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Prospective case series on trabecular-iris angle status after an acute episode of phacomorphic angle closure

International Journal of Ophthalmology(English edition) 2013年第1期6卷 67-70页

作者： Jacky Lee Jimmy Lai doris Yick Can Yuen Department of Ophthalmology University of Hong Kong Department of Ophthalmology Caritas Medical Centre

AIM:To investigate the trabecular-iris angle with ultrasound biomicroscopy (UBM) post cataract extraction after an acute attack of phacomorphic angle closure. ·METHODS:This prospective study involved 10 cases of phacomorphic angle closure that underwent cataract extraction and intraocular lens insertion after intraocular pressure (IOP) lowering. Apart from visual acuity and IOP, the trabecular-iris angle was measured by gonioscopy and UBM at 3 months post attack. ·RESULTS:In 10 consecutive cases of acute phaco-morphic angle closure from December 2009 to December 2010, gonioscopic findings showed peripheral anterior synechiae (PAS) ≤90° in 30% of phacomorphic patients and a mean Shaffer grading of (3.1±1.0). UBM showed a mean angle of (37.1°±4.5°) in the phacomorphic eye with the temporal quadrant being the most opened and (37.1°±8.0°) in the contralateral uninvolved eye. The mean time from consultation to cataract extraction was (1.4 ± 0.7) days and the mean total duration of phacomorphic angle closure was (3.6 ±2.8) days but there was no correlation to the degree of angle closure on UBM (Spearman correlation P =0.7). The presenting mean IOP was (50.5±7.4) mmHg and the mean IOP at 3 months was (10.5±3.4) mmHg but there were no correlations with the degree of angle closure (Spearman correlations P =0.9). CONCLUSION:Anopentrabecular-irisangleandnormal IOP can be achieved after an acute attack of pha-comorphic angle closure if cataract extraction is performed within 1 day-2 days after IOP control. Gonioscopic findings were in agreement with UBM,which provided a more specific and object angle measurement. The superior angle is relatively more narrowed compared to the other quadrants. All contralateral eyes in this series had open angles.

关键词： angle ultrasound biomicroscopy phacomorphic intraocular pressure

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Recent progress of cultivated meat in Asia

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Food Materials Research 2022年第1期2卷 113-120页

作者： Yeshi Liang doris Lee GFI Consultancy Yuanjiang Rd#5500Minxing DistrictShanghai 201111China

Accelerated by recent technological advancements,alternative proteins(AP)offer new opportunities to produce meat alternatives in a more sustainable,efficient,and secure way compared to conventional animal *** a primary category of AP,cultivated meat(CM),which is grown in vitro from animal cells,rather than raising livestock,provides a new approach to creating meat that is identical to conventional *** Asia was not the first region to invest in CM research,scientists and technologists have made significant strides across the continent in recent *** article summarizes some of the most notable CM developments and advancements in four Asian countries(China,Japan,South Korea,and Singapore)spanning the areas of research and education,commercialization,and policy and ***,key insights into the challenges and opportunities that Asia’s cultivated meat industry will encounter in the years ahead are also provided.

关键词： policy education advancement

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Perioperative chemotherapy for advanced gastric cancer - results from a tertiary-care hospital in Germany

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World Journal of Gastrointestinal Oncology 2020年第5期12卷 559-568页

作者： Katrin Bauer Giulia Manzini doris Henne-Bruns Peter Buechler Department for General VisceralThoracic and Paediatric SurgeryClinic of KemptenKempten 87439Germany Department of General and Visceral Surgery University Hospital of UlmUlm 89081Germany

