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The Journal of Biomedical Research 2024年第1期38卷 87-91页

作者： Qian Gu Qin Wang Rui Hua Wenhao Zhang Jianzhen Teng Jiazheng Ma zhou dong Xiaoxuan Gong Chunjian Li Department of Cardiology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

Dear Editor,Cardiovascular disease is the leading cause of deaths worldwide,with coronary artery disease(CAD)accounting for approximately 50%of its *** antiplatelet therapy,including aspirin and a P2Y12 inhibitor,is the most important treatment for CAD patients undergoing percutaneous coronary intervention(PCI)to prevent recurrent ischemic events and cardiac *** is one of the commonly used P2Y12 ***,up to 30%of patients treated with a standard dose of clopidogrel present with high on-treatment platelet reactivity(HOPR),which is associated with the increased ischemic risks[1].The causes of HOPR are multifactorial and complex.

关键词： coronary patients mortality

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人工智能时代教师的身份镜像:困境与建构

中国远程教育 2024年第4期44卷 81-93页

作者：周东华中师范大学人工智能教育学部武汉430079

人工智能以技术驱动显著地重塑了传统教育情境,也给教师身份镜像的映射及建构带来了困境,从自我镜像、环境生态、自我实现等角度挑战着教师的身份认同。为破解这一困局,促进人工智能时代教师身份的建构,基于自我镜像及教师身份镜像的内... 详细信息

人工智能以技术驱动显著地重塑了传统教育情境,也给教师身份镜像的映射及建构带来了困境,从自我镜像、环境生态、自我实现等角度挑战着教师的身份认同。为破解这一困局,促进人工智能时代教师身份的建构,基于自我镜像及教师身份镜像的内涵,采用理论分析法分析了人工智能所带来的教育变革及影响,创新性地提出,人工智能时代的教师身份应建构为:努力实现自我价值的教育者、积极探索生态建构的研究者和能动推进专业发展的学习者。最后从教师个体、教育生态等角度提出应对之策:教师要能动参与人机协同,创新自我实现路径,在变化发展中动态建构身份镜像,同时教育部门、各级学校及社会各界应合力重塑教育生态,赋权增能教师发展,营造良好环境氛围。

关键词：人工智能教师教育情境身份镜像建构策略

Frequency and risk factors of psychological distress among individuals with epilepsy before and during the outbreak of the SARS-CoV-2 Omicron variant in China:an online questionnaire survey

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Acta Epileptologica 2024年第1期7卷 36-43页

作者： Xiaoting Hao Qi Zhang Chenxi Zhong Enzhi Li Yingqi Jiang Jiajun Xu Yuanyuan Li dong zhou Bo Yan Department of Neurology West China HospitalSichuan University No37 Guoxue AlleyChengduSichuan Province610000China Department of Psychiatry and Mental Health West China HospitalSichuan University/West China School of Clinical MedicineSichuan UniversityChengdu610000China Department of Neurology Chengdu Shangjin Nanfu HospitalChengdu611730China West China School of Nursing Sichuan University Chengdu610000China Department of Clinical Research Management West China HospitalSichuan UniversityChengdu610000China

Background The COVID-19 pandemic substantially increases the risk of severe psychological distress among people with epilepsy(PWE),especially those with monthly household income12 should consult a psychiatrist,especially during major *** study was aimed to compare the frequency of psychological distress among Chinese PWE before and during the outbreak of the SARS-CoV-2 Omicron variant,and to identify risk factors for such *** In this prospective study,we collected sociodemographic data of PWE aged>14 years,who were treated at our center during December 1 to 15,*** participants completed the 6-item Kessler Psychological Distress Scale before the outbreak and again during the *** visitors who were unrelated to those patients during the outbreak were included as a *** logistic regression analysis was performed to identify risk factors of severe psychological distress and its *** Of the 223 PWE,127 were tested positive for SARS-CoV-2,while 174 of 218 controls were positive for *** neurological symptoms were similar between PWE and controls with *** average Kessler score of PWE was significantly higher during the outbreak than before it(9.93±3.98 vs.8.52±0.23,P<0.001).The average score of controls during the outbreak(5.146±0.35,P<0.001)was significantly lower than that of the *** identified three independent predictors for severe psychological distress in PWE during the outbreak,i.e.,monthly household income<5000 RMB(OR=0.252,95%CI 0.064–0.998,P=0.048),severe psychological distress before the outbreak(OR=0.067,95%CI 0.026–0.174,P<0.001),and seizure onset within 30 days before the assessment during the outbreak(OR=0.356,95%CI 0.157–0.805,P=0.013).Of the three predictors,the last one was also an independent predictor for exacerbation of psychological distress during the outbreak(OR=0.302,95%CI 0.123–0.741,P

