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Genotype 3-hepatitis C virus’last line of defense

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World Journal of Gastroenterology 2021年第11期27卷 1006-1021页

作者： dorota Zarębska-Michaluk Department of Infectious Diseases Jan Kochanowski UniversityKielce 25-369ŚwiętokrzyskiePoland

Chronic infection with hepatitis C virus(HCV)is one of the leading causes of liver disease globally,affecting approximately 71 million *** majority of them are infected with genotype(GT)1 but infections with GT3 are second in *** many years,GT3 was considered to be less pathogenic compared to other GTs in the HCV family due to its favorable response to interferon(IFN)-based ***,the growing evidence of a higher rate of steatosis,more rapid progression of liver fibrosis,and lower efficacy of antiviral treatment compared to infection with other HCV GTs has changed this *** review presents the specifics of the course of GT3 infection and the development of therapeutic options for GT3-infected patients in the era of direct-acting antivirals(DAA).The way from a standard of care therapy with pegylated IFNalpha(pegIFNα)and ribavirin(RBV)through a triple combination of pegIFNα+RBV and DAA to the highly potent IFN-free pangenotypic DAA regimens is discussed along with some treatment options which appeared to be dead *** the implementation of highly effective pangenotypic regimens is the most recent stage of revolution in the treatment of GT3 infection,there is still room for improvement,especially in patients with liver cirrhosis and those who fail to respond to DAA therapies,particularly those containing inhibitors of HCV nonstructural protein 5A.

关键词： Hepatitis C virus Genotype 3 Antiviral treatment Interferon Direct-acting antivirals Pangenotypic

Analysis of solid sorbents for control and removal processes for elemental mercury from gas streams:a review

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International Journal of Coal Science & Technology 2021年第1期8卷 23-46页

作者： Piotr Kunecki dorota Czarna-Juszkiewicz Magdalena Wdowin Mineral and Energy Economy Research Institute Polish Academy of SciencesWybickiego 7a31-261KrakówPoland

Due to the restriction such as the Minamata Convention as well as the IED of the European Commission,mercury removal from flue gases of coal-fired power plants(CPP)is an increasingly important environmental *** makes this topic very crucial for both the energy industry and *** paper shows how mercury arises from natural resources,i.e.,coals,through their combustion processes in CPP and considers the issue of mercury content in flue gases and solid-state coal combustion *** main part of this paper presents a review of the solid sorbents available for elemental mercury control and removal processes,tested on a laboratory *** described solutions have a potential for wider usage in exhaust gas treatment processes in the energy production *** solutions represent the latest developments in the field of elemental mercury removal from *** authors present an overview of the wide range of solid sorbents and their modifications intended to increase affinity for Hg^(0).Among the presented sorbents are the wellknown activated carbon solutions but also novel modifications to these and other innovative sorbent proposals based on,e.g.,zeolites,biochars,other carbon-based materials,metal-organic *** paper presents a wide range of characteristics of the described sorbents,as well as the conditions for the Hg^(0) removal experiments summarizing the compendium of novel solid sorbent solutions dedicated to the removal of elemental mercury from gases.

关键词： Solid sorbents Textural properties Elemental mercury removal Flue gas Gas stream

Electrochemical and in silico approaches for liver metabolic oxidation of antitumor-active triazoloacridinone C-1305

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Journal of Pharmaceutical Analysis 2020年第4期10卷 376-384页

作者： Agnieszka Potega dorota Zelaszczyk Zofia Mazerska Department of Pharmaceutical Technology and Biochemistry Faculty of ChemistryGdansk University of TechnologyGabriela Narutowicza St.11/12Gdansk80-233Poland Department of Organic Chemistry Faculty of PharmacyJagiellonian UniversityMedyczna St.9Krakow30-688Poland

5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone(C-1305)is a promising antitumor compound developed in our laboratory.A better understanding of its metabolic transformations is still needed to explain the multidirectional mechanism of pharmacological action of triazoloacridinone derivatives at ***,the aim of the current work was to predict oxidative pathways of C-1305 that would reflect its phase I *** multi-tool analysis of C-1305 metabolism included electrochemical conversion and in silico sites of metabolism predictions in relation to liver microsomal *** the framework of the first approach,an electrochemical cell was coupled on-line to an electrospray ionization mass *** effluent of the electrochemical cell was also injected onto a liquid chromatography column for the separation of different products formed prior to mass spectrometry *** silico studies were performed using MetaSite *** microsomal incubation was employed as a reference *** found that C-1305 underwent electrochemical oxidation primarily on the dialkylaminoalkylamino *** unknown N-dealkylated and hydroxylated C-1305 products have been *** electrochemical system was also able to simulate oxygenation *** pattern of C-1305 metabolism has been predicted using in silico *** proposed strategies showed high agreement in relation to the generated metabolic products of ***,we conclude that they can be considered as simple alternatives to enzymatic assays,affording time and cost efficiency.