BACKGROUND Neoadjuvant/perioperative chemotherapy is the recommended treatment for advanced stages of gastric cancer(>T2,N+)before tumour resection in many European ***,there is no consensus as to whether perioperative chemotherapy is as effective in distal as in proximal tumours,in addition to a relevant uncertainty concerning appropriate treatment modalities for elderly *** To investigate the role of perioperative chemotherapy in advanced gastric cancer in patients from a German tertiary clinic with respect to efficacy,localisation,and *** We performed a retrospective analysis of 158 patients from our clinic with adenocarcinoma of the stomach or the gastroesophageal junction who underwent resection between 2008 and *** data were evaluated particularly in relation to patient age,tumour site,and perioperative *** Administration of perioperative chemotherapy did not lead to a significant survival advantage in our study *** 5-year survival rates were 40%for patients who received perioperative chemotherapy and 29%for the group without perioperative chemotherapy(P=0.125).Our patients were on average distinctly older than patients in most of the published randomised controlled *** elder than 75 years received perioperative chemotherapy far less *** with a proximal tumour received perioperative chemotherapy much more *** This analysis reconfirms our previous data concerning the effectiveness of perioperative chemotherapy for advanced gastric *** is reasonable doubt that the quality of the existing randomized controlled trials is sufficient to generally justify perioperative chemotherapy in patients with advanced gastric cancer independent of tumour localization or age.

关键词： Gastric cancer Perioperative Chemotherapy Tumour localisation Age distribution Validity

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Validity of studies suggesting preoperative chemotherapy for resectable thoracic esophageal cancer:A critical appraisal of randomized trials

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World Journal of Gastrointestinal Oncology 2020年第1期12卷 113-123页

作者： Giulia Manzini Ursula Klotz doris Henne-Bruns Michael Kremer Department of General and Visceral Surgery University of UlmUlm 89081Germany Department of General and Visceral Surgery Hospital of AarauAarau 5000Switzerland

BACKGROUND In 2015,Kidane published a Cochrane review and meta-analysis to summarise the impact of preoperative chemotherapy versus surgery alone on survival for resectable thoracic esophageal *** authors concluded that preoperative chemotherapy improved overall survival(OS).AIM The aim of this article was to assess the validity of the three most powerful studies included in the Cochrane review and the meta-analysis supporting the advantage of preoperative chemotherapy and to investigate the impact of an exclusion of these three studies on the result of the *** OS was selected as the endpoint of *** the ten included papers which analysed this endpoint,we identified the three publications with the highest weights influencing the final *** validity of these papers was analysed using the CONSORT checklist for randomized controlled *** performed a new meta-analysis without the three studies to assess their impact on the general result of the original *** The three analysed studies revealed several *** answers were found in up to one third of the items of the CONSORT *** information about sample-size calculation and power,unclear or inadequate randomisation,and missing blinded set-up were the most common *** the three criticized studies were excluded in the meta-analysis,preoperative chemotherapy showed no benefit in *** The three most powerful publications in the Cochrane review show substantial *** the exclusion of these studies from the meta-analysis,preoperative chemotherapy does not seem to result in an advantage in *** suggest a more critical appraisal regarding the validity of single studies.

关键词： Esophageal cancer Assessment of validity Meta-analysis CONSORT Overall survival

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重新审视建筑物立面,将其作为基础设施

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Engineering 2016年第1期2卷 63-68页

作者： doris Sung School of Architecture University of Southern California DOSU Studio Architecture

如城市里街道和人行道的坚硬表面一样,城市建筑物的水平或垂直表面也造成了世界范围内大城市气温的不断上升。但是,人们并没有采取任何改善措施,而是把建筑物立面看作为室内人员提供舒适环境的结构,并忽略其对室外产生的影响,或是把它... 详细信息

如城市里街道和人行道的坚硬表面一样,城市建筑物的水平或垂直表面也造成了世界范围内大城市气温的不断上升。但是,人们并没有采取任何改善措施,而是把建筑物立面看作为室内人员提供舒适环境的结构,并忽略其对室外产生的影响,或是把它当做其所有者可识别美感的象征。本文提出了将建筑物立面作为"户外行人福利管家"的反思,以及将公共健康作为建筑物立面附加功能的概念,该概念强调要考虑户外行人的利益和健康。如果把一个城市建筑物的全部表面积看做是城市基础设施的一部分,那么它的作用不仅是使室外的空间更加舒适、卫生、宜人,还要有助于缓解城市气温上升这一更大的问题。

关键词：城市基础设施建筑立面城市环境面貌外观表现地表面积建筑外部公共健康

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Chitosan-mediated synthesis of carbon nanotube-gold nanohybrids

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Science China Chemistry 2010年第9期53卷 2015-2018页

作者： GRAVEL Edmond FOILLARD Stéphanie doris Eric CEA iBiTecSService de Chimie Bioorganique et de Marquage

Metal-nanotube nanohybrids were produced by in situ synthesis and stabilization of gold nanoparticles on chitosan-functionalized carbon *** formation of gold nanoparticles from tetrachloroauric acid was observed after only a few minutes of contact with the functionalized nanotubes,at room *** results suggest that adsorption of chitosan at the surface of carbon nanotubes permits smooth reduction of the metallic salt and efficient anchoring of gold nanoparticles to the nanotubes.

