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Retrograde intrarenal surgery for lower pole stones utilizing stone displacement technique yields excellent results

Asian Journal of Urology 2023年第1期10卷 58-63页

作者： dor golomb Hanan Goldberg Shlomi Tapiero Yariv Stabholz Paz Lotan Abd Elhalim Darawsha Ronen Holland Yaron Ehrlich David Lifshitz Department of Urology Rabin Medical Center-Beilinson HospitalPetach TikvaSackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Urology State University of New York Upstate Medical UniversitySyracuseNYUSA

Objective:To evaluate the long-term stone-free rate(SFR)of retrograde intrarenal surgery(RIRS)in the treatment of lower pole renal calculi using only basket relocation and identify independent predictors of stone-free ***:All consecutive patients undergoing RIRS lower pole renal calculi at a single highvolume tertiary center were analyzed *** pole stones were relocated to the upper pole,where laser lithotripsy was *** patients were followed up in the clinic following the surgery and yearly *** stone-free status was assessed with a combination of an abdominal ultrasound and abdominal X-ray,or an abdominal non-contrast computed tomography if the stones were known to be ***:A total of 480 consecutive patients who underwent RIRS for treatment of lower pole renal calculi,between January 2012 and December 2018,were analyzed from a prospectively maintained database of 3000 *** a median follow-up time of 18.6 months,the mean SFR was 94.8%.The procedures were unsuccessful in 26(5.4%)patients due to unreachable *** median stone size of the unreachable stones was 12 mm(range 10e30 mm).Multivariable logistic regression analysis revealed two predictors of SFR for lower pole stones:a small cumulative stone burden(odds ratio[OR]:0.903,95%confidence interval[CI]:0.867e0.941,p<0.0001)and preoperative ureteral stent insertion(OR:0.515,95%CI:0.318e0.835,pZ0.007).Conclusion:The long-term SFR of RIRS for the treatment of lower pole stones with basket displacement with appropriate patient selection is high.

关键词： Ureteroscopy Lower pole stones Retrograde intrarenal surgery Stone-free rate Basketing

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The role of melatonin receptor 1B gene(MTNR1B)in the susceptibility to depression and type 2 diabetes comorbidity

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Genes & Diseases 2024年第3期11卷 113-115页

作者： Mutaz Amin Benjamin Rafla Rongling Wu Teodor T.Postolache Cclaudia Gragnoli INSERM US14-OrphanetParis 75014France Department of Biochemistry and Molecular Biology Faculty of MedicineAl-Neelain UniversityKhartoum 11121Sudan Division of Endocrinology Department of MedicineCreighton University School of MedicineOmahaNE 68124USA Department of Public Health Sciences Penn State College of MedicineHersheyPA 17033USA Department of Statistics Penn State College of MedicineHersheyPA 17033USA Mood and Anxiety Program Department of PsychiatryUniversity of Maryland School of MedicineBaltimoreMD 21201USA Rocky Mountain Mental llness Research Education and Clinical Center(MIRECC) Veterans Integrated Service Network(VISN)19Military and Veteran Microbiome:Consortium for Research and Education(MVM-CoRE)DenverCO 80246USA Mental Ilness Research Education and Clinical Center(MIRECC) Veterans Integrated Service Network(VISN)5VA Capitol Health Care NetworkBaltimoreMD 21090USA Molecular Biology Laboratory Bios Biotech Multi-Diagnostic Health CenterRome00197Italy

Melatonin is an endogenous monoamine hormone secreted by the pineal *** signaling has been shown to play a role in circadian rhythm regulation,lipid and glucose metabolism,and obesity,and it has anti-inflammatory and antioxidant *** melatonin receptor 1B gene(MTNR1B)is expressed in,among other tissues,the brain and pancreatic beta cells,and risk variants for T2D have been reported as impairing early insulin secretion and increasing fasting glucose levels.^(1) Variants in the MTNR1B gene also have been reported in patients with depression(MDD).

关键词： MTNR1B metabolism properties.