关键词： Antitumor triazoloacridinone P450-catalyzed reactions Electrochemistry/mass spectrometry In silico metabolism Prediction Liver microsomal assay

Fiber-based optical frequency comb at 3.3 μm for broadband spectroscopy of hydrocarbons [Invited]

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Chinese Optics Letters 2021年第8期19卷 58-62页

作者： Karol Krzempek dorota Tomaszewska Aleksandra Foltynowicz Grzegorz Sobon Laser&Fiber Electronics Group Faculty of ElectronicsWrocław University of Science and Technology50-370 WroclawPoland Department of Physics Umea University90187 UmeåSweden

A 125 MHz fiber-based frequency comb source in the mid-infrared wavelength region is presented. The source is based on difference frequency generation from a polarization-maintaining Er-doped fiber pump laser and covers a spectrum between2900 cm^(-1) and 3400 cm^(-1) with a simultaneous bandwidth of 170 cm^(-1) and an average output power up to 70 m W. The source is equipped with actuators and active feedback loops, ensuring long-term stability of the repetition rate, output power, and spectral envelope. An absorption spectrum of ethane and methane was measured using a Fourier transform spectrometer to verify the applicability of the mid-infrared comb to multispecies detection. The robustness and good long-and short-term stability of the source make it suitable for optical frequency comb spectroscopy of hydrocarbons.

关键词： fiber laser femtosecond laser difference frequency generation nonlinear frequency conversion

Genetic distinctness of parthenogenetic forms of European Polydrusus weevils of the subgenus Scythodrusus

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Insect Science 2012年第2期19卷 183-194页

作者： Lukasz Kajtoch Boris Korotyaev dorota Lachowska-Cierlik Institute of Systematics and Evolution of Animals Polish Academy of Sciences Krakow Poland Zoological Institute Russian Academy of Sciences St. Petersburg Russia Institute of Zoology Jagiellonian University Krakow Poland

Among eight species of Polydrusus weevils which belong to subgenus Scythodrusus, at least two possess parthenogenetic forms： P （S.） inustus and P （S.）pilifer. Both of these species consist of dioecious populations in the Caspian area and of parthenogenetic populations in Eastern Europe （R （S.） inustus）, the Caucasus region （both species） and Middle Asia （P （S.）pilifer）. The origin of parthenogenesis in this subgenus is unresolved; however some data suggest that the parthenogenetic forms are of hybrid ancestry. The genetic distinctness of parthenogenetic Scythodrusus was assessed on the basis of COII, ITS2, EFI-a and Wolbachia wsp, 16S ribosomal DNA, ftsZ and hcpA sequence comparisons. Both taxa turned out to be monophyletic for all markers, which is an evidence against hybridization of their dioecious ancestors. On the other hand, a high frequency of heterozygous P （S.） inustus females suggests an origin resulting from hybridization between genetically distinct dioecious representatives of this species. Very similar strains of Wolbachia supergroup A were found in both species, indicating that they have been either inherited from a common ancestor or were transmitted between parthenogenetic Scythodrusus weevils and probably spread randomly across their ranges.

关键词： Coleoptera Curculionidae hybridization parthenogenesis phylogeny Polydrusus Wolbachia

The relationship between the black carbon and bisphenol A in sea and river sediments(Southern Baltic)

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Journal of Environmental Sciences 2016年第3期28卷 24-32页

作者： Marta Staniszewska Iga Koniecko Lucyna Falkowska dorota Burska Joanna Kielczewska Institute of Oceanography University of OdanskA1.Marszaika Pilsudskiego 4681-378 GdyniaPoland

This study was derived from field investigations to assess bisphenol A（BPA）concentrations in the sea and river sediments of the Gulf of *** carbon（BC）and total organic carbon（TOC）were identified as influencing factors on the *** a result of the transportation of BC with organic matter via rivers into the Gulf of Gdansk,the highest mean concentrations（11.26 ng BPA/（g dry weight（dw）））,were determined in the sediments of river *** in coastal stations were characterized by the lowest mean concentrations（5.73 ng BPA/（g dw））.TOC content below 0.1% determined the sorption of BPA on BC particles in sediments,and statistically significant correlation between the concentration of BPA and the BC/TOC ratio was found in these *** addition,dependency between the concentration of BPA and the content of BC was discovered in sediments where the BC/TOC ratio was 〉 0.33.

关键词： Bisphenol A Total organic carbon Black carbon Sediments Gulf of Gdansk

Refractive lens exchange in modern practice: when and when not to do it?

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Eye and Vision 2014年第1期1卷 59-71页

作者： Jorge L Alió Andrzej Grzybowski dorota Romaniuk Vissum Corporation AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain Department of Ophthalmology Poznan City HospitalPoznańPoland Chair of Ophthalmology University of Warmia and MazuryOlsztynPoland Clinical Department of Ophthalmology Silesian University of MedicineKatowicePoland Avda de Denia s/n Edificio Vissum03016 AlicanteSpain

Cataract surgery due to advances in small incision surgery evolved from a procedure concerned with the primary focus on the safe removal of cataractous lens to a procedure focused on the best possible postoperative refractive *** the outcomes of cataract surgery became better,the use of lens surgery as a refractive modality in patients without cataracts has increased in interest and in *** of the crystalline lens for refractive purposes or refractive lens exchange(RLE)presents several advantages over corneal refractive *** with high degrees of myopia,hyperopia and astigmatism are still not good candidates for laser ***,presbyopia can currently only be corrected with monovision or reading *** supplemented with multifocal or accommodating intraocular lenses(IOLs)in combination with corneal astigmatic procedures might address all refractive errors including presbyopia,and eliminate the future need for cataract surgery.