关键词： nanohybrid carbon nanotube gold nanoparticle

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NK cell detachment from target cells is regulated by successful cytotoxicity and influences cytokine production

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Cellular & Molecular Immunology 2020年第4期17卷 347-355页

作者： Moritz Anft Petra Netter doris Urlaub Isabel Prager Samantha Schaffner Carsten Watzl IfADo-Leibniz Research Centre for Working Environment and Human Factors Technical University DortmundDortmundGermany University of British Columbia VancouverBCCanada

Natural killer(NK)cells participate in early immune defenses against pathogens and tumors and play a major role as immune effector and regulatory *** NK cell-mediated elimination of an infected or cancerous cell is a highly regulated process that requires the formation of a cell contact,the establishment of an immunological synapse and the polarization and release of lytic ***,the detachment of NK cells from target cells is important for NK cells to bind and kill other cells in a process called serial ***,very little is known about this detachment ***,we show that NK detachment is directly connected to the successful killing of a target *** inhibition of killing due to reduced NK cell cytotoxicity or increased target cell resistance results in defective detachment and prolonged contact *** effect leads to sustained Ca^(2+) flux in NK cells and the hypersecretion of proinflammatory *** defective cytotoxicity with enhanced cytokine secretion via reduced detachment may explain inflammatory pathologies in several diseases.

关键词： Cellular cytotoxicity immunological synapse adhesion

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Indirect costs associated with deaths from the Ebola virus disease in West Africa

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Infectious Diseases of Poverty 2015年第1期4卷 95-104页

作者： Joses Muthuri Kirigia Felix Masiye doris Gatwiri Kirigia Patricia Akweongo Health Systems and Services Cluster World Health OrganizationRegional Office for AfricaBrazzavilleCongo Department of Economics University of ZambiaLusakaZambia The KEMRI-Wellcome Trust Research Programme NairobiKenya School of Public Health University of GhanaAccraGhana

Background:By 28 June 2015,there were a total of 11,234 deaths from the Ebola virus disease(EVD)in five West African countries(Guinea,Liberia,Mali,Nigeria and Sierra Leone).The objective of this study was to estimate the future productivity losses associated with EVD deaths in these West African countries,in order to encourage increased investments in national health ***:A cost-of-illness method was employed to calculate future non-health(NH)gross domestic product(GDP)(NHGDP)losses associated with EVD *** future non-health GDP loss(NHGDPLoss)was discounted at 3%.Separate analyses were done for three different age groups(45 years)for the five countries(Guinea,Liberia,Mali,Nigeria,and Sierra Leone)affected by *** also conducted a one-way sensitivity analysis at 5 and 10%discount rates to gauge their impacts on expected ***:The discounted value of future NHGDPLoss due to the 11,234 deaths associated with EVD was estimated to be Int$(international dollars)155,663,*** 27.86%of the loss would be borne by Guinea,34.84%by Liberia,0.10%by Mali,0.24%by Nigeria and 36.96%by Sierra *** 27.27%of the loss is attributed to those aged under 14 years,66.27%to those aged 15–44 years and 6.46%to those aged over 45 *** average NHGDPLoss per EVD death was estimated to be Int$17,473 for Guinea,Int$11,283 for Liberia,Int$25,126 for Mali,Int$47,364 for Nigeria and Int$14,633 for Sierra ***:In spite of alluded limitations,the estimates of human and economic losses reported in this paper,in addition to those projected by the World Bank,show that EVD imposes a significant economic burden on the affected West African *** heavy burden,coupled with human rights and global security concerns,underscores the urgent need for increased domestic and external investments to enable Guinea,Liberia and Sierra Leone(and other vulnerable African countries)to develop resilient health systems,including

