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Much room for optimism on measuring diet, preventing cancer and cardiovascular disease, and correcting for measurement error – discussion of the paper by R. L. Prentice and Y. Huang

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Statistical Theory and Related Fields 2018年第1期2卷 14-20页

作者： donna Spiegelman Harvard T.H.Chan School of Public Health BostonMAUSA

I commend *** and Huang(PH)for their continued and longstanding commitment to the generation of knowledge concerning the nutritional causes of chronic diseases,and in their dedication to applying their extensive,and in the case of ***,virtually unparalleled,expertise towards the development of statistical methods in this regard,to which this paper is one of a long line of such contributions.

关键词： diseases cardiovascular continued

Deciphering the dual role and prognostic potential of PINK1 across cancer types

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Neural Regeneration Research 2021年第4期16卷 659-665页

作者： Katherine Dai Daniel P.Radin donna Leonardi Department of Molecular Cellularand Developmental BiologyYale UniversityNew HavenCTUSA Department of Pharmacology Stony Brook University School of MedicineStony BrookNYUSA Bergen County Academies HackensackNJUSA

Metabolic rewiring and deregulation of the cell cycle are hallmarks shared by many *** mutations in key tumor suppressor genes,such as PTEN,and oncogenes predispose cancer cells for marked utilization of resources to fuel accelerated cell proliferation and chemotherapeutic *** research has demonstrated that PTEN-induced putative kinase 1(PINK1)acts as a pivotal regulator of mitochondrial homeostasis in several cancer types,a function that also extends to the regulation of tumor cell proliferative *** addition,involvement of PINK1 in modulating inflammatory responses has been highlighted by recent studies,further expounding PINK1’s multifunctional *** review discusses the oncogenic roles of PINK1 in multiple tumor cell types,with an emphasis on maintenance of mitochondrial homeostasis,while also evaluating literature suggesting a dual oncolytic mechanism based on PINK1’s modulation of the Warburg *** a clinical standpoint,its expression may also dictate the response to genotoxic stressors commonly used to treat multiple *** detailing the evidence suggesting that PINK1 possesses distinct prognostic value in the clinical setting and reviewing the duality of PINK1 function in a context-dependent manner,we present avenues for future studies of this dynamic protein.

关键词： apoptosis cancer cell cycle inflammation metabolic stress mitochondral quality control mitophagy PINK1 tumor Warburg effect

Thiopurine use associated with reduced B and natural killer cells in inflammatory bowel disease

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World Journal of Gastroenterology 2017年第18期23卷 3240-3251页

作者： James D Lord donna M Shows Translational Research Program Benaroya Research Institute Gastroenterology Division Virginia Mason Medical Center

To identify which blood and mucosal lymphocyte populations are specifically depleted by thiopurine use in *** thiopurines azathioprine and 6-mercaptopurine have been a mainstay of inflammatory bowel disease (IBD) therapy for decades, but their mechanism of action in vivo remains obscure. Although thiopurines are lymphotoxic at high doses, and have been reported to cause T cell apoptosis in vitro, their ability to control IBD at lower doses suggests that they may selectively deplete particular lymphocyte populations. Blood cells from 19 IBD patients on a thiopurine, 19 IBD patients not on a thiopurine, and 38 matched healthy control subjects were analyzed by multiple multi-color flow cytometry panels to quantify the immune cell subsets contained therein, both as a percent of cells, and as an absolute cell count. Similar analyses were performed on colon biopsies from 17 IBD patients on a thiopurine, 17 IBD patients not on a thiopurine, and 49 healthy screening colonoscopy *** blood counts revealed lower lymphocyte, but not monocyte or granulocyte, counts in IBD patients who were taking thiopurines at the time of sampling. This reduction was restricted to CD3-negative lymphocytes, wherein both natural killer (NK) and B cells were significantly reduced among thiopurine recipients. Among CD19+ B cells, the transitional B cells were particularly depleted, being nearly absent in both blood and colon biopsies of thiopurine recipients. No differences were associated with thiopurine use in CD8+ T cells, mucosa-associated invariant T (MAIT) cells, invariant natural killer T (iNKT) cells, gamma/delta T cells, Th1, Th17, regulatory T cells (Tregs) or naïve CD4+ T cells. However, patients with IBD had significantly more circulating FOXP3+, Helios+ Tregs and fewer iNKT and MAIT cells than healthy *** use is associated with reduced B and NK cell, but not T cell, subpopulations in the blood of IBD patients.

关键词： Thiopurine Azathioprine Mercaptopurine Lymphocyte Natural killer cell Transitional B cell Inflammatory bowel disease

The impact of aging on cardiac remodeling in chronic mitral regurgitation

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Journal of Geriatric Cardiology 2023年第10期20卷 748-755页

作者： David Leibowitz donna Zwas Ronen Beeri Ronny Alcalai Israel Gotsman Heart Institute Hadassah Medical Center and Faculty of MedicineHebrew University of JerusalemJerusalemIsrael

