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LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis

Genes & diseases 2024年第3期11卷 417-426页

作者： Zijian Xu elizabeth R.davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani Ben G.Marshall david Hancock Tim Wallis Julian downward Rob M.ewing donna e.d.vies Mark G.Jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK University Hospital Southampton Southampton SO166YDUK Oncogene Biology The Francis Crick InstituteLondon NW11ATUK

The factors that determine fibrosis progression or normal tissue repair are largely *** previously demonstrated that autophagy inhibition-mediated epithelial-mesenchymal transition(eMT)in human alveolar epithelial type Il(ATIl)cells augments local myofibroblast differentiation in pulmonary fibrosis by paracrine ***,we report that liver kinase B1(LKB1)inactivation in ATIl cells inhibits autophagy and induces eMT as a *** IPF lungs,this is caused by the down-regulation of CAB39L,a key subunit within the LKB1 complex.3d co-cultures of ATIl cells and MRC5 lung fibroblasts coupled with RNA sequencing(RNA-seq)confirmed that paracrine signaling between LKB1-depleted ATIl cells and fibroblasts augmented myofibroblast ***,these data suggest that reduced autophagy caused by LKB1 inhibition can induce eMT in ATIl cells and contribute to fibrosis via aberrant epithelial-fibroblast crosstalk.

关键词： CAB39L Crosstalk eMT LKB1 Pulmonary fibrosis

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Neuroimmune actions in the brain and interactions with the effects of alcohol

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Neural Regeneration Research 2021年第9期16卷 1791-1792页

作者： donna L.Gruol Neuroscience department The Scripps Research InstituteLa JollaCAUSA

The neuroimmune system of the brain:early studies(1990’s)on the neurological consequences of human immunodeficiency virus-1(HIV-1)infection in the brain were instrumental in establishing that specific brain cell types can function as an innate immune system within the brain and in that role influence cognitive function(Kaul et al.,2005).

关键词： Neuroimmune actions in the brain and interactions with the effects of alcohol

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Medical-surgical nursing : critical thinking for collaborative care / [edited by] donna d. Ignatavicius, M. Linda Workman. Fifth Edition

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2006年

作者： [edited by] donna d. Ignatavicius M. Linda Workman.

Accompanying Cd-ROM (part # 9996004309) entitled: Student Cd-ROM to accompany Medical-surgical nursing : critical thinking for collaborative care.

ISBN: (纸本)9780721604466

Accompanying Cd-ROM (part # 9996004309) entitled: Student Cd-ROM to accompany Medical-surgical nursing : critical thinking for collaborative care.

关键词： Surgical nursing.Nursing.

来源：畅想之星图书光盘版（南... 评论

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Phase 3 trial of first generation protease inhibitor therapy for hepatitis C virus/human immunodeficiency virus coinfection

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World Journal of Hepatology 2017年第4期9卷 217-223页

作者： Kenneth e Sherman Minhee Kang Richard Sterling Triin Umbleja Kristen Marks Jennifer J Kiser Beverly Alston-Smith Wayne Greaves Adeel A Butt 无 division of digestive diseases University of Cincinnati College of Medicine harvard T.h. Chan School of Public health department of Gastroenterology Virginia Commonwealth University division of Infectious disease Weill Cornell Medical School University of Colorado School of Pharmacy NIAId-division of AIdS Merck and Co Inc. University of Pittsburgh School of Medicine hamad healthcare Quality Institute the ACTG 5294 BIRTH Study Team

AIMTo evaluate efficacy/safety of hepatitis C virus (HCV) protease inhibitor boceprevir with pegylated interferon (PeG-IFN) alfa and weight-based ribavirin (RBV) in a phase 3 trial. MeTHOdSA prospective, multicenter, phase 3, open-label, single-arm study of PeG-IFN alfa, weight-based RBV, and boceprevir, with a PeG-IFN/RBV lead-in phase was performed. The HCV/human immunodeficiency virus coinfected study population included treatment naïve (TN) and treatment experienced (Te) patients. Treatment duration ranged from 28 to 48 wk dependent upon response-guided criteria. All patients had HCV Genotype 1 with a viral load > 10000 IU/mL. Compensated cirrhosis was allowed. Sample size was determined to establish superiority to historical (PeG-IFN plus RBV) rates in sustained viral response (SVR). ReSULTSA total of 257 enrolled participants were analyzed (135 TN and 122 Te). In the TN group, 81.5% were male and 54.1% were black. In the Te group, 76.2% were male and 47.5% were white. Overall SVR12 rates (HCV RNA P = 0.002). Among the TN, SVR12 was 42.1% among whites and 27.4% among blacks (P = 0.09). CONCLUSIONThe trial met its hypothesis of improved SVR compared to historical controls but overall SVR rates were low. All-oral HCV treatments will mitigate these difficulties.

关键词： Human immunodeficiency virus Hepatitis C virus Boceprevir Pegylated interferon alfa Ribavirin

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