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Mining The Cancer Genome Atlas database for tumor mutation burden and its clinical implications in gastric cancer

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World Journal of Gastrointestinal Oncology 2021年第1期13卷 37-57页

作者： dong-yan zhao Xi-Zhen Sun Shu-Kun Yao Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Graduate school Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Tumor mutational burden(TMB)is an important independent biomarker for the response to immunotherapy in multiple ***,the clinical implications of TMB in gastric cancer(GC)have not been fully *** To explore the landscape of mutation profiles and determine the correlation between TMB and microRNA(miRNA)expression in *** Genomic,transcriptomic,and clinical data from The Cancer Genome Atlas were used to obtain mutational profiles and investigate the statistical correlation between mutational burden and the overall survival of GC *** difference in immune infiltration between high-and low-TMB subgroups was evaluated by Wilcoxon rank-sum ***,miRNAs differentially expressed between the high-and low-TMB subgroups were identified and the least absolute shrinkage and selection operator method was employed to construct a miRNA-based signature for TMB *** biological functions of the predictive miRNAs were identified with DIANA-miRPath *** C>T single nucleotide mutations exhibited the highest mutation incidence,and the top three mutated genes were TTN,TP53,and MUC16 in *** TMB values(top 20%)were markedly correlated with better survival outcome,and multivariable regression analysis indicated that TMB remained prognostic independent of TNM stage,histological grade,age,and *** TMB levels exhibited different immune infiltration *** differences between the high-and low-TMB subgroups were observed in the infiltration of CD8+T cells,M1 macrophages,regulatory T cells,and CD4+T *** addition,we developed a miRNA-based signature using 23 differentially expressed miRNAs to predict TMB values of GC *** predictive performance of the signature was confirmed in the testing and the whole *** operating characteristic curve analysis demonstrated the optimal performance of the ***,enrichment analysis demonstrated that the set of miRNAs was signific

关键词： Tumor mutational burden Gastric cancer Prognosis Immune infiltration microRNA Immunotherapy

Corticostriatal Neurons in the Anterior Auditory Field Regulate Frequency Discrimination Behavior

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Neuroscience Bulletin 2023年第6期39卷 962-972页

作者： zhao-Qun Wang Hui-Zhong Wen Tian-Tian Luo Peng-Hui Chen yan-dong zhao Guang-yan Wu Ying Xiong Department of Neurobiology Chongqing Key Laboratory of NeurobiologyArmy Medical UniversityChongqing400038China Experimental Center of Basic Medicine Army Medical UniversityChongqing400038China

The anterior auditory field(AAF)is a core region of the auditory cortex and plays a vital role in discrimination ***,the role of the AAF corticostriatal neurons in frequency discrimination remains ***,we used c-Fos staining,fiber photometry recording,and pharmacogenetic manipulation to investigate the function of the AAF corticostriatal neurons in a frequency discrimination task.c-Fos staining and fiber photometry recording revealed that the activity of AAF pyramidal neurons was significantly elevated during the frequency discrimination *** inhibition of AAF pyramidal neurons significantly impaired frequency *** addition,histological results revealed that AAF pyramidal neurons send strong projections to the ***,pharmacogenetic suppression of the striatal projections from pyramidal neurons in the AAF significantly disrupted the frequency ***,our findings show that AAF pyramidal neurons,particularly the AAF–striatum projections,play a crucial role in frequency discrimination behavior.

