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End-to-side neurorrhaphy repairs peripheral nerve injury：sensory nerve induces motor nerve regeneration

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Neural Regeneration Research 2017年第10期12卷 1703-1707页

作者： Qing yu she-hong Zhang Tao Wang Feng Peng dong Han yu-dong Gu Department of Hand Surgery Huashan Hospital of Fudan UniversityKey Laboratory of Hand Reconstructionthe Ministry of HealthKey Laboratory of Peripheral Nerve and MicrosurgeryShanghaiChina Department of Rehabilitation Medicine Huashan Hospital of Fudan UniversityShanghaiChina

End-to-side neurorrhaphy is an option in the treatment of the long segment defects of a *** involves suturing the distal stump of the disconnected nerve（recipient nerve） to the side of the intimate adjacent nerve（donor nerve）.However,the motor-sensory specificity after end-to-side neurorrhaphy remains *** study sought to evaluate whether cutaneous sensory nerve regeneration induces motor nerves after end-to-side *** rats were randomized into three groups：（1） end-to-side neurorrhaphy using the ulnar nerve（mixed sensory and motor） as the donor nerve and the cutaneous antebrachii medialis nerve as the recipient nerve;（2） the sham group：ulnar nerve and cutaneous antebrachii medialis nerve were just exposed;and（3） the transected nerve group：cutaneous antebrachii medialis nerve was transected and the stumps were turned over and *** 5 months,acetylcholinesterase staining results showed that 34% ± 16% of the myelinated axons were stained in the end-to-side group,and none of the myelinated axons were stained in either the sham or transected nerve *** fluorescent tracing of spinal motor neurons and dorsal root ganglion showed the proportion of motor neurons from the cutaneous antebrachii medialis nerve of the end-to-side group was 21% ± 5%.In contrast,no motor neurons from the cutaneous antebrachii medialis nerve of the sham group and transected nerve group were found in the spinal cord *** results confirmed that motor neuron regeneration occurred after cutaneous nerve end-to-side neurorrhaphy.

关键词： nerve regeneration peripheral nerve injury end-to-side neurorrhaphy motor-sensory specificity rat dorsal root ganglion motor neuron axon cutaneous antebrachii medialis nerve ulnar nerve acetylcholinesterase staining retrograde neuron tracing neural regeneration

Oswestry功能障碍指数评分中久坐和体力活动水平与椎间盘退变的因果关系

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中国组织工程研究 2025年第2期29卷 322-330页

作者：黄仁俊杨敬言马涉王超逸赵余炀于栋北京中医药大学第三临床医学院北京市100029 北京中医药大学第三附属医院脊柱科北京市100029

背景:观察性研究表明,椎间盘退变会影响久坐和体力活动水平,然而Oswestry功能障碍指数评分中久坐和体力活动水平与椎间盘退变之间的因果关系尚不明确。目的:通过孟德尔随机化方法探讨Oswestry功能障碍指数评分中久坐和体力活动水平与椎... 详细信息

背景:观察性研究表明,椎间盘退变会影响久坐和体力活动水平,然而Oswestry功能障碍指数评分中久坐和体力活动水平与椎间盘退变之间的因果关系尚不明确。目的:通过孟德尔随机化方法探讨Oswestry功能障碍指数评分中久坐和体力活动水平与椎间盘退变的因果关系。方法:从大规模人群全基因组关联分析中选择5个与Oswestry功能障碍指数评分中行为学相关的特征:看电视的时间、用电脑的时间、轻度/中度/剧烈体力活动,分别提取这些行为学相关特征的工具变量。结合Finn Gen最新第9版数据库中提取椎间盘退变作为结局,进行孟德尔随机化分析。使用逆方差加权法、MR-Egger回归、简单中位数法、加权中位数法、加权中值法等回归模型OR值和95%CI评估Oswestry功能障碍指数评分中久坐和体力活动水平与椎间盘退变的因果关系。使用Cochran’s Q检验异质性、MR-Egger截距检验多效性、“留一法”检验单核苷酸多态性观察暴露因素和椎间盘退变因果关系的敏感性。结果与结论:孟德尔随机化逆方差加权法结果显示,看电视/用电脑的时间与椎间盘退变发病风险呈正向因果关联(OR=1.775,95%CI:1.418-2.221,P<0.001)/(OR=1.384,95%CI:1.041-1.839,P<0.001),轻度体力活动与椎间盘退变发病风险呈反向因果关联(OR=1.000,95%CI:0.999-1.000,P=0.020);MR-Egger截距分析轻度体力活动与椎间盘退变存在潜在的水平多效性(P=0.005),看电视的时间、用电脑的时间与椎间盘退变不存在水平多效性(P=0.521,P=0.851)。Cochran’s Q异质性分析看电视的时间、用电脑的时间与椎间盘退变存在异质性(P=3.33×10^(-11),P=0.001),轻度体力活动与椎间盘退变没有观察到显著的异质性(P=0.186)。以上结果表明:Oswestry功能障碍指数评分中久坐和体力活动水平与椎间盘退变存在双向因果关系,即不仅椎间盘退变会影响Oswestry功能障碍指数评分中久坐和体力活动水平,Oswestry功能障碍指数评分中久坐和体力活动水平也会影响椎间盘退变。补充了轻度体力活动对椎间盘退变积极影响的遗传证据,表明中度/剧烈体力活动与椎间盘退变没有显著的因果关系,并扩大了长时间看电视/用电脑的久坐行为是椎间盘退变危险因素的证据基础。