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Prescription of Antibiotics in Oral-Dental Practice: Case of the Dental Practice at the Coyah Prefectoral Hospital in the Republic of Guinea 2019-2020

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Open Journal of Stomatology 2024年第9期14卷 373-381页

作者： Magna Condé Amadou Traoré Moussa doré Aly Badara Nabé David Ugai Seydouba Sylla Mory Doumbouya Alexandre Délamou African Center of Excellence for the Prevention and Control of Communicable Diseases (CEA-PCMT) Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea Department of Odontology Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea Department of Odontology and Maxillofacial Surgery Ignace Deen National Hospital Conakry Guinea Department of Public Health Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea

Introduction: Antibiotics are medications that have the property of destroying bacteria or preventing their proliferation. The aim of this study is to evaluate antibiotic prescriptions in oral practice: case of the dental office of the Coyah prefectural hospital. Methods: This is a descriptive cross-sectional study which took place from August 2019 to January 2020 inclusive, i.e. a duration of six (6) months, during which 400 patients were identified. Results: Our results revealed a frequency of 70% of antibiotic prescriptions. The 16 - 25-year-old age group was the most dismayed, at 47.25% and with an average age of 27.78 years. Men represent 55% compared to 45% of women, i.e. sex ratio of 1.22. Pulp gangrene was the most common pathology in 55% of cases. The most prescribed family was Betalactamine or 61.71% and the most represented molecules were Amoxicillin with 56.10% followed by Metronidazole or 34.16%. And the favorable prognosis was observed in 99% of cases. Conclusion: Prescription should always be based on the benefit-risk ratio. This prescription by practitioners aims to prevent or eradicate infections and pain in order to obtain a good therapeutic result.

关键词： Prescription Antibiotics Oral Practice Dental Office Prefectural Hospital Coyah

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Study on the Treatment of Reusable Care Equipment in Public and Private Dental Practices in the City of Conakry

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Open Journal of Stomatology 2024年第8期14卷 351-361页

作者： Magna Condé Aly Badara Nabé Moussa doré Julie Gaëlle Yepmo Sambou Alhassane Alpha Camara Amadou Traoré Kouamé Patrice Attogbain Department of Odontology Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea African Center of Excellence for the Prevention and Control of Communicable Diseases (CEA-PCMT) Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea Department of Odontology and Maxillofacial Surgery Ignace Deen National Hospital Conakry Guinea Department of Pathology and Therapeutics UFR Odonto-Stomatology Flix Houphouet University Boigny Abidjan Cte dIvoire

Introduction: The effective sterilization of reusable instruments in dental care is a crucial issue for public health. The aim of this study was to contribute to improving the processing conditions of reusable care instruments in dental practices in the city of Conakry. Methods: We carried out an observational and cross-sectional study of a descriptive type lasting three months from January to April 2022 in public and private dental practices approved for activities. Results: A total of 48 dental practices were surveyed, including 7 public and 41 private. 91.67% had the trays for instrument sterilization. 77.08% had a sterilization device. The instruments were: cleaned 100%, disinfected 70.83%, sterilized 20.83% and 20.83% reused the instruments without being sterilized. 72.97% sterilized the instruments at the end of the day. 50% of respondents declared that there were six stages of sterilization. According to standard standards, one dental office or 2.70% respected the normal sterilization process and 13.51% respected the duration and temperature. The storage quality was inadequate at 95.83%. 95.83% of dental practices are at high risk of contamination. The difficulties encountered by staff in daily activity during our study were lack of hygienists (87.50%), insufficient material resources (58.33%), and lack of protocol procedure (45.83%). Conclusion: This study allowed us to note shortcomings of dental surgeons in the process of processing reusable care materials.

关键词： Treatment Materials Care Reusable Dental Practices Conakry

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The Dental Absces: Epidemiological, Clinical and Therapeutic Aspects at the Dental Office of the Prefectoral Hospital of Siguiri in 2021 in the Republic of Guinea

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Open Journal of Stomatology 2024年第9期14卷 382-391页

作者： Magna Condé Aly Badara Nabé Fanta Madi Traoré Moussa doré Djibrila Camara Kaïn Condé Mory Sacko Francine Manto Kuete Kouamé Patrice Attogbain African Center of Excellence for the Prevention and Control of Communicable Diseases (CEA-PCMT) Faculty of Health Sciences and Techniques of the Gamal Abdel Nasser University of Conakry Conakry Guinea Department of Odontology Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea Department of Odontology and Maxillofacial Surgery of the Ignace Deen National Hospital Conakry Guinea Department of Pathology and Therapeutics UFR Odonto-Stomatology Felix Houphouet Boigny University Abidjan Ivory Coast

