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Standard-definition White-light,High-definition White-light versus Narrow-band Imaging Endoscopy for Detecting Colorectal Adenomas:A Multicenter Randomized Controlled Trial

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Current Medical Science 2024年第3期44卷 554-560页

作者： Chang-wei DUAN Hui-hong ZHAI Hui XIE Xian-zong MA dong-liang yu Lang YANG Xin WANG yu-fen TANG Jie ZHANG Hui SU Jian-qiu SHENG Jun-feng XU Peng JIN Chinese PLA General Hospital and Medical School Beijing100853China Department of Gastroenterology Xuanwu HospitalCapital Medical UniversityBeijing100053China Department of Gastroenterology The Seventh Medical Center of Chinese PLA General HospitalBeijing100700China Senior Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing100853China

Objective This study aimed to compare the performance of standard-definition white-light endoscopy(SD-WL),high-definition white-light endoscopy(HD-WL),and high-definition narrow-band imaging(HD-NBI)in detecting colorectal lesions in the Chinese *** This was a multicenter,single-blind,randomized,controlled trial with a non-inferiority *** undergoing endoscopy for physical examination,screening,and surveillance were enrolled from July 2017 to December *** primary outcome measure was the adenoma detection rate(ADR),defined as the proportion of patients with at least one adenoma *** associated factors for detecting adenomas were assessed using univariate and multivariate logistic *** Out of 653 eligible patients enrolled,data from 596 patients were *** ADRs were 34.5%in the SD-WL group,33.5%in the HD-WL group,and 37.5%in the HD-NBI group(P=0.72).The advanced neoplasm detection rates(ANDRs)in the three arms were 17.1%,15.5%,and 10.4%(P=0.17).No significant differences were found between the SD group and HD group regarding ADR or ANDR(ADR:34.5%vs.35.6%,P=0.79;ANDR:17.1%vs.13.0%,P=0.16,respectively).Similar results were observed between the HD-WL group and HD-NBI group(ADR:33.5%vs.37.7%,P=0.45;ANDR:15.5%vs.10.4%,P=0.18,respectively).In the univariate and multivariate logistic regression analyses,neither HD-WL nor HD-NBI led to a significant difference in overall adenoma detection compared to SD-WL(HD-WL:OR 0.91,P=0.69;HD-NBI:OR 1.15,P=0.80).Conclusion HD-NBI and HD-WL are comparable to SD-WL for overall adenoma detection among Chinese *** can be concluded that HD-NBI or HD-WL is not superior to SD-WL,but more effective instruction may be needed to guide the selection of different endoscopic methods in the *** study’s conclusions may aid in the efficient allocation and utilization of limited colonoscopy resources,especially advanced imaging technologies.

关键词： standard-definition white-light endoscopy high-definition white-light endoscopy narrow-band imaging colonoscopy colorectal cancer screening adenoma detection rate

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基于网络药理学和体外实验探讨金银花治疗IgA肾病的作用机制

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中南药学 2024年第8期22卷 2019-2024页

作者：王蕾梁冬雨曹励欧上海市嘉定区中心医院仁济医院嘉定分院肾内科上海201800 上海市嘉定区中心医院仁济医院嘉定分院临床科研中心上海201800

目的运用网络药理学预测金银花治疗IgA肾病(IgAN)潜在作用机制,进一步通过体外实验进行验证。方法通过TCMSP平台获取金银花的主要活性成分,运用GeneCards、OMIM数据库检索IgAN相关靶点,并映射到金银花的潜在作用靶点中,将IgAN和金银花... 详细信息

目的运用网络药理学预测金银花治疗IgA肾病(IgAN)潜在作用机制,进一步通过体外实验进行验证。方法通过TCMSP平台获取金银花的主要活性成分,运用GeneCards、OMIM数据库检索IgAN相关靶点,并映射到金银花的潜在作用靶点中,将IgAN和金银花靶点取交集,通过构建药物-成分-疾病-靶点网络图,进行KEGG通路富集分析。最后通过重组人IgA刺激共培养人肾小球血管内皮细胞(HRGECs)和人肾小球系膜细胞(HMCs)构建IgAN细胞模型,并给予不同浓度木犀草素进行干预,验证网络药理学结果。结果网络药理学分析结果发现PI3K-AKT信号通路可能是金银花治疗IgAN的潜在作用靶点。网络图拓扑学分析显示,活性成分木犀草素与PI3K-AKT信号通路关系最大。体外实验发现,木犀草素能抑制HMCs增殖,减少IL-6分泌,从而增强HRGECs间黏附分子的表达,改善细胞间的紧密连接,减少HRGECs单层通透性。对HMCs内PI3K-AKT信号通路相关蛋白检测发现,木犀草素可以抑制细胞内PI3K和AKT的磷酸化水平。结论木犀草素通过抑制HMCs内PI3K-AKT信号通路,抑制HMCs增殖和IL-6分泌,进而改善肾小球滤过屏障发挥治疗IgAN作用。

