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Genomes reveal selective sweeps in kiang and donkey for high-altitude adaptation

Zoological Research 2021年第4期42卷 450-460页

作者： Lin Zeng He-Qun Liu Xiao-Long Tu Chang-Mian Ji Xiao Gou Ali Esmailizadeh Sheng Wang Ming-Shan Wang Ming-Cheng Wang Xiao-Long Li Hadi Charati Adeniyi CAdeola Rahamon Akinyele Moshood Adedokun Olatunbosun Oladipo Sunday Charles Olaogun Oscar JSanke Mangbon Godwin F Sheila Cecily Ommeh Bernard Agwanda Jacqueline Kasiiti Lichoti Jian-Lin Han Hong-Kun Zheng Chang-Fa Wang Ya-Ping Zhang Laurent A.F.Frantz dong-dong wu State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Hainan Key Laboratory for Biosafety Monitoring and Molecular Breeding in Off-Season Reproduction Regions Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural SciencesHaikouHainan 571101China College of Animal Science and Technology Yunnan Agricultural UniversityKunmingYunnan 650201China Department of Animal Science Faculty of AgricultureShahid Bahonar University of KermanKermanPB 76169-133Iran Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Sino-Africa Joint Research Center Chinese Academy of SciencesKunmingYunnan 650223China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China Institute of Three-River-Source National Park Chinese Academy of SciencesXiningQinghai 810008China School of Biological and Chemical Sciences Queen Mary University of LondonLondon E14NSUK Department of Genetics Albert Einstein College of MedicineBronxNew YorkNY 10461USA Annoroad Gene Tech.(Beijing)Co. Ltd.Beijing 100176China State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsGermplasm Bank of Wild SpeciesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Department of Veterinary Medicine University of IbadanIbadan 200284Nigeria Federal College of Animal Health and Production Technology Moor-PlantationIbadan 234102Nigeria Taraba State Ministry of Agriculture and Natural Resources Jalingo 660221Nigeria Division of Veterinary Office Serti 663101Nigeria Institute For Biotechnology Research Jomo Kenyatta University of Agriculture and Technology Nairobi 62000-00200Kenya Department of Zoology National Museums of KenyaNairobi 40658-00100Kenya State Department of Livestock Ministry of AgricultureLivestockFisheries and IrrigationN

Over the last several hundred years,donkeys have adapted to high-altitude conditions on the Tibetan ***,the kiang,a closely related equid species,also inhabits this *** reports have demonstrated the importance of specific genes and adaptive introgression in divergent lineages for adaptation to hypoxic conditions on the Tibetan ***,we assessed whether donkeys and kiangs adapted to the Tibetan Plateau via the same or different biological pathways and whether adaptive introgression has *** assembled a de novo genome from a kiang individual and analyzed the genomes of five kiangs and 93 donkeys(including 24 from the Tibetan Plateau).Our analyses suggested the existence of a strong hard selective sweep at the EPAS1 locus in *** Tibetan donkeys,however,another gene,i.e.,EGLN1,was likely involved in their adaptation to high *** addition,admixture analysis found no evidence for interspecific gene flow between kiangs and Tibetan *** findings indicate that despite the short evolutionary time scale since the arrival of donkeys on the Tibetan Plateau,as well as the existence of a closely related species already adapted to hypoxia,Tibetan donkeys did not acquire adaptation via admixture but instead evolved adaptations via a different biological pathway.

关键词： Kiang Donkey High altitude Adaptation Selection

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Characterization and genomic analysis of Pseudoalteromonas phage v B_Pal P_Y7,representing a novel viral genus,Miuvirus

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Journal of Oceanology and Limnology 2025年第1期43卷 299-312页

作者： Miaolan wu Hongmin WANG Ye MI Yantao LIANG Kaiyang ZHENG Yundan LIU Yue dong Linyi REN Yue SU Hongbing SHAO Yeong Yik SUNG Wen Jye MOK Li Lian WONG Min WANG College of Marine Life Sciences Institute of Evolution and Marine BiodiversityMoE Laboratory of Evolution and Marine BiodiversityFrontiers Science Center for Deep Ocean Multispheres and Earth SystemCenter for Ocean Carbon NeutralityOcean University of ChinaQingdao 266100China Qingdao City Center for Disease Control and Prevention Qingdao Institute of Prevention MedicineQingdao 266033China UMT-OUC Joint Centre for Marine Studies Qingdao 266100China Institute of Marine Biotechnology Universiti Malaysia TerengganuKuala Terengganu 21030Malaysia Haide College Ocean University of ChinaQingdao 266100China The Affiliated Hospital of Qingdao University Qingdao 266000China