关键词： Anterior auditory field Corticostriatal neuron Frequency discrimination AAF-striatum projection

A Hybrid Level Set Optimization Design Method of Functionally Graded Cellular Structures Considering Connectivity

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Computers, Materials & Continua 2024年第4期79卷 1-18页

作者： yan dong Kang zhao Liang Gao Hao Li The State Key Lab of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan430074China Institute of Systems Engineering China Academy of Engineering PhysicsMianyang621900China

With the continuous advancement in topology optimization and additive manufacturing(AM)technology,the capability to fabricate functionally graded materials and intricate cellular structures with spatially varying microstructures has grown ***,a critical challenge is encountered in the design of these structures–the absence of robust interface connections between adjacent microstructures,potentially resulting in diminished efficiency or macroscopic failure.A Hybrid Level Set Method(HLSM)is proposed,specifically designed to enhance connectivity among non-uniform microstructures,contributing to the design of functionally graded cellular *** HLSM introduces a pioneering algorithm for effectively blending heterogeneous microstructure ***,an interpolation algorithm is presented to construct transition microstructures seamlessly connected on both ***,the algorithm enables the morphing of non-uniform unit cells to seamlessly adapt to interconnected adjacent *** method,seamlessly integrated into a multi-scale topology optimization framework using the level set method,exhibits its efficacy through numerical examples,showcasing its prowess in optimizing 2D and 3D functionally graded materials(FGM)and multi-scale topology *** essence,the pressing issue of interface connections in complex structure design is not only addressed but also a robust methodology is introduced,substantiated by numerical evidence,advancing optimization capabilities in the realm of functionally graded materials and cellular structures.

关键词： Hybrid level set method functionally graded cellular structure connectivity interpolated transition optimization design

Understanding Discrepancy of Power System Dynamic Security Assessment with Unknown Faults: A Reliable Transfer Learning-based Method

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 427-431页

作者： Chao Ren Han Yu yan Xu zhao yang dong School of Computer Science and Engineering Nanyang Technological UniversitySingapore School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore

This letter proposes a reliable transfer learning(RTL)method for pre-fault dynamic security assessment(DSA)in power systems to improve DSA performance in the presence of potentially related unknown *** takes individual discrepancies into consideration and can handle unknown faults with incomplete *** experiment results demonstrate high DSA accuracy and computational efficiency of the proposed RTL *** analysis shows RTL can guarantee system performance.

关键词： Adversarial training dynamic security assessment maximum classifier discrepancy missing data transfer learning

Data delivery delay and cross-layer packet size analysis for reliable transmission of Licklider transmission protocol in space networks

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Science China(Information Sciences) 2024年第9期67卷 229-244页

作者： Guannan yanG Ruhai WANG Kanglian zhao Wenfeng LI dong yan School of Information Engineering Nanjing University of Finance and Economics Drayer Department of Electrical and Computer Engineering Lamar University School of Electronic Science and Engineering Nanjing University Beijing Aircraft Overall Design Department

Delay/disruption tolerant networking(DTN) is proposed as a networking architecture to overcome challenging space communication characteristics for reliable data transmission service in presence of long propagation delays and/or lengthy link disruptions. Bundle protocol(BP) and Licklider Transmission Protocol(LTP) are the main key technologies for DTN. LTP red transmission offers a reliable transmission mechanism for space networks. One of the key metrics used to measure the performance of LTP in space applications is the end-to-end data delivery delay, which is influenced by factors such as the quality of spatial channels and the size of cross-layer packets. In this paper, an end-to-end reliable data delivery delay model of LTP red transmission is proposed using a roulette wheel algorithm, and the roulette wheel algorithm is more in line with the typical random characteristics in space networks. The proposed models are validated through real data transmission experiments on a semi-physical testing platform. Furthermore, the impact of cross-layer packet size on the performance of LTP reliable transmission is analyzed, with a focus on bundle size, block size, and segment size. The analysis and study results presented in this paper offer valuable contributions towards enhancing the reliability of LTP transmission in space communication scenarios.