关键词：金银花 IgA肾病网络药理学体外实验木犀草素

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Analysis and experimental study on resistance-increasing behavior of composite high efficiency autonomous inflow control device

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Petroleum Science 2024年第2期21卷 1290-1304页

作者： liang-liang dong yu-Lin Zhang School of Mechatronic Engineering Southwest Petroleum UniversityChengdu610500SichuanChina State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina Oil and Gas Equipment Technology Sharing and Service Platform of Sichuan ProvinceChengdu610500SichuanChina

Bottom water coning is the main reason to reduce the recovery of horizontal bottom water reservoir. By water coning, we mean the oil-water interface changes from a horizontal state to a mound-shaped cone and breaks through to the wellbore. Autonomous inflow control device(AICD) is an important instrument maintain normal production after bottom water coning, however, the resistance increasing ability of the swirl type AICD is insufficient at present, which seriously affects the water control effect. Aiming this problem, this paper designs a multi-stage resistance-increasing and composite type AICD. The separation mechanism of oil-water two phases in this structure, the resistance form of oil-water single phase and the resistance-increasing principle of water phase are analyzed. Establishing the dual-phase multi-stage separation and resistance-increasing model, and verified by measuring the throttling pressure drop and oil-water volume fraction of the AICD, it is found that the composite type AICD has the effect of ICD and AICD at the same time, which can balance the production rate of each well section at the initial stage of production, delay the occurrence of bottom water coning. In the middle and later stages of production, water-blocking can be effectively increased to achieve water control and stable *** structural sensitivity analysis, the influence law of various structural parameters on the water control performance of composite AICD was obtained. The simulation calculation results show that,compared with the existing swirl type AICD, composite AICD has higher sensitivity to moisture content,the water phase throttling pressure drop is increased by 4.5 times on average. The composite AICD is suitable for the entire stage of horizontal well production.

关键词： Water control Flow separation Flow resistance-increasing AICD device Simulation and experiment

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Conservative resection for benign tumors of the proximal pancreas

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World Journal of Gastroenterology 2009年第32期15卷 4044-4048页

作者： Hai Huang Xin dong Shun-liang Gao yu-Lian Wu Department of Surgery. Second Affiliated Hospital College of Medicine Zhejiang University 88 Jiefang Road Hangzhou 310009 Zhejiang Province China

AIM:To evaluate the safety and long-term prognosis of conservative resection (CR) for benign or borderline tumor of the proximal ***: We retrospectively analyzed 20 patients who underwent CR at the Second Affi liated Hospital of Zhejiang University School of Medicine between April 2000 and October 2008. For pancreaticojejunostomy, a modified invagination method, continuous circular invaginated pancreaticojejunostomy (CCI-PJ) was used. Modified continuous closed lavage (MCCL) was performed for patients with pancreatic ***: The indications were: serous cystadenomas in eight patients, insulinomas in six, non-functional islet cell tumors in three and solid pseudopapillary tumors in three. Perioperative mortality was zero and morbidity was 25%. Overall, pancreatic fistula was present in 25% of patients. At a mean follow up of 42.7 mo, all patients were alive with no recurrence and no new-onset diabetes mellitus or exocrine ***: CR is a safe and effective procedure for patients with benign tumors in the proximal pancreas, with careful CCI-PJ and postoperative MCCL.

关键词： Adenoma Islet cell Conservative resection Cystadenoma Enucleation Insulinoma Pancreatectomy Pancreatic fistula Pancreatic neoplasms

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A visual modeling method for spatiotemporal and multidimensional features in epidemiological analysis:Applied COVID-19 aggregated datasets

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Computational Visual Media 2024年第1期10卷 161-186页

作者： yu dong Christy Jie liang Yi Chen Jie Hua School of Computer Science University of Technology SydneySydneyNSW2007Australia Beijing Key Laboratory of Big Data Technology for Food Safety Beijing Technology and Business UniversityBeijing100048China

