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Best therapy for the easiest to treat hepatitis C virus genotype 1binfected patients

World Journal of Gastroenterology 2022年第45期28卷 6380-6396页

作者： dorota Zarębska-michaluk Michal Brzdęk Jerzy Jaroszewicz Magdalena Tudrujek-Zdunek Beata Lorenc Jakub Klapaczyński Włodzimierz Mazur Adam Kazek Marek Sitko Hanna Berak Justyna Janocha-Litwin dorota Dybowska Łukasz Supronowicz Rafal Krygier Jolanta Citko Anna Piekarska Robert Flisiak Department of Infectious Diseases Jan Kochanowski UniversityKielce 25-317Poland Department of Infectious Diseases and Hepatology Medical University of SilesiaKatowice 40-055Poland Department of Infectious Diseases Medical University of LublinLublin 20-059Poland Pomeranian Center of Infectious Diseases Medical University GdańskGdańsk 80-214Poland Department of Internal Medicine and Hepatology Central Clinical Hospital of the Ministry of Internal Affairs and AdministrationWarszawa 00-241Poland Clinical Department of Infectious Diseases Medical University of SilesiaChorzów 41-500Poland ID Clinic Mysłowice 41-400Poland Department of Infectious and Tropical Diseases Jagiellonian UniversityKraków 31-088Poland Hospital for Infectious Diseases Hospital for Infectious DiseasesWarszawa 02-091Poland Department of Infectious Diseases and Hepatology Medical University WrocławWrocław 50-367Poland Department of Infectious Diseases and Hepatology Faculty of MedicineNicolaus Copernicus UniversityBydgoszcz 85-030Poland Department of Infectious Diseases and Hepatology Medical University of BiałystokBiałystok 15-089Poland Infectious Diseases and Hepatology Outpatient Clinic Gemini NZOZŻychlin 62-571Poland Medical Practice of Infections Regional HospitalOlsztyn 10-561Poland Department of Infectious Diseases and Hepatology Medical UniversityŁódźŁódź90-419Poland

BACKGROUND The revolution in treatment of patients with chronic hepatitis C virus(HCV)infection dates back to the introduction of direct-acting antivirals(DAAs).The increase in efficacy was most pronounced in patients infected with genotype(GT)1b,as this was the most poorly responsive population to treatment during the interferon *** To identify the most effective interferon-free therapy for GT1b-infected patients and to determine positive and negative predictors of virological *** This real-world retrospective analysis included patients chronically infected with GT1b HCV whose data were obtained from the multicenter observational EpiTer-2 *** effectiveness was evaluated for each therapeutic regimen as the percentage of sustained virological responses(SVR).Assessment of the safety was based on the evaluation of the course of therapy,the occurrence of adverse events including serious ones,deaths during treatment and in the post 12-wk follow-up *** The studied population consisted of 11385 patients with a mean age of 53±14.8 years and a female predominance(53.4%).The majority of them were treatment-naïve(74.6%)and patients with cirrhosis accounted for 24.3%.Of the DAA regimens used,76.9%were GT-specific with ombitasvir/paritaprevir/ritonavir+dasabuvir±ribavirin being the most used option(32.4%).A total of 10903 patients responded to treatment resulting in a 98.1%in the per-protocol analysis after excluding 273 patients without SVR *** effectiveness of all regimens exceeded 90%and the highest SVR of 98.9%was achieved in patients treated with a combination of glecaprevir/*** regression analyses showed that the virologic response was independently associated with female sex[odds ratio(OR)=1.67],absence of decompensated cirrhosis at baseline(OR=2.42)and higher baseline platelets(OR=1.004 per 1000/μL increase),while the presence of human immunodeficiency virus(HIV)coinfection significantly decreased the odds

关键词： Hepatitis C Genotype 1b Direct-acting antivirals Pangenotypic Genotype-specific Sustained virologic response

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Neural control of the soleus H-reflex correlates tothe laterality pattern in limbs

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Neural Regeneration Research 2010年第5期5卷 390-395页

