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膜式干燥器的原理与应用

压缩机技术 2013年第4期 66-71页

作者：董鹏举贝克欧技术(中国)有限公司上海200122

从膜材料的结构构成入手,分析了分子膜因高低选择性不同而对膜式干燥器构成的性能影响,并以此解释了膜式干燥器的工作原理;结合几个典型案例来阐述膜式干燥器的适用场合。

关键词：膜式干燥器高分子膜渗透分子扩散露点降

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无需信源数目的相干信号方位估计算法

火力与指挥控制 2012年第9期37卷 55-57页

作者：曾耀平董鹏举西安邮电学院通信与信息工程学院西安710121

针对空间平滑MUSIC算法会损失阵列的有效孔径且需要信源先验数目的问题,提出了一种新算法。该算法从矢量重构的思路出发,通过对接收数据协方差矩阵的最大特征向量进行矢量重构,即可实现不损失阵列孔径的解相干处理,同时利用全空间加权MU... 详细信息

针对空间平滑MUSIC算法会损失阵列的有效孔径且需要信源先验数目的问题,提出了一种新算法。该算法从矢量重构的思路出发,通过对接收数据协方差矩阵的最大特征向量进行矢量重构,即可实现不损失阵列孔径的解相干处理,同时利用全空间加权MUSIC算法,实现了信源数目未知下的相干信号准确定位。仿真结果证实了该方法的有效性。

关键词：相干信号矢量重构波达方向估计

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厂级AGC系统概要

电力系统装备 2019年第16期 18-19页

作者：董鹏举中国电建集团山东电力建设有限公司山东济南250102

长期以来,国内电厂中,安全就是效益的理念早已深入人心,安全运行早已是电厂运行各级管理人员日常工作的主题,并且也早已成为电厂运行的唯一宗旨,因此很少有人去真正关心如何更经济运行,降低运营成本.随着电厂自动化程度的提高,安全运行... 详细信息

长期以来,国内电厂中,安全就是效益的理念早已深入人心,安全运行早已是电厂运行各级管理人员日常工作的主题,并且也早已成为电厂运行的唯一宗旨,因此很少有人去真正关心如何更经济运行,降低运营成本.随着电厂自动化程度的提高,安全运行的压力已大大降低,如何节约运营成本、提高经济效益便逐渐进入电厂生产管理的舞台.本文主要介绍厂级AGC系统及其功能.

关键词：厂级AGC 控制模式功能实现

广州(NBA)国际体育演艺中心工程现浇混凝土楼板裂缝控制

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建筑技术 2010年第5期41卷 440-442页

作者：曾兆平董鹏举周凯北京城建集团北京100088

在广州(NBA)国际体育演艺中心工程结构施工中,针对楼板施工过程中可能产生的裂缝类型和裂缝出现的原因,分别进行了分类和分析,并制定了相应的预防措施,达到了预期的效果。

关键词：广州(NBA)国际体育演艺中心现浇混凝土楼板裂缝控制措施

Protective effect of tubuloside B on TNFα-induced apoptosis in neuronal cells

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Acta Pharmacologica Sinica 2004年第10期 36-44页

作者： Min DENG, Jin-yuan ZHAO, Xiao-dong ju, peng-fei TU, Yong JIANG, Zheng-bin LIResearch Center of Occupational Medicine, Department of Orthopaedics, Peking University Third Hospital, Beijing 100083, China Peking University Modem Research Center for Traditional Chinese Medicine, Beijing 100083, China Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China

AIM: To investigate the neuroprotective effect of tubuloside B, one of the phenylethanoids isolated from the stems of Cistanche salsa, on tumor necrosis factor-alpha (TNFα)-induced apoptosis in SH-SY5Y neuronal cells. METHODS: Cell viability was analyzed using MTT assay. Apoptotic cells were detected using Hoechst33342 staining, and confirmed by DNA fragmentation and flow cytometric analysis. The activity of caspase-3 was measured with special assay kit. The concentration of free intracellular calcium was determined with the probe Indo-1 by spectrometer. The level of intracellular reactive oxygen species and the potential of mitochondrial membrane were determined by laser scanning confocal microscopy (LSCM) combined with fluorescence probe H2DCFDA or JC-1 respectively. RESULTS: SH-SY5Y cells treated with TNFa 100 μg/L for 36 h showed typical morphological changes of apoptosis. DNA ladder could be observed by agarose gel electrophoresis. The highest percentage of apoptotic cells accumulated to 37.5 %. F

关键词： tubuloside B apoptosis tumor necrosis factor SH-SY5Y cells mitochondria membrane potential reactive oxygen species caspase-3 calcium

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智能调峰e型零气耗鼓风热干燥器系统的研究

压缩机技术 2023年第4期 58-62页

作者：许鹏程董鹏举贝克欧净化科技南通有限公司江苏南通226010

系统采用网络搜索跟踪技术通过对国家电网各省的分时电价进行实时监测,由云端服务器通过强大的云计算功能,对干燥器运行大数据进行趋势分析及智能判断,通过自行研发的基于IIoT技术的智联云管家,把干燥器再生时的耗能阶段精准控制在夜间... 详细信息

