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World Journal of Emergency Medicine 2024年第3期15卷 223-228页

作者： Ji Ho lee dong hun lee Byung Kook lee Seok Jin Ryu Department of Emergency Medicine Chonnam National University HospitalGwangju 61469Republic of Korea Department of Emergency Medicine Chonnam National University Medical SchoolGwangju 61469Republic of Korea

The global incidence rates of in-hospital cardiac arrest(IHCA)range from1.2 to 9.0 per1,000 hospitalized patients,as per the National Cardiac Arrest Database.[1] While IHCAs tend to exhibit superior 30-day survival rates relative to out-of-hospital cardiac arrests (OHCA) due to situational advantages,such as immediate access to medical personnel and treatments.

关键词： patients cardiac IHC

Sodium nitrite-derived nitric oxide protects rat testes against ischemia/reperfusion injury

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Asian Journal of Andrology 2019年第1期21卷 92-97页

作者： Jae Won lee dong-hun lee Jae Keun Park Jin Soo Han Center for Convergence Bioceramic Materials Korea Institute of Ceramic Engineering and TechnologyChungcheongbuk-do 28160Korea Department of Awan Diseases Laboratory College of Veterinary MedicineKonkuk UniversitySeoul 05029Korea Viral Pathogenesls Section Laboratory of Infectious DiseasesNational Institute of Allergy and infectious DiseasesNational institutes of HealthBethesdaMD 20892USA The institute for the 3Rs & Department of Laboratory Animal Medicine College of Veterinary Medicine and Veterinary Science Research instituteKonkuk UniversitySeoul 05029Korea.

Testicular torsion,a common urologic emergency,is primarily caused by ischemia/reperfusion (I/R)injury of the *** oxide (NO)-derived from nitrite (NO2-)has been reported to have prominent therapeutic effects on I/R injury in the heart,liver,and brain;however,its effects on testicular I/R injury have not been *** study,therefore,investigated whether NO from NO2^-is beneficial in a rat model of testicular I/R injury which eventually results in impaired *** Sprague-Dawley rats were assigned to the following seven groups:group A,sham-operated control group;Group B,I/R with no treatment;Groups C, D,and E,I/R followed by treatment with three different doses of NO2^-;Group F,I/R followed by administration of NO2-and NO scavenger (2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-l-oxyl-3-oxide potassium salt [C-PTIO]);and Group G,I/R followed by administration of nitrate (NO3^-).NO2^-,NO3^-,and C-PTIO were intravenously *** examination of the testes and the western blot analysis of caspase-3 were *** of antioxidant enzymes and lipid peroxidation were measured. Germ cell apoptosis,oxidative stress,antioxidant enzymatic function,and lipid peroxidation in Group B were significantly higher than those in Group *** B exhibited an abnormal testicular morphology and impaired *** contrast,testicular damages were attenuated in the NO2^-treatment groups,which were caused by reduction in superoxide and peroxynitrite levels and an inhibition of caspase-3-dependent *** results of this study suggest NO2^-to be a promising therapeutic agent with anti-oxidant and anti-apoptotic properties in testicular I/R injury.

关键词： ischemia/reperfusion injury nitric oxide nitrite rat testis

The protective roles of integrin α4β7 and Amphiregulin-expressing innate lymphoid cells in lupus nephritis

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Cellular & Molecular Immunology 2024年第7期21卷 723-737页

作者： Seungwon Ryu Kyung Ah Kim Jinwoo Kim dong hun lee Yong-Soo Bae Hajeong lee Byoung Choul Kim Hye Young Kim Department of Microbiology Gachon University College of MedicineIncheon21999South Korea Department of Nano-Bioengineering Incheon National UniversityIncheon22012South Korea Laboratory of Mucosal Immunology Department of Biomedical SciencesSeoul National University College of MedicineSeoul03080South Korea Department of Dermatology Seoul National University College of MedicineSeoul03080South Korea Laboratory of Cutaneous Aging Research Biomedical Research InstituteSeoul National University HospitalSeoul03080South Korea Institute of Human–Environment Interface Biology Medical Research CenterSeoul National UniversitySeoul03080South Korea Department of Biological Sciences SRC Center for Immune Research on Non-lymphoid OrgansSungkyunkwan UniversitySuwon16419South Korea Department of Biological Sciences Sungkyunkwan UniversitySuwon16419South Korea Division of Nephrology Department of Internal MedicineSeoul National University Hospital and Seoul National University College of MedicineSeoul03080South Korea Institute of Allergy and Clinical Immunology Seoul National University Medical Research CenterSeoul National University College of MedicineSeoul03080South Korea

