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Long-term effect of intrathecal baclofen treatment on bone health and body composition after spinal cord injury:A case matched report

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World Journal of Orthopedics 2020年第10期11卷 453-464页

作者： dora E Ifon Mina P Ghatas John C Davis Refka E Khalil Robert A Adler Ashraf S Gorgey Spinal Cord Injury and Disorders Center Central Virginia VA Health Care SystemRichmondVA 23249United States Medical Service Central Virginia VA Health Care SystemRichmondVA 23249United States Department of Internal Medicine Division of EndocrinologyDiabetes and MetabolismVirginia Commonwealth UniversityRichmondVA 23298United States Department of Physical Medicine and Rehabilitation Virginia Commonwealth UniversityRichmondVA 23298United States

BACKGROUND Severe spasticity may negatively impact functionality and quality of life after spinal cord injury(SCI).Intrathecal baclofen treatment(IBT)is effectively used to manage severe spasticity and reduce ***,long-term IBT may have a negative effect on bone mineral content(BMC),bone mineral density(BMD)and body composition(such as percentage fat mass and lean body mass).We demonstrated the negative effects of long-term IBT use in a single case compared with two non-IBT *** SUMMARY A 46-year old Caucasian male Veteran(case)with a 21 year history of complete tetraplegia(complete C6 SCI)was implanted with IBT for 20 *** case was matched to two participants with different time since injuries[2(match 1)and 13(match 2)years]without *** BMC and BMD at the epiphysis and metaphysis of the distal femur and proximal tibia were evaluated using dual knee and the dual femur modules of GE Lunar iDXA *** and leg body composition assessments were also conducted for the three *** effect of long-term IBT was demonstrated by changes in BMD,consistent with bone demineralization,at the distal femur and proximal tibia and changes in percentage fat mass and lean mass of *** case showed 113%lower BMD at the distal femur,and 78.1%lower at the proximal tibia compared to match 1,moreover the case showed 45%lower BMD at the distal femur,and no observed changes at the proximal tibia compared to match *** case had 27.1%and 16.5%greater leg%fat mass compared to match 1 and match 2,***,the case had 17.4%and 11.8%lower%leg lean mass compared to match 1 and match 2,*** Long-term IBT may impact bone health and body composition parameters in persons with complete *** may be prudent to encourage regular screening of individuals on long-term IBT considering the prevalence of osteoporosis related fractures,cardiovascular diseases,and metabolic disorders in this population.

关键词： Intrathecal baclofen Spasticity Bone mineral density Epiphysis Metaphysis Spinal cord injury Case report

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Control programs for strongyloidiasis in areas of high endemicity: an economic analysis of different approaches

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Infectious Diseases of Poverty 2021年第3期10卷 72-81页

作者： dora Buonfrate Lorenzo Zammarchi Zeno Bisoffi Antonio Montresor Sara Boccalin Department of Infectious Tropical Diseases and Microbiology IRCCS Sacro Cuore Don Calabria HospitalNegrarVeronaItaly Department of Experimental and Clinical Medicine University of FlorenceFlorenceItaly Referral Center for Tropical Diseases of Tuscany Infectious and Tropical Diseases UnitCareggi University HospitalFlorenceItaly. Department of Diagnostics and Public Health University ofVeronaVeronaItaly Department of Control of Neglected Tropical Diseases World Health OrganizationGenevaSwitzerland Department of Health Sciences University of FlorenceFloreneeItaly.

Background:Implementation of control programmes for Strongyloides stercoralis infection is among the targets of the World Health Organization Roadmap to *** ofthis work was to evaluate the possible impact in terms of economic resources and health status of two different strategies of preventive chemotherapy(PC)compared to the current situation(strategy A,no PC):administration of ivermectin to school-age children(SAC)and adults(strategy B)versus ivermectin to SAC only(strategy C).Methods:The study was conducted at the IRCCS Sacro Cuore Don Calabria hospital,Negrar di Valpolicella,Verona,Italy,at the University of Florence,Italy,and at the WHO,Geneva,Switzerland,from May 2020 to April *** for the model were extracted from literature.A mathematical model was developed in Microsoft Excel to assess the impact of strategies B and C in a standard population of 1 million subjects living in a strongyloidiasis endemic *** a case base seenario,15%prevalence of strongyloidiasis was considered;the 3 strategies were then evaluated at different thresholds of prevalenee,ranging from 5 to 20%.The results were reported as number of infected subjects,deaths,costs,and Incremental-Effectiveness Ratio(ICER).A 1-year and a 10-year horizons were ***:In the case base seenario,cases of infections would reduce dramatically in the first year of implementation of PC with both strategy B and C:from 172500 cases to 77040 following strategy B and 146700 following strategy *** additional cost per recovered person was United States Dollar(USD)2.83 and USD 1.13 in strategy B and C,respectively,compared to no treatment in the first *** both strategies,there was a downtrend in costs per recovered person with increasing *** number of adverted deaths was larger for strategy B than C,but cost to advert one death was lower for strategy C than ***:This analysis permits to estimate the impact of two PC strategies for the control of strongyloidiasis in

