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乳山震群震源谱参数的稳健反演

地球物理学报 2016年第11期59卷 4100-4112页

作者：郑建常王鹏徐长朋许崇涛刘凯李冬梅李翠芹山东省地震局济南250014 五莲地震台山东五莲262300 德州地震台山东德州253000

本文引入截止频率f_(max)提出基于Brune模型的高频截止(High-Cut)模型,采用两步反演的方法来拟合求解震源谱的特征参数,并给出其误差范围;实际应用显示该模型的理论谱对观测谱有很好的拟合,可明显改善拐角频率识别的准确度.将该方法应用... 详细信息

本文引入截止频率f_(max)提出基于Brune模型的高频截止(High-Cut)模型,采用两步反演的方法来拟合求解震源谱的特征参数,并给出其误差范围;实际应用显示该模型的理论谱对观测谱有很好的拟合,可明显改善拐角频率识别的准确度.将该方法应用于2013—2015年的乳山震群,计算了乳山震群25次M_L≥3.0事件的震源参数(地震矩、破裂半径、应力降等),进一步对乳山震群的震源破裂特性进行了讨论.结果显示:拐角频率、应力降与震源尺度大小明显相关;高频衰减系数γ与震源破裂区的复杂程度以及破裂性质有关,当观测记录中混杂有其他事件的波形或微破裂时,高频衰减系数大于2,并且不确定性增大;截止频率f_(max)与地震大小存在一定相关性;使用Beresnev(2001)给出的震源半径计算公式,得到的乳山震群的结果显示与华北地区的经验关系较为一致;乳山震群的应力降明显偏小(最大不超过0.15 MPa),一方面反映了震中区域的构造应力水平,另一方面可能还意味着此次震群是一个相对非耗散型的脆性破裂过程,属于低摩擦应力的断层作用.

关键词：震源参数拐角频率破裂半径应力降高频衰减系数

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漫反射光谱技术快速无创检测皮肤胆固醇

光谱学与光谱分析 2016年第10期36卷 3215-3221页

作者：候华毅董美丽王贻坤朱灵马祖长刘勇中国科学院合肥物质科学研究院应用技术研究所安徽合肥230031 中国科学技术大学安徽合肥230026 皖江新兴产业技术发展中心安徽省生物医学光学仪器工程技术研究中心安徽铜陵244000

针对皮肤胆固醇无创检测的迫切需求,设计了一种基于微型光谱仪的便携式和智能化的皮肤漫反射光谱实时测量系统。配制毛地黄皂苷—辣根过氧化物酶共聚物溶液,利用毛地黄皂苷可与皮肤胆固醇分子中的羟基特异性结合和辣根过氧化物酶能与TM... 详细信息

针对皮肤胆固醇无创检测的迫切需求,设计了一种基于微型光谱仪的便携式和智能化的皮肤漫反射光谱实时测量系统。配制毛地黄皂苷—辣根过氧化物酶共聚物溶液,利用毛地黄皂苷可与皮肤胆固醇分子中的羟基特异性结合和辣根过氧化物酶能与TMB试剂（主要成分为3,3’,5,5’-四甲基联苯胺）反应显色的特性,实现皮肤胆固醇的高灵敏和高特异的识别与指示,并通过测量反应后颜色的变化程度来定量皮肤胆固醇的浓度。以与人体皮肤结构相近的猪皮肤为实验对象,采用萃取法获得梯度浓度的胆固醇样本,利用上述光谱测量系统检测样本内的胆固醇浓度来验证该方法的可行性。实验结果显示,相对漫反射率能够区分不同浓度的胆固醇样本,在特征单波长（442,450和463nm）处和特征波段442-500nm内,漫反射率强度因子均可以定量反映样本内的胆固醇浓度,经线性拟合,判定系数R2分别为0.960,0.959,0.958和0.958。研究结果表明,使用漫反射光谱技术可以实现皮肤胆固醇的快速无创检测,将其应用于动脉粥样硬化性疾病风险评估,对于该类疾病的防控具有重要意义。

关键词：皮肤胆固醇无创检测漫反射光谱动脉粥样硬化

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建构主义理论及其对大学英语教学的启示

佳木斯教育学院学报 2013年第10期 302-304页

作者：董美黎南京铁道职业技术学院江苏南京210031

建构主义认为学习是积极主动的建构过程,强调以学生为中心,在整个教学过程中教师起组织者、指导者、帮助者和促进者的作用,利用情境、协作、会话等要素充分发挥学生的主体性和首创精神,使学生有效地实现对当前所学知识的意义建构。建构... 详细信息

建构主义认为学习是积极主动的建构过程,强调以学生为中心,在整个教学过程中教师起组织者、指导者、帮助者和促进者的作用,利用情境、协作、会话等要素充分发挥学生的主体性和首创精神,使学生有效地实现对当前所学知识的意义建构。建构主义理论对大学英语教学有积极的启示作用。