关键词：椎间盘退变 Oswestry功能障碍指数评分孟德尔随机化因果关系单核苷酸多态性久坐行为体力活动水平

Spatial distribution of the oxygen-18 in precipitation in China based on a new empirical model

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Journal of Mountain Science 2019年第11期16卷 2605-2614页

作者： ZHAO Pei GUO Zheng-sheng she dong-li TANG Xiang-yu Department of Geography Shangluo UniversityShangluo 726000China Key Laboratory of Mountain Surface Processes and Ecological Regulation Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China College of Urban and Environment Sciences Shanxi Normal UniversityLinfen 041000China State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Research Center of Soil and Water Conservation and Ecological EnvironmentChinese Academy of Sciences&Ministry of EducationYangling 712100China

Modeling the oxygen-18 in precipitation based on regional topography and meteorological factors is helpful to constrain missing isotopic data in some regions that is required for many paleoclimate,eco-hydrological and atmospheric circulation ***,the relationship betweenδ18Oin precipitation(δ18OPPT)and the affecting factors need to be thoroughly *** present a model considering the combined effects of temperature,altitude,and latitude on the spatial variability of annual average of stable isotopes in precipitation across *** new model performed significantly better(P<0.05)than the widely used Farquhar and Bowen&*** model allows modelling the spatial distribution of isotopes in precipitation depending on temperature *** residuals of presented model did not significantly correlate with *** on the model and residuals,a high-resolution map of annual averageδ18Opptacross China was generated.δ18OPPTdecreased from low toward high latitudes and from low towards high altitudes *** model application provides important information forancient climate,hydrological cycle and water vapor sources studies.

关键词： Climate change Isotope hydrology Geographic information Spatial distribution

The application of C–H bond functionalization in the total syntheses of indole natural products

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Organic Chemistry Frontiers 2022年第4期9卷 1195-1210页

作者： dong-Xing Tan Fu-she Han CAS Key Lab of High-Performance Synthetic Rubber and its Composite Materials Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchunJilin 130022China

The direct functionalization of unactivated C–H bonds has been a rapidly growing field in organic chem-istry in recent years because of its indisputable advantages in bond forming reactions in terms of step and atom-... 详细信息

关键词： functionalization bonds bond

Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain

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Chinese Chemical Letters 2016年第2期27卷 235-240页

作者： Chen-yu Ling yun-Liang Tao Wen-Jing Chu Hui Wang Hai-dong Wang yu-she Yang State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences School of Petrochemical Engineering Changzhou University Department of Microbiology China Pharmaceutical University

A series of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain have been designed and synthesized. In vitro antibacterial activity evaluation showed that most of the derivatives exhibited potent antibacterial activity against drug resistant Gram-positive strains. Compounds 12 a, 12 d, and 28 are the most active derivatives in this series, displaying activity comparable to that of retapamulin and BC-3781. As the metabolic stability of this series is not satisfactory, further modifications are going on to improve their pharmacokinetic profile.

