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World Journal of Gastroenterology 2019年第23期25卷 2898-2910页

作者： wei-dong fan Tao Chen Peng-Jun Liu Department of Gastroenterology the Affiliated Zhangjiagang Hospital of Soochow UniversityZhangjiagang 215600Jiangsu ProvinceChina Department of Gastroenterology the Wujin Hospital Affiliated to Jiangsu UniversityChangzhou 213002Jiangsu ProvinceChina

BACKGROUND NIMA related kinase 2(NEK2) is closely related to mitosis, and it is currently considered to be over-expressed frequently in many poorly prognostic ***, the effect of the up-regulated NEK2 on cellular signaling in tumors,such as gastric cancer(GC), is *** To determine the role of the up-regulation of NEK2 in *** To investigate the pathological significance of NEK2 in GC, the expression pattern of NEK2 in GC was investigated based on the 'Oncomain' database and compared between 30 pairs of cancer samples and adjacent tissues. The coexpression of NEK2 and ERK in GC was analyzed using The Cancer Genome Atlas(TCGA) database and confirmed in clinical samples by quantitative realtime PCR(qRT-PCR), and the survival curve was also plotted. Western blot or qRT-PCR was used to analyze the effect of NEK2 on the phosphorylation levels of ERK and c-JUN in two GC cell lines(BGC823 and SGC7901) with NEK2 overexpression, and the expression of the downstream effector cyclin ***, CCK8, EdU incorporation assay, and flow cytometry were used to detect the proliferative ability of BGC823 and SGC7901 cells with stably silenced *** NEK2 was significantly up-regulated in human GC tissues. ERK was significantly associated with NEK2 expression in human clinical specimens, and combined overexpression of NEK2 and ERK potentially forecasted a poor prognosis andsurvival in GC patients. NEK2 knockdown in GC cells inhibited ERK and c-JUN phosphory-lation and reduced the transcription of cyclin D1. More interestingly,NEK2 can rescue the inhibition of cellular viability, proliferation, and cell cycle progression due to ERK *** Our results indicate that NEK2 plays a carcinogenic role in the malignant proliferation of GC cells via the ERK/MAPK signaling, which may be important for treatment and improving patient survival.

关键词： NIMA related kinase 2 ERK/MAPK signaling Cyclin D1 Cell proliferation Gastric cancer

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Rabi Oscillations in Two-Component Bose-Einstein Condensates with a Coupling Drive

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Communications in Theoretical Physics 2002年第5期38卷 547-552页

作者： LI wei-dong fan Wen-Bing ZHOU Xiao-Ji WANG Yi-Qiu LIANG Jiu-Qing Department of Physics and Institute of Theoretical Physics Shanxi University Taiyuan 030006 China State Key Lab of Magnetism Institute of Physics the Chinese Academy of Sciences Beijing 100080 China Key Laboratory for Quantum Information and Measurements Ministry of Education of China State Key Lab of Magnetism Institute of Physics the Chinese Academy of Sciences Beijing 100080 China Key Laboratory for Quantum Information and Measurements Ministry of Education of China Department of Electronics Peking University Beijing 100871 China Key Laboratory for Quantum Information and Measurements Ministry of Education of China Department of Electronics Peking University Beijing 100871 China Department of Physics and Institute of Theoretical Physics Shanxi University Taiyuan 030006 China

The Rabi oscillations in two-component Bose-Einstein condensates with a coupling drive are studiedby means of a pair of bosonic operators. The coupling drive and initial phase difference will affect the amplitudeand the period of the Rabi oscillations. The Rabi oscillations will vanish in the evolution of the condensate densityfor some special initial phase differences (ψ = 0 or π). Our theory provides not only an analytical framework forquantitative predictions for two-component condensates, but also gives an intuitive understanding of some mysteriousfeatures observed in experiments and numerical. simulations.

关键词： Bose-Einstein condensates, R.abi oscillations

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β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

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Bone Research 2024年第2期12卷 302-313页

作者： Jie Huang Tong Wu Yi-Rong Jiang Xuan-Qi Zheng Huan Wang Hao Liu Hong Wang Hui-Jie Leng dong-wei fan Wan-Qiong Yuan Chun-Li Song Department of Orthopedics Peking University Third Hospital100191 BeijingChina Beijing Key Laboratory of Spinal Disease 100191 BeijingChina Engineering Research Center of Bone and Joint Precision Medicine 100191 BeijingChina

The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone *** found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)***,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX *** effect of this treatment is superior to that of treatment with PTH or propranolol *** vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by ***,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of Rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by ***,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR ***1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast *** together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.

关键词： blocker metabolism inhibited

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All-sky Guide Star Catalog for CSST

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Research in Astronomy and Astrophysics 2024年第4期24卷 35-59页

作者： Hui-Mei Feng Zi-Huang Cao Man I Lam Ran Li Hao Tian Da-Yi Yin Yuan-Yu Yang Xin Zhang dong-wei fan Yi-Qiao dong Xin-Feng Li wei Wang Long Li Hugh RAJones Yi-Han Tao Jia-Lu Nie Pei-Pei Wang Mao-Yuan Liu He-jun Yang Chao Liu Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of ChineseAcademy of Sciences Beijing 100049China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai200083China Technology and Engineering Center for Space Utilization.Chinese Academy of Sciences Beijing 100094China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Centre for Astrophysics University of HertfordshireHatfieldUK Beijing University of Technology Beijing 100124China