Pseudoalteromonas is a group of marine bacteria widespread in diverse marine sediments,producing a wide range of bioactive ***,only a limited number of Pseudoalteromonas phages have been isolated and *** this study,a novel lytic Pseudoalteromonas phage,denoted as vB_PalP_Y7,was isolated from sewage samples collected at the Seafood Market in Qingdao,***_PalP_Y7 remained stable across a wide range of temperatures(-20–50℃)and a wide pH range(3–12).The vB_PalP_Y7 phage harbors a linear double-stranded DNA molecule of 57699 base pairs(bp)with a G+C content of 45.90%.Furthermore,it is predicted to contain 58 open reading frames(ORFs).Phylogenetic analysis and protein network relationship analysis revealed low similarity between vB_PalP_Y7 and viruses in the ICTV and IMG/VR4 database,suggesting that vB_PalP_Y7 may be a potential new genus,*** study contributed valuable insights to comprehend the relationship between Pseudoalteromonas phages and their host organisms.

关键词： Pseudoalteromonas phage genomic analysis phylogenetic analysis viral cluster

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Behavior and outcomes of 141 acquired lacrimal sac mucoceles treated via endoscopic dacryocystorhinostomy

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 244-250页

作者： Ying-Jie Ma Guang-Ming Zhou Zhi-Rong Liu Jin-Fei Wei Xin-Yu Li Bin dong Lin-Juan wu Wen-Can wu Bo Yu National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina The Eye Hospital School of Ophthalmology&OptometryWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To investigate the clinical profile of patients with acquired lacrimal sac mucocele(ALSM)and evaluate the efficacy of endoscopic dacryocystorhinostomy(En-DCR)for this ***:En-DCRs were performed on 141 patients with ALSM patients from January 2016 to March *** clinical baseline information and magnetic resonance imaging(MRI)images were recorded and *** assess the effectiveness of En-DCR therapy,both anatomical and functional success rate was assessed during a 12mo ***:A total of 141 patients,with a mean age of 57.70±14.11y,were enrolled in this *** of the patients were female(n=91;64.54%)and all had unilateral *** patients had a previous history of epiphora and purulent secretion,and the duration from lacrimal duct obstruction to mucocele formation ranged from 6 to *** findings consistently revealed an enlarged sac diameter,fluid accumulation separated by a thin rim from adjacent tissues,which is indicative of lacrimal sac ***-DCR was performed with an anatomical success rate of 93.62%and a functional success rate of 81.56%.CONCLUSION:ALSM is more commonly seen in females and *** is essentially a complication of lacrimal duct *** characteristics can be used for precise clinical diagnosis,while En-DCR emerges as an optimal therapy for this *** results provide a comprehensive reference for the diagnosis and treatment of ALSM.

关键词： acquired lacrimal sac mucocele clinical profile magnetic resonance imaging endoscopic dacryocystorhinostomy

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高职院校学生事务管理信息化建设及对策——以闽西职业技术学院为例

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闽西职业技术学院学报 2017年第2期19卷 26-30,76页

作者：董东明吴丹闽西职业技术学院办公室福建龙岩364021 龙岩学院人事处福建龙岩364012

近年来,信息技术给高等职业教育带来了全新的机遇和挑战。学生事务管理作为高职院校管理中的重要内容,也发生了许多变化,但仍存在管理理念落后、信息系统不完善、组织结构不合理等问题。高职院校应树立以生为本理念,搭建信息化平台,简... 详细信息

近年来,信息技术给高等职业教育带来了全新的机遇和挑战。学生事务管理作为高职院校管理中的重要内容,也发生了许多变化,但仍存在管理理念落后、信息系统不完善、组织结构不合理等问题。高职院校应树立以生为本理念,搭建信息化平台,简化组织结构,再造流程,以推进学生事务管理的信息化。

关键词：高职院校学生事务管理信息化

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不同土壤改良物质对越桔叶片酶活性影响的研究

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土壤通报 2005年第1期36卷 76-79页

作者：唐雪东李亚东吴林张志东吉林农业大学园艺学院吉林长春130118

黑土中加入有机物料和硫磺粉(S),对越桔叶片的过氧化氢酶、过氧化物酶、硝酸还原酶都产生显著影响,不同处理有较大差异,其中,加入苔藓、苔藓和草炭及只加入1.5kgS-2kgS的处理,叶片的过氧化氢酶活性较高,过氧化物酶和硝酸还原酶活性较低... 详细信息

黑土中加入有机物料和硫磺粉(S),对越桔叶片的过氧化氢酶、过氧化物酶、硝酸还原酶都产生显著影响,不同处理有较大差异,其中,加入苔藓、苔藓和草炭及只加入1.5kgS-2kgS的处理,叶片的过氧化氢酶活性较高,过氧化物酶和硝酸还原酶活性较低,叶片生长发育良好。

