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Dynamic changes in growth factor levels over a 7-day period predict the functional outcomes of traumatic brain injury

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Neural Regeneration Research 2018年第12期13卷 2134-2140页

作者： Shuai Zhou dong-pei yin Yi Wang Ye Tian Zeng-Guang Wang Jian-Ning Zhang Department of Intensive Care Unit Tianjin Medical University General Hospital Tianjin China Tianjin Neurological Institute Tianjin China Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System Ministry of Education Tianjin China Tianjin Key Laboratory of Injuries Variations and Regeneration of Nervous System Tianjin China Department of Neurosurgery Tianjin Medical University General Hospital Tianjin China

Traumatic brain injury（TBI） can result in poor functional outcomes and death, and overall outcomes are varied. Growth factors, such as angiopoietin-1（Ang-1）, vascular endothelial growth factor（VEGF）, and granulocyte-colony stimulating factor（G-CSF）, play important roles in the neurological functions. This study investigated the relationship between serum growth factor levels and long-term outcomes after TBI. Blood samples from 55 patients were collected at 1, 3 and 7 days after TBI. Blood samples from 39 healthy controls were collected as a control group. Serum Ang-1, G-CSF, and VEGF levels were measured using ELISA. Patients were monitored for 3 months using the Glasgow Outcome Scale-Extended（GOSE）. Patients having a GOSE score of 〉 5 at 3 months were categorized as a good outcome, and patients with a GOSE score of 1-5 were categorized as a bad outcome. Our data demonstrated that TBI patients showed significantly increased growth factor levels within 7 days compared with healthy controls. Serum levels of Ang-1 at 1 and 7 days and G-CSF levels at 7 days were significantly higher in patients with good outcomes than in patients with poor outcomes. VEGF levels at 7 days were remarkably higher in patients with poor outcomes than in patients with good outcomes. Receiver operating characteristic analysis showed that the best cut-off points of serum growth factor levels at 7 days to predict functional outcome were 1,333 pg/mL for VEGF, 447.2 pg/mL for G-CSF, and 90.6 ng/mL for Ang-1. These data suggest that patients with elevated levels of serum Ang-1, G-CSF, and decreased VEGF levels had a better prognosis in the acute phase of TBI（within 7 days）. This study was registered with the Chinese Clinical Trial Registry（registration number： ChiCTR1800018251） on September 7, 2018.

关键词： nerve regeneration traumatic brain injury vascular endothelial growth factor angiopoietin-1 granulocyte-colony stimulating factor outcomes secondary brain injuries blood-brain barrier brain edema acute phase clinical trial neural regeneration

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li yin Wang peifeng Li Hai Zhu dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Low-Temperature Fabrication of Stable Black-Phase CsPbI₃ Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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NANO-MICRO LETTERS 2025年第1期17卷 1-14页

作者： Zhao, yingjie Sun, Yicheng pei, Chaoxin yin, Xing Li, Xinyi Hao, Yi Zhang, Mengru Yuan, Meng Zhou, Jinglin Chen, Yu Song, Yanlin Zhengzhou Univ Coll Chem Zhengzhou 450001 Peoples R China Zhengzhou Univ Pingyuan Lab Zhengzhou 450001 Peoples R China Chinese Acad Sci Inst Chem Key Lab Green Printing Beijing 100190 Peoples R China Chinese Acad Sci Tech Inst Phys & Chem Key Lab Bioinspired Mat & Interfacial Sci Beijing 100190 Peoples R China Chinese Acad Sci Inst High Energy Phys Beijing 100049 Peoples R China

Low-temperature fabrication of black-phase CsPbI3 perovskite films is first demonstrated by using diphenylphosphinic chloride additive under 30-50 degrees C, arising from the steric effect and chloride insertion ***-area high-quality all-inorganic perovskite films with fewer defects enhanced crystallographic orientation, and excellent environmental stability is *** record performances are demonstrated for flexible wearable photodetectors with a responsivity of 42.1 A W-1, a detectivity of 1.3 x 1014 Jones, high-fidelity image, photoplethysmography sensor functions, and high mechanical stability. Flexible wearable optoelectronic devices fabricated from organic-inorganic hybrid perovskites significantly accelerate the development of portable energy, biomedicine, and sensing fields, but their poor thermal stability hinders further applications. Conversely, all-inorganic perovskites possess excellent thermal stability, but black-phase all-inorganic perovskite film usually requires high-temperature annealing steps, which increases energy consumption and is not conducive to the fabrication of flexible wearable devices. In this work, an unprecedented low-temperature fabrication of stable black-phase CsPbI3 perovskite films is demonstrated by the in situ hydrolysis reaction of diphenylphosphinic chloride additive. The released diphenyl phosphate and chloride ions during the hydrolysis reaction significantly lower the phase transition temperature and effectively passivate the defects in the perovskite films, yielding high-performance photodetectors with a responsivity of 42.1 A W-1 and a detectivity of 1.3 x 1014 Jones. Furthermore, high-fidelity image and photoplethysmography sensors are demonstrated based on the fabricated flexible wearable photodetectors. This work provides a new perspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