关键词： Ebola virus disease Non-health GDP loss Indirect cost Cost-of-illness

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First determination of the highly genotoxic fungal contaminant altertoxin II in a naturally infested apple sample

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Emerging Contaminants 2020年第1期6卷 82-86页

作者： Hannes Puntscher doris Marko Benedikt Warth Department of Food Chemistry and Toxicology Faculty of ChemistryUniversity of ViennaWahringer Str.381090ViennaAustria

Altertoxin II is an epoxide-holding perylene quinone and secondary metabolite produced by Alternaria *** genotoxic potential and the high concentrations determined in laboratory fungal cultures resulted in an increased scientific interest in this emerging ***,no natural occurrence in food has been reported to date to the best of our ***,we unambiguously identified altertoxin II in a naturally infected,unprocessed *** a validated LC-MS/MS method,fruit peel spots(approx.1 mm in diameter),typically associated with Alternaria infestation,were tested for 17 mycotoxins produced by this *** concentrations of tentoxin were determined 24 h after harvest,and the dibenzopyrones alternariol,alternariol monomethyl ether(AME)and AME-3-sulfate after six months of ***,these contamination patterns can be considered unlikely to be of toxicological concern for ***,an inconspicuous peel lesion(0.5×1 cm)separately sampled from a stored apple,exhibited considerably high concentrations of 14 Alternaria toxins,including dibenzopyrones,their barely studied modified forms(glucosides and sulfates),as well as genotoxic perylene quinones including altertoxin *** the toxicological potential of this compound,contaminations in such infected fruit parts should not be underestimated,*** the case of exposure through the consumption of fresh smoothies or fruit juices.

关键词： Alternaria alternata Emerging contaminants Genotoxicity Food safety Plant pathology Liquid chromatography tandem mass spectrometry

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Impact of intraocular pressure fluctuations on progression of normal tension glaucoma

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1553-1559页

作者： Susanne Hopf doris Schwantuschke Irene Schmidtmann Norbert Pfeiffer Esther Maria Hoffmann Department of Ophthalmology University Medical Center MainzMainz 55131Germany Pediatric Dentistry Nieder-Olm 55268Germany Institute of Medical Biostatistics Epidemiology and Informatics(IMBEI)University Medical Center MainzMainz 55131Germany

AIM:To investigate short-and long-term intraocular pressure(IOP)fluctuations and fur ther ocular and demographic parameters as predictors for normal tension glaucoma(NTG)***:This retrospective,longitudinal cohort study included 137 eyes of 75 patients with NTG,defined by glaucomatous optic disc or visual field defect with normal IOP(<21 mm Hg),independently from therapy *** fluctuation,mean,and maximum were inspected with a mean follow-up of 38 mo[standard deviation(SD)18 mo].Inclusion criteria were the performance of minimum two 48-hour profiles including perimetry,Heidelberg retina tomograph(HRT)imaging,and optic disc *** impact of IOP parameters,myopia,sex,cup-to-disc-ratio,and visual field results on progression of NTG were analyzed using Cox regression models.A sub-group analysis with results from optical coherence tomography(OCT)was ***:IOP fluctuations,average,and maximum were not risk factors for progression in NTG patients,although maximum IOP at the initial IOP profile was higher in eyes with progression than in eyes without progression(P=0.054).The 46/137(33.5%)eyes progressed over the followup *** progression(at least three progression confirmations)occurred in 28/137 eyes(20.4%).Most progressions were detected by perimetry(36/46).Longterm IOP mean over all pressure profiles was 12.8 mm Hg(SD 1.3 mm Hg);IOP fluctuation was 1.4 mm Hg(SD 0.8 mm Hg).The progression-free five-year rate was 58.2%(SD 6.5%).CONCLUSION:Short-and long-term IOP fluctuations do not result in progression of *** functional changes are most likely to happen,NTG should be monitored with visual field testing more often than with other devices.

关键词： intraocular pressure intraocular pressure fluctuation glaucoma progression visual field optical optical coherence tomography

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