The China Space Station Telescope(CSST)is a two-meter space telescope with multiple back-end *** Fine Guidance Sensor(FGS)is an essential subsystem of the CSST Precision Image Stability System to ensure the required absolute pointing accuracy and line-of-sight *** this study,we construct the Main Guide Star Catalog for *** accomplish this,we utilize the information about the FGS and object information from the Gaia Data Release *** provide an FGS instrument magnitude and exclude variables,binaries,and high proper motion stars from the catalog to ensure uniform FGS guidance ***,we generate a HEALPix index,which provides a hierarchical tessellation of the celestial sphere,and employ the Voronoi algorithm to achieve a homogeneous distribution of stars across the *** distribution ensures adequate coverage and sampling of the *** performance of the CSST guide star catalog was assessed by simulating the field of view of the FGS according to the CSST mock survey strategy *** analysis of the results indicates that this catalog provides adequate coverage and *** catalog's performance meets the FGS requirements,ensuring the functioning of the FGS and its guidance capabilities.

关键词： catalogs astrometry instrumentation:detectors

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The first data release of LAMOST low-resolution single-epoch spectra

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Research in Astronomy and Astrophysics 2021年第10期21卷 73-85页

作者： Zhong-Rui Bai Hao-Tong Zhang Hai-Long Yuan dong-wei fan Bo-Liang He Ya-Juan Lei Yi-Qiao dong Si-Cheng Yu Yong-Heng Zhao Yong Zhang Yong-Hui Hou Yao-Quan Chu CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesBeijing 100101China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Astronomical Data Center Beijing 100101China Nanjing Institute of Astronomical Optics&Technology National Astronomical ObservatoriesChinese Academy of SciencesNanjing 210042China University of Science and Technology of China Hefei 230026China

LAMOST Data Release 5,covering 17000 deg^(2) from-10°to 80°in declination,contains 9 million co-added low-resolution spectra of celestial objects,each spectrum combined from repeat exposure of two to tens of times during Oct 2011 to Jun *** this paper,we present the spectra of individual exposures for all the objects in LAMOST Data Release *** each spectrum,the equivalent width of 60lines from 11 different elements are calculated with a new method combining the actual line core and fitted line *** stars earlier than F type,the Balmer lines are fitted with both emission and absorption profiles once two components are *** velocity of each individual exposure is measured by minimizing χ^(2) between the spectrum and its best *** database for equivalent widths of spectral lines and radial velocities of individual spectra are available *** velocity uncertainties with different stellar type and signal-to-noise ratio are quantified by comparing different exposure of the same *** notice that the radial velocity uncertainty depends on the time lag between *** stars observed in the same day and with signal-to-noise ratio higher than 20,the radial velocity uncertainty is below 5 km s^(-1),and increases to 10 km s^(-1) for stars observed in different nights.

关键词： surveys stars:general methods:data analysis

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Establishment of goat osteoradionecrosis animal model

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中国口腔颌面外科杂志 2008年第B5期6卷 86-87页

作者： Jie He Yue He Zhong He Wang Xin dong fan wei Liu Qiu Department of Stomatology Ninth People's Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200011 China

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骨质疏松症与痴呆关系的研究进展

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中国现代医学杂志 2021年第20期31卷 1-5页

作者：范东伟陈仲强北京大学第三医院骨科北京100191

近年来研究显示骨质疏松症与痴呆密切相关。骨质疏松症人群痴呆发病风险高、发病率高;另一方面,痴呆人群骨质疏松症发病率高,发生骨质疏松性骨折风险大,致残、致死率高。骨质疏松症和痴呆在危害患者健康的同时,也给照护家庭及社会带来... 详细信息

近年来研究显示骨质疏松症与痴呆密切相关。骨质疏松症人群痴呆发病风险高、发病率高;另一方面,痴呆人群骨质疏松症发病率高,发生骨质疏松性骨折风险大,致残、致死率高。骨质疏松症和痴呆在危害患者健康的同时,也给照护家庭及社会带来很大负担,成为世界范围内的慢性病研究热点问题。该文对骨质疏松症与痴呆关系的研究进展进行综述,重点讨论痴呆对骨质疏松症及骨质疏松性骨折的影响,也对相关骨-脑轴的病理生理机制进行综述,希望能为骨质疏松症伴痴呆的研究提供新思路。

关键词：骨质疏松症痴呆骨质疏松性骨折骨-脑轴

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一种新型半干法烟气脱硫方法的机理分析

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燃料化学学报 2004年第6期32卷 768-771页

作者：周月桂章明川范卫东范浩杰于娟上海交通大学机械与动力工程学院热能工程研究所上海200240

The advantages and disadvantages of a typical semi-dry flue gas desulfurization （FGD） method are analyzed and a novel semi-dry FGD method of simple and compact system with high efficiency is firstly put forward, named multi-fluid alkaline spray generator FGD method. The results show that the colliding activation efficiency between the sorbent particles and the spray water droplets in the prefixed alkaline spray generator may reach about 70%, which is significantly higher than the 25% colliding activation efficiency in in-duct injection FGD. And SO2 removal efficiency reaches 70%, higher than that of in-duct injection FGD at the same conditions. The study confirms it is a new simple compact and highly-efficient semi-dry FGD method.

关键词：烟气脱硫碰撞活化脱硫效率

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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo Le Tong Jianhong dong Ziwei fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao fangqing Zhao Jing-dong J.Han Qi Liu Xiaohui fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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