作者： dorota Olex-Zarychta Department of Theory and Methodology of Physical Education Academy of Physical Education

BACKGROUND： Previous studies have demonstrated the relationship of lower limb dominance with left- and right-handedness, supporting findings suggest that there is a role for peripheral factors in the neural control of movement. OBJECTIVE： To investigate the effect of laterality pattern on the neural mechanisms of motor control at the peripheral level. DESIGN, TIME AND SETTING： A controlled observation experiment was performed at the Motor Diagnostics Laboratory of the Academy of Physical Education in Katowice, Poland, in June 2009. PARTICIPANTS： Twenty young male adults aged 21-23 years and presenting two laterality patterns in hand-foot combination （right handed-right footed and left handed-left footed groups） took part in the experiment. All participants were carefully screened to eliminate any neurological or muscle disease or trauma. METHODS： The experiment included a laterality evaluation and the motor evoked potentials of dominant and non-dominant limbs. Measures were done through the use of the Hoffmann-reflex （H-reflex） circuitry. The soleus H-reflex parameters elicited at rest in lower extremities were compared. The soleus H-reflex and the direct motor response were elicited in lower extremities of each participant in the same laboratory session. MAIN OUTCOME MEASURES： Onset latencies and min-max amplitudes of the direct motor response and the H-reflex; the motor and sensory conduction velocities; and symmetry coefficients of response parameters. RESULTS： The analysis of symmetry coefficients of direct and late motor responses confirmed differences between two laterality patterns in amplitude and latency of the H-reflex as well as in a sensory conduction velocity （P 〈 0.05）, but not in direct motor response parameters. The amplitude of the H-reflex and the calculated sensory la afferent conduction velocity in the dominant lower extremity were significantly depressed in the right-sided group in comparison to the left-sided group （P = 0.001）. The right-sided

关键词： Hoffmann-reflex laterality motor control neural circuitry human peripheral factors

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Effects of Polar Organic Solvent on Separation of Y(edta)^-/Nd(edta)^- Complexes on Polyacrylic Anion Exchangers

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Journal of Rare Earths 2005年第1期23卷 124-128页

作者： Halina Hubicka dorota Kolodynska Department of Inorganic Chemistry Faculty of Chemistry Maria Curie-Sklodowska University Maria Curie-Sklodowska Sq.3 20-031 Lublin PolandDepartment of Inorganic Chemistry Faculty of Chemistry Maria Curie-Sklodowska University Maria Curie-Sklodowska Sq.3 20-031 Lublin Poland

The use of polar organic solvents for the separations of rare earth elements (Ⅲ) is effective especially for their extensive separations despite the solubility limitations. The study shows that polyacrylate anion exchangers, particularly the weakly basic, gel anion exchanger Amberlite IRA 68, can be applied to the separation of rare earth complexes with EDTA in H_2O-methanol and H_2O-ethanol systems. In most cases the determined distribution coefficients of Ln^(3+) complexes with EDTA in mixed media like water-methanol on polyacrylate anion exchangers are larger than those in pure water (media.)

关键词： polar organic solvent Y(edta)^-/Nd(edta)^- separation ion exchange rare earths

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Changes in characteristics of patients with hepatitis C virus-related cirrhosis from the beginning of the interferon-free era

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World Journal of Gastroenterology 2023年第13期29卷 2015-2033页