关键词： Multi-drug resistant bacteria Pleuromutilin 4H-Pyran-4-one Antibacterial activity

Chord length sampling correction analysis for dispersion fuel in Monte Carlo simulation

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Nuclear Science and Techniques 2024年第4期35卷 57-64页

作者： Zhao-yu Liang Ding she yu-Tong Wen Lei Shi Institute of Nuclear and New Energy Technology(INET) Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of EducationTsinghua UniversityBeijing 100084China

Dispersion fuels,knowned for their excellent safety performance,are widely used in advanced reactors,such as hightemperature gas-cooled *** with deterministic methods,the Monte Carlo method has more advantages in the geometric modeling of stochastic *** explicit modeling method has high computational accuracy and high computational *** chord length sampling(CLS)method can improve computational efficiency by sampling the chord length during neutron transport using the matrix chord length?s probability density *** study shows that the excluded-volume effect in realistic stochastic media can introduce certain deviations into the CLS.A chord length correction approach is proposed to obtain the chord length correction factor by developing the Particle code based on equivalent transmission *** numerical analysis against reference solutions from explicit modeling in the RMC code,it was demonstrated that CLS with the proposed correction method provides good accuracy for addressing the excludedvolume effect in realistic infinite stochastic media.

关键词： Stochastic media Monte Carlo Chord length sampling Excluded-volume effect Chord length correction

Direct Electroless Nickel Plating on AZ91D Magnesium Alloy from a Sulfate Solution and its Deposition Mechanism

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材料热处理学报 2004年第05B期25卷 1098-1101页

作者： GUChang-dong LIANJian-she LIGuang-yu NIULi-yuan JIANGZhong-hao TheKeyLabofAutomobileMaterials MinistryofEducationChinaCollegeofMaterialsScienceandEngineeringJilinUniversityNanlingCampusChangchun130025China

A bath of electroless plating Ni on the AZ91D magnesium alloy, containing sulfate nickel, was given in this paper. The nucleation mechanism of Ni-P deposits on the AZ91D magnesium alloy was studied by using XRD and SEM. The electroless Ni-P deposits were preferentially nucleated on the (Mg17Al12) phase and extended to the primary and eutectic a phases of the AZ91D magnesium alloy.

关键词：非电解淀积 AZ91D 镁合金硫酸盐溶液

Crystal structure and magnetic properties of SmFe_(9-x)Co_x alloys

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Rare Metals 2014年第1期33卷 54-57页

作者： Yang Luo Dun-Bo yu Hong-Wei Li Wei-dong Zhuang Kuo-she Li Wen-Long Yan National Engineering Research Center for Rare Earth Materials General Research Institute for Nonferrous Metals Grirem Advanced Materials Co. Ltd

The crystal structure and magnetic properties of SmFeg_xCox （x = 0, 1, 3, 5） alloys were studied by X-ray powder diffraction （XRD） and magnetic measurements. The Th2Znl7-type structure of the as-cast state is changed to TbCu7-type structure after quenching to a rotating molybdenum roll under certain velocity （12, 20, and 32 m.s-l）. The （002） XRD peak appears and ^-Fe phase disappears when the Co is added up to x = 5. Saturation magnetization of SmFe9 under different temperature shows 9 % change （112-102 A.m2.g-1） when the temperature is higher than 200 K. The saturation magnetization is 115 A.m2.g-1 and coercivity is 0.304 T at 5 K for SmFe9 alloys. Increased saturation magnetization and decreased coercivity can be obtained for Co added up to x = 5 at 5 K.

关键词： TbCu7-type Crystal structure SmFe Magnetic properties

Temperature analysis of the HTR-10 after full load rejection

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Nuclear Science and Techniques 2019年第11期30卷 127-138页

作者： Xiang-Cheng Zhang Ding she Fu-Bing Chen Lei Shi yu-Jie dong Zuo-Yi Zhang Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety Ministry of Education Tsinghua University

The HTR-10 is a small modular high-temperature reactor located in Tsinghua University,in *** the reactor ran continuously for 72 h at full power in the commissioning stage,a full load rejection test was conducted by manually disconnecting the generator from the *** this study,reactor transients were analyzed using the THERMIX *** of the important thermal–fluid phenomena that occurred after the test initiation are discussed here,including the natural convection of helium in the core and the temperature redistribution in the *** reproduced for the measuring points arranged in the internals were in agreement with the test *** demonstrated that the code and calculation model are suitable for posttest analysis *** the safety features of the reactor,there was a large margin between the predicted maximum fuel temperature of 997℃and the safety limit of 1620℃.

关键词： HTR-10 Load rejection THERMIX Code validation