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Network pharmacology-based exploration of molecular mechanisms underlying therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure with spleen Qi deficiency syndrome

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World Journal of Cardiology 2024年第7期16卷 422-435页

作者： Si-Qi Li dong-yu min Jun-Wen Jiang Xiao-Ying Li Xu-Na Yang Wen-Bo Gu Jia-Hui Jiang Li-Hao Chen Han Nan Ze-yu Chen Second Department of Cardiology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina

BACKGROUND Chronic heart failure is a complex clinical *** Chinese herbal compound preparation Jianpi Huatan Quyu recipe has been used to treat chronic heart failure;however,the underlying molecular mechanism is still not *** To identify the effective active ingredients of Jianpi Huatan Quyu recipe and explore its molecular mechanism in the treatment of chronic heart *** The effective active ingredients of eight herbs composing Jianpi Huatan Quyu recipe were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis *** target genes of chronic heart failure were searched in the Genecards *** target proteins of active ingredients were mapped to chronic heart failure target genes to obtain the common drugdisease targets,which were then used to construct a key chemical componenttarget network using Cytoscape 3.7.2 *** protein-protein interaction network was constructed using the String *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed through the Metascape ***,our previously published relevant articles were searched to verify the results obtained via network *** A total of 227 effective active ingredients for Jianpi Huatan Quyu recipe were identified,of which quercetin,kaempferol,7-methoxy-2-methyl isoflavone,formononetin,and isorhamnetin may be key active ingredients and involved in the therapeutic effects of TCM by acting on STAT3,MAPK3,AKT1,JUN,MAPK1,TP53,TNF,HSP90AA1,p65,MAPK8,MAPK14,IL6,EGFR,EDN1,FOS,and other *** pathways identified by KEGG enrichment analysis include pathways in cancer,IL-17 signaling pathway,PI3K-Akt signaling pathway,HIF-1 signaling pathway,calcium signaling pathway,cAMP signaling pathway,NF-kappaB signaling pathway,AMPK signaling pathway,*** studies on Jianpi Huatan Quyu recipe suggested that this Chinese compound preparation can regulate the TNF-α,IL-6,MAPK

关键词： Jianpi Huatan Quyu recipe Traditional Chinese medicine Chronic heart failure Data mining Network pharmacology Bioinformatics Spleen Qi deficiency syndrome

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Intracranial localization of arachnoid granulations in rats

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Neural Regeneration Research 2008年第4期3卷 441-443页

作者： Yanan dong min yu Lei Meng Yong Jiang Jun Gao Honghai Peng Jianguo Shi Department of Neurosurgery Jinan Central Hospital Ji＇nan 250013 Shandong Province China

BACKGROUND： This paper describes histomorphologic studies on arachnoid granulations in rats, which have not been investigated in China to our knowledge. OBJECTIVE： To observe the distribution of intracranial arachnoid granulations in rats. DESIGN, TIME AND SETTING： The observational experiment was performed in the Academy of Life Sciences of Shandong Taishan Medical College from May to August 2004. MATERIALS： Thirty healthy adult Wistar rats （3-4 months old） of SPF grade, equal numbers of each sex, were selected for this study. Methylene blue parenteral solution was provided by Jiangsu Jichuan Pharmaceutical Company （China）, and an optical microscope （Type： CH20; Olympus Co. Ltd., Japan） was used for observation of the histomorphology of the arachnoid granulations. METHOD： Injection of methylene blue parenteral solution into the cerebellomedullary cistern of rats. MAIN OUTCOME MEASURE： The blue stained parts of the lateral sinus were sectioned, stained by hematoxylin and eosin, and then observed under the microscope. RESULTS： The cavitas subarachnoidealis had extensive blue staining after methylene blue injection, while the arachnoid and dura were without dye accumulation. The blue dye indicated the location of the arachnoid granulations. The location of these granulations was fixed, mainly in the lateral sinus at both sides of confluence within 4 mm of the internal jugular vein. CONCLUSION： The arachnoid granulations of the rat were located mainly in the lateral sinuses of the dura mater.