作者： Michał Brzdęk dorota Zarębska-michaluk Piotr Rzymski Beata Lorenc Adam Kazek Magdalena Tudrujek-Zdunek Justyna Janocha-Litwin Włodzimierz Mazur dorota Dybowska Hanna Berak Anna Parfieniuk-Kowerda Jakub Klapaczyński Marek Sitko Barbara Sobala-Szczygieł Anna Piekarska Robert Flisiak Department of Infectious Diseases Jan Kochanowski UniversityKielce 25-317Poland Department of Infectious Diseases Jan Kochanowski UniversotyKielce 25-317Poland Department of Environmental Medicine Poznan University of Medical SciencesPoznań60-806Poland Integrated Science Association Universal Scientific Education and Research NetworkPoznań60-806Poland Pomeranian Center of Infectious Diseases Medical University GdańskGdańsk 80-214Poland ID Clinic Mysłowice 41-400Poland Department of Infectious Diseases Medical University of LublinLublin 20-059Poland Department of Infectious Diseases and Hepatology Medical University WrocławWrocław 50-367Poland Clinical Department of Infectious Diseases Clinical University of Silesia in KatowiceChorzów 41-500Poland Department of Infectious Diseases and Hepatology Faculty of MedicineNicolaus Copernicus UniversityBydgoszcz 85-030Poland Daily Department Hospital for Infectious Diseases in WarsawWarszawa 01-201Poland Department of Infectious Diseases and Hepatology Medical University of BiałystokBiałystok 15-089Poland Department of Internal Medicine and Hepatology Central Clinical Hospital of the Ministry of Internal Affairs and AdministrationWarszawa 00-241Poland Department of Infectious and Tropical Diseases Jagiellonian UniversityKraków 31-088Poland Department of Infectious Diseases Medical University of Silesia in KatowiceBytom 41-902Poland Department of Infectious Diseases and Hepatology Medical University ofŁódźŁódź90-419Poland

BACKGROUND Nearly 290000 patients with chronic hepatitis C die annually from the most severe complications of the *** of them is liver cirrhosis,which occurs in about 20%of patients chronically infected with the hepatitis C virus(HCV).Direct-acting antivirals(DAAs),which replaced interferon(IFN)-based regimens,significantly improved the prognosis of this group of patients,increasing HCV eradication rates and tolerability of *** study is the first to assess changes in patient profile,effectiveness,and safety in the HCV-infected cirrhotic population in the IFN-free *** To document changes in patient characteristics and treatment regimens along with their effectiveness and safety profile over the *** The studied patients were selected from 14801 chronically HCV-infected individuals who started IFN-free therapy between July 2015 and December 2021 in 22 Polish hepatology *** retrospective analysis was conducted in real-world clinical practice based on the EpiTer-2 multicenter *** measure of treatment effectiveness was the percentage of sustained virologic response(SVR)calculated after excluding patients lost to *** data collected during therapy and the 12-wk post-treatment period included information on adverse events,including serious ones,deaths,and treatment *** The studied population(n=3577)was balanced in terms of gender in 2015-2017,while the following years showed the dominance of *** decline in the median age from 63 in 2015-2016 to 61 years in 2021 was accompanied by a decrease in the percentage of patients with comorbidities and ***-experienced patients dominated in 2015-2016,while treatment-naive individuals gained an advantage in 2017 and reached 93.2%in ***(GT)-specific options were more prevalent in treatment in 2015-2018 and were supplanted by pangenotypic combinations in subsequent *** effectiveness of the therapy was comparable regardless of the

关键词： Hepatitis C Liver cirrhosis Direct-acting antivirals Pangenotypic Genotype-specific Epidemiology

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Determination of Poly(Diallyldimethylammonium Chloride)via Spectrophotometric Titration with Coomassie Brilliant Blue G Dye

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光谱学与光谱分析 2016年第2期36卷 583-587页

作者： Alexander Shyichuk dorota Ziókowska Jan Lamkiewicz UTP University of Science and Technology Faculty of Chemical Technology and Engineering

Poly(diallyldimethylammonium chloride)(PDDA)is used as organic coagulant in water purification and auxiliary agent in paper *** of PDDA in aqueous solutions is carried out usually by means of polyelectrolyte titration using streaming current detector or o-Toluidine Blue dye for endpoint *** proposed method of PDDA assay takes advantage of Coomassie Brilliant Blue G dye having strong affinity to cationic *** of PDDA solution with the dye is carried out measuring absorbance at *** points of the obtained zigzag photometric curves have good repeatability provided that titration rate is low enough to attain endpoint for 1hour or *** method assures rectilinear calibration(R2=0.999 5)in the broad range of PDDA concentrations from 0.3to 9.6mg·dm^(-3).

