgorzata Sznitowska Department of Pharmaceutical Technology Medical University of Gdansk Gdansk Poland Institute of Experimental Physics University of Gdansk Gdansk Poland

The aim of the work was to quantify possible interactions between surfactants and preservatives, comparing surface properties, in model pharmaceutical formulations. Surface parameters of 2-component surfactant-preservative aquous mixtures were determined with a Wilhelmy plate technique, for the so-called principal surfactants (polysorbate 80, egg lecithin, phosphatidylcholine) and preservatives, which were methylparaben and benzalkonium chloride (BA-C). A generalized surface tension vs. surfactant concentration plot signatures, in the presence of preservative at a fixed amount, allowed: the critical micellar concentration (cmc) shift, additive molecules partition from the surface to the bulk, mixed micelles formation concentration, and additive surface removal concentration to be determined in reference to surface activity of the added substance. Methylparaben is a compound of lower (in comparison to BAC) surface activity, lower partitioning coefficient possessing lower energy and concentration of its removal from the surface, that makes it play effectively an antimicrobial protection role in the bulk of pharmaceutical products, as already shown by chemical tests.

关键词： Drug-Preservative Mixtures Surface Tension Surface Activity Interfacial Partitioning Antim-icrobial Drug Protection

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Central Glutamatergic-Purinergic System Importance in Brain/Neural Plasticity

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Journal of Behavioral and Brain Science 2017年第7期7卷 259-272页

作者： Bogdan Feliks Kania Danuta Wronska dorota Zieba Veterinary Institute University Center for Veterinary MedicineJagiellonian University&Agriculture UniversityCracowPoland Department of Physiology and Endocrinology of Animals Faculty of Animal SciencesHugon Kollataj Agricultural University in CracowCracowPoland Department of Animal Biotechnology Faculty of Animal SciencesHugon Kollataj Agricultural University in CracowCracowPoland

The proteolysis of the extracellular matrix plays a key role in the synaptic neuroplasticity of the central nervous system (CNS), which results in learning and memory. Proteases from the serine family and metalloproteinases of the extracellular matrix are localized within the synapses and are released into the extracellular space in proportion to the degree of neuronal excitation. These enzymes cause changes in the morphology, shape and size, and the overall number of synapses and synthesize new synaptic connections. The proteinase also changes the function of receptors, and consequently, the secretion of neurotransmitter/neuromodulator from the presynaptic glutamatergic and/or purinergic elements are either strengthened or weakened. Neuroglia involved in homeostasis, melanin synthesis and defense of the brain contain different combinations of purinergic receptors, which contributes to many neurotransmitters. This review summarizes a concept of brain plasticity, the role of ATP and P2 receptors interaction with glutamatergic system during plasticity of the brain in the one hand and after physical exercise in the other, which may be triggering phenomena facilitative synaptic plasticity as well as potentiates an personal efficiency to react to biobehavioral adaptation and disorders.

关键词： Glutamatergic/Purinergic System Neuroplasticity Physical Exercise Neuroglia Dependences

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Hydroxyalkylation of Cyclic Imides with Oxiranes Part III. Mechanism of the Reaction in Presence of Sodium Hydroxide Catalyst

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Open Journal of Physical Chemistry 2018年第3期8卷 67-79页

作者： Jacek Lubczak Renata Lubczak dorota Naróg Faculty of Chemistry University of Technology Rzeszów Poland

The kinetics of reaction between cyclic monoimides (succinimide, phtalimide, and glutarimide) with ethylene and propylene oxides in presence of sodium hydroxide was studied. The effect of substrate and catalyst concentrations on the course of the reaction was investigated. Kinetics of reaction was studied by dilatometry, i.e. by measuring volume contraction of reaction mixture. The kinetic law describing the reaction of imides with oxiranes is: . where ccat, cAH and cB are concentrations of catalyst, imide, and oxirane, respectively. The relative reactivity of imides and oxiranes was: GI > PI ≥ SI and EO > PO. The reaction mechanism was proposed based upon experimentally determined rate law for the reaction of cyclic monoimides and oxiranes as well as analytical and instrumental analysis of products. The elementary reaction between oxirane and imide anion is rate determining step. The imide anion is formed by hydrogen cation transfer into catalytic hydroxide anion from dissociated NaOH. In the consecutive elemental reaction an imidate anion attack on the oxirane molecule occurs. It is the slowest stage of the reaction, limiting the entire process. All the studied reactions obey the same mechanism as can be concluded from isokinetic relationship of studied systems)

