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Molecular recognition of cyclophanes in water

Chinese Chemical Letters 2024年第5期35卷 32-44页

作者： Fang-Yuan Chen Wen-Chao Geng Kang Cai dong-sheng guo College of Chemistry State Key Laboratory of Elemento-Organic ChemistryKey Laboratory of Functional Polymer Materials(Ministry of Education)Frontiers Science Center for New Organic MatterCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071China College of Chemistry Nankai UniversityTianjin 300071China

Molecular recognition in water,the biological solvent,always receives significant research focus in supramolecular *** mechanisms of molecular recognition in water is key to comprehending biological processes at the molecular *** the past five decades,supramolecular chemists have developed a vast array of synthetic receptors with highly diverse structures and recognition *** them,cyclophanes represent an important family of macrocyclic receptors that have been extensively *** aromatic moieties in cyclophanes not only facilitate chemical modifications to impart water solubility but also enable forming hydrophobic cavities for guest inclusion in aqueous *** by Koga et al.,who reported the first inclusion complex of cyclophanes in water and solid state,numerous water-soluble cyclophanes,including derivatives of blue box,calixarenes,resorcinarenes,pillararenes,octopusarenes,biphenarenes,coronarenes,and naphthotubes,etc.,have been synthesized and subjected to investigation of the recognition capabilities in aqueous *** review provides an overview of cyclophane receptors designed to bind organic guests in *** categorize them into two classes based on the modifications made to their hydrophobic cavities:those with“exo-functionalized hydrophobic cavities”and those with“endo-functionalized hydrophobic cavities”.We introduce their distinctive features and discuss strategies to enhance recognition affinity and *** review aims to inspire the development of novel synthetic receptors with intriguing properties and foster practical applications of cyclophanes.

关键词： Biomimetic receptor Cyclophane Molecular recognition Hydrophobic effect High-affinity Macrocycles

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Azocalixarenes: a scaffold of universal excipients with high efficiency

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Science China Chemistry 2024年第5期67卷 1697-1706页

作者： Yu-Xin Yue Yi-Lin Lin Meng-Meng Chen Han-Wen Tian Rong Ma Ze-Han Wang Fang-Yuan Chen Yu-Chen Pan dong-sheng guo College of Chemistry State Key Laboratory of Elemento-Organic ChemistryKey Laboratory of Functional Polymer Materials(Ministry of Education)Frontiers Science Center for New Organic MatterCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071China

Excipients are important components of pharmaceutical preparations that affect their quality, safety, and efficacy. Macrocyclic receptors are a family of supramolecular excipients with several advantages, including molecular-level protection, small sizes,fast kinetics of host-guest recognition, and modular construction. With the continuous advances in the medical field, personalized and precision medicine requires the development of excipients with low dosages, integrated modifying effects, universality,and controlled release. To meet these requirements, we have developed a new family of macrocyclic excipients based on calixarenes by integrating their covalent(broad chemical design space) and noncovalent(wide range of substrates) ***, azocalixarenes(Azo CAs) were designed, showing high binding affinities to a broad spectrum of active pharmaceutical ingredients(APIs), selectivity to interferents, and responsiveness to hypoxic microenvironments. Due to their highly efficient and controllable recognition, Azo CAs serve as low-dose excipients for 30 APIs. Molecular encapsulation by Azo CAs results in the integrated modification of the physicochemical properties of APIs, including solubility, stability, bioavailability,and biocompatibility. Moreover, Azo CAs can be reduced by azoreductases overexpressed in hypoxic microenvironments,leading to the controlled release of APIs. Collectively, Azo CA excipients have broad application prospects for a series of diseases such as enteritis, arthritis, stroke, cancer, bacterial infection and kidney injury, with diverse therapeutic modalities,including chemotherapy, photodynamic therapy, photothermal therapy, immunotherapy, boron neutron capture therapy, radiotherapy, fluorescence imaging, and their combinations.

关键词： supramolecular chemistry host-guest systems excipient calixarene molecular recognition

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Supramolecular systems for bioapplications:recent research progress in China

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Science China Chemistry 2024年第5期67卷 1397-1441页