关键词：越桔不同土壤改良物质叶片酶活性

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Enhancing entanglement and steering in a hybrid atom–optomechanical system via Duffing nonlinearity

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Chinese Physics B 2025年第2期34卷 124-131页

作者： Ling-Hui dong Xiao-Jie wu Cheng-Hua Bai Shao-Xiong wu School of Semiconductor and Physics North University of ChinaTaiyuan 030051China

We introduce a novel scheme for achieving quantum entanglement and Einstein–Podolsky–Rosen(EPR) steering between an atomic ensemble and a mechanical oscillator within a hybrid atom–optomechanical system. The system comprises an optical cavity, a two-level atomic ensemble and a mechanical resonator that possesses Duffing nonlinearity. The interaction between these components is mediated by the cavity mode, which is driven by an external laser. Our findings indicate that optimizing the coupling strengths between photons and phonons, as well as between atoms and the cavity,leads to maximal entanglement and EPR steering. The amplitude of the driving laser plays a pivotal role in enhancing the coupling between photons and phonons, and the system maintains robust entanglement and EPR steering even under high dissipation, thereby mitigating the constraints on initial conditions and parameter precision. Remarkably, the Duffing nonlinearity enhances the system's resistance to thermal noise, ensuring its stability and entanglement protection. Our analysis of EPR steering conditions reveals that the party with lower dissipation exhibits superior stability and a propensity to steer the party with higher dissipation. These discoveries offer novel perspectives for advancing quantum information processing and communication technologies.

关键词： quantum entanglement EPR steering optomechanical system Duffing nonlinearity

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Dendrobium officinale extract exerts antioxidant effects against skin photoaging through MMP9-TNF pathway

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Traditional Medicine Research 2025年第3期10卷 32-41页

作者： Bei-Bei dong Yun Wang Han Zhao wu-Yan Guo Bo Zhang College of Pharmacy Nankai UniversityTianjin 300350China Hepatobiliary Pancreatic Center Xuzhou Central HospitalXuzhou 221009China Clinic for Kidney and Hypertensive Diseases Hanover Medical SchoolHanover 30625Germany Tianjin JiAnKang Bio&TCM-technology Development Co. Ltd.Tianjin 300457China Institute for TCM-X MOE Key Laboratory of BioinformaticsBioinformatics DivisionBNRistDepartment of AutomationTsinghua UniversityBeijing 100084China

Background:Skin photoaging is a physiological or pathological process caused by multiple *** anti-skin photoaging drugs is a hot topic in cosmetology research *** purpose of this study was to explore the therapeutic effect of Dendrobium officinale(***)on skin ***:The ingredients of *** were detected by UHPLC-Q-TOF/*** targets of *** were screened by Swiss Target Prediction ***,NCBI,and OMIM databases were utilized to find out the targets associated with skin *** targets of *** and skin photoaging were obtained by Venn *** ingredient-disease target network and protein-protein interaction network were constructed by using the STRING database and Cytoscape *** key compounds and hub genes were obtained by analyzing *** DAVID database was applied for Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the overlapping *** Vina software was used to simulate molecular docking and the results were visualized using ***,the skin photoaging models of cells and mice were established to validate the results predicted by network ***:In ***,a total of 59 compounds and 595 targets were detected,of which 59 proteins were intersectional with skin photoaging *** top 10 active ingredients(Dendrophenol,Herbacetin,Lyoniresinol,Trans-ferulaldehyde,Naringenin,and so on)and 8 hub genes(AKT1,TNF,VEGFA,MAPK3,CASP3,MMP9,CTNNB1,and EGFR)were *** the key active compounds could bind well with core protein targets(binding energy<-5 kcal/mol).The potential therapeutic targets were related to the response to reactive oxygen species,collagen catabolic process,extracellular matrix organization,and apoptotic process,*** also found that *** could enhance the cell viability and activity of anti-oxidases,reduce reactive oxygen species and MMP9 levels,and stable mitoc

关键词： Dendrobium officinale skin photoaging matrix metalloproteinase anti-oxidative stress

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Robustness of N=152 and Z=108 shell closures in superheavy mass region

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Chinese Physics C 2025年第1期49卷 1-6页

作者： Buyu Chen Jianmin dong Yaqian Wang Guoqing wu Department of Physics Hebei UniversityBaoding 071002China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