关键词： Imides Oxiranes Catalyst Kinetic Reactivity of Reagents Thermodynamic Parameters Mechanism of Reaction

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Leukocyte cell-derived chemotaxin-2 and fibroblast growth factor 21 in alcohol-induced liver cirrhosis

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World Journal of Hepatology 2021年第12期13卷 2071-2080页

作者： Jarosław Jerzy Sak Andrzej Prystupa PawełKiciński dorota Luchowska-Kocot Ewa Kurys-Denis Hanna Bis-Wencel Chair and Department of Humanities and Social Medicine Medical University of LublinLublin 20-093Poland Department of Internal Medicine Medical University of LublinLublin 20-081Poland Department of Experimental Hematooncology Medical University of LublinLublin 20-080Poland Department of Medical Chemistry Medical University of LublinLublin 20-093Poland The Second Department of Radiology Medical University of LublinLublin 20-081Poland Department of Microbiology and Reproductive Biology University of Life Sciences in LublinLublin 20-950Poland

BACKGROUND The importance of early diagnosis of alcoholic liver disease underscores the need to seek better and especially non-invasive diagnostic *** cellderived chemotaxin-2(LECT2)has been widely studied to determine its usefulness in monitoring the course of non-alcoholic fatty liver disease but not for alcoholic liver cirrhosis(ALC).AIM To determine the concentration of LECT2 in the blood serum of patients in relation to progressive stages of ALC,its relation to fibroblast growth factor 1(FGF-1)and FGF-21,and to examine the possible wider use of LECT2 in diagnosing *** A retrospective case-control study was conducted with 69 ALC cases and 17 controls with no *** were recruited from the region of Lublin(eastern Poland).Liver cirrhosis was diagnosed based on clinical features,history of heavy alcohol consumption,laboratory tests,and abdominal *** degree of ALC was evaluated according to Pugh-Child criteria(the Pugh-Child score).Blood was drawn and,after centrifugation,serum was collected for ***2,FGF-1,and FGF-21 were determined using enzyme-linked immunosorbent assay *** The LECT2 Levels in the control group were 18.99±5.36 ng/*** the study groups,they declined with the progression of cirrhosis to 11.06±6.47 ng/mL in one group and to 8.06±5.74 ng/mL in the other(P<0.0001).Multiple comparison tests confirmed the statistically significant differences in LECT2 Levels between the control group and both test groups(P=0.006 and P<0.0001).FGF-21 Levels were 44.27±64.19 pg/mL in the first test group,45.4±51.69 pg/mL in the second(P=0.008),and 13.52±7.51 pg/mL in the control *** difference between the control group and the second test group was statistically significant(P=0.007).CONCLUSION We suggest that LECT2 may be a non-invasive diagnostic factor for alcoholinduced liver *** usefulness of LECT2 for non-invasive monitoring of alcohol-induced liver cirrhosis was indirectly confirmed b

关键词： Leukocyte cell-derived chemotaxin-2 Fibroblast growth factor 21 Fibroblast growth factor 1 Alcoholic liver cirrhosis Pugh-Child score

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铝冶炉阴极碳块某些原材料适用性的评价

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新型炭材料 1990年第4期6卷 67-68页

作者： dorota Swierkot 刘银全

一、引言一些碳材料抵抗电解液破坏作用的能力是推断其适应作为铝冶炉阴极的基本标准之一。就人们通常所知,碳块基本的物理性能主要由原材料所决定。这一点已被测试并经多年的实践证明。无烟煤和电石墨的高度适应性以及石油焦和沥青焦... 详细信息