The visual modeling method enables flexible interactions with rich graphical depictions of data and supports the exploration of the complexities of epidemiological ***,most epidemiology visualizations do not support the combined analysis of objective factors that might influence the transmission situation,resulting in a lack of quantitative and qualitative *** address this issue,we developed a portrait-based visual modeling method called+*** method considers the spatiotemporal features of virus transmission patterns and multidimensional features of objective risk factors in communities,enabling portrait-based exploration and comparison in epidemiological *** applied+msRNAer to aggregate COVID-19-related datasets in New South Wales,Australia,combining COVID-19 case number trends,geo-information,intervention events,and expert-supervised risk factors extracted from local government area-based *** perfected the+msRNAer workflow with collaborative views and evaluated its feasibility,effectiveness,and usefulness through one user study and three subject-driven case *** feedback from experts indicates that+msRNAer provides a general understanding for analyzing comprehension that not only compares relationships between cases in time-varying and risk factors through portraits but also supports navigation in fundamental geographical,timeline,and other factor *** adopting interactions,experts discovered functional and practical implications for potential patterns of long-standing community factors regarding the vulnerability faced by the *** confirmed that+msRNAer is expected to deliver visual modeling benefits with spatiotemporal and multidimensional features in other epidemiological analysis scenarios.

关键词： visual modeling epidemiological analysis spatiotemporal multidimensional COVID-19

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Computational fluid dynamics modeling of rapid pyrolysis of solid waste magnesium nitrate hydrate under different injection methods

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Chinese Journal of Chemical Engineering 2024年第2期66卷 224-237页

作者： Wenchang Wu Kefan yu liang Zhao Hui dong SEP Key Laboratory of Eco-industry School of MetallurgyNortheastern UniversityShenyang 110819China Liaoning Engineering Research Center of Energy Saving and Green Low Carbon Technology for Process Industry Northeastern UniversityShenyang 110819China

This study developed a numerical model to efficiently treat solid waste magnesium nitrate hydrate through multi-step chemical *** model simulates two-phase flow,heat,and mass transfer processes in a pyrolysis furnace to improve the decomposition rate of magnesium *** performance of multi-nozzle and single-nozzle injection methods was evaluated,and the effects of primary and secondary nozzle flow ratios,velocity ratios,and secondary nozzle inclination angles on the decomposition rate were *** indicate that multi-nozzle injection has a higher conversion efficiency and decomposition rate than single-nozzle injection,with a 10.3%higher conversion rate under the design *** decomposition rate is primarily dependent on the average residence time of particles,which can be increased by decreasing flow rate and velocity ratios and increasing the inclination angle of secondary *** optimal parameters are injection flow ratio of 40%,injection velocity ratio of 0.6,and secondary nozzle inclination of 30°,corresponding to a maximum decomposition rate of 99.33%.

关键词： Multi-nozzle Computational fluid dynamics Thermal decomposition reaction Pyrolysis furnace

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Three-dimensional stability calculation method for high and large composite slopes formed by mining stope and inner dump in adjacent open pits

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International Journal of Mining Science and Technology 2024年第4期34卷 507-520页

作者： Zuchao liang dong Wang Guanghe Li Guangyu Sun Mingyu yu dong Xia Chunjian Ding College of Mining Engineering Liaoning Technical UniversityFuxin 123000China Inner Mongolia Pingxi Baiyinhua Coal Industry Co. Ltd.Xilingol League 026000China Guoneng Baorixile Energy Co. Ltd.Hulunbuir 021008China

The 2D limit equilibrium method is widely used for slope stability ***,with the advancement of dump engineering,composite slopes often exhibit significant 3D mechanical ***,it is of significant importance to develop an effective 3D stability calculation method for composite slopes to enhance the design and stability control of open-pit slope *** the composite slope formed by the mining stope and inner dump in Baiyinhua No.1 and No.2 open-pit coal mine as a case study,this research investigates the failure mode of composite slopes and establishes spatial shape equations for the sliding *** integrating the shear resistance and sliding force of each row of microstrip columns onto the bottom surface of the strip corresponding to the main sliding surface,a novel 2D equivalent physical and mechanical parameters analysis method for the strips on the main sliding surface of 3D sliding masses is ***,a comprehensive 3D stability calculation method for composite slopes is developed,and the quantitative relationship between the coordinated development distance and its 3D stability coefficients is *** analysis reveals that the failure mode of the composite slope is characterized by cutting-bedding sliding,with the arc serving as the side interface and the weak layer as the bottom interface,while the destabilization mechanism primarily involves shear *** spatial form equation of the sliding mass comprises an ellipsoid and weak plane *** analysis revealed that when the coordinated development distance is 1500 m,the error rate between the 3D stability calculation result and the 2D stability calculation result of the composite slope is less than 8%,thereby verifying the proposed analytical method of equivalent physical and mechanical parameters and the 3D stability calculation method for composite ***,the3D stability coefficient of the composite slope exhibits an exponential co