关键词： Strongyloides stercoralis Strongyloidiasis Control programme Preventive chemotherapy Ivermectin Economic Adverted death Adverted infection

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Appraisal of Clinical Practice Guidelines for Ischemic Stroke Management in Chinese Medicine with Appraisal of Guidelines for Research and Evaluation Instrument:A Systematic Review

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Chinese Journal of Integrative Medicine 2015年第9期21卷 707-715页

作者：宇文亚史楠楠韩学杰高颖徐建龙刘大胜 Bacon Ng dora Tsui 钟丽丹 Eric Ziea 卞兆祥吕爱平 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Xiyuan Hospital Affiliated to China Academy of Chinese Medical Sciences Chinese Medicine Department Hong Kong Hospital Authority School of Chinese Medicine Hong Kong Baptist University

Objective： To systematically review the clinical practice guidelines （CPGs） for ischemic stroke in Chinese medicine （CM） with the Appraisal of Guidelines for Research and Evaluation （AGREE II） instrument. Methods： CM CPGs for ischemic stroke were searched in 5 online databases and hand-searches in CPG- related handbooks published from January 1990 to December 2012. The CPGs were categorized into evidence based （EB） guideline, consensus based with no explicit consideration of evidence based （CB-EB） guideline and consensus based （CB） guideline according to the development method. Three reviewers independently appraised the CPGs based on AGREE II instrument, and compared the CPGs＇ recommendations on CM pattern classification and treatment. Results： Five CM CPGs for ischemic stroke were identified and included. Among them, one CPG was EB guideline, two were CB guidelines and two were CB-EB guidelines. The quality score of the EB guideline was higher than those of the CB-EB and CB guidelines. Five CM patterns in the CPGs were recommended in the EB CPG. The comprehensive protocol of integrative Chinese and Western medicine recommended in the EB CPG was mostly recommended for ischemic stroke in the CPGs. The recommendations varied based on the CM patterns. Conclusion： The quality of EB CPG was higher than those of CB and CB-EB CPGs in CM for ischemic stroke and integrative approaches were included in CPGs as major interventions.

关键词： clinical practice guideline ischemic stroke Appraisal of Guidelines for Research and Evaluation systematic review

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Intensity modulated radiotherapy （IMRT） and combined chemotherapy for nasopharyngeal carcinoma

Intensity modulated radiotherapy （IMRT） and combined chemo...

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第三届中国肿瘤学术大会

作者： Jonathan Sham dora Kwong Daniel Chua Department of Clinical Oncology Queen Mary HospitalUniversity of Hong Kong Department of Clinical Oncology Queen Mary HospitalUniversity of Hong Kong Department of Clinical Oncology Queen Mary HospitalUniversity of Hong Kong

＜正＞ The adoption of the 1997 stage classification of AJC for nasopharyngeal carcinoma（NPC）has allowed not only betterprediction of prognosis,but also allowed grouping of patients with different patterns of failure after treatment. Chua et al had analyzed the different stage sub—groups and the pattern of *** information,together with theadvances in radiotherapy and combination chemotherapy,allowed the adoption of different strategies to deal with the differentpatterns of failure.