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Decentralized fault diagnosis of discrete-event systems with unreliable sensors using linear temporal logic

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Science China(Information Sciences) 2025年第1期 322-341页

作者： Weijie dong Shaoyuan LI Xiang yin Key Laboratory of System Control and Information Processing Ministry of EducationDepartment of Automation Shanghai Jiao Tong University

In this paper,we investigate a decentralized diagnosis problem of a discrete-evnt system(DES) subject to unreliable sensors,where the sensor observations of local diagnosers may be non-deterministic as a result of possible *** studies on decentralized robust diagnosis can only deal with different types of sensor failures separately,e.g.,all sensors suffer from the same type of sensor failures such as intermittent sensor failures or permanent sensor ***,since sensors of different local diagnosers may face different external environments and have different internal characteristics,sensors corresponding to different local diagnosers may also have their own fault *** this paper,we propose a flexible framework of decentralized diagnosis for DES subject to unreliable sensors such that sensors of different local diagnosers are permitted to have different types of sensor *** this end,we extend the existing decentralized diagnosis framework to the case where there exist common sensors broadcasting their observations to all local *** apply linear temporal logic(LTL) to constrain infinite behaviors of private sensors of local diagnosers and common ***,a new notion of φ-codiagnosability is proposed as the necessary and sufficient condition for the existence of a decentralized diagnoser that works correctly under sensors,satisfying LTL-based sensor ***,we provide an effective approach to verify the φ-codiagnosability.

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Classifications of Isoparametric Hypersurfaces in Randers Space Forms

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Acta Mathematica Sinica,English Series 2020年第9期36卷 1049-1060页

作者： Qun HE pei Long dong Song Ting yin School of Mathematical Sciences Tongji UniversityShanghai 200092P.R.China Department of Mathematics and Computer Science Tongling UniversityTongling 244000P.R.China Key Laboratory of Applied Mathematics(Putian University) Fujian Province University

In this paper,we give the complete classifications of isoparametric hypersurfaces in Randers space *** studying the principal curvatures of anisotropic submanifolds in a Randers space(N,F)with the navigation data(h,W),we find that a Randers space form(N,F,dμBH)and the corresponding Riemannian space(N,h)have the same isoparametric hypersurfaces,but in general,their isoparametric functions are *** give a necessary and sufficient condition for an isoparametric function of(N,h)to be isoparametric on(N,F,dμBH),from which we get some examples of isoparametric functions.

关键词： Isoparametric hypersurface Randers space form principal curvature anisotropic sub-manifold

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The synthesis of micro-sized silicon carbide whiskers and the application for heat transfer enhancement

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Science China(Technological Sciences) 2014年第12期57卷 2371-2378页

作者： ZHANG pei Gen LIANG Jian dong yin Li ying GUO Sheng Min Jiangsu Key Laboratory of Advanced Metallic Materials School of Materials Science and Engineering Southeast University Mechanical Engineering Louisiana State University

This paper presents a simple and cost-effective method for the production of micro-sized silicon carbide whiskers at high yield and the effect on heat transfer enhancement for the whisker laden fluids. For SiC whisker synthesis, the starting powder mix- ture is obtained by milling short carbon fibers with the white ashes of rice hulls. Calcina：ion in argon, together with the subse- quent purification process, results in a high yield of SiC whiskers, which possess a diameter of 200-400 nm and a length of several tens of microns. The formation of the whiskers is discussed according to VS growth mechanism. Convective heat transfer performance in small channel tubes is then studied for fluid systems mixed with those micro-sized SiC whiskers at different concentrations. The heat transfer coefficient of SiC containing fluid can be significantly improved in comparison to the base fluid.