关键词： Licklider transmission protocol DTN bundle protocol cross-layer packets size space communication

EDTA interfacial chelation Ca^(2+) incorporates superhydrophobic coating for scaling inhibition of CaCO_(3) in petroleum industry

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Petroleum Science 2021年第3期18卷 951-961页

作者： Ming-Liang Zhu Hui-Juan Qian Rui-Xia Yuan dong-yan zhao Hai-Chao Huang Huai-Yuan Wang College of Chemistry and Chemical Engineering Northeast Petroleum UniversityDaqing 163318China College of Chemical Engineering Daqing Normal UniversityDaqing 163712China Beijing Smart-Chip Microelectronics Technology Co. LtdBeijing 102200China

In this paper,the superhydrophobic poly(vinylidene fuoride)/fuorinated ethylene propylene/SiO_(2)/CNTs-EDTA(PFSCEDTA)composite coating was successfully fabricated and applied for anti-scaling *** deposition of CaCO_(3) on the surface of the superhydrophobic PFSC-EDTA composite coating reached 0.0444 mg/cm^(2) for 192-h immersion into the supersaturated CaCO_(3) solution,which was only 11.4%that of the superhydrophobic PFSC composite *** the interface between the CaCO_(3) solution and the PFSC-EDTA coating,the Ca^(2+)could be frstly chelated by EDTA that was beneft for improving the anti-scaling performance of the superhydrophobic PFSC-EDTA composite *** another hand,the addition of EDTA to the CNTs played an important role in fabricating the SiO_(2)-centric and CNTs-EDTA-surrounded multilevel micro-nanostructure in the superhydrophobic PFSC-EDTA composite coating,in favor of maintaining the air flm under the water and the stability of the superhydrophobic *** research supplies a new way of improving antiscaling performance of superhydrophobic coating by incorporating the organic chelating agent at the interface and changing the traditional way of scale prevention.

关键词： Anti-scaling Superhydrophobic coating EDTA Poly(vinylidene fuoride) Carbon nanotubes

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Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer

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World Journal of Clinical Cases 2021年第18期9卷 4520-4541页

作者： Teng-Fei Yin dong-yan zhao Yuan-Chen Zhou Qian-Qian Wang Shu-Kun Yao Graduate school Peking University China-Japan Friendship School of Clinical MedicineBeijing 100029China Graduate School Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The high morbidity and mortality of colorectal cancer(CRC)have posed great threats to human *** RNA(CircRNA)and microRNA(miRNA),acting as competing endogenous RNAs(ceRNAs),have been found to play vital roles in ***,the biological function of ceRNAs in CRC pathogenesis and prognosis remains largely *** To identify the CRC-specific circRNA-miRNA-mRNA regulatory network and uncover the subnetwork associated with its *** CircRNAs,miRNAs and mRNAs differentially expressed(DE)in CRC tissues were selected by expression file analysis in the Gene Expression Omnibus(GEO)database,and the downstream target molecules of circRNAs and miRNAs were ***,the intersection of differentially expressed RNA molecules with the predicted targets was determined to obtain a ceRNA *** ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analyses were conducted to elucidate the possible mechanism of pathogenesis.A survival analysis using the gene profiles and clinical information in The Cancer Genome Atlas(TCGA)database was performed to identify the mRNAs associated with the clinical outcome of CRC patients and construct a prognostic *** We downloaded three datasets(GSE126095,GSE41655 and GSE41657)of largescale CRC samples from the GEO *** were 55 DEcircRNAs,114 DEmiRNAs and 267 DEmRNAs in CRC tissues compared with normal *** intersecting these molecules with predicted targets,19 circRNAs,13 miRNAs and 28 mRNAs were chosen to develop a circRNA-miRNA-mRNA *** and KEGG functional enrichment analyses indicated that the retinol metabolic process,leukocyte chemotaxis,extracellular matrix remodeling,endoplasmic reticulum stress,alcohol dehydrogenase activity,gastric acid secretion,nitrogen metabolism and NOD-like receptor signaling pathway might participate in the tumorigenesis of *** verifying the identified mRNA effect in the TCGA database,we finally

关键词： CircRNA miRNA Network Colorectal cancer Prognosis Biomarkers

Intestinal mucosal barrier in functional constipation:Dose it change?