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DNA Barcodes in Fig Cultivars (Ficus carica L.) Using ITS Regions of Ribosomal DNA, the psbA-trnH Spacer and the matK Coding Sequence

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American Journal of Plant Sciences 2015年第1期6卷 95-102页

作者： Carlos Castro Alejandro Hernandez Luis Alvarado dora Flores Agribiotecnología de Costa Rica S.A. Alajuela Costa Rica Instituto Tecnológico de Costa Rica (ITCR) Cartago Costa Rica

Molecular markers provide a useful method for genotype characterization and allow a high precision determination of the genetic relationship between cultivars and varieties. A system based on DNA sequences—which is known as DNA barcoding—will choose one or several standard loci which can be sequenced and compared to differentiate between species. In this research, the ITS, matK, and trnH-psbA sequences were evaluated for the molecular identification of seven F. carica genotypes, generating complete sequences for the first two loci, but unable to produce bidirectional sequences by using the trnH-psbA sequence. The ITS sequence presented the highest variation rates, while the phylogeny constructed with the matK sequence obtained the highest percentage of solved monophyletic groups. Through Pearson’s correlation analysis, it was possible to determine the existence of a significant correlation between the ITS region and psbA-trnH, and the matK and psbA-trnH sequences, but not between ITS and matK. The phylogenies constructed with the ITS + matK barcodes and ITS + matK + psbA-trnH presented the highest percentage for resolution. However, considering the cost efficiency and the facilitated recovery by using PCR, the matK + ITS combination is recommended.

关键词： Ficus carica DNA Barcodes ITS psbA-trnH matK

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Effects of Perinatal Undernutrition and Massage Stimulation upon the Ambiguus Nucleus in the Rat Prior to Weaning

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Journal of Behavioral and Brain Science 2013年第2期3卷 200-209页

作者： dora Lopez-Jimenez Carmen Torrero Mirelta Regalado Manuel Salas Department of Developmental Neurobiology and Neurophysiology Institute of Neurobiology National Autonomous University of Mexico Campus UNAM Juriquilla Queretaro Mexico Department of Developmental Neurobiology and Neurophysiology Institute of NeurobiologyNational Autonomous University of Mexico Campus UNAM Juriquilla Queretaro Mexico

Undernutrition produces morphological brain alterations and cognitive deficiencies in children of underdeveloped countries. The central nervous system (CNS) alterations mainly interfere with the anatomical organization of areas undergoing a phase of intense postnatal cell proliferation, disrupting plastic processes like learning, memory, and phonation. In the rat pup, prenatal malnutrition interferes with the elaboration of ultrasonic vocalizations (USVs) by poorly understood mechanisms. The neuronal caudal portion of the nucleus ambiguus (Ambc) innervates the laryngeal intrinsic muscles to produce phonation, a basic USV communication system. During postnatal development, enhanced plasticity phenomena play a fundamental role in improving brain function. Thus, the massage stimulation (MS) may accelerate growth and induce neurogenesis in different areas of the brain. The current study analyzed the effects of a daily 10-min MS on the dendritic tree and perikarya measurements of Ambc multipolar motoneurons (Golgi-Cox) of perinatally underfed (U), control (C), control massage-stimulated (CMS), and underfed massage-stimulated (UMS) groups at postnatal days (PDs) 8, 12, and 15. The data indicated that the dendritic scores were reduced (p < 0.05) in both number and density at PD8 and PD15 in the U subjects and that MS increased the values of these parameters (p < 0.05). In addition, MS induced body weight gain in both U and CMS groups, and it enhanced the dendritic density in CMS subjects. These results show that MS during the pre-weaning period restores the plastic properties of the Ambc over the hypoplastic multipolar motoneuron after the alterations caused by perinatal undernutrition.

关键词： Nucleus Ambiguus Development Massage Stimulation Perinatal Undernutrition Rat Pups

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Biodiversity Assessment of Sugar Beet Species and Its Wild Relatives:Linking Ecological Data with New Genetic Approaches

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American Journal of Plant Sciences 2013年第8期4卷 21-34页

作者： Filipa Monteiro Maria MRomeiras dora Batista Maria Cristina Duarte Faculdade de Ciências Universidade de LisboaBioFIGCampo GrandeLisboaPortugal Instituto de Investigacao Científica Tropical JBT&CIFC/BIOTROPTravessa Conde da RibeiraLisboaPortugal Universidade do Porto CIBIOCentro de Investi-gacao em Biodiversidade&Recursos GenéticosVairaoPortugal