系统采用网络搜索跟踪技术通过对国家电网各省的分时电价进行实时监测,由云端服务器通过强大的云计算功能,对干燥器运行大数据进行趋势分析及智能判断,通过自行研发的基于IIoT技术的智联云管家,把干燥器再生时的耗能阶段精准控制在夜间用电低谷时段,使用夜间电网上的过剩电能进行再生工作,降低了电网日间碳排放量,为实现碳中和做出了贡献。同时由于低谷电费大约是高峰电价的四分之一左右,这使得e型干燥器的综合运行成本相对于标准机型降低约55%~61%,为用户带来了明显的收益。

关键词：智能干燥器电力避峰就谷碳中和降低成本

基于极限梯度爬升算法与支持向量回归算法变权组合模型致密油的采收率预测

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科学技术与工程 2022年第12期22卷 4778-4787页

作者：张金水田冷黄诗慧董鹏举中国石油大学(北京)石油工程学院北京102200

致密油储层因具有渗透率与产能低下的特点,多采用大型水力压裂改造储层来提高采收率,根据不同的地质、压裂参数变化,预测改造后的采收率对于压裂施工改造有良好的指导作用。目前多因素影响的致密油压裂后采收率预测理论模型,难以实时准... 详细信息

致密油储层因具有渗透率与产能低下的特点,多采用大型水力压裂改造储层来提高采收率,根据不同的地质、压裂参数变化,预测改造后的采收率对于压裂施工改造有良好的指导作用。目前多因素影响的致密油压裂后采收率预测理论模型,难以实时准确地根据压裂方式及参数来预测压裂后油藏采收率变化。为进一步提升致密油的采收率预测精确度,引进机器学习进行预测,基于极限梯度爬升算法(extreme gradient boosting algorithm,XGBoost)和支持向量回归算法(support vector regression algorithm,SVR)进行了一定改进得到变权组合模型XGBoost-SVR,模型借鉴残差进化机制,实现加权融合系数的最优组合,该组合模型可对两种单模型进行优势互补,避免了因单一模型参数导致的范围性误差,增大模型预测容错率。首先对致密油的采收率影响因素进行收集整理,分析地质因素、储层因素和工程因素对采收率的影响,构造相关原始数据集;其次将预处理后数据集输入SVR单模型和XGBoost单模型分别进行训练,得出单模型预测值;最后采用基于残差的自适应的变权组合方法建立XGBoost-SVR组合模型,得到各模型最终预测结果,明确采收率影响因素及各影响因素权重比。模型预测结果表明:与SVR和XGBoost单模型相比,组合模型在预测精度达到94.63%,表现出更好的适应性。

关键词：致密油采收率预测极限梯度爬升算法-支持向量回归算法(XGBoost-SVR) 机器学习

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang ju-Yun Ma peng-peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Dermatitis bullosa caused by the immune checkpoint inhibitor camrelizumab:A case report

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World Journal of Clinical Cases 2025年第8期13卷 15-21页

作者： Yuan-Jing Jiang Lu Wu Xiao Yang Yu Pu Bing-Jie Ning Na peng Xiao-ju Zhu Cancer Center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Since the advent of the 20th century,alongside the progression of medical science and technological advancements,immunotherapy has emerged as a pivotal thera-peutic approach for tumor patients subsequent to undergoing radiotherapy and ***(camrelizumab),a flagship drug in the realm of immuno-therapy,functions as a monoclonal antibody specifically targeting the progra-mmed death protein 1(PD-1).This drug engages with the human PD-1 receptor,effectively inhibiting the PD-1/programmed death ligand 1 signaling *** inhibition results in the restoration of T cell activity and the induction of an anti-tumour ***,it is noteworthy that such interference could lead to immune-related adverse events resembling autoimmune *** grow-ing availability and clinical use of immune checkpoint inhibitors have raised sig-nificant clinical concerns regarding their *** instances of immune-related adverse reactions and the associated management strategies have been extensively *** identification and diagnosis,coupled with multidi-sciplinary consultation and the prompt administration of immunosuppressants,can effectively address severe immune-related adverse *** SUMMARY Arimab(camrelizumab),a monoclonal antibody targeting programmed death protein 1(PD-1),disrupts the PD-1/programmed death ligand 1(PD-L1)inter-action,reactivating T cell function and triggering anti-tumor ***,this disruption may trigger immune-mediated adverse events akin to autoim-mune *** 2.8%of such events manifest as immune-related dermatologic reactions,with 0.7%classified as grade 3,which are infrequently ***,this study describes a case of grade 3 bullous dermatitis occur-ring 15 days after initiating camrelizumab *** patient,a 67-year-old male with oesophageal squamous cell carcinoma,received camrelizumab plus paclitaxel alongside chemotherapy and radiotherapy in early ***

关键词： Camrelizumab Anti-programmed cell death protein-1 blockade Skin-related adverse events Immune-related dermatitis Case report