一、引言一些碳材料抵抗电解液破坏作用的能力是推断其适应作为铝冶炉阴极的基本标准之一。就人们通常所知,碳块基本的物理性能主要由原材料所决定。这一点已被测试并经多年的实践证明。无烟煤和电石墨的高度适应性以及石油焦和沥青焦的不适应性同样也被证明。

关键词：铝冶炉阴极碳块

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A deep convolutional neural network for real-time full profile analysis of big powder diffraction data

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npj Computational Materials 2021年第1期7卷 671-679页

作者： Hongyang Dong Keith T.Butler dorota Matras Stephen W.T.Price Yaroslav Odarchenko Rahul Khatry Andrew Thompson Vesna Middelkoop Simon D.M.Jacques Andrew M.Beale Antonis Vamvakeros Department of Chemistry University College London20 Gordon StreetLondon WC1H 0AJUnited Kingdom SciML Scientific Computer DivisionSTFCRutherford Appleton LaboratoryHarwell OX110QXUnited Kingdom Finden Limited Merchant House5 East St Helens StreetAbingdon OX145EGUnited Kingdom National Physical Laboratory Hampton RoadTeddington TW110LWUnited Kingdom Flemish Institute for Technological Research VITO NVBoeretang 200Mol 2400Belgium Research Complex at Harwell Rutherford Appleton LaboratoryHarwell Science and Innovation CampusDidcotOX110FA OxfordshireUnited Kingdom Present address:Diamond Light Source Harwell Science and Innovation CampusDidcotOxfordshire OX110DEUnited Kingdom Present address:The Faraday Institution Quad OneHarwell Science and Innovation CampusOX110RA OxfordshireUnited Kingdom

We present Parameter Quantification Network(PQ-Net),a regression deep convolutional neural network providing quantitative analysis of powder X-ray diffraction patterns from multi-phase *** network is tested against simulated and experimental datasets of increasing complexity with the last one being an X-ray diffraction computed tomography dataset of a multi-phase Ni-Pd/CeO_(2)-ZrO_(2)/Al_(2)O_(3) catalytic material system consisting of ca.20,000 diffraction *** is shown that the network predicts accurate scale factor,lattice parameter and crystallite size maps for all phases,which are comparable to those obtained through full profile analysis using the Rietveld method,also providing a reliable uncertainty measure on the *** main advantage of PQNet is its ability to yield these results orders of magnitude faster showing its potential as a tool for real-time diffraction data analysis during in situ/operando experiments.

关键词： network powder analysis

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Erratum to:Influence of structural defects on charge density waves in 1T-TaS_(2)

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Nano Research 2024年第3期17卷 2204-2204页

作者： Iaroslav Lutsyk Karol Szalowski Pawel Krukowski Pawel Dabrowski Maciej Rogala Witold Kozlowski Maxime Le Ster Michal Piskorski dorota A.Kowalczyk Wojciech Rys Rafal Dunal Aleksandra Nadolska Klaudia Toczek Przemyslaw Przybysz Ewa Lacinska Johannes Binder Andrzej Wysmolek Natalia Olszowska Jacek J.Kolodziej Martin Gmitra Takuma Hattori Yuji Kuwahara Guang Bian Tai-Chang Chiang Pawel J.Kowalczyk Faculty of Physics and Applied Informatics University of LodzPomorska 149/15390-236 LodzPoland Faculty of Physics University of WarsawPasteura 502-093 WarsawPoland Faculty of Physics Astronomyand Applied Computer ScienceJagiellonian UniversityLojasiewicza 1130-348 KrakowPoland National Synchrotron Radiation Centre SOLARIS Jagiellonian UniversityCzerwone Maki 9830-392 KrakówPoland Institute of Physics Faculty of SciencePavol JozefŠafárik University in KošicePark Angelinum 904001 KošiceSlovakia Institute of Experimental Physics Slovak Academy of SciencesWatsonova 4704001 KošiceSlovakia Department of Precision Engineering Graduate School of EngineeringOsaka University2-1 Yamada-okaSuita 565-0871Japan Department of Physics and Astronomy University of MissouriColumbiaMissouri 65211USA Department of Physics and Frederick Seitz Materials Research Laboratory University of Illinois at Urbana-ChampaignUrbanaIllinois 61801-3080USA

The name of the second author in original paper was unfortunately *** should be“Karol Szalowski”,instead of“Karoli Szalowski”.