关键词： methylene blue rats arachnoid ultrastructure cranial venous sinuses dura mater

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Field-based evidence for the enrichment of intrinsic antibiotic resistome stimulated by plant-derived fertilizer in agricultural soil

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Journal of Environmental Sciences 2024年第1期135卷 728-740页

作者： Shihai Liu Ziming Han dong Zhu Xiao Luan Liujie Deng Liping dong min Yang yu Zhang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Environmental Protection Engineering Center for Harmless Treatment and Resource Utilization of Antibiotic Residues Khorgos 835007China University of Chinese Academy of Sciences Beijing 100049China

Animal manures have been demonstrated to enhance antibiotic resistance in agricultural ***,little is known about the effects of plant-derived fertilizer on soil antibiotic ***,metagenomic sequencing was used to investigate the effects of a plantderived fertilizer processed from sugarcane and beet on soil antibiotic resistance genes(ARGs)in a soybean field along crop growth *** profiles in the soils amended by plant-derived fertilizer were compared with those in the soils amended by chicken *** abundance and diversity of total ARGs in the soils amended by plant-derived fertilizer were significantly(P<0.05)elevated at the sprout stage,to a level comparable to that in the manured ***,unlike chicken manure mainly introducing manure-borne ARGs to soil,the plant-derived fertilizer was indicated to mainly enrich multidrug resistance genes in soil by nourishing indigenous *** with abundances in amended soils significantly(P<0.05)higher than in unamended soils at the sprout stage of soybean were considered as enriched *** in the abundance of the enriched ARGs was observed in both the amended soils from the sprout to the *** analysis further identified Proteobacteria and Bacteroidetes as the primary bacterial taxa involved in the temporal variation of the enriched ARGs in the soils amended by plant-derived fertilizer,while in manured soils were Firmicutes and *** revealed by multivariate statistical analyses,variation of the enriched ARGs in the soils amended by plant-derived fertilizer was majorly attributed to the response of co-occurred bacteria to depleting nutrients,which was different from the failed establishment of manure-borne bacteria in the manured *** study provided field-based evidence that plant-derived fertilizer stimulated the intrinsic antibiotic resistome,and proposed attention to the un-perceived risk since some clinically relevant ARGs originate and evolve fr

关键词： Organic fertilizer Intrinsic antibiotic resistance Indigenous bacteria Metagenomic sequencing

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Study on viscosity mechanism of caffeine crystallization solutions Author links open overlay panel

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Particuology 2024年第8期91卷 341-350页

作者： Linjing yu min Su School of Chemical Engineering Hebei University of TechnologyTianjin300130China

The solid-liquid viscous system formed by high viscosity crystallization solution impacts the flow and separation ***,it is very important to study the viscosity mechanism to improve viscosity and regulate crystallization,ensuring a seamless production ***,the viscosity of crystallization solution was taken as the measurement parameter of caffeine as a model *** investigated the viscosity mechanism of caffeine crystallization solutions by combining experiment and *** results indicated that the weak interactions between caffeine and water result in increased viscosity of the caffeine crystallization ***,caffeine crystals possess elongated needle-like shapes,featuring a substantial specific surface ***,there isπ-πstacking occurring between the(200)crystal face and(110)crystal face,effectively fostering coalescence of the crystals towards the radial side of the crystal along its elongated axis,resulting in a more viscous crystallization *** results contribute to comprehending the viscosity mechanism of crystal systems and provide theoretical foundation to enhance engineering efficiency in crystallization.

关键词： Crystallization Caffeine Viscosity mechanism Molecular simulation

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Real-time in-situ monitoring of chiral changes during a reaction at single-molecule level

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Science China Chemistry 2024年第2期67卷 422-423页

作者： min Tan dong Xiang Institute of Modern Optics and Center of Single-Molecule Science Tianjin Key Laboratory of Micro-scale Optical Information Science and TechnologyNankai UniversityTianjin300350China School of Materials Science and Engineering Smart Sensing Interdisciplinary Science CenterNankai UniversityTianjin300350China TongLu FeiRan Garment–Nankai University Joint Laboratory Nankai UniversityTianjin300350China

Molecular chirality is a widespread phenomenon in nature,playing a critical role in various fields such as chemistry [1],life sciences [2], and materials science [3], and has therefore attracted significant attention and research by scholars [4–6].However, the chirality in chemical reactions is often dynamic, making real-time monitoring of chiral changes during chemical reactions at the single-molecule level extremely challenging.