Type 2 innate lymphoid cells (ILC2s) have emerged as key regulators of the immune response in renal inflammatory diseases such as lupus nephritis. However, the mechanisms underlying ILC2 adhesion and migration in the kidney remain poorly understood. Here, we revealed the critical role of integrin α4β7 in mediating renal ILC2 adhesion and function. We found that integrin α4β7 enables the retention of ILC2s in the kidney by binding to VCAM-1, E-cadherin, or fibronectin on structural cells. Moreover, integrin α4β7 knockdown reduced the production of the reparative cytokine amphiregulin (Areg) by ILC2s. In lupus nephritis, TLR7/9 signaling within the kidney microenvironment downregulates integrin α4β7 expression, leading to decreased Areg production and promoting the egress of ILC2s. Notably, IL-33 treatment upregulated integrin α4β7 and Areg expression in ILC2s, thereby enhancing survival and reducing inflammation in lupus nephritis. Together, these findings highlight the potential of targeting ILC2 adhesion as a therapeutic strategy for autoimmune kidney diseases.

关键词： Innate lymphoid cells Tissue residency Adhesion molecules Integrins Kidney Lupus nephritis Amphiregulin

Measles outbreaks in the Kyeongin area of the Republic of Korea,2013-2014:A single-center experience in a country of measles elimination

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Asian Pacific Journal of Tropical Medicine 2017年第1期10卷 67-72页

作者： Sun Hyoung Park dong hun lee Jang Yong Jin Young-Lim Shin Meeyong Shin Sung Shin Kim Won Suk Suh Jae Ock Park Yong Hee Hong Department of Pediatrics College of MedicineSoonchunhyang UniversityBucheon HospitalBucheonRepublic of Korea

Objective: To identify the source of infection and determine the clinical features and laboratory finding of measles infection,Methods: In 27 measles patients,except for 3 adult patients,the rest of 24 pediatric measles cases were analyzed with regard to age,sex,immunization status,transmission routes and molecular genotyping of measles virus,Eighteen measles patients who admitted in isolation ward were set apart to investigate clinical findings and its correlation with laboratory characteristics,Retrospective analysis of cases was conducted in this study,Results: Of the 24 pediatric patients,23(95.8%) had not received any measles-containing vaccine(MCV),Sixteen of the patients(66.7%) were aged <12 months,The suspicious index case of a girl aged 34 months was not vaccinated with MCV1 and got measles after a trip to Philippines,and molecular genotype was revealed as B3,Measles outbreaks in the community such as a restaurant were followed by this one imported case,According to analysis of 18 patients admitted in isolation ward,the median level of C-reactive protein(CRP) was 0.38 mg/d L and that of lactate dehydrogenase(LDH) was 1 200 IU/L,All of the 18 patients had LDH levels above the normal range,Age correlated with CRP(ρ = 0.528,P = 0.024) and LDH(ρ = 0.501,P = 0.034),The duration of fever was correlated with the duration of fever before rash(ρ = 0.898,P < 0.01),The duration of hospitalization was correlated with CRP(ρ = 0.586,P = 0.011),The white blood cell counts were correlated with the levels of LDH(ρ = 0.505,P = 0.033),aspartate aminotransferase(ρ = 0.507,P = 0.032),and alanine aminotransferase(ρ = 0.481,P = 0.043),Conclusions: Early weaning of maternally derived measles antibodies therefore vaccination of MCV1 at a young age from 9 months to 12 months should be considered in situations of early exposure,Furthermore there is a call for consideration of scheduling an earlier age for the first dose of MMR vaccine in Europe,It is necessary for Korea to investigat

关键词： Measles Disease outbreaks Pediatrics

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑Hee lee Byoungjoon Hwang Sojung Seo Ji‑hun Seo dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

Ru/NiMnB spherical cluster pillar for highly proficient green hydrogen electrocatalyst at high current density

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Journal of Energy Chemistry 2025年第1期100卷 397-408页

作者： Md Ahasan Habib Shusen Lin Mehedi Hasan Joni Sumiya Akter Dristy Rutuja Mandavkar Jae-hun Jeong Jihoon lee Department of Electronic Engineering College of Electronics and Information Kwangwoon University

Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen ***,Ru/NiMnB spherical cluster pillar （SCP）,denoted as Ru/NiMnB,is synthesized using a combination of electro-deposition and hydrothermal *** investigation of Ru doping in the NiMnB matrix revealed significant improvements in electrocatalytic *** Ru/NiMnB SCPs demonstrate superior OER/HER activity with low overpotentials of 150 and 103 mV at 50mA/cm2in 1 M KOH,making them highly competitive with state-of-the-art ***,the Ru/NiMnB SCPs exhibit a low 2-E cell voltage of 2.80 V at ultra-high current density of 2,000 m A/cm2in 1 M KOH,outperforming the standard benchmark electrodes of RuO2||Pt/C,thereby positioning Ru/NiMnB as one of the best bifunctional *** SCPs exhibit exceptional high-current characteristics,stability and corrosion resistance,as evidenced by continuous operation at 1,000 mA/cm2high-current density for over 150 h in 6 M KOH at elevated temperatures under harsh industrial *** a small amount of Ru incorporation significantly enhances the electrocatalytic performances of NiMnB,attributed to increased active sites and improved intrinsic properties such as conductivity,adsorption/desorption capability and reaction ***,Ru/NiMnB SCPs present a promising bi-functional electrode concept for efficient green H2production.

关键词： Advanced electrocatalyst High current Corrosion resistance Industrial requirement

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-hun lee Dan Cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

NUMERICAL SIMULATION OF SKIMMING FLOW OVER MILD STEPPED CHANNEL

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Journal of Hydrodynamics 2006年第3期18卷 367-371页

作者： dong Zhi-yong lee Joseph hun-wei School of Civil and Architecture Engineering Zhejiang University of Technology Hangzhou 310014 China Department of Civil Engineering The University of Hong Kong Hong Kong China

Numerical simulation of stepped channel flow was conducted using turbulence models based on the VOF technique. Stepped channel flow is a complicated air-water two-phase flow with free surface, which can be divided into three flow regimes： skimming flow, nappe flow and transition flow. The characteristics of skimming flow over mild stepped channel was investigated, including friction factors, air concentration profiles velocity field, clear-water and bulked depths, static pressure, etc. Smooth channel flow was also simulated to compare the hydraulic characteristics of the stepped channel flow with the smooth one. Comparisons between the computed and the measured were made. Furthermore, comparison of the computed air concentration with Straub and Anderson＇s data was also performed. The Fluent 6.1 software was employed to conduct this numerical simulation work.

关键词： numerical simulation skimming flow stepped channel Volume Of Fluid (VOF) technique

Cloning of heat shock protein genes from the brown planthopper, Nilaparvata lugens, and the small brown planthopper, Laodelphax striatellus, and their expression in relation to thermal stress

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Insect Science 2008年第5期15卷 415-422页

作者： dong hun Kim Sang-Chul lee Do-Yeon Kwak Kyeong-Yeoll lee School of Applied Biosciences College of Agricultura and Life Sciences Kyungpook National University Daegu Yeongnam Agricultural Research Institute Milyang Republic of Korea

Three heat shock protein （HSP） genes （hsp70, hsc70, hsp90） were partially cloned from the brown planthopper Nilaparvata lugens and the small brown planthopper Laodelphax striatellus （Homoptera： Delphacidae）, which are serious pests of the rice plant. Sequence comparisons at the deduced amino acid level showed that the three HSPs of planthoppers were most homologous to corresponding HSPs of dipteran and lepidopteran species. Identities of both heat shock cognate 70 and HSP90 were higher than HSP70 in both species. Identity of the HSP70 between the two planthopper species was only 81%, a value much lower than seen among fly and moth groups. Effects of heat and cold shocks were demonstrated on expression of the three hsp genes in the two planthopper species. Heat shock （40 ℃） upregulated the hsp90 level but did not change the hsc70 level in either the nymph and adult stages of either species. On the other hand, the hsp70 level was only upregulated in L. striatellus. This heat shock response was prompt and lasted only for 1 h after treatment. In contrast, cold shock at 4℃ did not change the expression levels of any hsp in either species.

关键词： cold shock gene expression heat shock heat shock protein genes planthoppers thermal stress

Enhanced Oxidation Resistance of Iron Nanoparticles via Surface Modification in Chemical Vapor Condensation Process

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Journal of Materials Science & Technology 2010年第4期26卷 367-370页

作者： dong-Won lee Ji-hun Yu Taesuk Jang Byoung-Kee Kim Korea Institute of Materials Science Changwon 641-831 Korea Department of Electronic Materials Sunmoon University Asan 336-708 Korea 不详

In order to prevent the oxide formation on the surface of nano-size iron particles and thereby to improve the oxidation resistance in ordinary condition, iron nanoparticles synthesized by a chemical vapor condensation method were directly soaked in hexadecanethiol solution to coat them with a polymer layer. Oxygen content in the polymer-coated iron nanoparticles was significantly lower than that in usual air-passivated particles possessing iron-core/oxide-shell structure. Accordingly, oxidation resistance of the polymer-coated particles at an elevated temperature below 130℃ in air was 10-40 times higher than that of the normally passivated particles.

关键词： Powder technology Nano materials Iron Chemical vapor condensation