Introduction: A dental abscess is a collection of pus located in the tissues surrounding the tooth roots. The aim of this work is to describe the epidemiological, clinical and therapeutic aspects of dental abscess in order to contribute to the management of patients suffering from this pathology at the dental office of the Siguiri Prefectural Hospital. Methods: This was a retrospective descriptive study lasting 2 months carried out on the registers of patients received between October 2017 and October 2020 at the dental office of the Siguiri prefectural hospital. Results: 4690 patient files were identified during the study, of which 546 met our selection criteria, i.e. a frequency of 11.64%. During our study, we found 51.83% female compared to 48.17% male, i.e. a sex ratio of 1.07. 54.21% of our patients resided in rural communes compared to 45.76% for the urban commune. The age group most affected was that of 16 - 25 years old or 33.69%. Swelling, pain and functional discomfort were the reasons for consultation in all patients followed by other associated reasons in 41.21%. The premolar-molar group was the most represented, i.e. 86.70%. 80.04% of our patients presented an acute abscess compared to 19.96% of chronic cases. Antibiotic, analgesic, and mouthwash were prescribed in all patients during the study followed by 96.37% of cases prescription of steroidal anti-inflammatory drugs. 93.04% of causal teeth were extracted followed by 6.78% of cases of conservative treatment in our study. In our study, 80.95% of our patients had a good post-therapeutic outcome. Conclusion: This study highlights the need for prevention and early management of dental abscesses.

关键词： Dental Abscess Epidemiological Clinical Therapeutic

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中国式现代化的历史演进

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攀登（藏文版） 2024年第3期 1-6页

作者：才多中共青海省委党校藏学研究中心

中国式现代化是中国共产党领导和团结全国各族人民,在革命、建设和改革的长期探索和实践中形成的智慧结晶。在中国式现代化的历史演进与理论创新中,社会主义革命和建设的伟大成就为中国式现代化奠定了坚实基础;改革开放和社会主义现代... 详细信息

中国式现代化是中国共产党领导和团结全国各族人民,在革命、建设和改革的长期探索和实践中形成的智慧结晶。在中国式现代化的历史演进与理论创新中,社会主义革命和建设的伟大成就为中国式现代化奠定了坚实基础;改革开放和社会主义现代化建设的伟大成就为中国式现代化提供了快速发展的物质条件;新时代中国特色社会主义伟大成就为中国式现代化提供了更为完善的制度保证、更为坚实的物质基础、更为主动的精神力量。党的十八大以来,以习近平同志为核心的党中央进一步深化社会主义现代化建设规律的认识,成功推进和拓展了中国式现代化道路,深刻展示了以中国式现代化全面推进中华民族伟大复兴的实践逻辑。

关键词：新中国中国式现代化历史演进

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习近平文化思想的实践要求

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攀登（藏文版） 2024年第1期 1-7页

作者：才多中共青海省委党校藏学研究中心

习近平文化思想是习近平新时代中国特色社会主义思想的重要组成部分,是新时代党领导文化建设实践经验的理论总结,为我们担负起新的文化使命、建设中华民族现代文明提供了根本遵循和行动指南。习近平文化思想的形成和提出,在党的宣传思... 详细信息

习近平文化思想是习近平新时代中国特色社会主义思想的重要组成部分,是新时代党领导文化建设实践经验的理论总结,为我们担负起新的文化使命、建设中华民族现代文明提供了根本遵循和行动指南。习近平文化思想的形成和提出,在党的宣传思想文化事业发展史上具有里程碑意义,在马克思主义文化理论发展史上也具有深远意义。新时代新征程,我们要坚定文化自信,在强根固魂中推进中华民族现代文明建设;秉持开放包容,在交流互鉴中推进中华民族现代文明建设;坚持守正创新,在继承发展中推进中华民族现代文明建设。

关键词：习近平文化思想文化自信守正创新

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Genome editing in cancer:Challenges and potential opportunities

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生物活性材料(英文) 2023年第3期21卷 394-402页

作者： dor Breier Dan Peer Laboratory of Precision Nanomedicine Shmunis School of Biomedicine and Cancer ResearchGeorge S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Department of Materials Sciences and Engineering Iby and Aladar Fleischman Faculty of EngineeringTel Aviv UniversityTel AvivIsrael Center for Nanoscience and Nanotechnology Tel Aviv UniversityTel AvivIsrael Cancer Biology Research Center Tel Aviv UniversityTel AvivIsrael

Ever since its mechanism was discovered back in 2012,the CRISPR/Cas9 system have revolutionized the field of genome *** at first it was seen as a therapeutic tool mostly relevant for curing genetic diseases,it has been recently shown to also hold the potential to become a clinically relevant therapy for ***,there are multiple challenges that must be addressed prior to clinical ***,the safety of the system when used for in-vivo therapies,including off-target activity and the effects of the double strand break induction on genomic ***,we will focus on the inherent challenges in the CRISPR/Cas9 system and discuss various opportunities to overcoming these challenges.