关键词： Epilepsy Neurological symptoms Psychological distress COVID-19 pandemic

Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1768-1776页

作者： Hang Chi Suo-Qun Zhao Ru-Yi Chen Xing-Xing Suo Rong-Rong Zhang Wen-Hui Yang dong-Sheng zhou Min Fang Bo Ying Yong-Qiang Deng Cheng-Feng Qin State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMS100071BeijingChina College of Life Sciences Inner Mongolia Agricultural UniversityHohhot010018Inner MongoliaChina School of Life Sciences Henan UniversityKaifeng475004HenanChina Suzhou Abogen Biosciences Co. LtdSuzhou215123JiangsuChina Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical Sciences100071BeijingChina

The Orthopoxvirus genus,especially variola virus(VARV),monkeypox virus(MPXV),remains a significant public health threat *** development of therapeutic antibodies against orthopoxviruses is largely hampered by the high cost of antibody engineering and manufacturing ***-encoded antibodies have emerged as a powerful and universal platform for rapid antibody ***,by using the established lipid nanoparticle(LNP)-encapsulated mRNA platform,we constructed four mRNA combinations that encode monoclonal antibodies with broad neutralization activities against *** vivo characterization demonstrated that a single intravenous injection of each LNP-encapsulated mRNA antibody in mice resulted in the rapid production of neutralizing *** importantly,mRNA antibody treatments showed significant protection from weight loss and mortality in the vaccinia virus(VACV)lethal challenge mouse model,and a unique mRNA antibody cocktail,Mix2a,exhibited superior in vivo protection by targeting both intracellular mature virus(IMV)-form and extracellular enveloped virus(EEV)-form *** summary,our results demonstrate the proof-of-concept production of orthopoxvirus antibodies via the LNP-mRNA platform,highlighting the great potential of tailored mRNA antibody combinations as a universal strategy to combat orthopoxvirus as well as otheremerging viruses.

关键词： proof universal neutral

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液晶在气体传感领域的研究进展

液晶与显示 2024年第3期39卷 369-383页

作者：周冬刘永军哈尔滨工程大学物理与光电工程学院光纤集成光学教育部重点实验室黑龙江哈尔滨150001

基于液晶的气体传感器是一个新兴的研究领域。液晶本身具有化学多样性、可逆的分子排列和固有的自组装能力,可以满足传感器高灵敏度、快速响应、低能耗和选择性等要求。随着相关研究的深入,液晶气体传感方法也不断被完善。本文回顾了近... 详细信息

基于液晶的气体传感器是一个新兴的研究领域。液晶本身具有化学多样性、可逆的分子排列和固有的自组装能力,可以满足传感器高灵敏度、快速响应、低能耗和选择性等要求。随着相关研究的深入,液晶气体传感方法也不断被完善。本文回顾了近几年基于液晶的气体传感技术,讨论了现有液晶气体传感技术的检测方法,主要包括向列相液晶的气体检测方法和胆甾相液晶的气体传感方法。向列相液晶的气体传感包括功能化基板的液晶膜传感、特性几何形貌的液晶传感和液晶液滴传感方法。胆甾相液晶的气体传感主要包括聚合物胆甾相液晶膜的气体传感、液晶液滴传感、基于光纤的气体检测以及纤维素气体传感。最后对液晶气体传感的应用和发展进行了阐述。

关键词：气体传感向列相液晶胆甾相液晶

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链上共有股东与企业商业信用融资

经济管理 2024年第7期46卷 146-167页

作者：周冬华周思阳江西财经大学会计学院江西南昌330013 中南财经政法大学会计学院湖北武汉430073

通过社会网络资源寻求资金支持已成为企业缓解融资约束问题的重要途径之一。本文以2009—2021年沪深A股上市企业为样本,基于产业链内纵向股权关联视角,深入考察了链上共有股东对企业商业信用融资的影响。研究发现,链上共有股东通过改善... 详细信息