关键词： Refractive lens exchange Clear lens exchange Refractive surgery Lens surgery Ophthalmology Eye surgery

Nest-site selection by the white-tailed eagle and black stork–implications for conservation practice

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Forest Ecosystems 2020年第4期7卷 781-792页

作者： Grzegorz Zawadzki dorota Zawadzka Anna Sołtys Stanisław Drozdowski Department of Forest Protection Institute of Forest SciencesWarsaw University of Life SciencesNowoursynowska 15902-776 WarszawaPoland. Department of Forestry University ofŁódźBranch in Tomaszów MazowieckiKonstytucji Maja 65/67 97-200 Tomaszów MazowieckiPoland.3Department of SilvicultureInstitute of Forest SciencesWarsaw University of Life SciencesNowoursynowska 15902-776 WarszawaPoland.

Background:Nesting trees and habitat represent the key factor underpinning stand selection by forest-dwelling *** two large European species–the black stork(Ciconia nigra L.)and white-tailed eagle(Haliaaetus albicilla L.)–are known to require old,large trees for nesting,we sought to investigate further by comparing species requirements at the levels of the nesting tree,nesting stand,and *** entailed a detailed examination of forest features within circles of radius 15 m surrounding 16 and 19 trees holding the nests of storks and eagles *** same parameters were also checked in the vicinity of 50 randomly-selected mature ***:Our results indicate different nesting preferences,with the eagles entirely confining themselves to Scots pine(Pinus sylvestris L.)–a species also chosen by black storks,which nevertheless regularly favour pedunculate oak(Quercus robur L.).Both species select trees of greater girth than the random ones,but white-tailed eagles choose to nest in the vicinity of patches of mature old stands with a loose canopy,to the extent that nesting trees and surrounding trees are of similar *** contrast,black storks prefer“veteran”trees with low-set crowns that are much older than any others in their *** trees of the eagles are away from roads and close to lakes,while black storks do not avoid ***:As the ages of nesting trees of both species are greater than ages at final cutting in this region’s managed forest,silvicultural measures will need to be adjusted,with small patches of forest spared,or larger areas as“islands”of ***,as tending and thinning are engaged in,certain trees with horizontal branches will need to remain,with relict trees also left *** it happens,all of these recommendations are anyway key elements of close-to nature silviculture and multifunctional forestry.

关键词： Augustów Forest Poland Ciconia nigra Haliaeetus albicilla Nesting requirements Protection of nest sites Old trees Forest management

Short Term Prediction of Preeclampsia

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Maternal-Fetal Medicine 2021年第2期3卷 107-115页

作者： dorota Sroka Stefan Verlohren Department of Obstetrics Charite-Universitatsmedizin BerlinChariteplatz 110117 BerlinGermany

Preeclampsia(PE),a multisystem disorder in pregnancy,is a main cause of perinatal mortality and is associated with long-term maternal *** a long time,PE was defined as the new onset hypertension and proteinuria after 20 weeks’*** had been shown that this“gold standard definition”is not able to provide a sufficient prediction of PE-related fetal and/or maternal *** 2018 the International Society for the Study of Hypertension in Pregnancy recommended a broader definition of the *** new definition of the International Society for the Study of Hypertension in Pregnancy ruled out proteinuria as mandatory for the diagnosis of *** new definition increases the number of patients diagnosed as preeclamptic by nearly 21%,which is not accompanied by an increased severity of maternal *** angiogenic biomarkers,however,has been shown to increase detection of adverse *** pathophysiology of PE is complex and not yet completely *** in prediction and diagnosis have been achieved by discovery and clinical evaluation of biomarkers,especially of placental origin.A broad spectrum of biomarkers has been tested,a few of them have been introduced into the clinical practice as of *** angiogenic biomarkers that are rooted in the pathophysiology of PE have been demonstrated to be important in the prediction and diagnosis of adverse *** a cut-off value of the soluble fms-like tyrosine kinase-1(sFlt-1)/placental growth factor(PlGF)-ratio of 85,early-onset PE<34+0 weeks of gestation can accurately be diagnosed with a sensitivity of 89%and a specificity of 97%.The Prediction of short-term outcome in pregnant women with suspected preeclampsia(PROGNOSIS)study has shown that the high negative predictive value(99.3%)of the sFlt-1/PlGF-ratio below 38 in patients with suspected PE rules out the onset of the disease within one *** Asia,evaluating the sFlt-1/PlGF-ratio cut-off of 38 in an

关键词： Biomarkers Prediction Preeclampsia sFlt-1/PlGF Test performance