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Erratum to:Influence of structural defects on charge density waves in 1T-TaS_(2)

Nano Research 2024年第3期17卷 2204-2204页

作者： Iaroslav Lutsyk Karol Szalowski Pawel Krukowski Pawel Dabrowski Maciej Rogala Witold Kozlowski Maxime Le Ster Michal Piskorski dorota a.kowalczyk Wojciech Rys Rafal Dunal Aleksandra Nadolska Klaudia Toczek Przemyslaw Przybysz Ewa Lacinska Johannes Binder Andrzej Wysmolek Natalia Olszowska Jacek J.Kolodziej Martin Gmitra Takuma Hattori Yuji Kuwahara Guang Bian Tai-Chang Chiang Pawel J.kowalczyk Faculty of Physics and Applied Informatics University of LodzPomorska 149/15390-236 LodzPoland Faculty of Physics University of WarsawPasteura 502-093 WarsawPoland Faculty of Physics Astronomyand Applied Computer ScienceJagiellonian UniversityLojasiewicza 1130-348 KrakowPoland National Synchrotron Radiation Centre SOLARIS Jagiellonian UniversityCzerwone Maki 9830-392 KrakówPoland Institute of Physics Faculty of SciencePavol JozefŠafárik University in KošicePark Angelinum 904001 KošiceSlovakia Institute of Experimental Physics Slovak Academy of SciencesWatsonova 4704001 KošiceSlovakia Department of Precision Engineering Graduate School of EngineeringOsaka University2-1 Yamada-okaSuita 565-0871Japan Department of Physics and Astronomy University of MissouriColumbiaMissouri 65211USA Department of Physics and Frederick Seitz Materials Research Laboratory University of Illinois at Urbana-ChampaignUrbanaIllinois 61801-3080USA

The name of the second author in original paper was unfortunately *** should be“Karol Szalowski”,instead of“Karoli Szalowski”.

关键词： structural charge defects

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Influence of structural defects on charge density waves in 1T-TaS_(2)

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Nano Research 2023年第8期16卷 11528-11539页

The influence of intrinsic defects of 1T-TaS_(2)on charge density waves(CDWs)is studied using scanning tunneling microscopy and spectroscopy(STM,STS),angle-resolved photoelectron spectroscopy(ARPES),and density functional theory(DFT).We identify several types of structural defects and find that most have a local character limited to a single CDW site,with a single exception which effectively behaves as a dopant,leading to band-bending and affecting multiple neighboring *** only one type of defect can be observed by STM topographic imaging,all defects are easily resolved in STS *** results indicate modulation of the Mott band gap commensurate with the CDW and breaking of the three-fold symmetry of electronic *** calculations(with included Coulomb interactions)are used to investigate the electronic structure,focusing on both sulfur vacancy and oxygen-sulfur *** sulfur vacancy system,characterized with a metallic behavior,is identified as the origin of one of the experimentally observed ***,the effect of oxidation of 1T-TaS_(2)depends on the substitution site,leading to the heterogeneity of electronic properties.

关键词： structural charge sulfur

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Novel opioid-neurotensin-based hybrid peptide with spinal long-lasting antinociceptive activity and a propensity to delay tolerance development

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Acta Pharmaceutica Sinica B 2020年第8期10卷 1440-1452页

作者： Karolina Fra˛czek Mattia Ferraiolo Emmanuel Hermans Magdalena Bujalska-Zadrozny Kaja Kasarello Anna Erdei Kamila Kulik Agnieszka.kowalczyk Piotr Wojciechowski dorota Sulejczak Piotr Sosnowski Sebastian Granica Sandor Benyhe Katarzyna Kaczynska Lukasz Nagraba Artur Stolarczyk Agnieszka Cudnoch-Jedrzejewska Patrycja Kleczkowska Department of Pharmacodynamics Centre for Preclinical Research(CBP)Medical University of WarsawWarsaw 02-097Poland Laboratory of Neuropharmacology Institute of NeurosciencesUniversite´Catholique de LouvainBrussels B-1200Belgium Department of Experimental and Clinical Physiology Centre for Preclinical Research(CBP)Medical University of WarsawWarsaw 02-097Poland Institute of Biochemistry Biological Research CentreHungarian Academy of SciencesSzeged H-6701Hungary Doctoral School of Therotecical Medicine University of SzegedSzeged H-6720Hungary Department of Respiration Physiology Mossakowski Medical Research CentrePolish Academy of SciencesWarsaw 02-106Poland Department of Experimental Pharmacology Mossakowski Medical Research CenterPolish Academy of SciencesWarsaw 02-106Poland Department of Neuropeptides Mossakowski Medical Research CentrePolish Academy of SciencesWarsaw 02-106Poland Department of Pharmacognosy and Molecular Basis of Phytotherapy Faculty of PharmacyMedical University of WarsawWarsaw 02-097Poland Department of Orthopaedics and Rehabilitation Medical University of WarsawWarsaw 04-749Poland