The neutron shell gap at N=152 has been experimentally confirmed through high-precision mass measurements on nobelium(Z=102)and lawrencium(Z=103)*** experimental measurements onα-decay properties suggest that deformed doubly-magic nature of ^(270)***,the magic gaps in the superheavy region are generally expected to be *** this study,we test the robustness of N=152 shell closure in N=152 isotones and Z=108 shell closure in Hs isotopes by employing an alternative approach where both theoretical analysis and available experimental data are *** with existing experimental measurements on a-decay energies,it is determined that robust N=152 neutron shell persists at least in Z=101-105 isotopes,and robust Z=108 proton shell persists in Hs isotopes with N=159,***,the relativistic mean-field model is determined as unable to provide N=152 ***,the conclusion that robust N=152 shell exists at least in Z=101-105 isotopes,provides crucial benchmarks for constraining effective interactions suitable for superheavy nuclei in nuclear energy-density functional theory in future.

关键词： superheavy nuclei shell gap a-decay decay energy

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Human cardiac organoid model reveals antibacterial triclocarban promotes myocardial hypertrophy by interfering with endothelial cell metabolism

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Science Bulletin 2025年第3期70卷 342-346页

作者： Nana Yang Jiahong Chen Yujie Zhu Wenxin Shan Zheng Cao Yiwen Fu Huanhuan Cao Yanyan Li Yukun Xiang Shusi Ding Huiqing Wang Yaobo Zhao Liang Ji Rui Zhan Yufei wu Zhaomeng Wang Manyuan dong Lemin Zheng School of Bioscience and Technology Weifang Key Laboratory of Animal Model Research on Cardiovascular and Cerebrovascular DiseasesShandong Second Medical UniversityWeifang 261053China The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine School of Basic Medical SciencesState Key Laboratory of Vascular Homeostasis and RemodelingNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijing Key Laboratory of Cardiovascular Receptors ResearchHealth Science CenterPeking UniversityBeijing 100191China University of Chinese Academy of Sciences Beijing 100049China Beijing Tiantan Hospital China National Clinical Research Center for Neurological DiseasesAdvanced Innovation Center for Human Brain ProtectionBeijing Institute of Brain DisordersThe Capital Medical UniversityBeijing 100050China Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital)School of Health and Life SciencesUniversity of Health and Rehabilitation SciencesQingdao 266071China

Environmental pollution is an important but often overlooked risk factor for cardiovascular diseases such as heart ***(3,4,4′-trichlorocarbanilide,TCC)is a broad-spectrum antibacterial agent commonly used in personal care products such as antibacterial soaps,detergents,toothpaste,and cosmetics[1].Unfortunately,due to its widespread use,TCC has become one of the top ten most common water pollutants globally,and it is present in the atmosphere,soil,and aquatic sediments[2].

关键词： metabolism cardiovascular diseases

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非均质孔隙介质中循环驱替对两相渗流及毛细捕获的影响

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岩土力学 2025年第2期46卷 505-514页

作者：邓汉鑫武东生王晓光王东坡成都理工大学地质灾害防治与地质环境保护国家实验室四川成都610059 天府永兴实验室四川成都610213 成都理工大学能源学院四川成都610059

孔隙介质中的两相渗流和毛细捕获是深部咸水层中二氧化碳(CO_(2))封存的重要过程和关键机制。尽管已有研究对两相流驱替模式及其判据进行了深入探讨,但循环驱替过程中两相渗流特性和毛细捕获机制的研究仍相对不足。通过孔隙尺度的水-油... 详细信息

孔隙介质中的两相渗流和毛细捕获是深部咸水层中二氧化碳(CO_(2))封存的重要过程和关键机制。尽管已有研究对两相流驱替模式及其判据进行了深入探讨,但循环驱替过程中两相渗流特性和毛细捕获机制的研究仍相对不足。通过孔隙尺度的水-油两相循环驱替可视化试验研究,分析了孔隙非均质性和循环驱替次数对两相渗流特性及毛细捕获效率的影响。试验结果显示,循环驱替破坏了非润湿相的连续性,使其分解为难以重新活化的孤立“液滴”,经过4次循环驱替后,毛细捕获效率最高可达40%。随着孔隙介质非均质性的增加,通过绕流机制大量捕获非润湿相,非均质孔隙结构中毛细捕获效率相比均质介质提高了32.5%。试验结果还揭示了循环驱替过程中4种典型的毛细捕获液滴类型:附着型、桥接型、团状型和簇状型液滴,其中,附着型液滴的数量占比最高,但其捕获体积较小,而簇状型液滴对毛细捕获效率贡献最大。该研究结果加深了对循环注入过程中毛细捕获机制的理解,并为提高深部咸水层CO_(2)地质封存的效率提供了理论支持和实践依据。

关键词：非均质孔隙介质两相渗流循环驱替毛细捕获微流控试验

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