关键词： Composite slope Destabilization mechanism 3D mechanical effect Three-dimensional stability Coordinated development distance

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Evaluation of the Relative Tectonic Activity from the Faults in the Gengma-Lancang-Menghai Seismic Belt(Southwestern China)

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Journal of Earth Science 2024年第1期35卷 131-143页

作者： Dan Wang Youpu dong Zhipeng Xi dongyue Zhang Jiaxin Duan Huayu yu liang yu Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming 650093China

The Gengma-Lancang-Menghai seismic belt,the southernmost part of the North-South seismic belt,is controlled by four active faults:the Nantinghe fault(NTHF),the Sanjianshan fault(SJSF),the Hanmuba-Lancang fault(HMB-LCF),and the Heihe fault(HHF),from northwest to ***,the tectonic activity of the faults in the Gengma-Lancang-Menghai seismic belt has not been fully studied *** the present work,we conducted tectonic geomorphic indices to analyze the relative tectonic activity along the faults in the seismic belt based on the digital elevation *** interpreted asymmetric factor,index of drainage basin shape,hypsometric integral,normalized streamlength gradient,valley floor-to-width to height ratio,and longitudinal profiles to show that the relative tectonic activity is higher in the north and lower in the south,and is strong in the region from Shanjia to Huimin in the center of the seismic belt.

关键词： Gengma-Lancang-Menghai seismic belt southeastern Tibetan Plateau geomorphic indices longitudinal profile

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A semi-analytical model for coupled flow in stress-sensitive multi-scale shale reservoirs with fractal characteristics

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Petroleum Science 2024年第1期21卷 327-342页

作者： Qian Zhang Wen-dong Wang yu-liang Su Wei Chen Zheng-dong Lei Lei Li Yong-Mao Hao Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Shale Oil Development Branch Changqing Oilfield CompanyPetroChinaQingyang745708GansuChina PetroChina Research Institute of Petroleum Exploration&Development Beijing100083China

A large number of nanopores and complex fracture structures in shale reservoirs results in multi-scale flow of oil. With the development of shale oil reservoirs, the permeability of multi-scale media undergoes changes due to stress sensitivity, which plays a crucial role in controlling pressure propagation and oil flow. This paper proposes a multi-scale coupled flow mathematical model of matrix nanopores, induced fractures, and hydraulic fractures. In this model, the micro-scale effects of shale oil flow in fractal nanopores, fractal induced fracture network, and stress sensitivity of multi-scale media are considered. We solved the model iteratively using Pedrosa transform, semi-analytic Segmented Bessel function, Laplace transform. The results of this model exhibit good agreement with the numerical solution and field production data, confirming the high accuracy of the model. As well, the influence of stress sensitivity on permeability, pressure and production is analyzed. It is shown that the permeability and production decrease significantly when induced fractures are weakly supported. Closed induced fractures can inhibit interporosity flow in the stimulated reservoir volume (SRV). It has been shown in sensitivity analysis that hydraulic fractures are beneficial to early production, and induced fractures in SRV are beneficial to middle production. The model can characterize multi-scale flow characteristics of shale oil, providing theoretical guidance for rapid productivity evaluation.

关键词： Multi-scale coupled flow Stress sensitivity Shale oil Micro-scale effect Fractal theory

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Energy Economic Dispatch for Photovoltaic-Storage via Distributed Event-Triggered Surplus Algorithm

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Energy Engineering 2024年第9期121卷 2621-2637页

作者： Kaicheng Liu Chen liang Naiyue Wu Xiaoyang dong Hui yu China Electric Power Research Institute Beijing100192China Electric Power Research Institute of State Grid Gansu Electric Power Company Lanzhou730000China State Key Laboratory of Power Grid Safety Beijing100084China

This paper presents a novel approach to economic dispatch in smart grids equipped with diverse energy *** method integrates features including photovoltaic(PV)systems,energy storage coupling,varied energy roles,and energy supply and demand *** systemmodel is developed by considering energy devices as versatile units capable of fulfilling various functionalities and playing multiple roles *** strike a balance between optimality and feasibility,renewable energy resources are modeled with considerations for forecasting errors,Gaussian distribution,and penalty ***,this study introduces a distributed event-triggered surplus algorithm designed to address the economic dispatch problem by minimizing production *** in surplus theory and finite time projection,the algorithm effectively rectifies network imbalances caused by directed graphs and addresses local inequality *** algorithm greatly reduces the communication burden through event triggering ***,both theoretical proofs and numerical simulations verify the convergence and event-triggered nature of the algorithm.

关键词： Fully distributed algorithm economic dispatch directed graph renewable energy resource

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