关键词： PDADMAC PolyDADMAC Cationic polyelectrolyte Colloid titration

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Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections

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World Journal of Gastroenterology 2019年第18期25卷 2188-2203页

作者： dorota Czerucka Patrick Rampall Department of Human Health Division of Ecosystems and Immunity Center Scientific of Monaco Center Scientific of Monaco

The yeast Saccharomyces boulardii CNCM I-745 is one of the probiotics recommended for the prevention of antibiotic-associated diarrhea. Studies conducted in vivo and in vitro demonstrated that in the case of infectious diseases there are two potential sites of action of Saccharomyces boulardii CNCM I-745:(1)An action on enteropathogenic microorganisms(adhesion of bacteria and their elimination or an effect on their virulence factors: Toxins, lipopolysaccharide,etc.); and(2) a direct action on the intestinal mucosa(trophic effects, effects on epithelial reconstitution, anti-secretory effects, anti-inflammatory,immunomodulators). Oral administration of Saccharomyces boulardii CNCM I-745 to healthy subjects does not alter their microbiota. However, in the case of diseases associated with the use of antibiotics or chronic diarrhea, Saccharomyces boulardii CNCM I-745 can restore the intestinal microbiota faster. The interaction of Saccharomyces boulardii CNCM I-745 with the innate immune system have been recently demonstrated thus opening up a new therapeutic potential of this yeast in the case of diseases associated with intestinal infections but also other pathologies associated with dysbiosis such as inflammatory diseases.

关键词： Saccharomyces boulardii CNCM I-745 Probiotics Yeast Intestinal infection Mechanism

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Analysis of solid sorbents for control and removal processes for elemental mercury from gas streams:a review

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International Journal of Coal Science & Technology 2021年第1期8卷 23-46页

作者： Piotr Kunecki dorota Czarna-Juszkiewicz Magdalena Wdowin Mineral and Energy Economy Research Institute Polish Academy of SciencesWybickiego 7a31-261KrakówPoland

Due to the restriction such as the Minamata Convention as well as the IED of the European Commission,mercury removal from flue gases of coal-fired power plants(CPP)is an increasingly important environmental *** makes this topic very crucial for both the energy industry and *** paper shows how mercury arises from natural resources,i.e.,coals,through their combustion processes in CPP and considers the issue of mercury content in flue gases and solid-state coal combustion *** main part of this paper presents a review of the solid sorbents available for elemental mercury control and removal processes,tested on a laboratory *** described solutions have a potential for wider usage in exhaust gas treatment processes in the energy production *** solutions represent the latest developments in the field of elemental mercury removal from *** authors present an overview of the wide range of solid sorbents and their modifications intended to increase affinity for Hg^(0).Among the presented sorbents are the wellknown activated carbon solutions but also novel modifications to these and other innovative sorbent proposals based on,e.g.,zeolites,biochars,other carbon-based materials,metal-organic *** paper presents a wide range of characteristics of the described sorbents,as well as the conditions for the Hg^(0) removal experiments summarizing the compendium of novel solid sorbent solutions dedicated to the removal of elemental mercury from gases.

关键词： Solid sorbents Textural properties Elemental mercury removal Flue gas Gas stream

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Sorption of lanthanide ions on biochar composites

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Journal of Rare Earths 2018年第11期36卷 1212-1220页

作者： dorota Kotodyniska Justyna Bak Malwina Majdariska Dominika Fila Department of Inorganic Chemistry Faculty of ChemistryMaria Curie-Sktodowska UniversityM.Curie Sktodowska 5q.220-031 tublinPoland