The behavioral responses exerted by spinal administration of the opioid-neurotensin hybrid peptide, PK23, were studied in adult male rats. The antinociceptive effect upon exposure to a thermal stimulus, as well as tolerance development, was assessed in an acute pain model. The PK23 chimera at a dose of 10 nmol/rat produced a potent pain-relieving effect, especially after its intrathecal administration. Compared with intrathecal morphine, this novel compound was found to possess a favourable side effect profile characterized by a reduced scratch reflex, delayed development of analgesic tolerance or an absence of motor impairments when given in the same manner, though some animals died following barrel rotation as a result of its i.c.v. administration(in particular at doses higher than 10 nmol/rat). Nonetheless, these results suggest the potential use of hybrid compounds encompassing both opioid and neurotensin structural fragments in pain management. This highlights the enormous potential of synthetic neurotensin analogues as promising future analgesics.

关键词： opioid neurotensin doses

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Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation

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World Journal of Gastroenterology 2013年第27期19卷 4363-4373页

作者： Piotr M Wierzbicki Krystian Adrych dorota Kartanowicz Marcin Stanislawowski Anna.kowalczyk Janusz Godlewski Iwona Skwierz-Bogdanska Krzysztof Celinski Tomasz Gach Jan Kulig Bartlomiej Korybalski Zbigniew Kmiec Department of Histology Faculty of MedicineMedical University of Gdansk Department of Hepatology and Gastroenterology Faculty of MedicineMedical University of Gdansk Department of Human Histology and Embryology Faculty of Medical SciencesUniversity of Varmia and Masuria Department of General Surgery Hospital Ministry Internal Affairs Department of Gastroenterology Medical University of Lublin 1st Department of General Surgery Jagiellonian University Endoscopy Unit St. Adalbert Hospital

AIM:To investigate large tumor suppressor 1 (LATS1 ) expression, promoter hypermethylation, and microsatellite instability in colorectal cancer (CRC).METHODS:RNA was isolated from tumor tissue of 142 CRC patients and 40 colon mucosal biopsies of healthy controls. After reverse transcription, quantitative polymerase chain reaction (PCR) was performed, and LATS1 expression was normalized to expression of the ACTB and RPL32 housekeeping genes. To analyze hypermethylation, genomic DNA was isolated from 44 tumor CRC biopsies, and methylation-specific PCR was performed. Microsatellite instability (MSI) status was checked with PCR using BAT26, BAT25, and BAT40 markers in the genomic DNA of 84 CRC patients, followed by denaturing gel electrophoresis. RESULTS:Decreased LATS1 expression was found in 127/142 (89.4%) CRC cases with the average ratio of the LATS1 level 10.33 ± 32.64 in CRC patients vs 32.85 ± 33.56 in healthy controls. The lowest expression was found in Dukes' B stage tumors and G1 (welldifferentiated) cells. Hypermethylation of the LATS1 promoter was present in 25/44 (57%) CRC cases analyzed. LATS1 promoter hypermethylation was strongly associated with decreased gene expression; methylated cases showed 162× lower expression of LATS1 than unmethylated cases. Although high-grade MSI (mutation in all three markers) was found in 14/84 (17%) cases and low-grade MSI (mutation in 1-2 markers) was found in 30/84 (36%) cases, we found no association with LATS1 expression. CONCLUSION:Decreased expression of LATS1 in CRC was associated with promoter hypermethylation, but not MSI status. Such reduced expression may promote progression of CRC.

关键词： Large tumor suppressor 1 Colorectal cancer Quantitative polymerase chain reaction Reduced expression Promoter hypermethylation Microsatellite instability Salvador-Warts-Hippo pathway

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