关键词： SiC whiskers Vapor-Solid whisker suspension heat transfer

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A MySQL-Based Software System of Urban Land Planning Database of Shanghai in China

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Computer Modeling in Engineering & Sciences 2023年第6期135卷 2387-2405页

作者： pei yin Jing Cheng Department of Civil Engineering School of Mechanics and Engineering ScienceShanghai UniversityShanghai200444China College of Civil and Transportation Engineering Shenzhen UniversityShenzhen518057China

With the development of the digital city,data and data analysis have become more and more *** database is the foundation of data *** this paper,the software system of the urban land planning database of Shanghai in China is developed based on *** conceptual model of the urban land planning database is proposed,and the entities,attributes and connections of this model are *** the E-R conceptual model is transformed into a logical structure,which is supported by the relational databasemanagement system(DBMS).Based on the conceptual and logical structures,by using Spring Boot as the back-end framework and using MySQL and Java API as the development tools,a platformwith datamanagement,information sharing,map assistance and other functions is *** functionalmodules in this platformare *** results of J Meter test show that the DBMS can add,store and retrieve information data stably,and it has the advantages of fast response and low error *** software system of the urban land planning database developed in this paper can improve the efficiency of storing and managing land data,eliminating redundant data and sharing data.

关键词： Software database database management system urban land planning MySQL

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Shear Strength and Dilatancy of Calcareous Sand in the South China Sea

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China Ocean Engineering 2022年第5期36卷 781-790页

作者： pei Hui-min WANG dong Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering Ocean University of ChinaQingdao 266100China Qingdao National Laboratory for Marine Science and Technology Qingdao 266100China

The shear strength and dilatancy of typical uncemented calcareous sand from the South China Sea are investigated by soil lab *** to drained triaxial tests at various relative densities and confining stresses,it is found that the constant volume friction angle is approximated as 39°and the traditional Bolton’s equations can be modified to estimate the peak friction angle and dilation *** reliability of the equation proposed for the peak friction angle is verified in terms of calcareous sands from more onshore and offshore sites worldwide,while the errors of the predicted dilation angles scatter in a relatively large ***,the dilation angles of sands in the South China Sea are estimated by the equation presented with an error of±30%.The peak friction angle measured by the undrained is similar to that by the drained tests as the relative density smaller than 60%,while the former is slightly lower for denser samples.

关键词： calcareous sand triaxial tests friction angle dilatancy drained South China Sea

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Analysis of parental strain DNA fragments existing in GEMs-Fhhh

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Journal of Environmental Sciences 2003年第5期15卷 590-594页

作者： HAOChun-bo YANJun QUMeng-meng WANGdong CHENGShu-pei GUJi-dong QIUWan-fei WANGyin-yin TheNationalKeyLaboratoryofPollutionControlandResourceReuse SchoolofEnvironmentalScienceNanjingUniversityNanjing210093China DepartmentofEcology&Biodiversity TheUniversityofHongKongPokfulamRoadHongKongChina

There were 6 target DNA fragments of the three parental strains existing in the cell of GEMs(genetically engineered microorganism strain) Fhhh measured in this research by PCR(polymerase chain reaction). The determination showed that GEMs Fhhh contained all the 6 target DNA fragments, mnp 1, mnp 2、 lip 1、 lip 2, FLO 1 and 16S rDNA, and had the molecular genetic stability. Meanwhile the PCR production of each parental strain could only had its target DNA fragments and was different from each other. It may illustrate that the technique of the inter kingdom protoplast fusion for the construction of GEMs Fhhh through the process of intercellular gene recombination could be used as a reliable bioengineering technique to create the specific functional stain for the pollution control.

关键词： GEMs protoplast fusion target gene DNA fragment PCR pollution control

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Ag/AgX nanostructures serving as antibacterial agents:achievements and challenges

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Rare Metals 2022年第2期41卷 519-539页

作者： pei-pei Li Hai-Xia Wu Alideertu dong College of Chemistry and Chemical Engineering Engineering Research Center of Dairy Quality and Safety Control TechnologyMinistry of EducationInner Mongolia UniversityHohhot 010021China

Bacterial infections,especially the frequently emerging "superbugs",seriously affect the quality of human life and even threaten human *** the emerging antimicrobial agents that effectively eradicate pathogens,nanomaterials have been widely explored due to their effectiveness against wide-spectrum bacteria and“superbugs”.Of them,Ag/AgX nanostructures(X representing Cl,Br or I)have emerged as an excellent antibacterial agent because of their excellent photocatalytic performance in inactivating pathogens under light irradiation,which provides a new opportunity for the development of high-efficient visible-light driven photocatalytic *** date,Ag/AgX nanostructures have been widely employed in antibacterial associated fields because they are efficient in producing reactive oxygen species(ROS)and reactive chlorine species(RCS)under visible light *** this review,we summarized the recent progress of Ag/AgX nanostructures as plasmonic photocatalysts in the antibacterial field,focusing on the antibacterial effects and mechanisms of Ag/AgX nanostructures,as well as their potent ***,the challenges and prospects of Ag/AgX nanostructures acting as active antibacterial agents were discussed.

关键词： Ag/AgX Photocatalytic Antibacterial Nanostructure Nanoengineering

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