作者： Yue-Yang Liu Xiao-Yong Yu Yu-Chen Pan Hang Yin Shuang Chao Yujie Li He Ma Minzan Zuo Kun-Xu Teng Jun-Li Hou Yong Chen dong-sheng guo Ruibing Wang Yuxin Pei Zhichao Pei Jiang-Fei Xu Xiao-Yu Hu Chunju Li Qing-Zheng Yang Leyong Wang Yu Liu Zhan-Ting Li State Key Laboratory of Organometallic Chemistry Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional MoleculesShanghai Institute of Organic ChemistryChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200032China Department of Chemistry Fudan UniversityShanghai 200438China College of Chemistry State Key Laboratory of Elemento-Organic ChemistryCollaborative Innovation Center of Chemical Science and EngineeringNankai UniversityTianjin 300071China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China College of Chemistry&Pharmacy Northwest A&F UniversityYangling 712100China Key Lab of Organic Optoelectronics&Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of ChemistryTianjin Normal UniversityTianjin 300387China State Key Laboratory of Analytical Chemistry for Life Science Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Supramolecular systems feature dynamic,reversible and stimuli-responsive characteristics,which are not easily achieved by molecular *** last decade has witnessed tremendous advances in the investigations of supramolecular systems for various bioapplications,which include drug delivery,anticancer therapy,antibacterial therapy,photodynamic therapy,photothermal therapy,combination therapy,antidotes for residual drugs or toxins,and bioimaging and ***-guest chemistry has played a key role in the development of such bioactive supramolecular systems,and natural macrocycles(such as cyclodextrins),synthetic macrocycles(such as calixarenes,cucurbit[n]urils,and pillararenes),and porous framework polymers(such as supramolecular organic frameworks and flexible organic frameworks)have been most successfully used as hosts to build different kinds of host-guest systems for attaining designed *** self-assembly of rationally designed amphiphilic molecules,macromolecules and polymers represent another important approach for the construction of supramolecular architectures with advanced *** this review,we summarize the important contributions made by Chinese researchers in this field,with emphasis on those reported in the past five years.

关键词： host-guest chemistry drug delivery anticancer and antibacterial photodynamic therapy photothermal therapy antidote transmembrane channel bioimaging and biosensing

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Hierarchically self-assembled fluorescent nanoparticles for near-infrared lysosome-targeted imaging

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Chinese Chemical Letters 2018年第12期29卷 1709-1710页

作者： dong-sheng guo College of Chemistry State Key Laboratory of Elemento-Organic ChemistryKey Laboratory of Functional Polymer MaterialsMinistry of EducationNankai University Collaborative Innovation Center of Chemical Science and Engineering Nankai University

Manipulating emitting properties of fluorescent dyes plays a critical role in various fields such as light emitting materials, living cell imaging, and phototheranostics [1]. In particular, supramolecular strategies, such as complexation-induced quenching, aggregation-induced emission, have attracted ever-growing attention[2]. Near-infrared (NIR) probes have been demonstrated to possess

关键词： NIR Hierarchically self-assembled fluorescent nanoparticles for near-infrared lysosome-targeted imaging CB

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Exact wave functions for atomic electron interacting with photon fields

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Frontiers of physics 2013年第1期8卷 39-43页

作者： dong-sheng guo State Key Laboratory of Precision Spectroscopy East China Normal University Shanghai 200062 China Permanent address: Department of Physics Southern University and A&M College Baton Rouge LA 70813 USA

Many nonlinear quantum optical physics phenomena need more accurate wave functions and corresponding energy or quasienergy levels to account for. An analytic expression of wave functions with corresponding energy levels for an atomic electron interacting with a photon field is presented as an exact solution to the Schrödinger-like equation involved with both atomic Coulomb interaction and electron-photon interaction. The solution is a natural generalization of the quantum-field Volkov states for an otherwise free electron interacting with a photon field. The solution shows that an Nlevel atom in light form stationary states without extra energy splitting in addition to the Floquet mechanism. The treatment developed here with computing codes can be conveniently transferred to quantum optics in classical-field version as research tools to benefit the whole physics community.

关键词： Volkov-Coulomb problem driven N -level atom exact wave functions and energy levels non-perturbative quantum electrodynamics strong laser fields

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[^(18)F]FDOPA放射标记合成工艺研究进展

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中国新药杂志 2024年第12期33卷 1233-1242页

作者：彭灿董国生李希臣李政韩雨霏张涛南京医科大学药学院核药学系南京211166 南京医科大学核医药临床转化中心南京210029

正电子发射断层扫描(positron emission tomography,PET)放射性示踪剂6-[^(18)F]氟-3,4-二羟基-L-苯丙氨酸([^(18)F]6-fluoro-3,4-dihydroxy-L-phenylalanine,[^(18)F]FDOPA)广泛用于中枢神经系统疾病的多巴胺代谢成像,然而以高产率放射性合成高比活度的[^(18)F]FDOPA极其困难。近年来随着[^(18)F]FDOPA在脑肿瘤、神经内分泌肿瘤和婴儿期局灶性高胰岛素血症等恶性疾病中的广泛应用,迫切需要开发更优的[^(18)F]FDOPA合成方法以满足日益增长的临床需求。该综述总结了[^(18)F]FDOPA放射合成工艺的研究进展,并且详细介绍了由不同放射标记方法所获得[^(18)F]FDOPA的放射性化学产率、比活度、对映体纯度和合成时间,为优化[^(18)F]FDOPA的放射性合成提供参考,以期获得适用于临床研究的高放射性化学放化产率和纯度以及高比活度的[^(18)F]FDOPA。

关键词： 6-[^(18)F]氟-3,4-二羟基-L-苯丙氨酸正电子发射断层扫描放射化学合成放化产率中枢神经系统疾病

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纳米材料中的界面现象

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大学化学 2024年第1期39卷 80-86页

作者：阮文娟李悦郭东升南开大学化学学院天津300071

在课程教学中融入科学前沿实例不仅可以阐明所学基本原理的实际意义,还可以为基本原理的灵活应用提供范例,启发学生独立思考能力。界面化学是物理化学课程中的重要学习内容,但由于在常规尺度的多相体系中界面现象并不显著,学生对该部分... 详细信息