关键词： structural charge defects

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CLN_3编码蛋白Battenin的N-端是与蛋白结合的功能域(英文)

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北京大学学报（医学版） 2006年第1期38卷 38-40页

作者： dorota N. MOROZIEWICZ Weina JU Rocksheng ZHONG Nanbert ZHONG Department of Human Genetics New York State Institute for Basic Research in Developmental Disabilities Staten Island NY 10314 USA Summer Student Harvard College Cambridge MA Deptartment Nenrology SUNY Heahh Science Center Brooklyn NY 北京大学医学遗传中心、北京大学基础医学院医学遗传学系北京100083

Objective: Batten disease （BD）, the juvenile form of neuronal ceroid lipofuscinosis （NCLs）, is pathological characterized by finding lysosomal storage of autofluorescent lipofuscins with unique ultrastructural profiles. The gene underlying BD is designated CLN3 and encodes a protein, Battenin, of unknown function that localizes in lysosomes and/or mitochondria. Previously, we hypothesized that Battenin associates with other membrane protein（s） to form a membrane complex. Dysfunction of this complex could result in the pathological changes of BD, and possibly in other NCLs. Two such membranous proteins, the slow and fast Battenin-interactive proteins （BIPs and BIPf） of unknown functions, have been identified. In this study, we have characterized the functional domains of Battenin that interact with both BIP proteins. Methods: Protein-protein interactions with a yeast two-hybrid system were employed. A “deletion assay” was employed to localize the interactive segment（s）. Different lengths of cDNA sequences lacking exon 1-5 were used to express CLN3-encoded proteins lacking N-terminal segments in the yeast two-hybrid system. N-terminal exons of CLN3 were deleted with PCR-cloning ***: We eliminated the possibility of interacting domains from the exon 7-encoded region because both Battenin and mBattenin interact with the BIP proteins. We have shown that peptide sequences encoded by exons 2 and 4 of CLN3 gene include the functional domains by which Battenin interacts with the BIP proteins. Conclusion: Our studies provide evidence that the N-terminus of Battenin is the functional domain for these protein interactions.

关键词：神经元蜡样质脂褐质沉积病基因 CLN3 蛋白质相互作用 N-端

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Recent Advances of Modern Protocol for C-C Bonds—The Suzuki Cross-Coupling

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Advances in Chemical Engineering and Science 2013年第3期3卷 19-32页

作者： Jadwiga Soloducho Kamila Olech Agnieszka Swist dorota Zajac Joanna Cabaj Faculty of Chemistry Wroclaw University of TechnologyWroclawPoland

Over the past 20 years, small molecule solid phase synthesis has become a powerful tool in the discovery of novel molecular materials. In the development of organic chemistry, the carbon-carbon bond formation has always been one of the most useful and fundamental reaction. The current review summarizes recent developments in metal-catalyzed coupling reactions. The following method is discussed in detail—the cross-coupling of aryl halides with aryl boronic acids (the Suzuki coupling), and the others C-C bond formation reactions as the palladium-catalyzed reaction between an aryl and (or) alkyl halide and a vinyl functionality (the Heck reaction);and the palladium-catalyzed cross-coupling reaction of organostannyl reagents with a variety of organic electrophiles (the Stille reaction)—are mentioned.

关键词： C-C Bond Formation Coupling Reactions Palladium Catalysts Suzuki Coupling Heterocyclic Copolymers

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