关键词： Genome editing CRISPR/Cas systems Cancer therapy Off-target activity

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Quantification and depth distribution analysis of carbon to nitrogen ratio in forest soils using reflectance spectroscopy

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International Soil and Water Conservation Research 2023年第1期11卷 112-124页

作者： Asa Gholizadeh Mohammadmehdi Saberioon Nastaran Pouladi Eyal Ben-dor Department of Soil Science and Soil Protection Faculty of AgrobiologyFood and Natural ResourcesCzech University of Life Sciences Prague16500PragueCzech Republic Section 1.4 Remote Sensing and Geoinformatics Helmholtz Centre Potsdam GFZ German Research Centre for GeosciencesTelegrafenberg14473Potsdam Germany knoell Germany GmbH Konrad-Zuse-Ring68163MannheimGermany Remote Sensing Laboratoryeparmentof Ggraphy and HumanEnvionmnt Porter Schoolf Evionmntand Earth ScienceTelAvivUniverty 69978TelAvivIsrael

Forest soils have large contents of carbon(C)and total nitrogen(TN),which have significant spatial variability laterally across landscapes and vertically with depth due to decomposition,erosion and ***,the ratio of C to TN contents(C∶N),a crucial indicator of soil quality and health,is also different depending on soil *** attributes can cost-effectively and rapidly be estimated using visible-near infrared-shortwave infrared(VNIR-SWIR)***,the effect of different soil layers,particularly over large scales of highly heterogeneous forest soils,on the perfor-mance of the technique has rarely been *** study evaluated the potential of VNIR-SWIR spectroscopy in quantification and variability analysis of C∶N in soils from different organic and min-eral layers of forested sites of the Czech *** each site,we collected samples from the litter(L),fragmented(F)and humus(H)organic layers,and from the A_(1)(depth of 2-10 cm)and A_(2)(depth of 10-40 cm)mineral layers providing a total of 2505 *** vector machine regression(SVMR)was used to train the prediction models of the selected attributes at each individual soil layer and the merged layer(profile).We further produced the spatial distribution maps of C∶N as the target attribute at each soil *** showed that the prediction accuracy based on the profile spectral data was adequate for all ***,F was the most accurately predicted layer,regardless of the soil attribute.C∶N models and maps in the organic layers performed well although in mineral layers,models were poor and maps were reliable only in areas with low and moderate C∶*** the other hand,the study indicated that reflectance spectra could efficiently predict and map organic layers of the forested ***,in mineral layers,high values of C∶N(≥50)were not detectable in the map created based on the reflectance *** general,the study suggests that VNIR-SWIR spectrosc

关键词： Forest soil Soilorganiccarbon C:N Soilhorizons VNIR-SWIRspectroscopy

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1976-2016年普若岗日冰川和流域湖泊变化及其对气候变化的响应

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气象与环境科学 2024年第2期47卷 54-61页

作者：拉巴拉巴卓玛边多拉珍西藏高原大气环境科学研究所拉萨850001 西藏自治区气候中心拉萨850001

基于藏北地区普若岗日冰川1976-2016年多时相Landsat系列卫星影像数据,以及气温、降水量数据,采用ARCGIS空间分析、线性趋势分析、相关分析等方法,研究了普若岗日冰川和流域湖泊面积变化及其对气候变化的响应。结果表明:近41年普若岗日... 详细信息

基于藏北地区普若岗日冰川1976-2016年多时相Landsat系列卫星影像数据,以及气温、降水量数据,采用ARCGIS空间分析、线性趋势分析、相关分析等方法,研究了普若岗日冰川和流域湖泊面积变化及其对气候变化的响应。结果表明:近41年普若岗日冰川面积呈显著退缩趋势,41年内冰川面积减少了52.32 km^(2),减小率为12.01%;冰川西北部退缩最为严重,冰川面积减少了12.29 km^(2),减小率为15.77%;且冰川西北部、北部、东部和东南部末端消融显著;其他区域也有不同程度的退缩。流域湖泊面积呈显著增长趋势,共增长了27.17 km^(2),增长率为22.22%;流域气温总体上呈显著增加趋势,平均每10年增加0.48℃;降水量呈不显著上升趋势,平均每10年增加15 mm。降水对冰川和流域湖泊面积影响较小,温度的持续升高是冰川和流域湖泊变化的主要因素。

关键词：普若岗日冰川湖泊面积气候变化

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