关键词： chiral chirality critical

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利用图模型存储算法依赖关系的方法

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计算机系统应用 2024年第4期33卷 162-170页

作者：谢昌佐李子扬董裕民李雪松舒展杨光中国科学院空天信息创新研究院中国科学院定量遥感信息技术重点实验室北京100094 中国科学院大学电子电气与通信工程学院北京100094

在大数据时代,用于数据处理的算法数量呈爆发式增长,当前对大量算法的管理方法通常是对算法分类、打标签或以任务为单位存储由算法构成的流程,对任务集合中的算法间拓扑关系未能给予足够的重视.随着领域知识与任务流程的积累,算法间的... 详细信息

在大数据时代,用于数据处理的算法数量呈爆发式增长,当前对大量算法的管理方法通常是对算法分类、打标签或以任务为单位存储由算法构成的流程,对任务集合中的算法间拓扑关系未能给予足够的重视.随着领域知识与任务流程的积累,算法间的依赖关系愈发重要.本文基于巨量算法管理的需求,提出了拆分有分支依赖关系为无分支依赖关系的管理方法,通过免索引邻接图数据库的指针搜寻拓扑关系,避免Join操作,在管理算法依赖关系时具有先天优势.另外为突出算法模块复用能力,提出“连接点”的概念,在图模型中用节点表示依赖关系边,区分算法模块在不同任务流程的位置,使被多个任务复用的算法模块在图中只需用一个算法模块节点表示.最后,基于具体项目验证了本文提出的算法关系管理方法,证明本文算法关系管理方法在算法数量成规模且算法模块高复用的场景下具有明显优势.

关键词：算法关系管理拓扑拆分模块复用图模型多任务

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Constructing energetic covalent organic frameworks with high stability and low sensitivity

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Chinese Chemical Letters 2024年第3期35卷 544-548页

作者： Hui-min Guo Xiao-yu dong Shan Wang Qian-You Wang Shuang-Quan Zang Henan Key Laboratory of Crystalline Molecular Functional Materials Green Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China

Developing new functional explosives that display high stability,good energy performance,and low sensitivity are one of the key directions of energetic materials *** this work,two-dimensional(2D)Schiff-based energetic covalent organic frameworks(COFs)are prepared based on triaminoguanidine salts with different anions as building *** from the robust covalent bond in 2D extended polygons and strongπ-πinteractions in the eclipsed interlayers,the synthesized energetic COFs showed higher thermal stability and lower mechanical sensitivity than their precursor *** importantly,incorporating triaminoguanidine salts into COFs effectively increase the corrosion resistance to metal under high humidity conditions,which is due to the imine moieties in COFs functioning asπacceptors and offering strong bonding with metallic *** work provides a new pathway for the development of high-performance energetic materials.

关键词： Covalent organic frameworks Energetic materials High thermal stability Low sensitivity Corrosion resistance

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Natural products inspired[3+2]cycloaddition enables efficient construction of hydroxylated tetrahydrofuran acetals and concise syntheses of lignans

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Science China Chemistry 2024年第7期67卷 2306-2313页

作者： dong-yue Cai Weiming Shi Zhao-Hui Jin Zhi-Xiang yu Jin-Xin Zhao Jian-min yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking UniversityBeijing 100871China

Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed[3+2]cycloaddition ofα-hydroxyketone andβ-keto enol ethers,affording tetrahydrofuran acetals in a highly diastereoselective manner and 100%atom *** studies on the mechanism disclosed a concerted but asynchronous Michael addition/aldol *** the same importance,this methodology provides a practical biomimetic approach for one-step construction of the dibenzylbutyrolactol lignan backbone starting from two phenyl propane derivatives,opening up a powerful new approach for lignan synthesis,which is showcased by succinct total syntheses of two biologically important aryltetralin-type lignans,β-apopicropodophyllin and *** the mild and operationally simple conditions,the developed chemistry might have a promising prospect in potential industrial applications.