BACKGROUND Chronic mitral regurgitation(MR)is a volume overload state that causes dilatation of the left sided cardiac *** presence of significant dilatation is considered an indication for mitral valve intervention,however,aging may affect left ventricular(LV)remodeling independently of valvular *** objective of this study was to examine age-related changes in cardiac remodeling in a broad population of patients with chronic *** Consecutive subjects that underwent echocardiography examinations recorded in the echocardiography database of a university-affiliated laboratory were *** were categorized into none/mild,moderate or severe *** purposes of analysis of differences with aging,the population was divided into groups above and below 70 years of age and standard echocardiographic measurements were compared between the *** A total of 3492 subjects with at least moderate MR(mean age:76 years,52%female)were included in the study and compared to 18,250 subjects with none or mild *** patients had significantly smaller LV end-diastolic diameters and volumes and significantly larger left atrial(LA)volumes when compared to the younger *** volume index increased in both age groups as MR severity increased,while LV end-diastolic volume increased with increasing MR only in the younger *** Cardiac remodeling in chronic MR is significantly influenced by *** based recommendations of timing of mitral valve interventions in asymptomatic MR patients,based on assessment of LA and LV remodeling,may need to take age into account.

关键词： remodeling mitral cardiac

In situ chemical oxidation of aniline by persulfate with iron(Ⅱ) activation at ambient temperature

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Chinese Chemical Letters 2010年第8期21卷 911-913页

作者： Yong Qing Zhang Wei Lin Huang donna E.Fennell College of Environmental Science and Engineering South China University of TechnologyGuangzhou 510006China The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationGuangzhou 510006China Department of Environmental Sciences RutgersThe State University of New JerseyNew BrunswickNJ 08901USA

The kinetics of aniline degradation by persulfate processes with iron（Ⅱ） activation at ambient temperature was investigated in this *** iron（Ⅱ） as initiator,the oxidation reactions were found to follow a biphasic rate phenomenon：a rapid transformation followed by a slow but sustained oxidation *** the first 30 s,the reaction mainly relies on the persulfate-Fe^（2＋） reaction in which aniline is oxidized *** 30 s,the aniline was still oxidized but the rate of reaction tended to be slower and the rates were clearly *** the initial fast oxidation,the reactions appeared to follow a pseudo-first-order model.

关键词： Persulfate Aniline In situ chemical oxidation

A review of resting-state fMRI and its use to examine psychiatric disorders

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Psychoradiology 2021年第1期1卷 42-53页

作者： Edgar Canario donna Chen Bharat Biswal Department of Biomedical Engineering New Jersey Institute of Technology619 Fenster HallNewarkNJ07102US

Resting-state fMRI(rs-fMRI)has emerged as an alternative method to study brain function in human and animal *** humans,it has been widely used to study psychiatric disorders including schizophrenia,bipolar disorder,autism spectrum disorders,and attention deficit hyperactivity *** this review,rs-fMRI and its advantages over task based fMRI,its currently used analysis methods,and its application in psychiatric disorders using different analysis methods are ***,several limitations and challenges of rs-fMRI applications are also discussed.

关键词： fMRI resting state connectivity

Preliminary landscape analysis of deep tomographic imaging patents

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Visual Computing for Industry,Biomedicine,and Art 2023年第1期6卷 20-32页

作者： Qingsong Yang donna L.Lizotte Wenxiang Cong Ge Wang Rensselaer Polytechnic Institute TroyNY 12180USA Murtha Cullina LLP BostonMA 02110USA

Over recent years,the importance of the patent literature has become increasingly more recognized in the aca-demic *** the context of artificial intelligence,deep learning,and data sciences,patents are relevant to not only industry but also academe and other *** this article,we focus on deep tomographic imaging and perform a preliminary landscape analysis of the related patent *** search tool is *** patent biblio-metric data is summarized in various figures and *** particular,we qualitatively analyze key deep tomographic patent literature.

关键词： Artificial intelligence Machine learning Deep learning Medical imaging Tomography Image reconstruction

Not all dead white men

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Not all dead white men

Integrating Sustainable Development into Global Institutions:Reforming the United Nations

作者： donna Zuckerberg.

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Chinese Journal of Population,Resources and Environment 2009年第4期7卷 3-14页

作者： donna Craig Michael I.Jeffery QC School of Law University of Western SydneyAustralia Social and Environment Responsibility Research Group School of LawUniversity of Western SydneyAustralia

This article will briefly outline the origins,structure and functions of United Nations Environment Program and the Commission on Sustainable Development in the context of the goals of ecologically sustainable development(ESD).Economic development,social development and environmental protection form the three interconnected parts of *** achievements of the key UN environmental institutions and programs in opening up the global system to civil society,the private sector and a diversity of actors and interests,promoting the role of poverty alleviation as part of ESD through the Millennium Development Goals,and facilitating important Multilateral Environmental Agreements should be ***,with these notable exceptions,organizations such as United Nations Environment Program and the Commission on Sustainable Development have become weak in scientific and technical leadership,global policy,co-ordination(inside and outside the UN) and has few achievements in the international and national implementation of obligations and standards in Global Environmental Governance-including enforcement,compliance and *** article will outline the key reasons for this *** will also be focused on the way forward through of a new United Nations Environment *** will require a clarification of purpose and function(within the UN system and as part of global governance structures) as well as consideration of whether it depends on system-wide UN *** is recommended that medium and long term strategies for reform are necessary.

关键词： ecologically sustainable development united nations environment organization UNEP global environmental governance commission on sustainable development