在课程教学中融入科学前沿实例不仅可以阐明所学基本原理的实际意义,还可以为基本原理的灵活应用提供范例,启发学生独立思考能力。界面化学是物理化学课程中的重要学习内容,但由于在常规尺度的多相体系中界面现象并不显著,学生对该部分知识常有忽视。近年来纳米材料已成为国内外研究的热点。纳米材料由于其高界面分子比例而表现出更为显著的界面现象。将界面化学的基本原理应用于纳米材料的研究中,已取得了一系列令人瞩目的成果。本文首先对附加压力、接触角等相关界面现象的基本原理进行梳理,然后分别介绍根据这些基本原理所发展出的分子马达、光控微流控器件、液体门控技术以及超疏水表面四项科技突破。

关键词：界面现象分子马达光控微流控器件液体门控技术超疏水表面

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Conditions for ponderomotive resonances in the Kapitza-Dirac effect

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Frontiers of physics 2015年第5期10卷 75-81页

作者： Chao Yu Jingtao Zhang Zhenrong Sun Ju Gao dong-sheng guo State Key Laboratory of Precision Spectroscopy Department of Physics East China Normal University Shanghai 200062 China Department of Physics Shanghai Normal University Shanghai 200234 China Suzhou Jingpin Advanced Materials Co. Ltd. Jiangsu FOHO Science Park Fenhu Town Suzhou 215211 China School of Physics Peking University Beijing 100871 China

By applying a nonperturbative quantum electrodynamic theory, we study ponderomotive resonances when an electron beam is scattered by a standing photon wave. Our study shows that the pondero- motive parameter Up, the ponderomotive energy per laser-photon energy, for each of the two traveling laser modes possesses a minimum valuehω/（mec2）. Ponderomotive resonances occur only when the ratio of the laser photon energy to the electron rest-mass energy is a fraction, where the denomina- tor is twice the square of a positive integer and the numerator is the total ponderomotive number, which is also a positive integer.

关键词： Kapitza-Dirac effect strong laser physics nonperturbative quantum electrodynamics

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多靶点药物的研究策略及进展

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中国新药杂志 2024年第16期33卷 1665-1675页

作者：李政彭灿李希臣董国生韩雨霏张涛唐立钧南京医科大学药学院核药学系南京211166 南京医科大学核医药临床转化中心南京210029 南京医科大学第一附属医院核医学科南京210029

自19世纪“锁钥模型”提出后,药物研究趋向于单一靶点策略开发并发展至今。然而由于疾病的复杂性,单靶点药物很难达到理想的治疗效果,于是联合给药(“鸡尾酒”疗法)和多靶点药物研究引起了广泛关注。联合给药具有一定的局限性,近年来开... 详细信息

自19世纪“锁钥模型”提出后,药物研究趋向于单一靶点策略开发并发展至今。然而由于疾病的复杂性,单靶点药物很难达到理想的治疗效果,于是联合给药(“鸡尾酒”疗法)和多靶点药物研究引起了广泛关注。联合给药具有一定的局限性,近年来开发同时作用于多个靶点的单一化学实体(多靶点药物)策略受到广泛关注并成为新的研究热点。本文将阐述多靶点药物的开发策略以及研究进展,除普通药物外,本文还将讨论多靶点药物研究策略在核医学与分子影像领域中放射性药物方面的应用。

关键词：单一靶点药物复杂疾病多靶点药物放射性药物核医学与分子影像

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A nonperturbative quantum electrodynamic approach to the theory of laser induced high harmonic generation

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Frontiers of physics 2015年第4期10卷 45-50页

作者： Chao Yu Jingtao Zhang Zhi-Wei Sun Zhenrong Sun dong-sheng guo State Key Laboratory of Precision Spectroscopy Department of Physics East China Normal University Shanghai 200062 China State Key Laboratory of High-field Laser Physics Shanghai Institute of Optical and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China Key Laboratory of Microgravity Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China School of Physics Peking University Beijing 100871 China

Using nonperturbative quantum electrodynamics, we develop a scattering theory for high harmonic generation （HHG）. A transition rate formula for HHG is obtained. Applying this formula, we cal- culate the spectra of high harmonics generated from different noble gases shined by strong laser light. We study the cutoff property of the spectra. The data show that the cutoff orders of high harmonics are greater than that predicted by the ＂3.17＂ cutoff law. As a numerical experiment, the data obtained from our repeated calculations support the newly derived theoretical expression of the cutoff law. The cutoff energy of high harmonics described by the new cutoff law, in terms of the ponderomotive energy Up and the ionization potential energy Ip, is 3.34Up 1.83Ip. The higher cutoff orders predicted by this theory are due to the absorption of the extra photons, which participate only the photon-mode up-conversion and do nothing in the photoionization process.

关键词： high harmonic generation (HHG) cutoff law strong laser physics nonperturbative quantum electrodynamics transition rate formula

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