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Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-Yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang dong-sheng guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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Hierarchically self-assembled fluorescent nanoparticles for near-infrared lysosome-targeted imaging

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Chinese Chemical Letters 2018年第12期29卷 1709-1710页

作者： dong-sheng guo College of Chemistry State Key Laboratory of Elemento-Organic ChemistryKey Laboratory of Functional Polymer MaterialsMinistry of EducationNankai University Collaborative Innovation Center of Chemical Science and Engineering Nankai University

Manipulating emitting properties of fluorescent dyes plays a critical role in various fields such as light emitting materials, living cell imaging, and phototheranostics [1]. In particular, supramolecular strategies, such as complexation-induced quenching, aggregation-induced emission, have attracted ever-growing attention[2]. Near-infrared (NIR) probes have been demonstrated to possess

关键词： NIR Hierarchically self-assembled fluorescent nanoparticles for near-infrared lysosome-targeted imaging CB

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Exact wave functions for atomic electron interacting with photon fields

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Frontiers of physics 2013年第1期8卷 39-43页

作者： dong-sheng guo State Key Laboratory of Precision Spectroscopy East China Normal University Shanghai 200062 China Permanent address: Department of Physics Southern University and A&M College Baton Rouge LA 70813 USA

Many nonlinear quantum optical physics phenomena need more accurate wave functions and corresponding energy or quasienergy levels to account for. An analytic expression of wave functions with corresponding energy levels for an atomic electron interacting with a photon field is presented as an exact solution to the Schrödinger-like equation involved with both atomic Coulomb interaction and electron-photon interaction. The solution is a natural generalization of the quantum-field Volkov states for an otherwise free electron interacting with a photon field. The solution shows that an Nlevel atom in light form stationary states without extra energy splitting in addition to the Floquet mechanism. The treatment developed here with computing codes can be conveniently transferred to quantum optics in classical-field version as research tools to benefit the whole physics community.

关键词： Volkov-Coulomb problem driven N-level atom exact wave functions and energy levels non-perturbative quantum electrodynamics strong laser fields

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Molecular recognition of cyclophanes in water

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Chinese Chemical Letters 2024年第5期35卷 32-44页

作者： Fang-Yuan Chen Wen-Chao Geng Kang Cai dong-sheng guo College of Chemistry State Key Laboratory of Elemento-Organic ChemistryKey Laboratory of Functional Polymer Materials(Ministry of Education)Frontiers Science Center for New Organic MatterCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071China College of Chemistry Nankai UniversityTianjin 300071China

Molecular recognition in water,the biological solvent,always receives significant research focus in supramolecular *** mechanisms of molecular recognition in water is key to comprehending biological processes at the molecular *** the past five decades,supramolecular chemists have developed a vast array of synthetic receptors with highly diverse structures and recognition *** them,cyclophanes represent an important family of macrocyclic receptors that have been extensively *** aromatic moieties in cyclophanes not only facilitate chemical modifications to impart water solubility but also enable forming hydrophobic cavities for guest inclusion in aqueous *** by Koga et al.,who reported the first inclusion complex of cyclophanes in water and solid state,numerous water-soluble cyclophanes,including derivatives of blue box,calixarenes,resorcinarenes,pillararenes,octopusarenes,biphenarenes,coronarenes,and naphthotubes,etc.,have been synthesized and subjected to investigation of the recognition capabilities in aqueous *** review provides an overview of cyclophane receptors designed to bind organic guests in *** categorize them into two classes based on the modifications made to their hydrophobic cavities:those with“exo-functionalized hydrophobic cavities”and those with“endo-functionalized hydrophobic cavities”.We introduce their distinctive features and discuss strategies to enhance recognition affinity and *** review aims to inspire the development of novel synthetic receptors with intriguing properties and foster practical applications of cyclophanes.