关键词：建构主义学习观大学英语教学启示

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汉简《神乌傅》引《诗》考述

牡丹江大学学报 2019年第3期28卷 19-22,34页

作者：董立梅苏州大学文学院江苏苏州215000

尹湾汉简《神乌傅》是至今为止出土的诗赋类简牍中保存最为完整的一篇赋作。《神乌傅》文中多处引《诗》,引《诗》范围与汉四家《诗》多有异同。很显然,汉代传《诗》,除了四家《诗》以外,还有其他的传《诗》系统。《齐诗》说以青蝇污白... 详细信息

尹湾汉简《神乌傅》是至今为止出土的诗赋类简牍中保存最为完整的一篇赋作。《神乌傅》文中多处引《诗》,引《诗》范围与汉四家《诗》多有异同。很显然,汉代传《诗》,除了四家《诗》以外,还有其他的传《诗》系统。《齐诗》说以青蝇污白喻恶妇以谗言破家,《毛诗》说、《鲁诗》说以青蝇比谗佞。据此看来,《神乌傅》所用《诗》说与《齐诗》说最为相近。《神乌傅》引《诗》既是先秦两汉引《诗》文学传统的继续,也是汉代儒学兴盛、经学发展的产物,并寄寓了作者浓烈的身世之悲,对身处末世人生际遇的感叹。

关键词：《神乌傅》异文《诗》说汉代《诗》学引《诗》意蕴

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大学英语与建构主义理论的科学结合

企业技术开发 2008年第11期27卷 159-160页

作者：董美黎南京铁道职业技术学院基础部江苏南京210015

建构主义认为教师是学生建构知识的指导者和帮助者,学生是知识的主动建构者,教学过程不是学习者被动地接受知识,而是主动地建构知识。文章结合大学英语教学实践,探讨了建构主义理论对大学英语教学的启示。

关键词：建构主义大学英语教学

Kerion celsi caused by Trichophyton violaceum:a case report

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International Journal of Dermatology and Venereology 2018年第3期1卷 178-181页

作者： Lei Shao Jing-Yao liang Si-Ying Xiong Xin Tian Xiao-dong li li-Jie Chen dong-mei li Yu-mei liu Jian-Qin Wang Institute of Dermatology Guangzhou Medical UniversityGuangzhouGuangdong 510095China Department of Dermatology Guangzhou Institute of DermatologyGuangzhouGuangdong 510095China Department of Microbiology and Immunology Georgetown University Medical CenterWashingtonDC 20057USA

Introduction Tinea capitis is defined as an infection of hair follicles on scalp and surrounding skin,and commonly caused by dermatophyte fungi[1].Tinea capitis remains a significant global public health concern in urban areas,and usually infects children aged from 3 to 7 years,but rarely affect adults and infants[2].The genera Microsporum and Trichophyton are the predominant pathogens of this disease[1].In Europe and other developed countries,the incidence of tinea capitis has substantially increased recently[1].According to a retrospective study[3],Microsporum canis (***)has been remaining the dominant pathogen for tinea capitis among children in China between 2000 and ***,the anthropophilic dermatophyte species-Trichophyton violaceum (***) was prevalent in the eastern China and therefore kerion celsi ranked as the second frequent agent of tinea capitis (12.73% in 7,684 cases)[3] Now,we report a case of kerion celsi caused by *** and retrospectively analyze kerion celsi reported in China from 2011 to 2018.

关键词： Kerion celsi Trichophyton violaceum a case report

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi li Yin Wang Peifeng li Hai Zhu dong Wang Jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-li Kang Yi Jiang Hua-Wei Zhang Xiao-mei Song Yu-Ze li Wen-li Huang dong-dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

Modular assembly of complex C-alkyl glycoside enabled via cooperative NHC and photoredox catalysis

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Science China Chemistry 2025年

作者： Rui-Qiang Jiao Ming li Xi Chen mei-Ze Xu Tian Ding Xiao-Ping Gong Zhuo-mei li Xue-Yuan liu Yong-Min liang State Key Laboratory of Applied Organic Chemistry Lanzhou University College of Chemistry and Chemical Engineering Northwest Normal University

C-Alkyl glycosides are found in natural products and are indispensable in drug development programs,owing to their diverse range of medicinal ***-component reactions involving glycosyl radical addition are well documented and proved efficient for the C-alkyl glycosides ***,multicomponent reactions for the rapid and controllable construction of structurally diversified C-alkyl glycosides in a single step remains a significant challenge due to the issues associated with balancing reactivity,compatibility,and ***,we report an NHC and photoredox co-catalyzed three-component method to access complex and valuable C-alkyl *** protocol exhibits broad substrate scope and excellent chemoand ***,nine types of sugars are compatible with this *** addition,the generality of this catalytic strategy was further highlighted by the potential for scalable production,the feasibility of further modifications of the products and its successful application in the late-stage functionalization of pharmaceutical skeletons.

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