通过社会网络资源寻求资金支持已成为企业缓解融资约束问题的重要途径之一。本文以2009—2021年沪深A股上市企业为样本,基于产业链内纵向股权关联视角,深入考察了链上共有股东对企业商业信用融资的影响。研究发现,链上共有股东通过改善企业信息环境和提高外部信任水平,显著增强了企业商业信用融资能力。进一步区分共有股东持股方向发现,链上共有股东同时持股上游企业能够通过信息和信任双重渠道提升企业应付类商业信用融资水平;而链上共有股东同时持股下游企业主要通过改善企业与客户之间的相互信任程度,进而提升企业预收类商业信用融资水平。在行业竞争平缓、地区法制环境良好以及地区信贷供给不足的企业中,链上共有股东对商业信用融资的提升作用更强;而相较于其他类型投资者,机构型共有股东能显著提升企业商业信用融资能力。本文不仅对链上共有股东这一新兴市场角色进行了深入剖析,也为如何缓解企业融资约束问题提供了可能的解决路径,研究结论对优化产业链资源配置以及促进企业高质量发展具有参考价值。

关键词：链上共有股东商业信用融资信息机制信任机制

Roadmap for rechargeable batteries:present and beyond

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Science China Chemistry 2024年第1期67卷 13-42页

作者： Sen Xin Xu Zhang Lin Wang Haijun Yu Xin Chang Yu-Ming Zhao Qinghai Meng Pan Xu Chen-Zi Zhao Jiahang Chen Huichao Lu Xirui Kong Jiulin Wang Kai Chen Gang Huang Xinbo Zhang Yu Su Yao Xiao Shu-Lei Chou Shilin Zhang Zaiping Guo Aobing Du Guanglei Cui Gaojing Yang Qing Zhao Liubing dong dong zhou Feiyu Kang Hu Hong Chunyi Zhi Zhizhang Yuan Xianfeng Li Yifei Mo Yizhou Zhu dongfang Yu Xincheng Lei Jianxiong Zhao Jiayi Wang dong Su Yu-Guo Guo Qiang Zhang Jun Chen Li-Jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences.Beijing 100049 China Institute of Advanced Battery Materials and Devices Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Key Laboratory of Advanced Functional Materials Ministry of EducationBeijing University of TechnologyBeijing 100124China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of Chemistry and Utilization of Carbon-Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China Department of Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChangchun 130022China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaide 5000Australia Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Frontiers Science Center for New Organic Matter Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education)College of ChemistryNankai UniversityTianjin 300071China College of Chemistry and Materials Science Jinan UniversityGuangzhou 511443China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Division of Energy Storage Dalian National Laboratory for Clean Energy(DNL)Dalian Institute of Chem

Rechargeable batteries currently hold the largest share of the electrochemical energy storage market,and they play a major role in the sustainable energy transition and industrial decarbonization to respond to global climate *** to the increased popularity of consumer electronics and electric vehicles,lithium-ion batteries have quickly become the most successful rechargeable batteries in the past three decades,yet growing demands in diversified application scenarios call for new types of rechargeable *** efforts are made to developing the next-generation post-Li-ion rechargeable batteries,which include,but are not limited to solid-state batteries,lithium–sulfur batteries,sodium-/potassium-ion batteries,organic batteries,magnesium-/zinc-ion batteries,aqueous batteries and flow *** the great achievements,challenges persist in precise understandings about the electrochemical reaction and charge transfer process,and optimal design of key materials and interfaces in a *** roadmap tends to provide an overview about the current research progress,key challenges and future prospects of various types of rechargeable *** computational methods for materials development,and characterization techniques will also be discussed as they play an important role in battery research.

