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Energy tunnels:concept and design aspects

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Underground Space 2018年第4期3卷 268-276页

作者： Marco Barla Alice Di donna Department of Structural Building and Geotechnical EngineeringPolitecnico di TorinoCorso Duca degli Abruzzi 2410129 TorinoItaly

Geotechnical structures are increasingly employed as energy geostructures in Europe and *** being constructed for their primary structural role,they are equipped to exchange heat with the ground and supply thermal energy for heating and cooling of buildings and de-icing of *** technology can play a fundamental role in the current challenge of addressing the increasing need for clean and renewable sources of *** study investigates the possibility of thermal activation of tunnel ***,attention will be paid on a new energy segment,which can be used together with tunnel boring machine tunneling to create so-called energy *** and mechanical designs need to be developed by making effective use of computational methods to quantify the exploitable heat and assess the possible consequences on the surrounding ground and the structure *** on how to proceed in this direction will be provided in this study,showing how thermo-hydro and thermo-mechanical numerical analyses can be used to achieve a proper and effective design of energy *** examples of possible applications will also be presented.

关键词： Energy tunnel Geothermal energy Heating and cooling Geotechnical design

High energy femtosecond mid-infrared generation pumped by a two-color Ti:sapphire multipass amplifier

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Chinese Science Bulletin 2008年第5期53卷 664-670页

作者： donna T. Strickland Department of Physics Guelph-Waterloo Physics Institute University of Waterloo 200 University Ave. W. Waterloo Ontario N2L 3G1 Canada

Intense mid-infrared was generated by direct frequency mixing two pulses from a dual-wavelength Ti:sapphire system. From a multipass amplifier we generated two tunable wavelength femtosecond pulses with a total energy of 15 mj. Pulse energy of 1.6 μj.and 7.4 μj.of mid-infrared light is achieved with and without its multipass amplifier at 9-11 μm, with pulse duration of 500 fs.

关键词：兰宝石激光器红外激光远红外激光超速激光激光放大器

Pharmacological applications of a novel neoepitope antibody to a modified amyloid precursor protein-derived beta-secretase product

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Protein & Cell 2011年第7期2卷 573-584页

作者： Guoxin Wu Sethu Sankaranarayanan donna L.Montgomery Adam j.Simon Zhiqiang An Mary j.Savage Department of Neurology Merck Research LaboratoryWest PointPA 19486USA Department of Biologics Research Merck Research LaboratoryWest PointPA 19486USA

We have previously described a novel artificial NFEVβ-secretase(BACE1)cleavage site,which when introduced into the amyloid-βprecursor protein(APP),significantly enhances APP cleavage by BACE1 in in vitro and cellular *** this study,we describe the identification and characterization of a single chain fragment of variable region(scFv),specific to the EV neo-epitope derived from BACE1 cleavage of the NFEV-containing peptide,and its conversion to *** the scFv displayed on phage and EV-IgG1 show exquisite specificity for binding to the EV neoepitope without cross-reactivity to other NFEV containing peptides or WT-APP KMDA cleavage ***-IgG1 can detect as little as 0.3 nmol/L of the EV ***-IgG1 antibody was purified,conj.gated with alkaline phosphatase and utilized in various biological *** the BACE1 enzymatic assay using NFEV substrate,a BACE1 inhibitor MRK-3 inhibited cleavage with an IC50 of 2.4 nmol/L with excellent *** an APP_NFEV stable SH-SY5Y cellular assay,the EC_(50) for inhibition of EV-Aβ peptide secretion with MRK-3 was 236 nmol/L,consistent with values derived using an EV polyclonal *** an APP_NFEV knock-in mouse model,both Aβ_EV40 and Aβ_EV42 peptides in brain homogenate showed excellent gene dosage *** conclusion,the EV neoepitope specific monoclonal antibody is a novel reagent for BACE1 inhibitor discovery for both in vitro,cellular screening assays and in vivo biochemical *** methods described herein are generally applicable to novel synthetic substrates and enzyme targets to enable robust screening platforms for enzyme inhibitors.