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World Journal of Clinical Cases 2022年第19期10卷 6385-6398页

作者： Jun-Ke Wang Wei Wei dong-yan zhao Hui-Fen Wang yan-Li Zhang Jie-Ping Lei Shu-Kun Yao Graduate School Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Department of Clinical Nutrition and Department of Health Medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Data and Project Management Unit Institute of Clinical Medical SciencesChina-Japan Friendship HospitalBeijing 100029China

BACKGROUND The intestinal mucosal barrier is the first line of defense against numerous harmful substances,and it contributes to the maintenance of intestinal *** studies reported that structural and functional changes in the intestinal mucosal barrier were involved in the pathogenesis of several intestinal ***,no study thoroughly evaluated this barrier in patients with functional constipation(FC).AIM To investigate the intestinal mucosal barrier in FC,including the mucus barrier,intercellular junctions,mucosal immunity and gut *** Forty FC patients who fulfilled the Rome IV criteria and 24 healthy controls were recruited in the Department of Gastroenterology of China-Japan Friendship *** colonic mucus barrier,intercellular junctions in the colonic epithelium,mucosal immune state and gut permeability in FC patients were comprehensively *** cells were stained with Alcian Blue/Periodic acid Schiff(AB/PAS)and *** ultrastructure of intercellular junctional complexes was observed under an electron *** and zonula occludens-1(ZO-1)in the colonic mucosa were located and quantified using immunohistochemistry and quantitative real-time polymerase chain *** CD3+intraepithelial lymphocytes(IELs)and CD3+lymphocytes in the lamina propria were identified and counted using *** serum levels of D-lactic acid and zonulin were detected using enzyme-linked immunosorbent *** Compared to healthy controls,the staining of mucus secreted by goblet cells was darker in FC patients,and the number of goblet cells per upper crypt in the colonic mucosa was significantly increased in FC patients(control,18.67±2.99;FC,22.42±4.09;P=0.001).The intercellular junctional complexes in the colonic epithelium were integral in FC *** distribution of mucosal occludin and ZO-1 was not altered in FC *** significant differences were found in occludin(control,5.76E-2

关键词： Intestinal mucosal barrier Functional constipation Goblet cells Intercellular junctions Mucosal immunity Gut permeability

Qualitative analysis of aromatic compounds via 1D TOCSY techniques

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Magnetic Resonance Letters 2024年第1期4卷 21-27页

作者： Wenbo dong Qi zhao Jiancheng zhao Jiarong Zhang Yingxiong Wang yan Qiao State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of Sciences27 South Taoyuan RoadTaiyuan030001China Graduate University of Chinese Academy of Sciences Beijing100049China Marine Biomedical Research Institution Guangdong Medical UniversityZhanjiang524023China College of Chemistry Taiyuan University of Technology79 Yingze West StreetWanbailin DistrictTaiyuan030024China

The aromatic compounds,including o-xylene,m-xylene,p-xylene,and ethylbenzene,primarily originate from the catalytic reforming of crude oil,and have a wide variety of ap***,because of similar physical and chemical properties,these compounds are difficult to be identified by gas chromatography(GC)without standard *** the development of modern nuclear magnetic resonance(NMR)techniques,NMR has emerged as a powerful and efficient tool for the rapid analysis of complex and crude mixtures without *** this study,the parameters of one-dimensional(1D)total correlation spectroscopy(TOCSY)NMR techniques,including 1D selective gradient TOCSY and 1D chemicalshift-selective filtration(CSSF)with TOCSY,were optimized to obtain comprehensive molecular structure *** results indicate that the overlapped signals in NMR spectra of nonpolar aromatic compounds(including o-xylene,m-xylene,p-xylene and ethylbenzene),polar aromatic compounds(benzyl alcohol,benzaldehyde,benzoic acid),and aromatic compounds with additional conjugated bonds(styrene)can be resolved in 1D *** importantly,full molecular structures can be clearly distinguished by setting appropriate mixing time in 1D *** approach simplifies the NMR spectra,provides structural information of entire molecules,and can be applied for the analysis of other structural isomers.

关键词： 1D TOCSY NMR technologies Xylenes Aromatic compounds Structure information of entire molecular Qualitative analysis

维普期刊数据库