关键词： Biomimetic receptor Cyclophane Molecular recognition Hydrophobic effect High-affinity Macrocycles

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Conditions for ponderomotive resonances in the Kapitza-Dirac effect

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Frontiers of physics 2015年第5期10卷 75-81页

作者： Chao Yu Jingtao Zhang Zhenrong Sun Ju Gao dong-sheng guo State Key Laboratory of Precision Spectroscopy Department of Physics East China Normal University Shanghai 200062 China Department of Physics Shanghai Normal University Shanghai 200234 China Suzhou Jingpin Advanced Materials Co. Ltd. Jiangsu FOHO Science Park Fenhu Town Suzhou 215211 China School of Physics Peking University Beijing 100871 China

By applying a nonperturbative quantum electrodynamic theory, we study ponderomotive resonances when an electron beam is scattered by a standing photon wave. Our study shows that the pondero- motive parameter Up, the ponderomotive energy per laser-photon energy, for each of the two traveling laser modes possesses a minimum valuehω/（mec2）. Ponderomotive resonances occur only when the ratio of the laser photon energy to the electron rest-mass energy is a fraction, where the denomina- tor is twice the square of a positive integer and the numerator is the total ponderomotive number, which is also a positive integer.

关键词： Kapitza-Dirac effect strong laser physics nonperturbative quantum electrodynamics

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A nonperturbative quantum electrodynamic approach to the theory of laser induced high harmonic generation

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Frontiers of physics 2015年第4期10卷 45-50页

作者： Chao Yu Jingtao Zhang Zhi-Wei Sun Zhenrong Sun dong-sheng guo State Key Laboratory of Precision Spectroscopy Department of Physics East China Normal University Shanghai 200062 China State Key Laboratory of High-field Laser Physics Shanghai Institute of Optical and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China Key Laboratory of Microgravity Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China School of Physics Peking University Beijing 100871 China

Using nonperturbative quantum electrodynamics, we develop a scattering theory for high harmonic generation （HHG）. A transition rate formula for HHG is obtained. Applying this formula, we cal- culate the spectra of high harmonics generated from different noble gases shined by strong laser light. We study the cutoff property of the spectra. The data show that the cutoff orders of high harmonics are greater than that predicted by the ＂3.17＂ cutoff law. As a numerical experiment, the data obtained from our repeated calculations support the newly derived theoretical expression of the cutoff law. The cutoff energy of high harmonics described by the new cutoff law, in terms of the ponderomotive energy Up and the ionization potential energy Ip, is 3.34Up 1.83Ip. The higher cutoff orders predicted by this theory are due to the absorption of the extra photons, which participate only the photon-mode up-conversion and do nothing in the photoionization process.

关键词： high harmonic generation (HHG) cutoff law strong laser physics nonperturbative quantum electrodynamics transition rate formula

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Calixarene-integrated nano-drug delivery system for tumortargeted delivery and tracking of anti-cancer drugsin vivo

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Nano Research 2022年第8期15卷 7295-7303页

作者： Lina Xu Jingshan Chai Ying Wang Xinzhi Zhao dong-sheng guo Linqi Shi Zhanzhan Zhang Yang Liu Key Laboratory of Functional Polymer Materials of Ministry of Education College of ChemistryNankai UniversityTianjin 300071China State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300071China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Nano-drug delivery systems(nanoDDS)have been extensively investigated clinically to improve the therapeutic effect of anticancer ***,the complicated synthesis during the preparation as well as the potential drug leakage during transportation has greatly limited their general *** this work,a calixarene-integrated nanoDDS(CanD)that achieves tumor-targeted delivery and tracking of anti-cancer drugs in vivo is *** hypoxia-responsive calixarene(SAC4A)exhibits high binding affinity to a series of anti-cancer drugs and rhodamine B(RhB)under normoxic condition while decreasing the binding affinity under hypoxic condition,which leads to the drug release and fluorescence recovery ***,the hypoxia-responsiveness of SAC4A conveys CanD with tumor-targeting ability,resulting in the enrichment of the drug in tumors and enhancement in tumor suppression in ***,CanD could become a general platform allowing the delivery of a wide scope of anti-cancer drugs that have strong host-guest interaction with SAC4A.