关键词： scFv antibody BACE1 amyloid-βprecursor protein(APP) immunoassay

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Editorial

CCS Chemistry 2024年第9期6卷 266-270页

作者： Zhang Xi Minton donna j 机构不详

“Our responsibility is to do what we can,learn what we can,improve the solutions,and pass them on.”—Richard ***,Nobel Laureate in Physics(1918–1988)With j.nuary behind us,we are well into 2024 and life has fallen back into its familiar *** is resuming,and students and professors alike are back in the lab and *** China,there is buzzing excitement for the Spring Festival and coming of the Year of the Dragon on February *** is said that,“龙行龘龘,前程朤朤”or“The dragon strides forward with determination,and the future is bright.”We have much to look forward to in the coming months.

关键词： has dragon Nobel

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CCS Chemistry 2023年第11期5卷 1-4页

作者： Xi Zhang donna j.Minton CCS Beijing Peoples R China

“A j.urney of a thousand miles begins with a single step.”—Laozi,Chinese philosopher Welcome to the first issue of CCS Chemistry for 2023!We are excited to be starting on our fifth volume of the *** our launch in 2019,we have gained a lot of momentum,reviewed thousands ofmanuscripts,and published some of the best work in *** have been very fortunate during that time to have Prof.

关键词： chemistry. j.urnal gained

Clinical supervision for novice millennial nurses in the perinatal setting: The need for generational sensitivity

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Open j.urnal of Nursing 2013年第5期3卷 373-378页

作者： j. Watson G. j. Macdonald donna Brown Lawrence S Bloomberg Faculty of Nursing University of Toronto Toronto Canada Sunnybrook Health Sciences Centre Toronto Canada

This paper reports on a qualitative research study that examined the experience of expert and novice nurses participating in a new, reflective program of “clinical supervision”, intending to facilitate the transition of new graduate nurses into the workforce. Three patterns emerged during the constructivist inquiry: readiness to reflect, valuing of clinical supervision, and sustainability of the clinical supervision model. The researchers suggest generational sensitivity as a key perspective to consider when developing engaging workplace strategies for millennial nurses. The article offers recommendations for the implementation of clinical supervision and would be of interest to nurse leaders in a clinical setting.

关键词： New Graduate Nurses Clinical Supervision Generational Sensitivity Constructivist Inquiry

Wong's nursing care of infants and children / senior consultant, donna L. Wong ; primary author, Marilyn j. Hockenberry ; section editors, David Wilson, Marilyn L. Winkelstein, Nancy E. Kline. 7th ed.

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Wong's nursing care of infants and children / senior consult...

2003年

作者： senior consultant donna L. Wong primary author Marilyn j. Hockenberry section editors David Wilson Marilyn L. Winkelstein Nancy E. Kline.

来源：畅想之星图书光盘版（南... 评论

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Editorial

CCS Chemistry 2023年第12期5卷 2674-2678页

作者： Qilin Zhou Xi Zhang donna j.Minton 不详 CCS

“These two tetrahedra are symmetrical;they cannot be superimposed:they are in relation to each other what an image is,in a mirror,in relation to the real thing.”1—Louis Pasteur,on the Discovery of Chirality,1848.

关键词： mirror symmetrical Chiral

Signaling at the Root Surface： The Role of Cutin Monomers in Mycorrhization

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Molecular Plant 2013年第5期6卷 1381-1383页

作者： j.remy D. Murray donna R. Cousins Kirsty j. j.ckson Chengwu Liu Cell and Developmental Biology John Innes Centre Norwich NR4 7UH UK

Most vascular plants interact with arbuscular mycorrhizal fungi （AMF） and are thereby provided significant advantages in nutrient acquisition, especially phosphate. The widespread retention of this symbiosis in vascular plants is testament to its importance and ancient origins. This highlight focuses on the reports of two of the first genes identified through for- ward genetic screens for AMF symbiotic mutants： Required for Abuscular Mycorrhization 1 （RAM1） and RAM2, which respectively encode a GRAS transcription factor and a glyc- erol-3-phosphate acyl-transferase （GPAT） that are required for the formation of fungal entry structures （hyphopodia） on the root surface.

关键词：共生植物转录因子转移酶类