Sorption of lanthanum（Ⅲ）, cerium（Ⅲ and neodymium（Ⅲ） ions from the aqueous solutions of mixtures through adsorption on the biochar composites was investigated as a function of sorbent mass, pH, phase contact time and initial concentration of solutions at 295 K. The maximum removal of lanthanide ions takes place under the following conditions： 0.1 g of sorbent mass, pH 4 and 360 rain contact time for all studied initial concentrations of solutions. Kinetics of La（Ⅲ）, Ce（Ⅲ） and Nd（Ⅲ） ions sorption proceeded by a fast initial uptake reached equilibrium. This process was modelled by means of the pseudo first order, pseudo second order, intraparticle diffusion and Elovich models. The desorption of three lanthahide ions by nitric, hydrochloric and sulfuric acids at a concentration of 1 mol/L from biochar composites was also studied. In order to investigate the sorption mechanism FFIR, XRD and XPS analyses were performed after sorption of ions from the mixture.

关键词： Lanthanide ions Biochar composites Sorption mechanism Zerovalent iron Rare earths

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Electrochemical and in silico approaches for liver metabolic oxidation of antitumor-active triazoloacridinone C-1305

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Journal of Pharmaceutical Analysis 2020年第4期10卷 376-384页

作者： Agnieszka Potega dorota Zelaszczyk Zofia Mazerska Department of Pharmaceutical Technology and Biochemistry Faculty of ChemistryGdansk University of TechnologyGabriela Narutowicza St.11/12Gdansk80-233Poland Department of Organic Chemistry Faculty of PharmacyJagiellonian UniversityMedyczna St.9Krakow30-688Poland

5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone(C-1305)is a promising antitumor compound developed in our laboratory.A better understanding of its metabolic transformations is still needed to explain the multidirectional mechanism of pharmacological action of triazoloacridinone derivatives at ***,the aim of the current work was to predict oxidative pathways of C-1305 that would reflect its phase I *** multi-tool analysis of C-1305 metabolism included electrochemical conversion and in silico sites of metabolism predictions in relation to liver microsomal *** the framework of the first approach,an electrochemical cell was coupled on-line to an electrospray ionization mass *** effluent of the electrochemical cell was also injected onto a liquid chromatography column for the separation of different products formed prior to mass spectrometry *** silico studies were performed using MetaSite *** microsomal incubation was employed as a reference *** found that C-1305 underwent electrochemical oxidation primarily on the dialkylaminoalkylamino *** unknown N-dealkylated and hydroxylated C-1305 products have been *** electrochemical system was also able to simulate oxygenation *** pattern of C-1305 metabolism has been predicted using in silico *** proposed strategies showed high agreement in relation to the generated metabolic products of ***,we conclude that they can be considered as simple alternatives to enzymatic assays,affording time and cost efficiency.

关键词： Antitumor triazoloacridinone P450-catalyzed reactions Electrochemistry/mass spectrometry In silico metabolism Prediction Liver microsomal assay

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Fiber-based optical frequency comb at 3.3 μm for broadband spectroscopy of hydrocarbons [Invited]

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Chinese Optics Letters 2021年第8期19卷 58-62页

作者： Karol Krzempek dorota Tomaszewska Aleksandra Foltynowicz Grzegorz Sobon Laser&Fiber Electronics Group Faculty of ElectronicsWrocław University of Science and Technology50-370 WroclawPoland Department of Physics Umea University90187 UmeåSweden

A 125 MHz fiber-based frequency comb source in the mid-infrared wavelength region is presented. The source is based on difference frequency generation from a polarization-maintaining Er-doped fiber pump laser and covers a spectrum between2900 cm^(-1) and 3400 cm^(-1) with a simultaneous bandwidth of 170 cm^(-1) and an average output power up to 70 m W. The source is equipped with actuators and active feedback loops, ensuring long-term stability of the repetition rate, output power, and spectral envelope. An absorption spectrum of ethane and methane was measured using a Fourier transform spectrometer to verify the applicability of the mid-infrared comb to multispecies detection. The robustness and good long-and short-term stability of the source make it suitable for optical frequency comb spectroscopy of hydrocarbons.

关键词： fiber laser femtosecond laser difference frequency generation nonlinear frequency conversion

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