关键词： drug delivery system calixarene host-guest interaction hypoxia-responsiveness drug tracking

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On the cutoff law of laser induced high harmonic spectra

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Frontiers of physics 2015年第2期10卷 91-96页

作者： dong-sheng guo Chao Yu Jingtao Zhang Ju Gao Zhi-Wei Sun Zhenrong Sun State Key Laboratory of Precision Spectroscopy Department of Physics East China Normal University Shanghai 200062 China School of Physics Peking University Beijing 100871 China State Key Laboratory of High-field Laser Physics Shanghai Institute of Optical and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China jingpin Opto-Electronic Co. Jiangsu FOHO Science Park Fenhu Town Wujiang 215211 China Key Laboratory of Microgravity Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China

The currently well accepted cutoff law for laser induced high harmonic spectra predicts the cutoff energy as a linear combination of two interaction energies, the ponderomotive energy Up and the atomic biding energy Ip, with coefficients 3.17 and 1.32, respectively. Even though, this law has been there for twenty years or so, the background information for these two constants, such as how they relate to fundamental physics and mathematics constants, is still unknown. This simple fact, keeps this cutoff law remaining as an empirical one. Based on the cutoff property of Bessel functions and the Einstein photoelectric law in the multiphoton case, we show these two coefficients are algebraic constants, 9 - 4√2 ≈ 3.34 and 2√2-1≈1.83, respectively. A recent spectra calculation and an experimental measurement support the new cutoff law.

关键词： high harmonic generation cutoff law strong laser physics nonperturbative quantumelectrodynamics Bessel functions Einstein photoelectric effect.

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Molecular recognition of sulfonatocalixarene with organic cations at the self-assembled interface：a thermodynamic investigation

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Chinese Chemical Letters 2017年第4期28卷 787-792页

作者： Yu-Chen Pan Han-Wen Tian Shu Peng Xin-Yue Hu dong-sheng guo Department of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China Collaborative Innovation Center of Chemical Science and Engineering Nankai University Tianjin 300071 China

A microcalorimetric study on molecular recognition of p-sulfonatocalix[4]arene derivatives at selfassembled interface in comparison with in bulk water was performed,inspired by the dramatic change in physicochemical characteristics from bulk water to interface.A total of six cationic molecules were screened as model guests,including ammonium（NH_4~＋）,guanidinium（Gdm~＋）.N,N＇-dimethyl-1,4-diazabicyclo[2.2.2]octane（DMDABCO^（2＋））,tropylium（Tpm~＋）,N-methyl pyridinium（N-mPY＊） and methyl viologen（MV^（2＋））.The complexation with NH_4~＋.Gdm~＋ and DMDABCO2＊ is pronouncedly enhanced when the recognition process moved from bulk water to interface,whereas the complexation stabilities with Tpm~＋,N-mPY~＋ and MV2＊ increase slightly or even decrease to some extent.A more interesting phenomenon arises from the NH_4~＋/Gdm~＋ pair that the thermodynamic origin at interface differs definitely from each other although with similar association *** results were discussed in terms of differential driving forces,electrostatic,hydrogen bond as well as π-stacking interactions,originating from the unique physicochemical features of interfaces,mainly the polarity and dielectric constant.

关键词： Molecular recognition Calixarene Interface Thermodynamics Self-assembly

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Growth and Interface Structure of Mn on InP (001)

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Chinese Physics Letters 1998年第10期15卷 730-731页

作者： dong guo-sheng CHEN Yan SHEN Xiao-liang JIN Xiao-feng Laboratory of Surface Physics Fudan UniversityShanghai 200433 Analysis and Measurement Center Fudan UniversityShanghai 200433

An attempt to grow single crystalline thin films of body-centered-cubic(bcc)Mn on InP(001)has been carried out by molecular beam *** situ reflection high energy electron diffraction and ex situ x-ray diffraction are used to characterize the film and interface *** is found that the metastable phase of bcc Mn fails to stabilize on the substrate despite of their perfect *** result suggests again the importance of interface structure in the epitaxy of 3d metals on semiconductors.

关键词： interface cubic perfect

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