关键词： [3+2]cycloaddition transition-metal catalysis tetrahydrofuran lignans natural products

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A probabilistic model based on the peak-over-threshold approach for risk assessment of airport controllers’performance

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Journal of Safety Science and Resilience 2024年第1期5卷 110-118页

作者： Lili Zu Yijie Lu min dong College of Economics and Management Nanjing University of Aeronautics and AstronauticsNanjing 211106China School of Engineering and Applied Science George Washington UniversityWashington DC 20052USA College of Civil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Airport tower control plays an instrumental role in ensuring airport ***,obtaining objective,quantitative safety evaluations is challenging due to the unavailability of pertinent human operation *** study introduces a probabilistic model that combines aircraft dynamics and the peak-over-threshold(POT)approach to assess the safety performance of airport *** applied the POT approach to model reaction times extracted from a radiotelephony dataset via a voice event detection *** model couples the risks of tower control and aircraft operation to analyze the influence of human *** data from radiotele-phony communications and the Base of Aircraft Data(BADA)database,we compared risk levels across *** findings revealed heightened airport control risks under low demand(0.374)compared to typical conditions(0.197).Furthermore,the risks associated with coupling under low demand exceeded those under typical de-mand,with the final approach stage presenting the highest risk(4.929×107).Our model underscores the significance of human factors and the implications of mental disconnects between pilots and controllers for safety ***,these consistent findings affirm the reliability of our probabilistic model as an evaluative tool for evaluating the safety performance of airport tower *** results also illuminate the path toward quantitative real-time safety evaluations for airport controllers within the *** recommend that airport regulators focus on the performance of airport controllers,particularly during the final approach stage.

关键词： Safety evaluation Performance Probabilistic model Task demand Airport controller

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Effects of synthetic site water on bentonite-concrete system for a potential nuclear waste repository

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3786-3797页

作者： Zhao Sun Yong-Gui Chen Wei-min Ye Qiong Wang dong-Bei Wu Zhen-yu Yin Key Laboratory of Geotechnical and Underground Engineering of ministry of Education Department of Geotechnical EngineeringTongji UniversityShanghai200092China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina School of Chemical Science and Engineering Tongji UniversityShanghai200092China

In high-level nuclear waste(HLW)repositories,concrete and compacted bentonite are designed to be employed as buffer materials,which may raise a problem of interactions between concrete and *** interactions would lead to mineralogy transformation and buffer performance decay of bentonite under the near field environment conditions in a repository.A small-scale experimental setup was established to simulate the concrete-bentonite-site water interaction system from a potential nuclear waste repository in *** types of mortars were prepared to correspond to the concrete at different degradation *** results permit the determination of the following:(1)The macroproperties of Gaomiaozi(GMZ)bentonite(*** pressure,permeability,the final dry density,and water content of reacted samples);(2)The composition evolution of fluids from the synthetic site water-concrete-bentonite interaction systems;(3)The sample characterization including Fourier transform infrared spectroscopy(FTIR)and X-ray powder diffraction(XRD).Under the infiltration of the synthesis Beishan site water(BSW),the swelling pressure of bentonite decreases slowly with time after reaching its second swelling *** flux decreases with time during the infiltrations,and it tends to be stable after more than 120 *** to the cation exchange reactions in the BSW-concrete-bentonite systems,the divalent cations(Ca and Mg)were consumed,and the monovalent cations(Na and K)were *** dissolution of minerals in the bentonite such as albite causes Si increasing in the pore *** was concluded that the hydro-mechanical property degradation of bentonite takes place when it comes into contact with concrete mortar,even under low-pH groundwater *** soil dispersion,the uneven water content,and the uneven dry density in bentonite samples may partly contribute to the swelling decay of ***,the direct contact with concrete has an obvious effect on the performance

关键词： Mock-up device GMZ bentonite Site water-concrete-bentonite system Geochemistry Buffer performance

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