The value of crop wild relatives has long been acknowledged and this wild resource has been used to improve crop performance with clear economic benefits. Sugar beet (Beta vulgaris subsp. vulgaris) is the most economically valuable crop species in the order Caryophyllales, B. vulgaris subsp. maritima being the ancestor of the cultivated beets. The wild species of the genus Beta s.l. are commonly found in coastal areas of Europe and Mediterranean Region, where a rich genetic heritage still exists. Broadening the genetic base of sugar beet by introgression with wild relatives is a growing need regarding the maintenance of ecologically important traits. Since wild relatives have adapted to specific habitats, they constitute an important source of novel traits for the beet breeding pool. So, we conducted a broader research project aiming to delimit taxa and identify priority locations to establish genetic reserves of the wild Beta species occurring in Portugal (Western Iberian Peninsula). The aim of this study was: 1) to identify and characterize the main habitats of these wild Beta species;and 2) to present a review of some genetic tools available for future application in sugar beet breeding. In this review, we have focused on EcoTILLING as a molecular tool to assess DNA polymerphisms in wild populations of Beta and identify candidate genes related to drought and salt tolerance, as well as addressed some issues related to next-generation sequencing (NGS) technologies as a new molecular tool to assess adaptive genetic variation on the wild relatives of sugar beet.

关键词： Crop Wild Relatives Beta vulgaris subsp.maritima Single Nucleotide Polymorphisms(SNPs) Western Mediterranean Region EcoTILLING

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沙游在心理治疗中的作用

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作者： (瑞士)dora M. Kalff

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Highly sensitive microfiber ultrasound sensor for photoacoustic imaging

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Opto-Electronic Advances 2023年第6期6卷 4-6页

作者： Perry Ping Shum Gerd Keiser Georges Humbert dora Juan Juan Hu APing Zhang Lei Su Department of Electronic and Electrical Engineering Southern University of Science and Technology1088 Xueyuan AvenueShenzhen 518055China Department of Electrical and Computer Engineering Boston University8 Saint Mary's StreetBoston 02215America XLIM Research Institute-UMR 7252 CNRS University of Limoges123avenue Albert ThomasLimoges 87060France Institute for Infocomm Research Agency for ScienceTechnology and Research1 Fusionopolis Way#21-01Connexis South Tower Singapore 138632Singapore The Hong Kong Polytechnic University Kowloon TongHong Kong 999077China School of Engineering and Materials Science Queen Mary University of LondonMile End RoadLondon E14NSUK

An ultrasound wave is a kind of acoustic signal with a frequency greater than 20 kHz,which is widely used in diverse fields such as medical imaging diagnosis,nondestructive testing and resource exploration.A variety of ultrasound sensors have been developed for ultrasound *** for photoacoustic imaging,specialized ultrasound sensors with high sensitivity,small size,and broad bandwidth are ***,achieving such sensor perform-ance still poses a great challenge to the current state-of-the-art in ultrasound sensor technology.A recent work pub-lished in Opto-Electronic Advances(DOI:10.29026/oea.2022.200076)proposes a microfiber-based ultrasound sensor that breaks the limitations of existing ultrasound *** from the large evanescent field characteristic of mi-crofiber,combined with the coherent detection technology,the proposed sensor realized highly sensitive ultrasound de-tection and demonstrated excellent performance in high-resolution photoacoustic *** highly sensitive and mini-aturized microfiber ultrasound sensor provides a competitive alternative for various applications,such as endoscopic photoacoustic imaging of the intestinal tract and blood vessels in animals.

关键词： Highly sensor competitive

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Ileus Caused by Large Diverticulum of Postbulbar Duodenum: Case Report

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Open Journal of Gastroenterology 2015年第9期5卷 115-118页

作者： Grgi? dora Zovak Mario Brkic Marina Brkic Tomislav Division of Gastroenterology and Hepatology Department of Internal Medicine University Hospital Rebro Zagreb Croatia Clinic of Surgery University Hospital Sestre Milosrdnice Zagreb Croatia Apnea Diagnostic Clinic of Internal Medicine Neurology and Anesthesiology Reanimation and Intensive Care Zagreb Croatia

Duodenal diverticula are common and are usually found in patients undergoing roentgenographic investigation of the upper gastrointestinal tract. The majority of these cases are asymptomatic and rarely require operative intervention. Occasionally they can result in the obstruction of the biliary and/or pancreatic ducts, haemorrhage or perforation. Symptomiatic cases may require endoscopic or surgical intervention. Herein, we present a case report of a female patient who underwent surgical procedure due to repetitive obstructive symptoms.

关键词： Duodenal Diverticulum Obstruction Upper Endoscopy Diverticulectomy

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