关键词： energy storage rechargeable batteries battery materials electrochemistry

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面向空间视觉目标检测的对抗攻击与防御算法

控制与决策 2024年第7期39卷 2161-2168页

作者：周栋孙光辉吴立刚哈尔滨工业大学航天学院哈尔滨150001

随着航天航空技术的发展,空间目标视觉检测技术作为航天器智能在轨服务的重要技术支撑,获得了国内外研究学者的广泛关注.考虑到太空中恶劣的光照条件以及未知的动态场景,空间目标视觉检测的鲁棒性问题亟待深入研究.首先,提出一种黑盒迁... 详细信息

随着航天航空技术的发展,空间目标视觉检测技术作为航天器智能在轨服务的重要技术支撑,获得了国内外研究学者的广泛关注.考虑到太空中恶劣的光照条件以及未知的动态场景,空间目标视觉检测的鲁棒性问题亟待深入研究.首先,提出一种黑盒迁移实例攻击方法,将图像识别领域的对抗样本攻击方法应用于空间目标检测任务,实现对EfficientDet目标检测模型的欺骗攻击;同时,提出一种协同防御策略,将对抗训练和SRMNet去噪器相结合,有效增强目标检测模型的鲁棒性.实验结果表明,所提出防御策略不仅能够成功抵御对抗样本攻击,还能取得高于原始空间目标检测模型的检测精度.

关键词：空间目标视觉检测黑盒迁移实例攻击对抗训练 SRMNet

短视频平台土木类专业就业文化探析——以B站UP主“大猛子ym”的视频评论为例

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高校辅导员学刊 2024年第2期16卷 80-85,99,100页

作者：周栋华侨大学学生处福建厦门361021

短视频平台土木类专业就业文化传播现象,已经影响了青年的就业选择和生涯规划,形成了以身份、价值、内容和行为为要素的四组对比强烈的符号,其成因主要为专业认知、身份认可、行业认同的迷失和自我宣泄、群体失意、流量至上的狂欢。要... 详细信息

短视频平台土木类专业就业文化传播现象,已经影响了青年的就业选择和生涯规划,形成了以身份、价值、内容和行为为要素的四组对比强烈的符号,其成因主要为专业认知、身份认可、行业认同的迷失和自我宣泄、群体失意、流量至上的狂欢。要破解青年土木人的困境,需要从个体、高校、行业、媒介和政府五个层面入手,多管齐下,共同施策,才能促使青年成长成才,勇担大任。

关键词：土木类专业就业文化短视频

甘肃省土地利用碳排放时空演变特征及影响因素

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环境科学 2024年第9期45卷 5040-5048页

作者：李梓赫周冬梅江晶马静朱小燕石鹏张军 dong Qing-han 甘肃农业大学资源与环境学院兰州730070 甘肃农业大学管理学院兰州730070 甘肃省节水农业工程技术研究中心兰州730070 Flemish Institute for Technological Research(VITO) Boeretang 2002400 MolBelgium

陆地生态系统是世界上最大的碳汇,而土地利用变化是导致区域碳排放变化的主要影响因素之一,通过对2000~2020年甘肃省土地利用碳排放时空演变特征和影响因素研究,为促进甘肃省土地低碳利用、低碳经济发展提供一定科学依据与参考.采用土... 详细信息

陆地生态系统是世界上最大的碳汇,而土地利用变化是导致区域碳排放变化的主要影响因素之一,通过对2000~2020年甘肃省土地利用碳排放时空演变特征和影响因素研究,为促进甘肃省土地低碳利用、低碳经济发展提供一定科学依据与参考.采用土地利用数据,结合温室气体排放系数法,研究甘肃省市域尺度土地利用碳排放增长趋势与省域尺度时空演变特征,并通过主成分分析研究其控制因素.结果表明:①2000~2020年甘肃省土地利用碳排放整体为增加趋势,由2428.93万t升至5773.96万t,其中2000~2014年第一阶段为显著增加阶段,2014~2020年第二阶段为稳定且略有降低阶段.建设用地为主要碳源,碳源强度仍呈增加态势.②空间上表现为“东高西低”的特征,河东碳排放量明显高于河西碳排放量.③根据排放特征将甘肃省划分为缓慢增长型、较慢增长型、中速增长型、较快增长型和迅猛增长型5类碳排放类型区.④经济发展水平、土地利用程度与能源消费是导致甘肃省土地利用碳排放不断增加的主要原因.

关键词：土地利用碳排放时空特征主成分分析甘肃省